Alcohol Consumption History as a Predictive Factor of Survival in Patients with Mouth and Oropharyngeal Squamous Cell Carcinoma: Follow-up of 15 Years
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por eng |
| Título da fonte: | Revista Brasileira de Cancerologia (Online) |
| Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/573 |
Resumo: | Introduction: Squamous cell carcinoma is the most important tumor in the head and neck region, due to its incidence and mortality. It is known that factors as alcohol consumption are related to the decrease of the survival of tumors, either stimulating tumor progression or causing considerable comorbidities, being an important study factor. Objective: Evaluate the influence of alcohol history on clinical and prognostic characteristics of patients with mouth oropharynx squamous cell carcinoma (MOSCC). Method: A retrospective cohort study in which 156 charts of alcoholic patients and 78 medical charts of non-alcoholic patients with MOSCC diagnosed at Haroldo Juaçaba Hospital in Fortaleza, state of Ceará were evaluated between 2000 and 2014 for data analysis such as age, gender and race, tumor location, TNM staging, treatments performed and 15-year survival through X², Long-Rank and Cox and multinomial regression models (SPSS 20.0; p <0.05). Results: Men were more prevalent among alcoholic patients (p <0.001), with T3/4 tumors (p = 0.003), positive lymph nodes (p = 0.006) who submitted to palliative treatments (p<0.001) and lower prevalence under 65 years (p <0.001), when there was a family history of cancer (p = 0.043). The survival of alcoholic patients was lower (p = 0.040) and the factors that independently reduced survival were male sex (p = 0.042), T3-T4 staging (p = 0.004), lymph node metastasis (p = 0.012), age> 65 years (p = 0.035) and tumor in the tongue (p = 0.042). Male sex was independently associated with alcohol consumption (p<0.001). Conclusion: Alcohol is a prognostic factor in patients with MOSCC, showing a higher prevalence in T3-T4 patients and, thus, negatively influencing the prognosis. |
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Alcohol Consumption History as a Predictive Factor of Survival in Patients with Mouth and Oropharyngeal Squamous Cell Carcinoma: Follow-up of 15 YearsHistoria del Consumo de Alcohol como Factor Predictivo para la Supervivencia en Pacientes con Carcinoma de Células Escamosas Bucales y Orofaríngeas: Seguimiento de 15 AñosHistórico de Consumo de Álcool como Fator Preditivo de Sobrevida em Pacientes com Carcinoma de Células Escamosas de Boca e Orofaringe: Follow-up de 15 AnosCarcinoma de Células EscamosasSobrevidaTranstornos Relacionados ao Uso de ÁlcoolCarcinoma, Squamous CellSurvivalAlcohol-Related DisordersCarcinoma de Células EscamosasSobrevidaTrastornos Relacionados con AlcoholIntroduction: Squamous cell carcinoma is the most important tumor in the head and neck region, due to its incidence and mortality. It is known that factors as alcohol consumption are related to the decrease of the survival of tumors, either stimulating tumor progression or causing considerable comorbidities, being an important study factor. Objective: Evaluate the influence of alcohol history on clinical and prognostic characteristics of patients with mouth oropharynx squamous cell carcinoma (MOSCC). Method: A retrospective cohort study in which 156 charts of alcoholic patients and 78 medical charts of non-alcoholic patients with MOSCC diagnosed at Haroldo Juaçaba Hospital in Fortaleza, state of Ceará were evaluated between 2000 and 2014 for data analysis such as age, gender and race, tumor location, TNM staging, treatments performed and 15-year survival through X², Long-Rank and Cox and multinomial regression models (SPSS 20.0; p <0.05). Results: Men were more prevalent among alcoholic patients (p <0.001), with T3/4 tumors (p = 0.003), positive lymph nodes (p = 0.006) who submitted to palliative treatments (p<0.001) and lower prevalence under 65 years (p <0.001), when there was a family history of cancer (p = 0.043). The survival of alcoholic patients was lower (p = 0.040) and