Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route

Detalhes bibliográficos
Autor(a) principal: Carrilho, Flair José
Data de Publicação: 1989
Outros Autores: Queiroz, Maria Lúcia, Silva, Luiz Caetano da, Fonseca, Luís Edmundo Pinto da, Granato, Celso, Oba, Isabel, Obara, Leda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28645
Resumo: Schedule for vaccination against HBV infection has usually been based on three separate injections of 20 meg of the vaccine by intramuscular route. One of the main shortcomings to its use in large scale programs has been its high cost. Ninety out of 300 health workers were submitted to three injections of 2 meg of plasma-derived vaccine (PDV) by intradermal (ID) route on days 0, 30, and 180. Anti-HBs was detected in 74 (82.2%) after the second dose and in 80 (88.9%) after the third dose, a non-significant difference. However, levels above 10 times the cut-off were observed in 29 (32.2%) and 77 (85.5%), respectively (p < 0.001). The results showed that a low-dose schedule is effective when used in health workers and should be tried with other risk groups.
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spelling Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route Imunização ativa contra o virus da Hepatite B com baixas doses da vacina plasma derivada por via intradérmica Hepatitis BHepatitis B virusHepatitis B vaccineImmunization Schedule for vaccination against HBV infection has usually been based on three separate injections of 20 meg of the vaccine by intramuscular route. One of the main shortcomings to its use in large scale programs has been its high cost. Ninety out of 300 health workers were submitted to three injections of 2 meg of plasma-derived vaccine (PDV) by intradermal (ID) route on days 0, 30, and 180. Anti-HBs was detected in 74 (82.2%) after the second dose and in 80 (88.9%) after the third dose, a non-significant difference. However, levels above 10 times the cut-off were observed in 29 (32.2%) and 77 (85.5%), respectively (p < 0.001). The results showed that a low-dose schedule is effective when used in health workers and should be tried with other risk groups. O esquema habitualmente utilizado para imunização ativa contra o vírus da hepatite B (VHB) consiste em 3 doses de 20 meg por via intramuscular (IM) no deltóide. Um dos problemas quanto à sua utilização em larga escala refere-se ao seu custo elevado. Poucas publicações têm se referido a doses menores, de 10 meg IM ou 2 meg intradérmica (ID). Pesquisou-se em 300 funcionários da área da saúde o anti-HBc-total. Todos os marcadores foram determinados pela técnica de ELISA. Em 43 (14,3%) o marcador foi positivo, correspondendo a 9 (3,0%) com AgHBs e a 34 (11,3%) com anti-HBs. Aos 257 funcionários sem anti-HBc propôs-se um esquema de vacinação, que foi aceito por 90 (35,0%). Idade média de 37,4 ± 8,4 anos, limites de 22 - 56 anos e 68 do sexo feminino. Esquema: 3 doses de 2 meg por via ID com intervalos de 1 e 6 meses. O anti-HBs, pesquisado após a 2ª dose mostrou-se positivo em 74 (82,2%) e após a 3ª dose em 80 (88,9%) - diferença não significativa. Contudo, a quantificação do anti-HBs mostrou níveis 10 vezes acima do "cut-off em 29 (32,2%) e em 77 (85,5%) após a 2ª e 3ª doses, respectivamente (p < 0,001). Portanto, o esquema proposto mostrou-se válido para este tipo de população e, apesar da freqüência semelhante de sero-conversão após a 2ª e 3ª doses, há necessidade desta última para aumentar o título de anticorpos. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1989-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28645Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 2 (1989); 91-94 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 2 (1989); 91-94 Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 2 (1989); 91-94 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28645/30498Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessCarrilho, Flair JoséQueiroz, Maria LúciaSilva, Luiz Caetano daFonseca, Luís Edmundo Pinto daGranato, CelsoOba, IsabelObara, Leda2012-07-02T01:08:42Zoai:revistas.usp.br:article/28645Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:23.406972Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route
Imunização ativa contra o virus da Hepatite B com baixas doses da vacina plasma derivada por via intradérmica
title Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route
spellingShingle Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route
Carrilho, Flair José
Hepatitis B
Hepatitis B virus
Hepatitis B vaccine
Immunization
title_short Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route
title_full Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route
title_fullStr Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route
title_full_unstemmed Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route
title_sort Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route
author Carrilho, Flair José
author_facet Carrilho, Flair José
Queiroz, Maria Lúcia
Silva, Luiz Caetano da
Fonseca, Luís Edmundo Pinto da
Granato, Celso
Oba, Isabel
Obara, Leda
author_role author
author2 Queiroz, Maria Lúcia
Silva, Luiz Caetano da
Fonseca, Luís Edmundo Pinto da
Granato, Celso
Oba, Isabel
Obara, Leda
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carrilho, Flair José
Queiroz, Maria Lúcia
Silva, Luiz Caetano da
Fonseca, Luís Edmundo Pinto da
Granato, Celso
Oba, Isabel
Obara, Leda
dc.subject.por.fl_str_mv Hepatitis B
Hepatitis B virus
Hepatitis B vaccine
Immunization
topic Hepatitis B
Hepatitis B virus
Hepatitis B vaccine
Immunization
description Schedule for vaccination against HBV infection has usually been based on three separate injections of 20 meg of the vaccine by intramuscular route. One of the main shortcomings to its use in large scale programs has been its high cost. Ninety out of 300 health workers were submitted to three injections of 2 meg of plasma-derived vaccine (PDV) by intradermal (ID) route on days 0, 30, and 180. Anti-HBs was detected in 74 (82.2%) after the second dose and in 80 (88.9%) after the third dose, a non-significant difference. However, levels above 10 times the cut-off were observed in 29 (32.2%) and 77 (85.5%), respectively (p < 0.001). The results showed that a low-dose schedule is effective when used in health workers and should be tried with other risk groups.
publishDate 1989
dc.date.none.fl_str_mv 1989-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28645
url https://www.revistas.usp.br/rimtsp/article/view/28645
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28645/30498
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 No. 2 (1989); 91-94
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 31 Núm. 2 (1989); 91-94
Revista do Instituto de Medicina Tropical de São Paulo; v. 31 n. 2 (1989); 91-94
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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