Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/220565 |
Resumo: | One of the main challenges in the clinical management of dengue is the early identification of cases that could progress to severe forms of the disease. A biomarker that may enable this identification is the presence of genetic polymorphisms in genes associated with immune responses. The objective of this study was to perform a systematic review of the Latin American literature on these genes. An electronic literature search was carried out in PubMed, Scopus, Lilacs, and the Virtual Health Library, and reference lists of systematic reviews in the area. Case-control studies conducted in Latin American countries examining at least one form of genetic polymorphism related to immune responses against severe dengue were included. In total, 424 articles were identified and 26 were included in this systematic review. Of the 26 selected articles, 16 reported polymorphisms associated with the risk of developing severe dengue (Risk); Similarly, 16 articles reported polymorphisms associated with a decreased risk of severe dengue (Protective). The final analysis revealed that multiple polymorphisms in immune system genes were early markers of the progression of dengue in Latin Americans and found that polymorphisms of the TNF-alpha gene may have a critical role in dengue pathogenesis. |
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Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic reviewDenguePolymorphismImmunityOne of the main challenges in the clinical management of dengue is the early identification of cases that could progress to severe forms of the disease. A biomarker that may enable this identification is the presence of genetic polymorphisms in genes associated with immune responses. The objective of this study was to perform a systematic review of the Latin American literature on these genes. An electronic literature search was carried out in PubMed, Scopus, Lilacs, and the Virtual Health Library, and reference lists of systematic reviews in the area. Case-control studies conducted in Latin American countries examining at least one form of genetic polymorphism related to immune responses against severe dengue were included. In total, 424 articles were identified and 26 were included in this systematic review. Of the 26 selected articles, 16 reported polymorphisms associated with the risk of developing severe dengue (Risk); Similarly, 16 articles reported polymorphisms associated with a decreased risk of severe dengue (Protective). The final analysis revealed that multiple polymorphisms in immune system genes were early markers of the progression of dengue in Latin Americans and found that polymorphisms of the TNF-alpha gene may have a critical role in dengue pathogenesis.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2023-12-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/22056510.1590/S1678-9946202365058 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e58Revista do Instituto de Medicina Tropical de São Paulo; v. 65 (2023); e58Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e581678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/220565/201514Copyright (c) 2023 Jorge Emilio Salazar Flórez, Ángela María Segura Cardona, Berta Nelly Restrepo Jaramillo, Margarita Arboleda Naranjo, Luz Stella Giraldo Cardona, Ángela Patricia Echeverri Rendónhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccess Flórez, Jorge Emilio Salazar Cardona, Ángela María Segura Jaramillo, Berta Nelly RestrepoNaranjo, Margarita Arboleda Cardona, Luz Stella Giraldo Rendón, Ángela Patricia Echeverri 2023-12-22T12:42:07Zoai:revistas.usp.br:article/220565Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2023-12-22T12:42:07Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)false |
dc.title.none.fl_str_mv |
Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review |
title |
Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review |
spellingShingle |
Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review Flórez, Jorge Emilio Salazar Dengue Polymorphism Immunity |
title_short |
Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review |
title_full |
Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review |
title_fullStr |
Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review |
title_full_unstemmed |
Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review |
title_sort |
Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review |
author |
Flórez, Jorge Emilio Salazar |
author_facet |
Flórez, Jorge Emilio Salazar Cardona, Ángela María Segura Jaramillo, Berta Nelly Restrepo Naranjo, Margarita Arboleda Cardona, Luz Stella Giraldo Rendón, Ángela Patricia Echeverri |
author_role |
author |
author2 |
Cardona, Ángela María Segura Jaramillo, Berta Nelly Restrepo Naranjo, Margarita Arboleda Cardona, Luz Stella Giraldo Rendón, Ángela Patricia Echeverri |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Flórez, Jorge Emilio Salazar Cardona, Ángela María Segura Jaramillo, Berta Nelly Restrepo Naranjo, Margarita Arboleda Cardona, Luz Stella Giraldo Rendón, Ángela Patricia Echeverri |
dc.subject.por.fl_str_mv |
Dengue Polymorphism Immunity |
topic |
Dengue Polymorphism Immunity |
description |
One of the main challenges in the clinical management of dengue is the early identification of cases that could progress to severe forms of the disease. A biomarker that may enable this identification is the presence of genetic polymorphisms in genes associated with immune responses. The objective of this study was to perform a systematic review of the Latin American literature on these genes. An electronic literature search was carried out in PubMed, Scopus, Lilacs, and the Virtual Health Library, and reference lists of systematic reviews in the area. Case-control studies conducted in Latin American countries examining at least one form of genetic polymorphism related to immune responses against severe dengue were included. In total, 424 articles were identified and 26 were included in this systematic review. Of the 26 selected articles, 16 reported polymorphisms associated with the risk of developing severe dengue (Risk); Similarly, 16 articles reported polymorphisms associated with a decreased risk of severe dengue (Protective). The final analysis revealed that multiple polymorphisms in immune system genes were early markers of the progression of dengue in Latin Americans and found that polymorphisms of the TNF-alpha gene may have a critical role in dengue pathogenesis. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/220565 10.1590/S1678-9946202365058 |
url |
https://www.revistas.usp.br/rimtsp/article/view/220565 |
identifier_str_mv |
10.1590/S1678-9946202365058 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/220565/201514 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e58 Revista do Instituto de Medicina Tropical de São Paulo; v. 65 (2023); e58 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e58 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951636620541952 |