The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities

Detalhes bibliográficos
Autor(a) principal: dos-Santos, Maria Cristina
Data de Publicação: 1992
Outros Autores: Gonçalves, Luís Roberto de Camargo, Fortes-Dias, Consuelo L., Cury, Yara, Gutiérrez, José Maria, Furtado, Maria de Fátima D.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28899
Resumo: Myonecrosis is one of the effects of Bothrops jararacussu venom, from which a myotoxin was isolated showing structural homology to phospholipase A2 (PLA2), but without enzimatic activity. Such myotoxic activity is also present in the Crotalus durissus terrificus venom, and is atributed to crotoxin and to PLA2 (crotoxin B), the basic component of the crotoxin complex. The Bothrops jararacussu venom showed three proteins with immunologic identity to PLA2 from crotoxin. The bothropic (AB) and the bothropic/crotalic (AB/C) antivenoms, two commercial polyvalent antivenoms produced at Instituto Butantan, were compared in order to assess their capacity for neutralization of the lethal, hemorrhagic, coagulant and myotoxic activities of Bothrops jararacussu venom. Both antivenoms showed the same level of hemorrhagic activity neutralization. However, AB/C was about three times more efficient than AB in neutralizing the myotoxic activity, and two times more potent for neutralization of lethality and coagulant activity of Bothrops jararacussu venom. These data suggest that the use of AB/C could be of value in the treatment of patients bitten by snakes of this species
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spelling The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities A eficácia do antiveneno botrópico-crotálico na neutralização das principais atividades do veneno de Bothrops jararacussu Bothrops jararacussuSoroterapia Myonecrosis is one of the effects of Bothrops jararacussu venom, from which a myotoxin was isolated showing structural homology to phospholipase A2 (PLA2), but without enzimatic activity. Such myotoxic activity is also present in the Crotalus durissus terrificus venom, and is atributed to crotoxin and to PLA2 (crotoxin B), the basic component of the crotoxin complex. The Bothrops jararacussu venom showed three proteins with immunologic identity to PLA2 from crotoxin. The bothropic (AB) and the bothropic/crotalic (AB/C) antivenoms, two commercial polyvalent antivenoms produced at Instituto Butantan, were compared in order to assess their capacity for neutralization of the lethal, hemorrhagic, coagulant and myotoxic activities of Bothrops jararacussu venom. Both antivenoms showed the same level of hemorrhagic activity neutralization. However, AB/C was about three times more efficient than AB in neutralizing the myotoxic activity, and two times more potent for neutralization of lethality and coagulant activity of Bothrops jararacussu venom. These data suggest that the use of AB/C could be of value in the treatment of patients bitten by snakes of this species A mionecrose é um dos efeitos causados pelo veneno de Bothrops jararacussu. Uma miotoxina com homologia estrutural à fosfolipase A2 (PLA2), mas sem atividade enzimática, foi isolada desse veneno. O veneno de Crotalus durissus terrificus apresenta também atividade miotóxica, que vem sendo atribuída à crotoxina e à PLA2 (crotoxina B), o componente básico do complexo crotoxina. O veneno de Bothrops jararacussu apresenta três proteínas, que têm identidade imunológica com a PLA2 da crotoxina. O presente trabalho comparou a eficiência dos antivenenos polivalentes comerciais produzidos pelo Instituto Butantan - o antiveneno botrópico (AB) e o antiveneno botrópico-crotálico (AB/C) - na neutralização das atividades letal, hemorrágica, coagulante e miotóxica do veneno de B. jararacussu. Os dois antivenenos neutralizaram de maneira semelhante a atividade hemorrágica, mas o AB/C foi três vezes mais potente que o AB em neutralizar a ação miotóxica e duas vezes mais potente na neutralização da letalidade e na ação coagulante do veneno de B. jararacussu. Os dados sugerem que a utilização do AB/C pode ser vantajosa no tratamento de pacientes picados por serpentes dessa espécie Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1992-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28899Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 2 (1992); 77-83 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 2 (1992); 77-83 Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 2 (1992); 77-83 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/28899/30754Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessdos-Santos, Maria CristinaGonçalves, Luís Roberto de CamargoFortes-Dias, Consuelo L.Cury, YaraGutiérrez, José MariaFurtado, Maria de Fátima D.2012-07-02T01:32:33Zoai:revistas.usp.br:article/28899Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:39.838911Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities
A eficácia do antiveneno botrópico-crotálico na neutralização das principais atividades do veneno de Bothrops jararacussu
title The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities
spellingShingle The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities
dos-Santos, Maria Cristina
Bothrops jararacussu
Soroterapia
title_short The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities
title_full The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities
title_fullStr The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities
title_full_unstemmed The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities
title_sort The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities
author dos-Santos, Maria Cristina
author_facet dos-Santos, Maria Cristina
Gonçalves, Luís Roberto de Camargo
Fortes-Dias, Consuelo L.
Cury, Yara
Gutiérrez, José Maria
Furtado, Maria de Fátima D.
author_role author
author2 Gonçalves, Luís Roberto de Camargo
Fortes-Dias, Consuelo L.
Cury, Yara
Gutiérrez, José Maria
Furtado, Maria de Fátima D.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv dos-Santos, Maria Cristina
Gonçalves, Luís Roberto de Camargo
Fortes-Dias, Consuelo L.
Cury, Yara
Gutiérrez, José Maria
Furtado, Maria de Fátima D.
dc.subject.por.fl_str_mv Bothrops jararacussu
Soroterapia
topic Bothrops jararacussu
Soroterapia
description Myonecrosis is one of the effects of Bothrops jararacussu venom, from which a myotoxin was isolated showing structural homology to phospholipase A2 (PLA2), but without enzimatic activity. Such myotoxic activity is also present in the Crotalus durissus terrificus venom, and is atributed to crotoxin and to PLA2 (crotoxin B), the basic component of the crotoxin complex. The Bothrops jararacussu venom showed three proteins with immunologic identity to PLA2 from crotoxin. The bothropic (AB) and the bothropic/crotalic (AB/C) antivenoms, two commercial polyvalent antivenoms produced at Instituto Butantan, were compared in order to assess their capacity for neutralization of the lethal, hemorrhagic, coagulant and myotoxic activities of Bothrops jararacussu venom. Both antivenoms showed the same level of hemorrhagic activity neutralization. However, AB/C was about three times more efficient than AB in neutralizing the myotoxic activity, and two times more potent for neutralization of lethality and coagulant activity of Bothrops jararacussu venom. These data suggest that the use of AB/C could be of value in the treatment of patients bitten by snakes of this species
publishDate 1992
dc.date.none.fl_str_mv 1992-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28899
url https://www.revistas.usp.br/rimtsp/article/view/28899
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28899/30754
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 2 (1992); 77-83
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 2 (1992); 77-83
Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 2 (1992); 77-83
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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