The Human papillomavirus: a factor related with the formation of neoplasias
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/1975 |
Resumo: | Recent studies using new technologies on viral detection, allow us to consider the human papillomavirus (HPV) as the etiological agent of the cervix cancer. Besides its action on genital regions, other anatomic sites have been infected by the HPV, mainly the head and neck regions. This virus infects both the mucosal and the cutaneous tissue, and can be also classified according to its tropism as mucosotropic or cutaneotropic. However, according to its capacity of causing malignant or benign lesions, it can be divided into high and low-risk oncogenic HPV. The HPV oncogenic potencial is related to two viral proteins, E6 and E7, which are capable to interact with proteins that regulate the cell cicle and act as tumor suppressors, like p53 and pRB. This interaction provokes the degradation and inactivation of the celular proteins, leading to cellular transformation, immortalization and, later, to the formation of neoplasias. |
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The Human papillomavirus: a factor related with the formation of neoplasiasO Papilomavírus Humano: um fator relacionado com a formação de neoplasiasPapilomavírus humanoOncogenesSupressores de tumorNeoplasiasHuman papillomavirusOncogenesTumor suppressorsNeoplasmsRecent studies using new technologies on viral detection, allow us to consider the human papillomavirus (HPV) as the etiological agent of the cervix cancer. Besides its action on genital regions, other anatomic sites have been infected by the HPV, mainly the head and neck regions. This virus infects both the mucosal and the cutaneous tissue, and can be also classified according to its tropism as mucosotropic or cutaneotropic. However, according to its capacity of causing malignant or benign lesions, it can be divided into high and low-risk oncogenic HPV. The HPV oncogenic potencial is related to two viral proteins, E6 and E7, which are capable to interact with proteins that regulate the cell cicle and act as tumor suppressors, like p53 and pRB. This interaction provokes the degradation and inactivation of the celular proteins, leading to cellular transformation, immortalization and, later, to the formation of neoplasias.Os estudos realizados nos últimos anos, com o auxílio de novas tecnologias de detecção viral, permitem-nos considerar o Papilomavírus Humano (HPV) como o agente causal do câncer do colo de útero. Além da interação com as regiões genitais, outros sítios anatômicos têm sido acometidos pelo HPV, tendo destaque as regiões da cabeça e pescoço. Esse vírus infecta tanto as mucosas quanto os tecidos cutâneos, podendo ser classificado segundo seu tropismo como mucosotrópicos ou cutaneotrópicos. Quanto à sua capacidade de causar lesões malignas ou benignas, pode ser dividido em HPV de alto e baixo risco oncogênico. O potencial carcinogênico do HPV é relacionado a duas proteínas virais, E6 e E7, as quais são capazes de interagir com proteínas que regulam o ciclo celular e que atuam como supressoras de tumores, como a p53 e pRb. Essa interação provoca a degradação e inativação das proteínas celulares, o que conduziria a transformação, imortalização celular, e posteriormente, a formação de neoplasias.INCA2005-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/197510.32635/2176-9745.RBC.2005v51n2.1975Revista Brasileira de Cancerologia; Vol. 51 No. 2 (2005): Apr/May/June; 155-160Revista Brasileira de Cancerologia; Vol. 51 Núm. 2 (2005): abr./mayo/jun.; 155-160Revista Brasileira de Cancerologia; v. 51 n. 2 (2005): abr./maio/jun.; 155-1602176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1975/1203Souto, Rafael Falhari, Júlio Pedro Borgo Cruz, Aparecido Divino da info:eu-repo/semantics/openAccess2021-11-29T20:30:18Zoai:rbc.inca.gov.br:article/1975Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:30:18Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
The Human papillomavirus: a factor related with the formation of neoplasias O Papilomavírus Humano: um fator relacionado com a formação de neoplasias |
title |
The Human papillomavirus: a factor related with the formation of neoplasias |
spellingShingle |
The Human papillomavirus: a factor related with the formation of neoplasias Souto, Rafael Papilomavírus humano Oncogenes Supressores de tumor Neoplasias Human papillomavirus Oncogenes Tumor suppressors Neoplasms |
title_short |
The Human papillomavirus: a factor related with the formation of neoplasias |
title_full |
The Human papillomavirus: a factor related with the formation of neoplasias |
title_fullStr |
The Human papillomavirus: a factor related with the formation of neoplasias |
title_full_unstemmed |
The Human papillomavirus: a factor related with the formation of neoplasias |
title_sort |
The Human papillomavirus: a factor related with the formation of neoplasias |
author |
Souto, Rafael |
author_facet |
Souto, Rafael Falhari, Júlio Pedro Borgo Cruz, Aparecido Divino da |
author_role |
author |
author2 |
Falhari, Júlio Pedro Borgo Cruz, Aparecido Divino da |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Souto, Rafael Falhari, Júlio Pedro Borgo Cruz, Aparecido Divino da |
dc.subject.por.fl_str_mv |
Papilomavírus humano Oncogenes Supressores de tumor Neoplasias Human papillomavirus Oncogenes Tumor suppressors Neoplasms |
topic |
Papilomavírus humano Oncogenes Supressores de tumor Neoplasias Human papillomavirus Oncogenes Tumor suppressors Neoplasms |
description |
Recent studies using new technologies on viral detection, allow us to consider the human papillomavirus (HPV) as the etiological agent of the cervix cancer. Besides its action on genital regions, other anatomic sites have been infected by the HPV, mainly the head and neck regions. This virus infects both the mucosal and the cutaneous tissue, and can be also classified according to its tropism as mucosotropic or cutaneotropic. However, according to its capacity of causing malignant or benign lesions, it can be divided into high and low-risk oncogenic HPV. The HPV oncogenic potencial is related to two viral proteins, E6 and E7, which are capable to interact with proteins that regulate the cell cicle and act as tumor suppressors, like p53 and pRB. This interaction provokes the degradation and inactivation of the celular proteins, leading to cellular transformation, immortalization and, later, to the formation of neoplasias. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-06-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Revisão de literatura |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1975 10.32635/2176-9745.RBC.2005v51n2.1975 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/1975 |
identifier_str_mv |
10.32635/2176-9745.RBC.2005v51n2.1975 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1975/1203 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 51 No. 2 (2005): Apr/May/June; 155-160 Revista Brasileira de Cancerologia; Vol. 51 Núm. 2 (2005): abr./mayo/jun.; 155-160 Revista Brasileira de Cancerologia; v. 51 n. 2 (2005): abr./maio/jun.; 155-160 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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