Endothelial activation is associated with albuminuria in multibacillary leprosy

Detalhes bibliográficos
Autor(a) principal: Tessarolo, Louise Donadello
Data de Publicação: 2021
Outros Autores: Meneses , Gdayllon Cavalcante, Bezerra, Gabriela Freire, Rocha, Thaiany Pereira da, Azevedo, Isabella Evelyn Prado de, Silva Junior, Geraldo Bezerra, Pontes, Maria Araci Andrade, Daher, Elizabeth De Francesco, Martins, Alice Maria Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/187877
Resumo: Leprosy may present kidney and endothelial abnormalities, being a risk factor for complications. However, the involvement of renal and vascular endothelia has been poorly investigated. We aimed to investigate if the levels of systemic endothelial biomarkers are associated with kidney abnormalities and the clinical forms of leprosy. This is a cross-sectional study with leprosy patients enrolled in January 2017 to December 2018, before the initiation of the multidrug therapy. Leprosy-associated clinical and epidemiological data were collected. Two groups were investigated: Paucibacillary (PB) and Multibacillary (MB) infections, for the comparisons. Serum and urine samples were obtained for laboratory analysis. In serum samples, were evaluated the endothelial biomarkers VCAM-1 and ICAM-1. In total, 101 leprosy patients were included, the mean age was 48±١٥ years and 71 (70%) were male. The multibacillary form occurred in 81 cases (80%), among which 22 had the Virchowian form. Serum creatinine was more elevated in the MB group than in PB patients. In addition, VCAM-1 was elevated in the MB group and was correlated with the bacteriological index (rho = 0.372, p <0.01), the duration of disease symptoms (rho = 0.234, p = 0.04), and the number of skin lesions (rho = 0.468, p <0.001). Moreover, in MB patients who presented albuminuria >15 mg/g of creatinine, VCAM-1 showed a significant correlation with increased albuminuria and improved the correlation with the number of skin lesions (rho= 0.563, p=0.010). In conclusion, higher systemic VCAM-1 levels were associated with the multibacillary clinical form of leprosy and with increased albuminuria. Prospective studies are necessary to establish a cause-effect and evaluate the preventive role of these biomarkers to improve the clinical care.
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spelling Endothelial activation is associated with albuminuria in multibacillary leprosyLeprosyEndotheliumKidney diseaseAlbuminuriaPaucibacillary leprosyMultibacillary leprosyLeprosy may present kidney and endothelial abnormalities, being a risk factor for complications. However, the involvement of renal and vascular endothelia has been poorly investigated. We aimed to investigate if the levels of systemic endothelial biomarkers are associated with kidney abnormalities and the clinical forms of leprosy. This is a cross-sectional study with leprosy patients enrolled in January 2017 to December 2018, before the initiation of the multidrug therapy. Leprosy-associated clinical and epidemiological data were collected. Two groups were investigated: Paucibacillary (PB) and Multibacillary (MB) infections, for the comparisons. Serum and urine samples were obtained for laboratory analysis. In serum samples, were evaluated the endothelial biomarkers VCAM-1 and ICAM-1. In total, 101 leprosy patients were included, the mean age was 48±١٥ years and 71 (70%) were male. The multibacillary form occurred in 81 cases (80%), among which 22 had the Virchowian form. Serum creatinine was more elevated in the MB group than in PB patients. In addition, VCAM-1 was elevated in the MB group and was correlated with the bacteriological index (rho = 0.372, p <0.01), the duration of disease symptoms (rho = 0.234, p = 0.04), and the number of skin lesions (rho = 0.468, p <0.001). Moreover, in MB patients who presented albuminuria >15 mg/g of creatinine, VCAM-1 showed a significant correlation with increased albuminuria and improved the correlation with the number of skin lesions (rho= 0.563, p=0.010). In conclusion, higher systemic VCAM-1 levels were associated with the multibacillary clinical form of leprosy and with increased albuminuria. Prospective studies are necessary to establish a cause-effect and evaluate the preventive role of these biomarkers to improve the clinical care.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2021-06-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/18787710.1590/S1678-9946202163044Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e44Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e44Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e441678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/187877/173509Copyright (c) 2021 Louise Donadello Tessarolo, Gdayllon Cavalcante Meneses , Gabriela Freire Bezerra, Thaiany Pereira da Rocha, Isabella Evelyn Prado de Azevedo, Geraldo Bezerra Silva Junior, Maria Araci Andrade Pontes, Elizabeth De Francesco Daher, Alice Maria Costa Martinshttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessTessarolo, Louise Donadello Meneses , Gdayllon Cavalcante Bezerra, Gabriela Freire Rocha, Thaiany Pereira da Azevedo, Isabella Evelyn Prado de Silva Junior, Geraldo Bezerra Pontes, Maria Araci Andrade Daher, Elizabeth De Francesco Martins, Alice Maria Costa 2022-05-16T13:44:35Zoai:revistas.usp.br:article/187877Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:58.438552Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Endothelial activation is associated with albuminuria in multibacillary leprosy
