Impact of COVID-19 on liver transplant recipients during the first pandemic wave, in a tertiary hospital, in Northeastern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/194817 |
Resumo: | Worldwide, transplant programs have suffered a setback during the coronavirus disease 2019 (COVID-19) pandemic and most have temporarily suspended their transplant activities. . We identified 36 liver transplant patients who tested positive for COVID-19. The cases were confirmed by the nucleic acid test (RT-PCR). Epidemiological, demographic, clinical, laboratory, management and outcome data were obtained from the patients’ medical records. Fourteen patients (38.9%) required admission to the Intensive Care Unit and/or invasive ventilatory support (severe cases). The mean age of these severe cases was 63.8 years. Regarding the time since the transplant, 71.4% (10/14 patients) had undergone the procedure less than one year before. The immunosuppressive therapy was reduced in patients who required Intensive Care Unit. A total of 12 cases (12/14, 85.7%) required invasive ventilatory support. Eight cases (8/14, 57.1%) required renal replacement therapy. In this group of patients, nine died (64.3 %). In turn, 22 patients had mild to moderate symptoms of COVID-19, not requiring invasive ventilatory support or admission to the Intensive Care Unit. The mean age in these patients was 56.5 years and comorbidities were present in 15 (68.2%) of the cases. In this group, only five patients (5/22, 22.7%) required hospitalization due to complications and there were no deaths This report describes the results of COVID-19 infection in a very specific population, suggesting that liver transplant patients have a significant higher risk of progressing to severeCOVID-19 , with a mortality rate among critically-ill patients above that of the general population. |
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Impact of COVID-19 on liver transplant recipients during the first pandemic wave, in a tertiary hospital, in Northeastern BrazilCoronavirus infectionsLiver transplantationCOVID-19Worldwide, transplant programs have suffered a setback during the coronavirus disease 2019 (COVID-19) pandemic and most have temporarily suspended their transplant activities. . We identified 36 liver transplant patients who tested positive for COVID-19. The cases were confirmed by the nucleic acid test (RT-PCR). Epidemiological, demographic, clinical, laboratory, management and outcome data were obtained from the patients’ medical records. Fourteen patients (38.9%) required admission to the Intensive Care Unit and/or invasive ventilatory support (severe cases). The mean age of these severe cases was 63.8 years. Regarding the time since the transplant, 71.4% (10/14 patients) had undergone the procedure less than one year before. The immunosuppressive therapy was reduced in patients who required Intensive Care Unit. A total of 12 cases (12/14, 85.7%) required invasive ventilatory support. Eight cases (8/14, 57.1%) required renal replacement therapy. In this group of patients, nine died (64.3 %). In turn, 22 patients had mild to moderate symptoms of COVID-19, not requiring invasive ventilatory support or admission to the Intensive Care Unit. The mean age in these patients was 56.5 years and comorbidities were present in 15 (68.2%) of the cases. In this group, only five patients (5/22, 22.7%) required hospitalization due to complications and there were no deaths This report describes the results of COVID-19 infection in a very specific population, suggesting that liver transplant patients have a significant higher risk of progressing to severeCOVID-19 , with a mortality rate among critically-ill patients above that of the general population.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2022-05-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/19481710.1590/S1678-9946202264008Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e08Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e08Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e081678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/194817/179988Copyright (c) 2022 Marina Seixas Studart e Neves, José Hícaro Hellano Gonçalves Lima Paiva, Natália Stefani de Assunção Ferreira, Francisca Patrícia Almeida Queiroz, Camilla Bezerra Bastos Limeira, Camila Monteiro Veras, Themístocles Mesquita Teles de Carvalho, Taina Veras de Sandes Freitas, Ronaldo de Matos Esmeraldo, Ivelise Regina Canito Brasilhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessNeves, Marina Seixas Studart e Paiva, José Hícaro Hellano Gonçalves Lima Ferreira, Natália Stefani de Assunção Queiroz, Francisca Patrícia Almeida Limeira, Camilla Bezerra Bastos Veras, Camila Monteiro Carvalho, Themístocles Mesquita Teles de Freitas, Taina Veras de Sandes Esmeraldo, Ronaldo de Matos Brasil, Ivelise Regina Canito 2022-10-10T13:01:46Zoai:revistas.usp.br:article/194817Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:53:01.520089Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Impact of COVID-19 on liver transplant recipients during the first pandemic wave, in a tertiary hospital, in Northeastern Brazil |
