Serum Albumin is Independent Predictor of Hospital Mortality in Patients with Cancer
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/1209 |
Resumo: | Introduction: Cancer is one of the leading causes of morbidity and mortality worldwide. There are few studies showing adjusted models with other predictors of mortality by a conceptual model perspective. Objective: The objective of this study was to verify the prediction of albumin and Prognostic Nutritional Index (PNI) with in-hospital mortality in cancer patients. Method: Retrospective study was performed from 2014 to 2016 with 262 cancer patients (gastrointestinal tract, male genital organs, breast, metastasis, urinary tract, head and neck and others). Demographic data, blood counts, C-reactive protein, albumin, and haematological indexes (Prognosis nutritional index - PNI, Neutrophils to lymphocytes ratio - NLR, Monocytes lymphocytes ratio - MLR, Platelets to lymphocytes ratio - PLR and Platelets to albumin ratio - PAR), nutritional diagnoses and hospital outcomes (discharge or death) were collected. The cumulative probability of death was calculated by Kaplan-Meier curves, and survival analyses were performed using the Cox proportional hazards model. Results: The frequency of death among the study patients was 10.7% (28). Among the patients who died, 99.2% (26) presented some degree of malnutrition (p=0.004). In the multivariate analysis, serum albumin (<3 g/dL) was independently associated with in-hospital mortality (HR=3.43, 95% CI 1.11-10.63). On the other hand, the PNI was not associated with in-hospital mortality. Conclusion: Serum albumin levels during hospitalization were predictors of in-hospital mortality in the population evaluated. These results suggest that the serum levels of this protein can be used in clinical practice, adding prognostic information in patients with cancer. |
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Serum Albumin is Independent Predictor of Hospital Mortality in Patients with CancerLa Albúmina Sérica es un Predictor Independiente de Mortalidad Hospitalaria en Pacientes con CáncerA Albumina Sérica é Preditor Independente de Mortalidade Hospitalar em Pacientes com CâncerAlbumina SéricaMortalidade HospitalarAvaliação NutricionalNeoplasiasPrognósticoSerum AlbuminHospital MortalityNutritional AssessmentNeoplasmsPrognosisAlbúmina SéricaMortalidad HospitalariaEvaluación NutricionalNeoplasiasPrognósticoIntroduction: Cancer is one of the leading causes of morbidity and mortality worldwide. There are few studies showing adjusted models with other predictors of mortality by a conceptual model perspective. Objective: The objective of this study was to verify the prediction of albumin and Prognostic Nutritional Index (PNI) with in-hospital mortality in cancer patients. Method: Retrospective study was performed from 2014 to 2016 with 262 cancer patients (gastrointestinal tract, male genital organs, breast, metastasis, urinary tract, head and neck and others). Demographic data, blood counts, C-reactive protein, albumin, and haematological indexes (Prognosis nutritional index - PNI, Neutrophils to lymphocytes ratio - NLR, Monocytes lymphocytes ratio - MLR, Platelets to lymphocytes ratio - PLR and Platelets to albumin ratio - PAR), nutritional diagnoses and hospital outcomes (discharge or death) were collected. The cumulative probability of death was calculated by Kaplan-Meier curves, and survival analyses were performed using the Cox proportional hazards model. Results: The frequency of death among the study patients was 10.7% (28). Among the patients who died, 99.2% (26) presented some degree of malnutrition (p=0.004). In the multivariate analysis, serum albumin (<3 g/dL) was independently associated with in-hospital mortality (HR=3.43, 95% CI 1.11-10.63). On the other hand, the PNI was not associated with in-hospital mortality. Conclusion: Serum albumin levels during hospitalization were predictors of in-hospital mortality in the population evaluated. These results suggest that the serum levels of this protein can be used in clinical practice, adding prognostic information in patients with cancer.Introducción: El cáncer es una de las principales causas de morbilidad y mortalidad en todo el mundo. Hay pocos estudios que muestren modelos ajustados con otros predictores de mortalidad desde una perspectiva de modelo conceptual. Objetivo: El objetivo de este estudio fue verificar la predicción