title Endothelial activation is associated with albuminuria in multibacillary leprosy
spellingShingle Endothelial activation is associated with albuminuria in multibacillary leprosy
Tessarolo, Louise Donadello
Leprosy
Endothelium
Kidney disease
Albuminuria
Paucibacillary leprosy
Multibacillary leprosy
title_short Endothelial activation is associated with albuminuria in multibacillary leprosy
title_full Endothelial activation is associated with albuminuria in multibacillary leprosy
title_fullStr Endothelial activation is associated with albuminuria in multibacillary leprosy
title_full_unstemmed Endothelial activation is associated with albuminuria in multibacillary leprosy
title_sort Endothelial activation is associated with albuminuria in multibacillary leprosy
author Tessarolo, Louise Donadello
author_facet Tessarolo, Louise Donadello
Meneses , Gdayllon Cavalcante
Bezerra, Gabriela Freire
Rocha, Thaiany Pereira da
Azevedo, Isabella Evelyn Prado de
Silva Junior, Geraldo Bezerra
Pontes, Maria Araci Andrade
Daher, Elizabeth De Francesco
Martins, Alice Maria Costa
author_role author
author2 Meneses , Gdayllon Cavalcante
Bezerra, Gabriela Freire
Rocha, Thaiany Pereira da
Azevedo, Isabella Evelyn Prado de
Silva Junior, Geraldo Bezerra
Pontes, Maria Araci Andrade
Daher, Elizabeth De Francesco
Martins, Alice Maria Costa
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tessarolo, Louise Donadello
Meneses , Gdayllon Cavalcante
Bezerra, Gabriela Freire
Rocha, Thaiany Pereira da
Azevedo, Isabella Evelyn Prado de
Silva Junior, Geraldo Bezerra
Pontes, Maria Araci Andrade
Daher, Elizabeth De Francesco
Martins, Alice Maria Costa
dc.subject.por.fl_str_mv Leprosy
Endothelium
Kidney disease
Albuminuria
Paucibacillary leprosy
Multibacillary leprosy
topic Leprosy
Endothelium
Kidney disease
Albuminuria
Paucibacillary leprosy
Multibacillary leprosy
description Leprosy may present kidney and endothelial abnormalities, being a risk factor for complications. However, the involvement of renal and vascular endothelia has been poorly investigated. We aimed to investigate if the levels of systemic endothelial biomarkers are associated with kidney abnormalities and the clinical forms of leprosy. This is a cross-sectional study with leprosy patients enrolled in January 2017 to December 2018, before the initiation of the multidrug therapy. Leprosy-associated clinical and epidemiological data were collected. Two groups were investigated: Paucibacillary (PB) and Multibacillary (MB) infections, for the comparisons. Serum and urine samples were obtained for laboratory analysis. In serum samples, were evaluated the endothelial biomarkers VCAM-1 and ICAM-1. In total, 101 leprosy patients were included, the mean age was 48±١٥ years and 71 (70%) were male. The multibacillary form occurred in 81 cases (80%), among which 22 had the Virchowian form. Serum creatinine was more elevated in the MB group than in PB patients. In addition, VCAM-1 was elevated in the MB group and was correlated with the bacteriological index (rho = 0.372, p <0.01), the duration of disease symptoms (rho = 0.234, p = 0.04), and the number of skin lesions (rho = 0.468, p <0.001). Moreover, in MB patients who presented albuminuria >15 mg/g of creatinine, VCAM-1 showed a significant correlation with increased albuminuria and improved the correlation with the number of skin lesions (rho= 0.563, p=0.010). In conclusion, higher systemic VCAM-1 levels were associated with the multibacillary clinical form of leprosy and with increased albuminuria. Prospective studies are necessary to establish a cause-effect and evaluate the preventive role of these biomarkers to improve the clinical care.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/187877
10.1590/S1678-9946202163044
url https://www.revistas.usp.br/rimtsp/article/view/187877
identifier_str_mv 10.1590/S1678-9946202163044
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/187877/173509
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e44
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e44
Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e44
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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