Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/195674 |
Resumo: | Despite the many efforts of researchers around the world, there is currently no effective vaccine for malaria. Numerous studies have been developed to find vaccine antigens that are immunogenic and safe. Among antigen candidates, Plasmodium falciparum merozoite surface protein 3 (MSP3) has stood out in a number of these studies for its ability to induce a consistent and protective immune response, also being safe for use in humans. This review presents the main studies that explored MSP3 as a vaccine candidate over the last few decades. MSP3 formulations were tested in animals and humans and the most advanced candidate formulations are MSP3-LSP, a combination of MSP3 and LSP1, and GMZ2 (a vaccine based on the recombinant protein fusion GLURP and MSP3) which is currently being tested in phase II clinical studies. This brief review highlights the history and the main formulations of MSP3-based vaccines approaches against P. falciparum. |
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Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief reviewMalariaMSP3Plasmodium falciparumVaccineImmunityDespite the many efforts of researchers around the world, there is currently no effective vaccine for malaria. Numerous studies have been developed to find vaccine antigens that are immunogenic and safe. Among antigen candidates, Plasmodium falciparum merozoite surface protein 3 (MSP3) has stood out in a number of these studies for its ability to induce a consistent and protective immune response, also being safe for use in humans. This review presents the main studies that explored MSP3 as a vaccine candidate over the last few decades. MSP3 formulations were tested in animals and humans and the most advanced candidate formulations are MSP3-LSP, a combination of MSP3 and LSP1, and GMZ2 (a vaccine based on the recombinant protein fusion GLURP and MSP3) which is currently being tested in phase II clinical studies. This brief review highlights the history and the main formulations of MSP3-based vaccines approaches against P. falciparum.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2022-05-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/19567410.1590/S1678-9946202264023Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e23Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e23Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e231678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/195674/180633Copyright (c) 2022 Késsia Caroline Souza Alves, Jander Matos Guimarães, Maria Edilene Martins de Almeida, Luís André Morais Mariúbahttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessAlves, Késsia Caroline Souza Guimarães, Jander Matos Almeida, Maria Edilene Martins de Mariúba, Luís André Morais 2022-10-10T13:01:46Zoai:revistas.usp.br:article/195674Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:53:02.408851Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review |
title |
Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review |
spellingShingle |
Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review Alves, Késsia Caroline Souza Malaria MSP3 Plasmodium falciparum Vaccine Immunity |
title_short |
Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review |
title_full |
Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review |
title_fullStr |
Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review |
title_full_unstemmed |
Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review |
title_sort |
Plasmodium falciparum merozoite surface protein 3 as a vaccine candidate: a brief review |
author |
Alves, Késsia Caroline Souza |
author_facet |
Alves, Késsia Caroline Souza Guimarães, Jander Matos Almeida, Maria Edilene Martins de Mariúba, Luís André Morais |
author_role |
author |
author2 |
Guimarães, Jander Matos Almeida, Maria Edilene Martins de Mariúba, Luís André Morais |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Alves, Késsia Caroline Souza Guimarães, Jander Matos Almeida, Maria Edilene Martins de Mariúba, Luís André Morais |
dc.subject.por.fl_str_mv |
Malaria MSP3 Plasmodium falciparum Vaccine Immunity |
topic |
Malaria MSP3 Plasmodium falciparum Vaccine Immunity |
description |
Despite the many efforts of researchers around the world, there is currently no effective vaccine for malaria. Numerous studies have been developed to find vaccine antigens that are immunogenic and safe. Among antigen candidates, Plasmodium falciparum merozoite surface protein 3 (MSP3) has stood out in a number of these studies for its ability to induce a consistent and protective immune response, also being safe for use in humans. This review presents the main studies that explored MSP3 as a vaccine candidate over the last few decades. MSP3 formulations were tested in animals and humans and the most advanced candidate formulations are MSP3-LSP, a combination of MSP3 and LSP1, and GMZ2 (a vaccine based on the recombinant protein fusion GLURP and MSP3) which is currently being tested in phase II clinical studies. This brief review highlights the history and the main formulations of MSP3-based vaccines approaches against P. falciparum. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/195674 10.1590/S1678-9946202264023 |
url |
https://www.revistas.usp.br/rimtsp/article/view/195674 |
identifier_str_mv |
10.1590/S1678-9946202264023 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/195674/180633 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e23 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e23 Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e23 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951636707573760 |