Cardiac beta-receptors in experimental Chagas' disease

• Autor(a) principal: Enders, Julio E.
• Data de Publicação: 1995
• Outros Autores: Paglini, Patricia, Fernandez, Alicia R., Marco, Fernanda, Palma, José A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
• Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/29231
• topic: Chagas' disease; beta receptors

Experimental Chagas' disease (45 to 90 days post-infection) showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase). Chagasic infection did not change the beta receptors density (78.591 &plusmn; 3.125 fmol/mg protein and 73.647 &plusmn; 2.194 fmol/mg protein for controls) but their affinity was significantly diminished (Kd = 7.299 &plusmn; 0.426 nM and Kd = 3.759 &plusmn; 0.212 nM for the control) p < 0.001. This results demonstrate that the alterations in pharmacological response previously reported in chagasic myocardium are related to a significantly less beta cardiac receptor affinity. During this experimental period serious cardiac cell alterations take place and functional consequences will be detected in the chronic phase.