the factors that independently reduced survival were male sex (p = 0.042), T3-T4 staging (p = 0.004), lymph node metastasis (p = 0.012), age> 65 years (p = 0.035) and tumor in the tongue (p = 0.042). Male sex was independently associated with alcohol consumption (p<0.001). Conclusion: Alcohol is a prognostic factor in patients with MOSCC, showing a higher prevalence in T3-T4 patients and, thus, negatively influencing the prognosis.Introducción: El carcinoma de células escamosas es el tumor de mayor importancia en la región de cabeza y cuello, debido a su incidencia y mortalidad. Se sabe que factores como el consumo de alcohol están relacionado con la disminución de la supervivencia de tumores tanto estimulando la progresión tumoral, como provocando comorbilidades considerables, siendo un factor de estudio importante. Objetivo: Evaluar la influencia del historial del consumo de alcohol en las características clínicas-pronósticas de pacientes con carcinoma de células escamosas oral y orofaringe (CCEOO). Método: Estudio retrospectivo en el que se evaluaron 156 registros médicos de pacientes consumidores de alcohol y 78 de pacientes no alcohólicos con CCEOO diagnosticados en el Hospital Haroldo Juaçaba, en Fortaleza, Ceará, entre 2000 y 2014, para el análisis de datos como edad, sexo raza, escolaridad, los antecedentes familiares, vínculo matrimonial, registro en el servicio, ubicación del tumor, clasificación de TNM, los tratamientos realizados y la supervivencia durante 15 años a través de las pruebas X² Long-Rank y modelos de regresión multinomial y de Cox (SPSS 20.0; p<0,05). Resultados: Hubo una mayor prevalencia de hombres entre pacientes alcohólicos (p<0,001), con tumores T3-T4 (p=0,003), ganglios linfáticos positivos (p=0,006), y realizó tratamientos paliativos (p<0,001) y menor prevalencia en paciente menores de 65 años (p <0,001); cuando se presentaron antecedentes familiares de cáncer (p=0,043). La supervivencia de los pacientes alcohólicos fue menor (p=0,040); y los factores que disminuyeron la supervivencia de forma independiente fueron hombres (p=0,042); estadificación t3-t4 (p=0,004); metástasis a ganglios linfáticos (p=0,012); edad > 65 años (p=0,035); localización de la lengua (p=0,042). El sexo masculino se asoció independientemente con el consumo de alcohol (p<0,001). Conclusión: El alcohol define el pronóstico en pacientes con CCEOO, muestra una mayor prevalencia en pacientes con T3-T4, por lo tanto, influye negativamente en el pronóstico.Introdução: O carcinoma de células escamosas é o tumor de maior importância na região de cabeça e pescoço, em razão da sua incidência e mortalidade. Sabe-se que fatores como consumo de álcool estão relacionados à diminuição da sobrevida de tumores tanto estimulando a progressão tumoral como causando comorbidades importantes, sendo um fator relevante para estudo. Objetivo: Avaliar a influência do histórico de álcool em características clinicoprognósticas de pacientes com carcinoma de células escamosas de boca e orofaringe (CCEBO). Método: Estudo de coorte, retrospectivo, no qual 156 prontuários de pacientes etilistas e 78 prontuários de pacientes não etilistas com CCEBO diagnosticados no Hospital Haroldo Juaçaba, em Fortaleza, Ceará, foram avaliados, entre 2000 e 2014, para análise de dados como idade, sexo, raça, localização do tumor, estadiamento TNM, tratamentos realizados e sobrevida em 15 anos por meio dos testes X², Long-Rank e modelos de regressão multinomial e de Cox (SPSS 20,0; p<0,05). Resultados: Houve maior prevalência de homens entre os pacientes etilistas (p<0,001), com tumores T3-T4 (p=0,003), linfonodos positivos (p=0,006) que realizaram tratamentos paliativos (p<0,001) e menor prevalência abaixo de 65 anos (p<0,001), quando havia histórico familiar de câncer (p=0,043). A sobrevida dos pacientes etilistas foi menor (p=0,040) e os fatores que diminuíram a sobrevida de maneira independente foram sexo masculino (p=0,042), estadiamento T3-T4 (p=0,004), metástase linfonodal (p=0,012), idade >65 anos (p=0,035) e localização na língua (p=0,042). O sexo masculino foi independentemente associado