de la albumina y el Índice Nutricional Pronostico (IPN) con la mortalidad hospitalaria en pacientes con cáncer (tracto gastrointestinal, órganos genitales masculinos, mama, metástasis, tracto urinario, cabeza y cuello y otros). Método: Se realizo un estudio retrospectivo de 2014 a 2016 con 262 pacientes con cáncer. Se recogieron datos demográficos, hemogramas, proteína C reactiva, albumina y índices hematológicos (Índice de Pronostico Nutricional - IPN, proporción neutrófilos/linfocitos - NLR, proporción monocitos/linfocitos - MLR, proporción plaquetas/linfocitos - PLR y proporción plaquetas/albumina - PAR), diagnósticos nutricionales y resultados hospitalarios (alta o muerte). La probabilidad acumulada de muerte se calculó mediante curvas de Kaplan-Meier y se realizaron análisis supervivencia utilizando el modelo de riesgos proporcionales de Cox. Resultados: La frecuencia de muerte entre los pacientes del estudio fue del 10,7% (28). Entre los pacientes fallecidos, el 99,2% (26) presentaba algún grado de desnutrición (p=0,004). En el análisis multivariado, la albumina sérica (<3 g/dL) se asoció de forma independiente con la mortalidad hospitalaria (HR=3,43, IC 95% 1,11-10,63). Por otro lado, el IPN no se asoció con mortalidad intrahospitalaria. Conclusión: Los niveles de albumina sérica durante la hospitalización fueron predictores de mortalidad intrahospitalaria en la población evaluada. Nuestros resultados sugieren que los niveles séricos de esta proteína se pueden utilizar en la práctica clínica, agregando información de pronóstico en pacientes con cáncer.Introdução: O câncer e uma das principais causas de morbidade e mortalidade em todo o mundo. Existem poucos estudos mostrando modelos ajustados com outros preditores de mortalidade por uma perspectiva de modelo conceitual. Objetivo: Verificar a predição de albumina e do Índice Nutricional Prognostico (IPN) com mortalidade intra-hospitalar em pacientes com câncer. Método: Estudo retrospectivo realizado de 2014 a 2016 com 262 pacientes com câncer (trato gastrointestinal, órgãos genitais masculinos, mama, metástases, trato urinário, cabeça e pescoço e outros). Foram coletados dados demográficos, hemograma, proteína C reativa, albumina e índices hematológicos (índice de prognostico nutricional - IPN; relação neutrófilo por linfócitos - RNL; relação monócitos por linfócitos - RML; relação plaquetas por linfócitos - RPL; e relação plaquetas por albumina – RPA), diagnósticos nutricionais e desfechos hospitalares (alta ou óbito). A probabilidade cumulativa de morte foi calculada pelas curvas de Kaplan-Meier e as análises de sobrevivência realizadas usando o modelo de risco proporcional de Cox. Resultados: A frequência de óbito entre os pacientes do estudo foi de 10,7% (28). Entre os pacientes que morreram, 99,2% (26) apresentavam algum grau de desnutrição (p=0,004). Na análise multivariada, a albumina sérica (<3 g/dL) associou-se de forma independente a mortalidade hospitalar (HR=3,43, IC95% 1,11-10,63). Por outro lado, o IPN não foi associado com mortalidade intra-hospitalar. Conclusão: Os níveis de albumina sérica durante a internação foram preditores de mortalidade intra-hospitalar na população avaliada. Esses resultados sugerem que os níveis séricos dessa proteína podem ser utilizados na prática clínica, agregando informações prognosticas em pacientes com câncer.INCA2021-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/120910.32635/2176-9745.RBC.2021v67n4.1209Revista Brasileira de Cancerologia; Vol. 67 No. 4 (2021): Oct./Nov./Dec.; e-071209Revista Brasileira de Cancerologia; Vol. 67 Núm. 4 (2021): oct./nov./dic.; e-071209Revista Brasileira de Cancerologia; v. 67 n. 4 (2021): out./nov./dez.; e-0712092176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAenghttps://rbc.inca.gov.br/index.php/revista/article/view/1209/1521Copyright (c) 2021 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLima, Emanuelle do Nascimento Santos Ferreira, Isabela Borges Silva, Nayara Cristina da Prestes, Isaías Valente Pena, Geórgia das Graças2022-10-14T18:57:34Zoai:rbc.inca.gov.br:article/1209Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2022-10-14T18:57:34Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Serum Albumin is Independent Predictor of Hospital Mortality in Patients with Cancer La Albúmina Sérica es un Predictor Independiente de Mortalidad Hospitalaria en Pacientes con Cáncer A Albumina Sérica é Preditor Independente de Mortalidade Hospitalar em Pacientes com Câncer |
