Leprosy among patient contacts: a multilevel study of risk factors

Detalhes bibliográficos
Autor(a) principal: Sales, Anna M.
Data de Publicação: 2011
Outros Autores: Ponce de Leon, Antonio, Düppre, Nádia C., Hacker, Mariana A., Nery, José Augusto C., Sarno, Euzenir N., Penna, Maria L. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16785
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
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spelling Sales, Anna M.Ponce de Leon, AntonioDüppre, Nádia C.Hacker, Mariana A.Nery, José Augusto C.Sarno, Euzenir N.Penna, Maria L. F.2017-01-10T16:01:30Z2017-01-10T16:01:30Z2011SALES, Anna M. et al. Leprosy among Patient Contacts: A Multilevel Study of Risk Factors. PLoS Negl Trop Dis., v.5, n.3, e1013, 6p, Mar. 2011.1935-2727https://www.arca.fiocruz.br/handle/icict/1678510.1371/journal.pntd.00010131935-2735engPublic Library of ScienceHanseníaseFatores de RiscoLeprosyRisk FactorsLeprosy among patient contacts: a multilevel study of risk factorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Departamento de Epidemiologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Departamento de Epidemiologia. Rio de Janeiro, RJ, BrasilBackground: This study aimed to evaluate the risk factors associated with developing leprosy among the contacts of newlydiagnosed leprosy patients. Methodology/Principal Findings: A total of 6,158 contacts and 1,201 leprosy patients of the cohort who were diagnosed and treated at the Leprosy Laboratory of Fiocruz from 1987 to 2007 were included. The contact variables analyzed were sex; age; educational and income levels; blood relationship, if any, to the index case; household or non-household relationship; length of time of close association with the index case; receipt of bacillus Calmette-Gue´rin (BGG) vaccine and presence of BCG scar. Index cases variables included sex, age, educational level, family size, bacillary load, and disability grade. Multilevel logistic regression with random intercept was applied. Among the co-prevalent cases, the leprosy-related variables that remained associated with leprosy included type of household contact, [odds ratio (OR) = 1.33, 95% confidence interval (CI): 1.02, 1.73] and consanguinity with the index case, (OR = 1.89, 95% CI: 1.42–2.51). With respect to the index case variables, the factors associated with leprosy among contacts included up to 4 years of schooling and 4 to 10 years of schooling (OR = 2.72, 95% CI: 1.54–4.79 and 2.40, 95% CI: 1.30–4.42, respectively) and bacillary load, which increased the chance of leprosy among multibacillary contacts for those with a bacillary index of one to three and greater than three (OR = 1.79, 95% CI: 1.19–2.17 and OR: 4.07–95% CI: 2.73, 6.09), respectively. Among incident cases, household exposure was associated with leprosy (OR = 1.96, 95% CI: 1.29–2.98), compared with non-household exposure. Among the index case risk factors, an elevated bacillary load was the only variable associated with leprosy in the contacts. Conclusions/Significance: Biological and social factors appear to be associated with leprosy among co-prevalent cases, whereas the factors related to the infectious load and proximity with the index case were associated with leprosy that appeared in the incident cases during follow-up.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16785/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjoseaugusto_nery_etal_IOC_2011.pdfjoseaugusto_nery_etal_IOC_2011.pdfapplication/pdf107396https://www.arca.fiocruz.br/bitstream/icict/16785/2/joseaugusto_nery_etal_IOC_2011.pdf7b988b47b0af68daf5ca4ff1925291dfMD52TEXTjoseaugusto_nery_etal_IOC_2011.pdf.txtjoseaugusto_nery_etal_IOC_2011.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Leprosy among patient contacts: a multilevel study of risk factors
title Leprosy among patient contacts: a multilevel study of risk factors
spellingShingle Leprosy among patient contacts: a multilevel study of risk factors
Sales, Anna M.
Hanseníase
Fatores de Risco
Leprosy
Risk Factors
title_short Leprosy among patient contacts: a multilevel study of risk factors
title_full Leprosy among patient contacts: a multilevel study of risk factors
title_fullStr Leprosy among patient contacts: a multilevel study of risk factors
title_full_unstemmed Leprosy among patient contacts: a multilevel study of risk factors
title_sort Leprosy among patient contacts: a multilevel study of risk factors
author Sales, Anna M.
author_facet Sales, Anna M.
Ponce de Leon, Antonio
Düppre, Nádia C.
Hacker, Mariana A.
Nery, José Augusto C.
Sarno, Euzenir N.
Penna, Maria L. F.
author_role author
author2 Ponce de Leon, Antonio
Düppre, Nádia C.
Hacker, Mariana A.
Nery, José Augusto C.
Sarno, Euzenir N.
Penna, Maria L. F.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sales, Anna M.
Ponce de Leon, Antonio
Düppre, Nádia C.
Hacker, Mariana A.
Nery, José Augusto C.
Sarno, Euzenir N.
Penna, Maria L. F.
dc.subject.other.pt_BR.fl_str_mv Hanseníase
Fatores de Risco
topic Hanseníase
Fatores de Risco
Leprosy
Risk Factors
dc.subject.en.pt_BR.fl_str_mv Leprosy
Risk Factors
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2017-01-10T16:01:30Z
dc.date.available.fl_str_mv 2017-01-10T16:01:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SALES, Anna M. et al. Leprosy among Patient Contacts: A Multilevel Study of Risk Factors. PLoS Negl Trop Dis., v.5, n.3, e1013, 6p, Mar. 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16785
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0001013
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv SALES, Anna M. et al. Leprosy among Patient Contacts: A Multilevel Study of Risk Factors. PLoS Negl Trop Dis., v.5, n.3, e1013, 6p, Mar. 2011.
1935-2727
10.1371/journal.pntd.0001013
1935-2735
url https://www.arca.fiocruz.br/handle/icict/16785
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/16785/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/16785/2/joseaugusto_nery_etal_IOC_2011.pdf
https://www.arca.fiocruz.br/bitstream/icict/16785/3/joseaugusto_nery_etal_IOC_2011.pdf.txt
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