The Human papillomavirus: a factor related with the formation of neoplasias

Detalhes bibliográficos
Autor(a) principal: Souto, Rafael
Data de Publicação: 2005
Outros Autores: Falhari, Júlio Pedro Borgo, Cruz, Aparecido Divino da
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1975
Resumo: Recent studies using new technologies on viral detection, allow us to consider the human papillomavirus (HPV) as the etiological agent of the cervix cancer. Besides its action on genital regions, other anatomic sites have been infected by the HPV, mainly the head and neck regions. This virus infects both the mucosal and the cutaneous tissue, and can be also classified according to its tropism as mucosotropic or cutaneotropic. However, according to its capacity of causing malignant or benign lesions, it can be divided into high and low-risk oncogenic HPV. The HPV oncogenic potencial is related to two viral proteins, E6 and E7, which are capable to interact with proteins that regulate the cell cicle and act as tumor suppressors, like p53 and pRB. This interaction provokes the degradation and inactivation of the celular proteins, leading to cellular transformation, immortalization and, later, to the formation of neoplasias.
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spelling The Human papillomavirus: a factor related with the formation of neoplasiasO Papilomavírus Humano: um fator relacionado com a formação de neoplasiasPapilomavírus humanoOncogenesSupressores de tumorNeoplasiasHuman papillomavirusOncogenesTumor suppressorsNeoplasmsRecent studies using new technologies on viral detection, allow us to consider the human papillomavirus (HPV) as the etiological agent of the cervix cancer. Besides its action on genital regions, other anatomic sites have been infected by the HPV, mainly the head and neck regions. This virus infects both the mucosal and the cutaneous tissue, and can be also classified according to its tropism as mucosotropic or cutaneotropic. However, according to its capacity of causing malignant or benign lesions, it can be divided into high and low-risk oncogenic HPV. The HPV oncogenic potencial is related to two viral proteins, E6 and E7, which are capable to interact with proteins that regulate the cell cicle and act as tumor suppressors, like p53 and pRB. This interaction provokes the degradation and inactivation of the celular proteins, leading to cellular transformation, immortalization and, later, to the formation of neoplasias.Os estudos realizados nos últimos anos, com o auxílio de novas tecnologias de detecção viral, permitem-nos considerar o Papilomavírus Humano (HPV) como o agente causal do câncer do colo de útero. Além da interação com as regiões genitais, outros sítios anatômicos têm sido acometidos pelo HPV, tendo destaque as regiões da cabeça e pescoço. Esse vírus infecta tanto as mucosas quanto os tecidos cutâneos, podendo ser classificado segundo seu tropismo como mucosotrópicos ou cutaneotrópicos. Quanto à sua capacidade de causar lesões malignas ou benignas, pode ser dividido em HPV de alto e baixo risco oncogênico. O potencial carcinogênico do HPV é relacionado a duas proteínas virais, E6 e E7, as quais são capazes de interagir com proteínas que regulam o ciclo celular e que atuam como supressoras de tumores, como a p53 e pRb. Essa interação provoca a degradação e inativação das proteínas celulares, o que conduziria a transformação, imortalização celular, e posteriormente, a formação de neoplasias.INCA2005-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/197510.32635/2176-9745.RBC.2005v51n2.1975Revista Brasileira de Cancerologia; Vol. 51 No. 2 (2005): Apr/May/June; 155-160Revista Brasileira de Cancerologia; Vol. 51 Núm. 2 (2005): abr./mayo/jun.; 155-160Revista Brasileira de Cancerologia; v. 51 n. 2 (2005): abr./maio/jun.; 155-1602176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1975/1203Souto, Rafael Falhari, Júlio Pedro Borgo Cruz, Aparecido Divino da info:eu-repo/semantics/openAccess2021-11-29T20:30:18Zoai:rbc.inca.gov.br:article/1975Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:30:18Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv The Human papillomavirus: a factor related with the formation of neoplasias
O Papilomavírus Humano: um fator relacionado com a formação de neoplasias
title The Human papillomavirus: a factor related with the formation of neoplasias
spellingShingle The Human papillomavirus: a factor related with the formation of neoplasias
Souto, Rafael
Papilomavírus humano
Oncogenes
Supressores de tumor
Neoplasias
Human papillomavirus
Oncogenes
Tumor suppressors
Neoplasms
title_short The Human papillomavirus: a factor related with the formation of neoplasias
title_full The Human papillomavirus: a factor related with the formation of neoplasias
title_fullStr The Human papillomavirus: a factor related with the formation of neoplasias
title_full_unstemmed The Human papillomavirus: a factor related with the formation of neoplasias
title_sort The Human papillomavirus: a factor related with the formation of neoplasias
author Souto, Rafael
author_facet Souto, Rafael
Falhari, Júlio Pedro Borgo
Cruz, Aparecido Divino da
author_role author
author2 Falhari, Júlio Pedro Borgo
Cruz, Aparecido Divino da
author2_role author
author
dc.contributor.author.fl_str_mv Souto, Rafael
Falhari, Júlio Pedro Borgo
Cruz, Aparecido Divino da
dc.subject.por.fl_str_mv Papilomavírus humano
Oncogenes
Supressores de tumor
Neoplasias
Human papillomavirus
Oncogenes
Tumor suppressors
Neoplasms
topic Papilomavírus humano
Oncogenes
Supressores de tumor
Neoplasias
Human papillomavirus
Oncogenes
Tumor suppressors
Neoplasms
description Recent studies using new technologies on viral detection, allow us to consider the human papillomavirus (HPV) as the etiological agent of the cervix cancer. Besides its action on genital regions, other anatomic sites have been infected by the HPV, mainly the head and neck regions. This virus infects both the mucosal and the cutaneous tissue, and can be also classified according to its tropism as mucosotropic or cutaneotropic. However, according to its capacity of causing malignant or benign lesions, it can be divided into high and low-risk oncogenic HPV. The HPV oncogenic potencial is related to two viral proteins, E6 and E7, which are capable to interact with proteins that regulate the cell cicle and act as tumor suppressors, like p53 and pRB. This interaction provokes the degradation and inactivation of the celular proteins, leading to cellular transformation, immortalization and, later, to the formation of neoplasias.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1975
10.32635/2176-9745.RBC.2005v51n2.1975
url https://rbc.inca.gov.br/index.php/revista/article/view/1975
identifier_str_mv 10.32635/2176-9745.RBC.2005v51n2.1975
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1975/1203
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 51 No. 2 (2005): Apr/May/June; 155-160
Revista Brasileira de Cancerologia; Vol. 51 Núm. 2 (2005): abr./mayo/jun.; 155-160
Revista Brasileira de Cancerologia; v. 51 n. 2 (2005): abr./maio/jun.; 155-160
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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