Cardiac beta-receptors in experimental Chagas' disease
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/29231 |
Resumo: | Experimental Chagas' disease (45 to 90 days post-infection) showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase). Chagasic infection did not change the beta receptors density (78.591 ± 3.125 fmol/mg protein and 73.647 ± 2.194 fmol/mg protein for controls) but their affinity was significantly diminished (Kd = 7.299 ± 0.426 nM and Kd = 3.759 ± 0.212 nM for the control) p < 0.001. This results demonstrate that the alterations in pharmacological response previously reported in chagasic myocardium are related to a significantly less beta cardiac receptor affinity. During this experimental period serious cardiac cell alterations take place and functional consequences will be detected in the chronic phase. |
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Revista do Instituto de Medicina Tropical de São Paulo |
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Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental Chagas' diseasebeta receptors Experimental Chagas' disease (45 to 90 days post-infection) showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase). Chagasic infection did not change the beta receptors density (78.591 ± 3.125 fmol/mg protein and 73.647 ± 2.194 fmol/mg protein for controls) but their affinity was significantly diminished (Kd = 7.299 ± 0.426 nM and Kd = 3.759 ± 0.212 nM for the control) p < 0.001. This results demonstrate that the alterations in pharmacological response previously reported in chagasic myocardium are related to a significantly less beta cardiac receptor affinity. During this experimental period serious cardiac cell alterations take place and functional consequences will be detected in the chronic phase. Estudaram-se os receptores beta cardíacos de camundongos infectados pelo Trypanosoma cruzi na fase pós-aguda da doença de Chagas para estabelecer em que medida os mesmos contribuem a gerar respostas anômalas às catecolaminas observadas nestes miocardios. Utilizara-se 3-H/DHA para a marcação dos receptores beta cardíacos dos camundongos normais e dos infectados na fase pós-aguda (45 a 90 dias pós-infecção). O número dos sítios de fixação foi similar nos dois grupos, 78.591 ± 3.125 fmol/mg. Proteína nos chagásicos e 73.647 ± 2.194 fmol/mg. Proteína no grupo controle. Em vez disso, a afinidade verificou-se significativamente diminuida no grupo chagásico (Kd = 7.299 ± 0.426 nM) respeito do controle (Kd = 3.759 ± 0.212 nM) p < 0.001. Os resultados obtidos demonstram que as modificações observadas na estimulação adrenérgica do miocárdio chagásico se correlacionam com a menor afinidade dos receptores beta cardíacos e que estas alterações exerceriam uma parte determinante para as consequências funcionais que são detectadas na fase crônica. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1995-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/29231Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 1 (1995); 59-63 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 1 (1995); 59-63 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 1 (1995); 59-63 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/29231/31088Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessEnders, Julio E.Paglini, PatriciaFernandez, Alicia R.Marco, FernandaPalma, José A.2012-07-02T01:39:39Zoai:revistas.usp.br:article/29231Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:58.962030Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental |
title |
Cardiac beta-receptors in experimental Chagas' disease |
spellingShingle |
Cardiac beta-receptors in experimental Chagas' disease Enders, Julio E. Chagas' disease beta receptors |
title_short |
Cardiac beta-receptors in experimental Chagas' disease |
title_full |
Cardiac beta-receptors in experimental Chagas' disease |
title_fullStr |
Cardiac beta-receptors in experimental Chagas' disease |
title_full_unstemmed |
Cardiac beta-receptors in experimental Chagas' disease |
title_sort |
Cardiac beta-receptors in experimental Chagas' disease |
author |
Enders, Julio E. |
author_facet |
Enders, Julio E. Paglini, Patricia Fernandez, Alicia R. Marco, Fernanda Palma, José A. |
author_role |
author |
author2 |
Paglini, Patricia Fernandez, Alicia R. Marco, Fernanda Palma, José A. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Enders, Julio E. Paglini, Patricia Fernandez, Alicia R. Marco, Fernanda Palma, José A. |
dc.subject.por.fl_str_mv |
Chagas' disease beta receptors |
topic |
Chagas' disease beta receptors |
description |
Experimental Chagas' disease (45 to 90 days post-infection) showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase). Chagasic infection did not change the beta receptors density (78.591 ± 3.125 fmol/mg protein and 73.647 ± 2.194 fmol/mg protein for controls) but their affinity was significantly diminished (Kd = 7.299 ± 0.426 nM and Kd = 3.759 ± 0.212 nM for the control) p < 0.001. This results demonstrate that the alterations in pharmacological response previously reported in chagasic myocardium are related to a significantly less beta cardiac receptor affinity. During this experimental period serious cardiac cell alterations take place and functional consequences will be detected in the chronic phase. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29231 |
url |
https://www.revistas.usp.br/rimtsp/article/view/29231 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29231/31088 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 1 (1995); 59-63 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 1 (1995); 59-63 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 1 (1995); 59-63 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
_version_ |
1798951641099010048 |