Endothelial activation is associated with albuminuria in multibacillary leprosy
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/187877 |
Resumo: | Leprosy may present kidney and endothelial abnormalities, being a risk factor for complications. However, the involvement of renal and vascular endothelia has been poorly investigated. We aimed to investigate if the levels of systemic endothelial biomarkers are associated with kidney abnormalities and the clinical forms of leprosy. This is a cross-sectional study with leprosy patients enrolled in January 2017 to December 2018, before the initiation of the multidrug therapy. Leprosy-associated clinical and epidemiological data were collected. Two groups were investigated: Paucibacillary (PB) and Multibacillary (MB) infections, for the comparisons. Serum and urine samples were obtained for laboratory analysis. In serum samples, were evaluated the endothelial biomarkers VCAM-1 and ICAM-1. In total, 101 leprosy patients were included, the mean age was 48±١٥ years and 71 (70%) were male. The multibacillary form occurred in 81 cases (80%), among which 22 had the Virchowian form. Serum creatinine was more elevated in the MB group than in PB patients. In addition, VCAM-1 was elevated in the MB group and was correlated with the bacteriological index (rho = 0.372, p <0.01), the duration of disease symptoms (rho = 0.234, p = 0.04), and the number of skin lesions (rho = 0.468, p <0.001). Moreover, in MB patients who presented albuminuria >15 mg/g of creatinine, VCAM-1 showed a significant correlation with increased albuminuria and improved the correlation with the number of skin lesions (rho= 0.563, p=0.010). In conclusion, higher systemic VCAM-1 levels were associated with the multibacillary clinical form of leprosy and with increased albuminuria. Prospective studies are necessary to establish a cause-effect and evaluate the preventive role of these biomarkers to improve the clinical care. |
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Endothelial activation is associated with albuminuria in multibacillary leprosyLeprosyEndotheliumKidney diseaseAlbuminuriaPaucibacillary leprosyMultibacillary leprosyLeprosy may present kidney and endothelial abnormalities, being a risk factor for complications. However, the involvement of renal and vascular endothelia has been poorly investigated. We aimed to investigate if the levels of systemic endothelial biomarkers are associated with kidney abnormalities and the clinical forms of leprosy. This is a cross-sectional study with leprosy patients enrolled in January 2017 to December 2018, before the initiation of the multidrug therapy. Leprosy-associated clinical and epidemiological data were collected. Two groups were investigated: Paucibacillary (PB) and Multibacillary (MB) infections, for the comparisons. Serum and urine samples were obtained for laboratory analysis. In serum samples, were evaluated the endothelial biomarkers VCAM-1 and ICAM-1. In total, 101 leprosy patients were included, the mean age was 48±١٥ years and 71 (70%) were male. The multibacillary form occurred in 81 cases (80%), among which 22 had the Virchowian form. Serum creatinine was more elevated in the MB group than in PB patients. In addition, VCAM-1 was elevated in the MB group and was correlated with the bacteriological index (rho = 0.372, p <0.01), the duration of disease symptoms (rho = 0.234, p = 0.04), and the number of skin lesions (rho = 0.468, p <0.001). Moreover, in MB patients who presented albuminuria >15 mg/g of creatinine, VCAM-1 showed a significant correlation with increased albuminuria and improved the correlation with the number of skin lesions (rho= 0.563, p=0.010). In conclusion, higher systemic VCAM-1 levels were associated with the multibacillary clinical form of leprosy and with increased albuminuria. Prospective studies are necessary to establish a cause-effect and evaluate the preventive role of these biomarkers to improve the clinical care.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2021-06-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/18787710.1590/S1678-9946202163044Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e44Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e44Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e441678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/187877/173509Copyright (c) 2021 Louise Donadello Tessarolo, Gdayllon Cavalcante Meneses , Gabriela Freire Bezerra, Thaiany Pereira da Rocha, Isabella Evelyn Prado de Azevedo, Geraldo Bezerra Silva Junior, Maria Araci Andrade Pontes, Elizabeth De Francesco Daher, Alice Maria Costa Martinshttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessTessarolo, Louise Donadello Meneses , Gdayllon Cavalcante Bezerra, Gabriela Freire Rocha, Thaiany Pereira da Azevedo, Isabella Evelyn Prado de Silva Junior, Geraldo Bezerra Pontes, Maria Araci Andrade Daher, Elizabeth De Francesco Martins, Alice Maria Costa 2022-05-16T13:44:35Zoai:revistas.usp.br:article/187877Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:58.438552Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Endothelial activation is associated with albuminuria in multibacillary leprosy |