title |
Impact of COVID-19 on liver transplant recipients during the first pandemic wave, in a tertiary hospital, in Northeastern Brazil |
spellingShingle |
Impact of COVID-19 on liver transplant recipients during the first pandemic wave, in a tertiary hospital, in Northeastern Brazil Neves, Marina Seixas Studart e Coronavirus infections Liver transplantation COVID-19 |
title_short |
Impact of COVID-19 on liver transplant recipients during the first pandemic wave, in a tertiary hospital, in Northeastern Brazil |
title_full |
Impact of COVID-19 on liver transplant recipients during the first pandemic wave, in a tertiary hospital, in Northeastern Brazil |
title_fullStr |
Impact of COVID-19 on liver transplant recipients during the first pandemic wave, in a tertiary hospital, in Northeastern Brazil |
title_full_unstemmed |
Impact of COVID-19 on liver transplant recipients during the first pandemic wave, in a tertiary hospital, in Northeastern Brazil |
title_sort |
Impact of COVID-19 on liver transplant recipients during the first pandemic wave, in a tertiary hospital, in Northeastern Brazil |
author |
Neves, Marina Seixas Studart e |
author_facet |
Neves, Marina Seixas Studart e Paiva, José Hícaro Hellano Gonçalves Lima Ferreira, Natália Stefani de Assunção Queiroz, Francisca Patrícia Almeida Limeira, Camilla Bezerra Bastos Veras, Camila Monteiro Carvalho, Themístocles Mesquita Teles de Freitas, Taina Veras de Sandes Esmeraldo, Ronaldo de Matos Brasil, Ivelise Regina Canito |
author_role |
author |
author2 |
Paiva, José Hícaro Hellano Gonçalves Lima Ferreira, Natália Stefani de Assunção Queiroz, Francisca Patrícia Almeida Limeira, Camilla Bezerra Bastos Veras, Camila Monteiro Carvalho, Themístocles Mesquita Teles de Freitas, Taina Veras de Sandes Esmeraldo, Ronaldo de Matos Brasil, Ivelise Regina Canito |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Neves, Marina Seixas Studart e Paiva, José Hícaro Hellano Gonçalves Lima Ferreira, Natália Stefani de Assunção Queiroz, Francisca Patrícia Almeida Limeira, Camilla Bezerra Bastos Veras, Camila Monteiro Carvalho, Themístocles Mesquita Teles de Freitas, Taina Veras de Sandes Esmeraldo, Ronaldo de Matos Brasil, Ivelise Regina Canito |
dc.subject.por.fl_str_mv |
Coronavirus infections Liver transplantation COVID-19 |
topic |
Coronavirus infections Liver transplantation COVID-19 |
description |
Worldwide, transplant programs have suffered a setback during the coronavirus disease 2019 (COVID-19) pandemic and most have temporarily suspended their transplant activities. . We identified 36 liver transplant patients who tested positive for COVID-19. The cases were confirmed by the nucleic acid test (RT-PCR). Epidemiological, demographic, clinical, laboratory, management and outcome data were obtained from the patients’ medical records. Fourteen patients (38.9%) required admission to the Intensive Care Unit and/or invasive ventilatory support (severe cases). The mean age of these severe cases was 63.8 years. Regarding the time since the transplant, 71.4% (10/14 patients) had undergone the procedure less than one year before. The immunosuppressive therapy was reduced in patients who required Intensive Care Unit. A total of 12 cases (12/14, 85.7%) required invasive ventilatory support. Eight cases (8/14, 57.1%) required renal replacement therapy. In this group of patients, nine died (64.3 %). In turn, 22 patients had mild to moderate symptoms of COVID-19, not requiring invasive ventilatory support or admission to the Intensive Care Unit. The mean age in these patients was 56.5 years and comorbidities were present in 15 (68.2%) of the cases. In this group, only five patients (5/22, 22.7%) required hospitalization due to complications and there were no deaths This report describes the results of COVID-19 infection in a very specific population, suggesting that liver transplant patients have a significant higher risk of progressing to severeCOVID-19 , with a mortality rate among critically-ill patients above that of the general population. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/194817 10.1590/S1678-9946202264008 |
url |
https://www.revistas.usp.br/rimtsp/article/view/194817 |
identifier_str_mv |
10.1590/S1678-9946202264008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/194817/179988 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e08 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 64 (2022); e08 Revista do Instituto de Medicina Tropical de São Paulo; v. 64 (2022); e08 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
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Instituto de Medicina Tropical (IMT) |
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IMT |
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IMT |
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Revista do Instituto de Medicina Tropical de São Paulo |
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Revista do Instituto de Medicina Tropical de São Paulo |
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Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
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