Histological and immunohistochemical aspects of cutaneous leishmaniasis in nicaragua

Detalhes bibliográficos
Autor(a) principal: Mariscotti, Cesare
Data de Publicação: 1987
Outros Autores: Barbareschi, Mattia, Missoni, Eduardo, Morelli, Rosella, Guevara, Uriel, Munguia-Barrera, Juan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28521
Resumo: Sixty skin biopsies of fifty-eight non-treated patients with cutaneous leishmaniasis from Nicaragua were studied. Biopsies were classified according to Ridley's histopathologic groups: 36 (60%) were included in group B (diffuse necrosis), 14 in group C (focal necrosis), 7 (11.6%) in group D (reactive tuberculoid). Only three biopsies remained unclassified. None of our cases could be included in groups A and E. Immunohistochemistry disclosed in 17 cases Russel's bodies secreting IgM and only one IgG positive. There was no correlation between the histopathologic groups and the presence of Russel's bodies. However, we believe the presence of Russel's bodies help the diagnosis of leishmaniasis. Correlation between morphological patterns and the different leishmania species was also considered.
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spelling Histological and immunohistochemical aspects of cutaneous leishmaniasis in nicaragua Aspectos histológicos e imunohistoquírnicos da leishmaniose cutânea na Nicarágua Cutaneous leishmaniasisNicaraguaPathologyHistological classificationImmunohistochemistryRussel's bodies Sixty skin biopsies of fifty-eight non-treated patients with cutaneous leishmaniasis from Nicaragua were studied. Biopsies were classified according to Ridley's histopathologic groups: 36 (60%) were included in group B (diffuse necrosis), 14 in group C (focal necrosis), 7 (11.6%) in group D (reactive tuberculoid). Only three biopsies remained unclassified. None of our cases could be included in groups A and E. Immunohistochemistry disclosed in 17 cases Russel's bodies secreting IgM and only one IgG positive. There was no correlation between the histopathologic groups and the presence of Russel's bodies. However, we believe the presence of Russel's bodies help the diagnosis of leishmaniasis. Correlation between morphological patterns and the different leishmania species was also considered. Foram estudadas 60 biopsias cutâneas de 58 pacientes nicaraguenses com leishmaniose tegumentar e ainda não em tratamento terapêutico. Quase todas as biopsias foram classificadas nos grupos histopatológicos de Ridley: 36 (60%) foram incluídas no grupo B ("diffuse necrosis"), 14 (23%) no grupo C ("focal necrosis"), 7 (11.6%) no grupo D ("reactive tuberculoid"). Somente 3 biopsias ficaram sem classificação. Não se achou nenhum caso que se pudesse classificar nos grupos A e E. Em 18 casos, usando método imunohis-toquímico, foram observados corpúsculos de Russel. Destes 18 casos 17 eram IgM positivos e só 1 IgG positivo. Não se descobriu correlação entre os grupos histopatológicos e a presença de corpúsculos de Russel. Todavia se imagina que os corpúsculos de Russel possam ter um significado diagnóstico (como um critério adjunto). Pode-se supor também uma correlação entre as numerosas alterações morfológicas e as diferentes espécies de leishmanias. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1987-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28521Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 4 (1987); 213-218 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 Núm. 4 (1987); 213-218 Revista do Instituto de Medicina Tropical de São Paulo; v. 29 n. 4 (1987); 213-218 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28521/30374Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessMariscotti, CesareBarbareschi, MattiaMissoni, EduardoMorelli, RosellaGuevara, UrielMunguia-Barrera, Juan2012-07-02T00:57:38Zoai:revistas.usp.br:article/28521Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:15.101227Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Histological and immunohistochemical aspects of cutaneous leishmaniasis in nicaragua
Aspectos histológicos e imunohistoquírnicos da leishmaniose cutânea na Nicarágua
title Histological and immunohistochemical aspects of cutaneous leishmaniasis in nicaragua
spellingShingle Histological and immunohistochemical aspects of cutaneous leishmaniasis in nicaragua
Mariscotti, Cesare
Cutaneous leishmaniasis
Nicaragua
Pathology
Histological classification
Immunohistochemistry
Russel's bodies
title_short Histological and immunohistochemical aspects of cutaneous leishmaniasis in nicaragua
title_full Histological and immunohistochemical aspects of cutaneous leishmaniasis in nicaragua
title_fullStr Histological and immunohistochemical aspects of cutaneous leishmaniasis in nicaragua
title_full_unstemmed Histological and immunohistochemical aspects of cutaneous leishmaniasis in nicaragua
title_sort Histological and immunohistochemical aspects of cutaneous leishmaniasis in nicaragua
author Mariscotti, Cesare
author_facet Mariscotti, Cesare
Barbareschi, Mattia
Missoni, Eduardo
Morelli, Rosella
Guevara, Uriel
Munguia-Barrera, Juan
author_role author
author2 Barbareschi, Mattia
Missoni, Eduardo
Morelli, Rosella
Guevara, Uriel
Munguia-Barrera, Juan
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Mariscotti, Cesare
Barbareschi, Mattia
Missoni, Eduardo
Morelli, Rosella
Guevara, Uriel
Munguia-Barrera, Juan
dc.subject.por.fl_str_mv Cutaneous leishmaniasis
Nicaragua
Pathology
Histological classification
Immunohistochemistry
Russel's bodies
topic Cutaneous leishmaniasis
Nicaragua
Pathology
Histological classification
Immunohistochemistry
Russel's bodies
description Sixty skin biopsies of fifty-eight non-treated patients with cutaneous leishmaniasis from Nicaragua were studied. Biopsies were classified according to Ridley's histopathologic groups: 36 (60%) were included in group B (diffuse necrosis), 14 in group C (focal necrosis), 7 (11.6%) in group D (reactive tuberculoid). Only three biopsies remained unclassified. None of our cases could be included in groups A and E. Immunohistochemistry disclosed in 17 cases Russel's bodies secreting IgM and only one IgG positive. There was no correlation between the histopathologic groups and the presence of Russel's bodies. However, we believe the presence of Russel's bodies help the diagnosis of leishmaniasis. Correlation between morphological patterns and the different leishmania species was also considered.
publishDate 1987
dc.date.none.fl_str_mv 1987-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28521
url https://www.revistas.usp.br/rimtsp/article/view/28521
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28521/30374
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 4 (1987); 213-218
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 Núm. 4 (1987); 213-218
Revista do Instituto de Medicina Tropical de São Paulo; v. 29 n. 4 (1987); 213-218
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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