title |
Serum Albumin is Independent Predictor of Hospital Mortality in Patients with Cancer |
spellingShingle |
Serum Albumin is Independent Predictor of Hospital Mortality in Patients with Cancer Lima, Emanuelle do Nascimento Santos Albumina Sérica Mortalidade Hospitalar Avaliação Nutricional Neoplasias Prognóstico Serum Albumin Hospital Mortality Nutritional Assessment Neoplasms Prognosis Albúmina Sérica Mortalidad Hospitalaria Evaluación Nutricional Neoplasias Prognóstico |
title_short |
Serum Albumin is Independent Predictor of Hospital Mortality in Patients with Cancer |
title_full |
Serum Albumin is Independent Predictor of Hospital Mortality in Patients with Cancer |
title_fullStr |
Serum Albumin is Independent Predictor of Hospital Mortality in Patients with Cancer |
title_full_unstemmed |
Serum Albumin is Independent Predictor of Hospital Mortality in Patients with Cancer |
title_sort |
Serum Albumin is Independent Predictor of Hospital Mortality in Patients with Cancer |
author |
Lima, Emanuelle do Nascimento Santos |
author_facet |
Lima, Emanuelle do Nascimento Santos Ferreira, Isabela Borges Silva, Nayara Cristina da Prestes, Isaías Valente Pena, Geórgia das Graças |
author_role |
author |
author2 |
Ferreira, Isabela Borges Silva, Nayara Cristina da Prestes, Isaías Valente Pena, Geórgia das Graças |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Lima, Emanuelle do Nascimento Santos Ferreira, Isabela Borges Silva, Nayara Cristina da Prestes, Isaías Valente Pena, Geórgia das Graças |
dc.subject.por.fl_str_mv |
Albumina Sérica Mortalidade Hospitalar Avaliação Nutricional Neoplasias Prognóstico Serum Albumin Hospital Mortality Nutritional Assessment Neoplasms Prognosis Albúmina Sérica Mortalidad Hospitalaria Evaluación Nutricional Neoplasias Prognóstico |
topic |
Albumina Sérica Mortalidade Hospitalar Avaliação Nutricional Neoplasias Prognóstico Serum Albumin Hospital Mortality Nutritional Assessment Neoplasms Prognosis Albúmina Sérica Mortalidad Hospitalaria Evaluación Nutricional Neoplasias Prognóstico |
description |
Introduction: Cancer is one of the leading causes of morbidity and mortality worldwide. There are few studies showing adjusted models with other predictors of mortality by a conceptual model perspective. Objective: The objective of this study was to verify the prediction of albumin and Prognostic Nutritional Index (PNI) with in-hospital mortality in cancer patients. Method: Retrospective study was performed from 2014 to 2016 with 262 cancer patients (gastrointestinal tract, male genital organs, breast, metastasis, urinary tract, head and neck and others). Demographic data, blood counts, C-reactive protein, albumin, and haematological indexes (Prognosis nutritional index - PNI, Neutrophils to lymphocytes ratio - NLR, Monocytes lymphocytes ratio - MLR, Platelets to lymphocytes ratio - PLR and Platelets to albumin ratio - PAR), nutritional diagnoses and hospital outcomes (discharge or death) were collected. The cumulative probability of death was calculated by Kaplan-Meier curves, and survival analyses were performed using the Cox proportional hazards model. Results: The frequency of death among the study patients was 10.7% (28). Among the patients who died, 99.2% (26) presented some degree of malnutrition (p=0.004). In the multivariate analysis, serum albumin (<3 g/dL) was independently associated with in-hospital mortality (HR=3.43, 95% CI 1.11-10.63). On the other hand, the PNI was not associated with in-hospital mortality. Conclusion: Serum albumin levels during hospitalization were predictors of in-hospital mortality in the population evaluated. These results suggest that the serum levels of this protein can be used in clinical practice, adding prognostic information in patients with cancer. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1209 10.32635/2176-9745.RBC.2021v67n4.1209 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/1209 |
identifier_str_mv |
10.32635/2176-9745.RBC.2021v67n4.1209 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/1209/1521 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 67 No. 4 (2021): Oct./Nov./Dec.; e-071209 Revista Brasileira de Cancerologia; Vol. 67 Núm. 4 (2021): oct./nov./dic.; e-071209 Revista Brasileira de Cancerologia; v. 67 n. 4 (2021): out./nov./dez.; e-071209 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042246200066048 |