title |
Endothelial activation is associated with albuminuria in multibacillary leprosy |
spellingShingle |
Endothelial activation is associated with albuminuria in multibacillary leprosy Tessarolo, Louise Donadello Leprosy Endothelium Kidney disease Albuminuria Paucibacillary leprosy Multibacillary leprosy |
title_short |
Endothelial activation is associated with albuminuria in multibacillary leprosy |
title_full |
Endothelial activation is associated with albuminuria in multibacillary leprosy |
title_fullStr |
Endothelial activation is associated with albuminuria in multibacillary leprosy |
title_full_unstemmed |
Endothelial activation is associated with albuminuria in multibacillary leprosy |
title_sort |
Endothelial activation is associated with albuminuria in multibacillary leprosy |
author |
Tessarolo, Louise Donadello |
author_facet |
Tessarolo, Louise Donadello Meneses , Gdayllon Cavalcante Bezerra, Gabriela Freire Rocha, Thaiany Pereira da Azevedo, Isabella Evelyn Prado de Silva Junior, Geraldo Bezerra Pontes, Maria Araci Andrade Daher, Elizabeth De Francesco Martins, Alice Maria Costa |
author_role |
author |
author2 |
Meneses , Gdayllon Cavalcante Bezerra, Gabriela Freire Rocha, Thaiany Pereira da Azevedo, Isabella Evelyn Prado de Silva Junior, Geraldo Bezerra Pontes, Maria Araci Andrade Daher, Elizabeth De Francesco Martins, Alice Maria Costa |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Tessarolo, Louise Donadello Meneses , Gdayllon Cavalcante Bezerra, Gabriela Freire Rocha, Thaiany Pereira da Azevedo, Isabella Evelyn Prado de Silva Junior, Geraldo Bezerra Pontes, Maria Araci Andrade Daher, Elizabeth De Francesco Martins, Alice Maria Costa |
dc.subject.por.fl_str_mv |
Leprosy Endothelium Kidney disease Albuminuria Paucibacillary leprosy Multibacillary leprosy |
topic |
Leprosy Endothelium Kidney disease Albuminuria Paucibacillary leprosy Multibacillary leprosy |
description |
Leprosy may present kidney and endothelial abnormalities, being a risk factor for complications. However, the involvement of renal and vascular endothelia has been poorly investigated. We aimed to investigate if the levels of systemic endothelial biomarkers are associated with kidney abnormalities and the clinical forms of leprosy. This is a cross-sectional study with leprosy patients enrolled in January 2017 to December 2018, before the initiation of the multidrug therapy. Leprosy-associated clinical and epidemiological data were collected. Two groups were investigated: Paucibacillary (PB) and Multibacillary (MB) infections, for the comparisons. Serum and urine samples were obtained for laboratory analysis. In serum samples, were evaluated the endothelial biomarkers VCAM-1 and ICAM-1. In total, 101 leprosy patients were included, the mean age was 48±١٥ years and 71 (70%) were male. The multibacillary form occurred in 81 cases (80%), among which 22 had the Virchowian form. Serum creatinine was more elevated in the MB group than in PB patients. In addition, VCAM-1 was elevated in the MB group and was correlated with the bacteriological index (rho = 0.372, p <0.01), the duration of disease symptoms (rho = 0.234, p = 0.04), and the number of skin lesions (rho = 0.468, p <0.001). Moreover, in MB patients who presented albuminuria >15 mg/g of creatinine, VCAM-1 showed a significant correlation with increased albuminuria and improved the correlation with the number of skin lesions (rho= 0.563, p=0.010). In conclusion, higher systemic VCAM-1 levels were associated with the multibacillary clinical form of leprosy and with increased albuminuria. Prospective studies are necessary to establish a cause-effect and evaluate the preventive role of these biomarkers to improve the clinical care. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/187877 10.1590/S1678-9946202163044 |
url |
https://www.revistas.usp.br/rimtsp/article/view/187877 |
identifier_str_mv |
10.1590/S1678-9946202163044 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/187877/173509 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e44 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e44 Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e44 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
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Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
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1798951653197479936 |