ao etilismo (p<0,001). Conclusão: O álcool é um fator de prognóstico em pacientes com CCEBO, mostrando maior prevalência em pacientes T3-T4 e, assim, influenciando negativamente no prognóstico.INCA2020-03-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/57310.32635/2176-9745.RBC.2020v66n1.573Revista Brasileira de Cancerologia; Vol. 66 No. 1 (2020): Jan./Feb./Mar.; e-02573Revista Brasileira de Cancerologia; Vol. 66 Núm. 1 (2020): enero/feb./marzo; e-02573Revista Brasileira de Cancerologia; v. 66 n. 1 (2020): jan./fev.mar.; e-025732176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/573/554https://rbc.inca.gov.br/index.php/revista/article/view/573/678Copyright (c) 2020 Revista Brasileira de Cancerologiainfo:eu-repo/semantics/openAccessde Barros Silva, Paulo Goberlânio Leite Soares, Isabelde Oliveira Mendes, Felipe Herbert Sales de Paula Campêlod, ClarissaSaldanha de Cunha, Maria do Perpétuo SocorroLima Mota, Mário RogérioSousa Dantas, ThinaliBitu Sousa, Fabrício2021-11-29T20:03:04Zoai:rbc.inca.gov.br:article/573Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:03:04Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
| dc.title.none.fl_str_mv |
Alcohol Consumption History as a Predictive Factor of Survival in Patients with Mouth and Oropharyngeal Squamous Cell Carcinoma: Follow-up of 15 Years Historia del Consumo de Alcohol como Factor Predictivo para la Supervivencia en Pacientes con Carcinoma de Células Escamosas Bucales y Orofaríngeas: Seguimiento de 15 Años Histórico de Consumo de Álcool como Fator Preditivo de Sobrevida em Pacientes com Carcinoma de Células Escamosas de Boca e Orofaringe: Follow-up de 15 Anos |
| title |
Alcohol Consumption History as a Predictive Factor of Survival in Patients with Mouth and Oropharyngeal Squamous Cell Carcinoma: Follow-up of 15 Years |
| spellingShingle |
Alcohol Consumption History as a Predictive Factor of Survival in Patients with Mouth and Oropharyngeal Squamous Cell Carcinoma: Follow-up of 15 Years de Barros Silva, Paulo Goberlânio Carcinoma de Células Escamosas Sobrevida Transtornos Relacionados ao Uso de Álcool Carcinoma, Squamous Cell Survival Alcohol-Related Disorders Carcinoma de Células Escamosas Sobrevida Trastornos Relacionados con Alcohol |
| title_short |
Alcohol Consumption History as a Predictive Factor of Survival in Patients with Mouth and Oropharyngeal Squamous Cell Carcinoma: Follow-up of 15 Years |
| title_full |
Alcohol Consumption History as a Predictive Factor of Survival in Patients with Mouth and Oropharyngeal Squamous Cell Carcinoma: Follow-up of 15 Years |
| title_fullStr |
Alcohol Consumption History as a Predictive Factor of Survival in Patients with Mouth and Oropharyngeal Squamous Cell Carcinoma: Follow-up of 15 Years |
| title_full_unstemmed |
Alcohol Consumption History as a Predictive Factor of Survival in Patients with Mouth and Oropharyngeal Squamous Cell Carcinoma: Follow-up of 15 Years |
| title_sort |
Alcohol Consumption History as a Predictive Factor of Survival in Patients with Mouth and Oropharyngeal Squamous Cell Carcinoma: Follow-up of 15 Years |
| author |
de Barros Silva, Paulo Goberlânio |
| author_facet |
de Barros Silva, Paulo Goberlânio Leite Soares, Isabel de Oliveira Mendes, Felipe Herbert Sales de Paula Campêlod, Clarissa Saldanha de Cunha, Maria do Perpétuo Socorro Lima Mota, Mário Rogério Sousa Dantas, Thinali Bitu Sousa, Fabrício |
| author_role |
author |
| author2 |
Leite Soares, Isabel de Oliveira Mendes, Felipe Herbert Sales de Paula Campêlod, Clarissa Saldanha de Cunha, Maria do Perpétuo Socorro Lima Mota, Mário Rogério Sousa Dantas, Thinali Bitu Sousa, Fabrício |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
de Barros Silva, Paulo Goberlânio Leite Soares, Isabel de Oliveira Mendes, Felipe Herbert Sales de Paula Campêlod, Clarissa Saldanha de Cunha, Maria do Perpétuo Socorro Lima Mota, Mário Rogério Sousa Dantas, Thinali Bitu Sousa, Fabrício |
| dc.subject.por.fl_str_mv |
Carcinoma de Células Escamosas Sobrevida Transtornos Relacionados ao Uso de Álcool Carcinoma, Squamous Cell Survival Alcohol-Related Disorders Carcinoma de Células Escamosas Sobrevida Trastornos Relacionados con Alcohol |
