Studies on human anti-rabies immunization in Brazil: II - Preliminary evaluation of the 2-1-1 schedule for human pre-exposure anti-rabies immunization, employing suckling mouse brain vaccine
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/29289 |
Resumo: | This study reports preliminary results of virus neutralizing antibody (VNA) titers obtained on different days in the course of human anti-rabies immunization with the 2-1-1 schedule (one dose is given in the right arm and one dose in the left arm at day 0, and one dose is apllied on days 7 and 21), recommended by WHO for post-exposure treatment with cell culture vaccines. A variant schedule (double dose on day zero and another on day 14) was also tested, both employing suckling mouse brain vaccine. A complete seroconversion rate was obtained after only 3 vaccine doses, and almost all patients (11 of 12) presented titers higher than 1.0 IU/ml. Both neutralizing response and seroconversion rates were lower in the group receiving only 3 doses, regardless of the sample collecting day. Although our results are lower than those found with cell culture vaccines, the geometry mean of VNA is fully satisfactory, overcoming the lower limit recommended by WHO of 0.5 IU/ml. The 2-1-1 schedule could be an alternative one for pre exposure immunization, shorter than the classical 3+1 regimen (one dose on days 0, 2, 4 and 30) with only three visits to the doctor, instead of four. |
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Studies on human anti-rabies immunization in Brazil: II - Preliminary evaluation of the 2-1-1 schedule for human pre-exposure anti-rabies immunization, employing suckling mouse brain vaccine Estudos sobre imunização anti-rábica humana no Brasil: II - Avaliação preliminar do esquema 2-1-1 para imunização anti-rábica humana pré-exposição, empregando vacina de tecido nervoso de camundongos recém-nascidos RabiesHuman pre-exposure vaccination2-1-1 scheduleMouse brain vaccine This study reports preliminary results of virus neutralizing antibody (VNA) titers obtained on different days in the course of human anti-rabies immunization with the 2-1-1 schedule (one dose is given in the right arm and one dose in the left arm at day 0, and one dose is apllied on days 7 and 21), recommended by WHO for post-exposure treatment with cell culture vaccines. A variant schedule (double dose on day zero and another on day 14) was also tested, both employing suckling mouse brain vaccine. A complete seroconversion rate was obtained after only 3 vaccine doses, and almost all patients (11 of 12) presented titers higher than 1.0 IU/ml. Both neutralizing response and seroconversion rates were lower in the group receiving only 3 doses, regardless of the sample collecting day. Although our results are lower than those found with cell culture vaccines, the geometry mean of VNA is fully satisfactory, overcoming the lower limit recommended by WHO of 0.5 IU/ml. The 2-1-1 schedule could be an alternative one for pre exposure immunization, shorter than the classical 3+1 regimen (one dose on days 0, 2, 4 and 30) with only three visits to the doctor, instead of four. Este estudo apresenta resultados preliminares de títulos de anticorpos neutralizantes (AcN) obtidos em diferentes dias durante imunização anti-rábica humana empregando o esquema 2-1-1 (uma dose administrada em cada deltóide no dia 0, e uma dose nos dias 7 e 21), recomendado pela OMS para tratamento pós-exposição com vacinas de cultivo celular. Um esquema variante (dose dupla no dia zero e outra no dia 14) também foi testado; em ambos esquemas utilizamos a vacina produzida em cérebro de camundongos recém-nascidos. Obteve-se taxa de soroconversão total após 3 doses de vacina, e quase todos os pacientes (11 de 12) apresentaram títulos maiores que 1,0 UI/ml. Tanto os títulos de anticorpos neutralizantes como a taxa de soroconversão foram menores no grupo que recebeu apenas 3 doses, independentemente do dia da coleta de soro. Embora nossos resultados tenham sido inferiores àqueles encontrados com vacinas de cultivo celular, a média geométrica de AcN foi inteiramente satisfatória, sobrepondo o limite mínimo de 0,5 UI/ml recomendado pela OMS. O esquema 2-1-1 pode ser alternativa para tratamento pré-exposição: mais curto que o esquema clássico 3 + 1 (uma dose nos dias 0, 2, 4 e 30) e com apenas três idas ao médico, ao invés de quatro. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1995-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/29289Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 4 (1995); 353-356 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 4 (1995); 353-356 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 4 (1995); 353-356 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/29289/31146Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessZanetti, Carlos RobertoLee, Luiza MarnyChaves, Luciana BotelhoRodrigues, José LuizEleutério, Gilton CPereira, Octavio Augusto de C.2012-07-02T01:40:37Zoai:revistas.usp.br:article/29289Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:02.265527Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Studies on human anti-rabies immunization in Brazil: II - Preliminary evaluation of the 2-1-1 schedule for human pre-exposure anti-rabies immunization, employing suckling mouse brain vaccine Estudos sobre imunização anti-rábica humana no Brasil: II - Avaliação preliminar do esquema 2-1-1 para imunização anti-rábica humana pré-exposição, empregando vacina de tecido nervoso de camundongos recém-nascidos |
title |
Studies on human anti-rabies immunization in Brazil: II - Preliminary evaluation of the 2-1-1 schedule for human pre-exposure anti-rabies immunization, employing suckling mouse brain vaccine |
spellingShingle |
Studies on human anti-rabies immunization in Brazil: II - Preliminary evaluation of the 2-1-1 schedule for human pre-exposure anti-rabies immunization, employing suckling mouse brain vaccine Zanetti, Carlos Roberto Rabies Human pre-exposure vaccination 2-1-1 schedule Mouse brain vaccine |
title_short |
Studies on human anti-rabies immunization in Brazil: II - Preliminary evaluation of the 2-1-1 schedule for human pre-exposure anti-rabies immunization, employing suckling mouse brain vaccine |
title_full |
Studies on human anti-rabies immunization in Brazil: II - Preliminary evaluation of the 2-1-1 schedule for human pre-exposure anti-rabies immunization, employing suckling mouse brain vaccine |
title_fullStr |
Studies on human anti-rabies immunization in Brazil: II - Preliminary evaluation of the 2-1-1 schedule for human pre-exposure anti-rabies immunization, employing suckling mouse brain vaccine |
title_full_unstemmed |
Studies on human anti-rabies immunization in Brazil: II - Preliminary evaluation of the 2-1-1 schedule for human pre-exposure anti-rabies immunization, employing suckling mouse brain vaccine |
title_sort |
Studies on human anti-rabies immunization in Brazil: II - Preliminary evaluation of the 2-1-1 schedule for human pre-exposure anti-rabies immunization, employing suckling mouse brain vaccine |
author |
Zanetti, Carlos Roberto |
author_facet |
Zanetti, Carlos Roberto Lee, Luiza Marny Chaves, Luciana Botelho Rodrigues, José Luiz Eleutério, Gilton C Pereira, Octavio Augusto de C. |
author_role |
author |
author2 |
Lee, Luiza Marny Chaves, Luciana Botelho Rodrigues, José Luiz Eleutério, Gilton C Pereira, Octavio Augusto de C. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Zanetti, Carlos Roberto Lee, Luiza Marny Chaves, Luciana Botelho Rodrigues, José Luiz Eleutério, Gilton C Pereira, Octavio Augusto de C. |
dc.subject.por.fl_str_mv |
Rabies Human pre-exposure vaccination 2-1-1 schedule Mouse brain vaccine |
topic |
Rabies Human pre-exposure vaccination 2-1-1 schedule Mouse brain vaccine |
description |
This study reports preliminary results of virus neutralizing antibody (VNA) titers obtained on different days in the course of human anti-rabies immunization with the 2-1-1 schedule (one dose is given in the right arm and one dose in the left arm at day 0, and one dose is apllied on days 7 and 21), recommended by WHO for post-exposure treatment with cell culture vaccines. A variant schedule (double dose on day zero and another on day 14) was also tested, both employing suckling mouse brain vaccine. A complete seroconversion rate was obtained after only 3 vaccine doses, and almost all patients (11 of 12) presented titers higher than 1.0 IU/ml. Both neutralizing response and seroconversion rates were lower in the group receiving only 3 doses, regardless of the sample collecting day. Although our results are lower than those found with cell culture vaccines, the geometry mean of VNA is fully satisfactory, overcoming the lower limit recommended by WHO of 0.5 IU/ml. The 2-1-1 schedule could be an alternative one for pre exposure immunization, shorter than the classical 3+1 regimen (one dose on days 0, 2, 4 and 30) with only three visits to the doctor, instead of four. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29289 |
url |
https://www.revistas.usp.br/rimtsp/article/view/29289 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29289/31146 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 4 (1995); 353-356 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 4 (1995); 353-356 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 4 (1995); 353-356 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951641634832384 |