Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil

Detalhes bibliográficos
Autor(a) principal: Rosario, Virgílio Do
Data de Publicação: 1987
Outros Autores: Hollingdale, Michael R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28493
Resumo: 17 of 20 adult sera from the Amapa region of Brazil were active in the inhibition of P. falciparum sporozoite invasion (ISI) assay which has been correlated with protective antibodies. In contrast 11 sera were positive in IFA tests and 6 were positive in CSP tests. These results suggest that the ISI assay will be useful for evaluating naturally acquired protective anti-sporozoite antibodies in endemic areas, particularly during vaccine efficacy studies using sporozoite-based vaccines.
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spelling Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil Prevalência de anticorpos anti-esporozoitos de P: Falciparum em soros da região do Amapá, Brasil Anti-sporozoite antibodyinhibiton of sporozoite invasion (ISI) assaycircumsporozoite precipitation (CSP) assayimmunofluorescent antibody (IFA) assay 17 of 20 adult sera from the Amapa region of Brazil were active in the inhibition of P. falciparum sporozoite invasion (ISI) assay which has been correlated with protective antibodies. In contrast 11 sera were positive in IFA tests and 6 were positive in CSP tests. These results suggest that the ISI assay will be useful for evaluating naturally acquired protective anti-sporozoite antibodies in endemic areas, particularly during vaccine efficacy studies using sporozoite-based vaccines. 17 de 20 soros humanos coletados na região de Amapá (Brasil) mostraram atividade nos testes de inibição de invasão de esporozoitos (ISI) in vitro que estão correlacionados com proteção por presença de anticorpos. Em contraste 11 soros foram positivos para IFA e 6 foram positivos para CSP. Estes resultados sugerem que ISI seja um ensaio mais adequado para medir respostas imunológicas em futuros estudos sobre eficácia de uma potencial vacina anti-malárica. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1987-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28493Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 1 (1987); 63-66 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 Núm. 1 (1987); 63-66 Revista do Instituto de Medicina Tropical de São Paulo; v. 29 n. 1 (1987); 63-66 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28493/30346Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessRosario, Virgílio DoHollingdale, Michael R.2012-07-02T00:56:55Zoai:revistas.usp.br:article/28493Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:13.318134Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil
Prevalência de anticorpos anti-esporozoitos de P: Falciparum em soros da região do Amapá, Brasil
title Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil
spellingShingle Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil
Rosario, Virgílio Do
Anti-sporozoite antibody
inhibiton of sporozoite invasion (ISI) assay
circumsporozoite precipitation (CSP) assay
immunofluorescent antibody (IFA) assay
title_short Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil
title_full Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil
title_fullStr Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil
title_full_unstemmed Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil
title_sort Prevalence of anti-p: Falciparum sporozoite antibodies in adults in the amapa region of Brazil
author Rosario, Virgílio Do
author_facet Rosario, Virgílio Do
Hollingdale, Michael R.
author_role author
author2 Hollingdale, Michael R.
author2_role author
dc.contributor.author.fl_str_mv Rosario, Virgílio Do
Hollingdale, Michael R.
dc.subject.por.fl_str_mv Anti-sporozoite antibody
inhibiton of sporozoite invasion (ISI) assay
circumsporozoite precipitation (CSP) assay
immunofluorescent antibody (IFA) assay
topic Anti-sporozoite antibody
inhibiton of sporozoite invasion (ISI) assay
circumsporozoite precipitation (CSP) assay
immunofluorescent antibody (IFA) assay
description 17 of 20 adult sera from the Amapa region of Brazil were active in the inhibition of P. falciparum sporozoite invasion (ISI) assay which has been correlated with protective antibodies. In contrast 11 sera were positive in IFA tests and 6 were positive in CSP tests. These results suggest that the ISI assay will be useful for evaluating naturally acquired protective anti-sporozoite antibodies in endemic areas, particularly during vaccine efficacy studies using sporozoite-based vaccines.
publishDate 1987
dc.date.none.fl_str_mv 1987-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28493
url https://www.revistas.usp.br/rimtsp/article/view/28493
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28493/30346
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 No. 1 (1987); 63-66
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 29 Núm. 1 (1987); 63-66
Revista do Instituto de Medicina Tropical de São Paulo; v. 29 n. 1 (1987); 63-66
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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