| topic |
Carcinoma de Células Escamosas Sobrevida Transtornos Relacionados ao Uso de Álcool Carcinoma, Squamous Cell Survival Alcohol-Related Disorders Carcinoma de Células Escamosas Sobrevida Trastornos Relacionados con Alcohol |
| description |
Introduction: Squamous cell carcinoma is the most important tumor in the head and neck region, due to its incidence and mortality. It is known that factors as alcohol consumption are related to the decrease of the survival of tumors, either stimulating tumor progression or causing considerable comorbidities, being an important study factor. Objective: Evaluate the influence of alcohol history on clinical and prognostic characteristics of patients with mouth oropharynx squamous cell carcinoma (MOSCC). Method: A retrospective cohort study in which 156 charts of alcoholic patients and 78 medical charts of non-alcoholic patients with MOSCC diagnosed at Haroldo Juaçaba Hospital in Fortaleza, state of Ceará were evaluated between 2000 and 2014 for data analysis such as age, gender and race, tumor location, TNM staging, treatments performed and 15-year survival through X², Long-Rank and Cox and multinomial regression models (SPSS 20.0; p <0.05). Results: Men were more prevalent among alcoholic patients (p <0.001), with T3/4 tumors (p = 0.003), positive lymph nodes (p = 0.006) who submitted to palliative treatments (p<0.001) and lower prevalence under 65 years (p <0.001), when there was a family history of cancer (p = 0.043). The survival of alcoholic patients was lower (p = 0.040) and the factors that independently reduced survival were male sex (p = 0.042), T3-T4 staging (p = 0.004), lymph node metastasis (p = 0.012), age> 65 years (p = 0.035) and tumor in the tongue (p = 0.042). Male sex was independently associated with alcohol consumption (p<0.001). Conclusion: Alcohol is a prognostic factor in patients with MOSCC, showing a higher prevalence in T3-T4 patients and, thus, negatively influencing the prognosis. |
| publishDate |
2020 |
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2020-03-16 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
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article |
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publishedVersion |
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https://rbc.inca.gov.br/index.php/revista/article/view/573 10.32635/2176-9745.RBC.2020v66n1.573 |
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https://rbc.inca.gov.br/index.php/revista/article/view/573 |
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10.32635/2176-9745.RBC.2020v66n1.573 |
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por eng |
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por eng |
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https://rbc.inca.gov.br/index.php/revista/article/view/573/554 https://rbc.inca.gov.br/index.php/revista/article/view/573/678 |
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Copyright (c) 2020 Revista Brasileira de Cancerologia info:eu-repo/semantics/openAccess |
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Copyright (c) 2020 Revista Brasileira de Cancerologia |
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openAccess |
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application/pdf application/pdf |
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INCA |
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INCA |
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Revista Brasileira de Cancerologia; Vol. 66 No. 1 (2020): Jan./Feb./Mar.; e-02573 Revista Brasileira de Cancerologia; Vol. 66 Núm. 1 (2020): enero/feb./marzo; e-02573 Revista Brasileira de Cancerologia; v. 66 n. 1 (2020): jan./fev.mar.; e-02573 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
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Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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Revista Brasileira de Cancerologia (Online) |
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