The involvement of genes and proteins in apoptosis - Carcinogenesis regulation
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/2852 |
Resumo: | Apoptosis is an importante feature in many normal biological process, such as embryogenesis, development of the immune system, cell maturation and differentiation. In occurrence of diseases, apoptosis seems to be involved in immunodeficiency, drug resistance and carcinogenesis. It is well known that carcinogenesis involves cumulative genetic alterations in oncogenes and tumor suppressor genes. Therefore the prognosis of each human tumor seems to be dependent on several genes, and it is foreseeable that a deeper knowledge on the co-operation and antagonism the these genes could provide, in the future, clinically relevant informations. We review some of the most recent developments concerning the genes involved in apoptosis and human cancers (p53, bcl-2, c-myc, fas-APO-l, mdr-l) and their clinical implications. |
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The involvement of genes and proteins in apoptosis - Carcinogenesis regulationO envolvimento de genes e proteínas na regulação da apoptose – CarcinogêneseApoptoseOncogenesGenes Supressores de TumorCarcinogêneseApoptosisOncogenesTumor Suppressor GenesCarcinogenesisApoptosis is an importante feature in many normal biological process, such as embryogenesis, development of the immune system, cell maturation and differentiation. In occurrence of diseases, apoptosis seems to be involved in immunodeficiency, drug resistance and carcinogenesis. It is well known that carcinogenesis involves cumulative genetic alterations in oncogenes and tumor suppressor genes. Therefore the prognosis of each human tumor seems to be dependent on several genes, and it is foreseeable that a deeper knowledge on the co-operation and antagonism the these genes could provide, in the future, clinically relevant informations. We review some of the most recent developments concerning the genes involved in apoptosis and human cancers (p53, bcl-2, c-myc, fas-APO-l, mdr-l) and their clinical implications.A apoptose é um fator importante em muitos processos biológicos normais, tais como a embriogênese, o desenvolvimento do sistema imune, a maturação e a diferenciação celular. Em situações patológicas, a apoptose parece estar implicada na imunodeficiência, resistência a drogas e carcinogênese. Sabe-se que a carcinogênese envolve alterações genéticas cumulativas em oncogenes e genes supressores de tumor. Dessa forma, o prognóstico de cada tumor humano parece depender do equilíbrio entre os diversos genes, sendo previsível que um conhecimento mais profundo da cooperação e antagonismo entre esses genes possa fornecer num futuro próximo informações clinicamente relevantes. Nós revisamos alguns dos mais recentes progressos a respeito de genes envolvidos na apoptose e nos cânceres humanos (p53, bcl-2, c-myc, fas-APO-l, mdr-1) e suas implicações clínicas.INCA2022-09-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/285210.32635/2176-9745.RBC.1997v43n3.2852Revista Brasileira de Cancerologia; Vol. 43 No. 3 (1997): July/Aug./Sept.; 173-186Revista Brasileira de Cancerologia; Vol. 43 Núm. 3 (1997): jul./ago./sept.; 173-186Revista Brasileira de Cancerologia; v. 43 n. 3 (1997): jul./ago./set.; 173-1862176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2852/1727https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDelfino, Ana Bárbara M.Barreto, Emandes CamposSilva Jr., Edejar Teixeira daMendonça, Renato Gonçalves deOrnellas, Maria Helena2023-01-18T14:51:28Zoai:rbc.inca.gov.br:article/2852Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-01-18T14:51:28Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
The involvement of genes and proteins in apoptosis - Carcinogenesis regulation O envolvimento de genes e proteínas na regulação da apoptose – Carcinogênese |
title |
The involvement of genes and proteins in apoptosis - Carcinogenesis regulation |
spellingShingle |
The involvement of genes and proteins in apoptosis - Carcinogenesis regulation Delfino, Ana Bárbara M. Apoptose Oncogenes Genes Supressores de Tumor Carcinogênese Apoptosis Oncogenes Tumor Suppressor Genes Carcinogenesis |
title_short |
The involvement of genes and proteins in apoptosis - Carcinogenesis regulation |
title_full |
The involvement of genes and proteins in apoptosis - Carcinogenesis regulation |
title_fullStr |
The involvement of genes and proteins in apoptosis - Carcinogenesis regulation |
title_full_unstemmed |
The involvement of genes and proteins in apoptosis - Carcinogenesis regulation |
title_sort |
The involvement of genes and proteins in apoptosis - Carcinogenesis regulation |
author |
Delfino, Ana Bárbara M. |
author_facet |
Delfino, Ana Bárbara M. Barreto, Emandes Campos Silva Jr., Edejar Teixeira da Mendonça, Renato Gonçalves de Ornellas, Maria Helena |
author_role |
author |
author2 |
Barreto, Emandes Campos Silva Jr., Edejar Teixeira da Mendonça, Renato Gonçalves de Ornellas, Maria Helena |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Delfino, Ana Bárbara M. Barreto, Emandes Campos Silva Jr., Edejar Teixeira da Mendonça, Renato Gonçalves de Ornellas, Maria Helena |
dc.subject.por.fl_str_mv |
Apoptose Oncogenes Genes Supressores de Tumor Carcinogênese Apoptosis Oncogenes Tumor Suppressor Genes Carcinogenesis |
topic |
Apoptose Oncogenes Genes Supressores de Tumor Carcinogênese Apoptosis Oncogenes Tumor Suppressor Genes Carcinogenesis |
description |
Apoptosis is an importante feature in many normal biological process, such as embryogenesis, development of the immune system, cell maturation and differentiation. In occurrence of diseases, apoptosis seems to be involved in immunodeficiency, drug resistance and carcinogenesis. It is well known that carcinogenesis involves cumulative genetic alterations in oncogenes and tumor suppressor genes. Therefore the prognosis of each human tumor seems to be dependent on several genes, and it is foreseeable that a deeper knowledge on the co-operation and antagonism the these genes could provide, in the future, clinically relevant informations. We review some of the most recent developments concerning the genes involved in apoptosis and human cancers (p53, bcl-2, c-myc, fas-APO-l, mdr-l) and their clinical implications. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2852 10.32635/2176-9745.RBC.1997v43n3.2852 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/2852 |
identifier_str_mv |
10.32635/2176-9745.RBC.1997v43n3.2852 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2852/1727 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 43 No. 3 (1997): July/Aug./Sept.; 173-186 Revista Brasileira de Cancerologia; Vol. 43 Núm. 3 (1997): jul./ago./sept.; 173-186 Revista Brasileira de Cancerologia; v. 43 n. 3 (1997): jul./ago./set.; 173-186 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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