The role of vitamin A and carotenoids in the liver carcinogenesis

Detalhes bibliográficos
Autor(a) principal: Peres, Wilza Arantes Ferreira
Data de Publicação: 2003
Outros Autores: Paula, Tatiana Pereira de, Silva, Rejane Andréa Ramalho Nunes da, Coelho, Henrique Sérgio Moraes
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2113
Resumo: Hepatocellular carcinoma (HCC) is a highly malignant neoplasm with an extremely poor prognosis. Considerable evidence in literature suggests a relationship between nutrition and cancer. Many epidemiological studies suggested that an increased consumption of vitamin A and carotenoids may prevent the development of a wide range of cancers. The objective of this work, therefore, was to review in the scientific literature the effects of vitamin A and carotenoids on hepatocarcinogenesis. A number of studies suggests that retinol acts as an agent that controls both cellular proliferation and differentiation, which may affect carcinogenesis. The antitumor action of vitamin A and carotenoids can be correlated with an enhancement of the immune response, gap junction communications, antioxidant properties and protection against pre-neoplasic changes. The cancer chemopreventive action in individuals with life-threatening liver disease, such as those with cirrhosis and hepatocellular carcinoma, may offer longer survival time and a better prognosis.
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spelling The role of vitamin A and carotenoids in the liver carcinogenesisA atuação da vitamina A e carotenóides na hepatocarcinogêneseCarcinoma HepatocelularNeoplasias HepáticasPrognósticoRetinóidesVitamina ACarotenóidesQuimioprevençãoHepatocellular CarcinomaLiver NeoplasmsPrognosticRetinoidsVitamin ACarotenoidsChemopreventionHepatocellular carcinoma (HCC) is a highly malignant neoplasm with an extremely poor prognosis. Considerable evidence in literature suggests a relationship between nutrition and cancer. Many epidemiological studies suggested that an increased consumption of vitamin A and carotenoids may prevent the development of a wide range of cancers. The objective of this work, therefore, was to review in the scientific literature the effects of vitamin A and carotenoids on hepatocarcinogenesis. A number of studies suggests that retinol acts as an agent that controls both cellular proliferation and differentiation, which may affect carcinogenesis. The antitumor action of vitamin A and carotenoids can be correlated with an enhancement of the immune response, gap junction communications, antioxidant properties and protection against pre-neoplasic changes. The cancer chemopreventive action in individuals with life-threatening liver disease, such as those with cirrhosis and hepatocellular carcinoma, may offer longer survival time and a better prognosis.O carcinoma hepatocelular (CHC) é um tumor maligno de baixo prognóstico. Evidências demonstrando a relação entre nutrição e risco de desenvolvimento de câncer são freqüentes na literatura. Vários estudos epidemiológicos têm sugerido que o consumo freqüente de alimentos com elevado teor de carotenóides e vitamina A está associado ao risco reduzido de desenvolvimento de certos tipos de neoplasias. Objetivando verificar o volume de evidências científicas da atuação da vitamina A e dos carotenóides no processo de hepatocarcinogênese, foram revisados dados na literatura. Diversos estudos realizados até o momento apontam os retinóides como agentes que controlam tanto a diferenciação como a proliferação celular, podendo, dessa forma, serem úteis na quimioprevenção do câncer. Os mecanismos propostos pelos quais a vitamina A e os carotenóides exercem sua ação protetora incluem o aumento da função imunológica, dos canais de comunicação intercelular e da atividade antioxidante, apresentando ação inibitória nas lesões pré-neoplásicas. A quimioprevenção por meio da vitamina A ou carotenóides, pode resultar em melhor prognóstico e aumento de sobrevida para população de alto risco, tais como, pacientes com cirrose e CHC.INCA2003-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/211310.32635/2176-9745.RBC.2003v49n2.2113Revista Brasileira de Cancerologia; Vol. 49 No. 2 (2003): Apr./May/June; 113-120Revista Brasileira de Cancerologia; Vol. 49 Núm. 2 (2003): abr./mayo/jun.; 113-120Revista Brasileira de Cancerologia; v. 49 n. 2 (2003): abr./maio/jun.; 113-1202176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2113/1309Peres, Wilza Arantes Ferreira Paula, Tatiana Pereira de Silva, Rejane Andréa Ramalho Nunes da Coelho, Henrique Sérgio Moraes info:eu-repo/semantics/openAccess2021-11-29T20:35:36Zoai:rbc.inca.gov.br:article/2113Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:35:36Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv The role of vitamin A and carotenoids in the liver carcinogenesis
A atuação da vitamina A e carotenóides na hepatocarcinogênese
title The role of vitamin A and carotenoids in the liver carcinogenesis
spellingShingle The role of vitamin A and carotenoids in the liver carcinogenesis
Peres, Wilza Arantes Ferreira
Carcinoma Hepatocelular
Neoplasias Hepáticas
Prognóstico
Retinóides
Vitamina A
Carotenóides
Quimioprevenção
Hepatocellular Carcinoma
Liver Neoplasms
Prognostic
Retinoids
Vitamin A
Carotenoids
Chemoprevention
title_short The role of vitamin A and carotenoids in the liver carcinogenesis
title_full The role of vitamin A and carotenoids in the liver carcinogenesis
title_fullStr The role of vitamin A and carotenoids in the liver carcinogenesis
title_full_unstemmed The role of vitamin A and carotenoids in the liver carcinogenesis
title_sort The role of vitamin A and carotenoids in the liver carcinogenesis
author Peres, Wilza Arantes Ferreira
author_facet Peres, Wilza Arantes Ferreira
Paula, Tatiana Pereira de
Silva, Rejane Andréa Ramalho Nunes da
Coelho, Henrique Sérgio Moraes
author_role author
author2 Paula, Tatiana Pereira de
Silva, Rejane Andréa Ramalho Nunes da
Coelho, Henrique Sérgio Moraes
author2_role author
author
author
dc.contributor.author.fl_str_mv Peres, Wilza Arantes Ferreira
Paula, Tatiana Pereira de
Silva, Rejane Andréa Ramalho Nunes da
Coelho, Henrique Sérgio Moraes
dc.subject.por.fl_str_mv Carcinoma Hepatocelular
Neoplasias Hepáticas
Prognóstico
Retinóides
Vitamina A
Carotenóides
Quimioprevenção
Hepatocellular Carcinoma
Liver Neoplasms
Prognostic
Retinoids
Vitamin A
Carotenoids
Chemoprevention
topic Carcinoma Hepatocelular
Neoplasias Hepáticas
Prognóstico
Retinóides
Vitamina A
Carotenóides
Quimioprevenção
Hepatocellular Carcinoma
Liver Neoplasms
Prognostic
Retinoids
Vitamin A
Carotenoids
Chemoprevention
description Hepatocellular carcinoma (HCC) is a highly malignant neoplasm with an extremely poor prognosis. Considerable evidence in literature suggests a relationship between nutrition and cancer. Many epidemiological studies suggested that an increased consumption of vitamin A and carotenoids may prevent the development of a wide range of cancers. The objective of this work, therefore, was to review in the scientific literature the effects of vitamin A and carotenoids on hepatocarcinogenesis. A number of studies suggests that retinol acts as an agent that controls both cellular proliferation and differentiation, which may affect carcinogenesis. The antitumor action of vitamin A and carotenoids can be correlated with an enhancement of the immune response, gap junction communications, antioxidant properties and protection against pre-neoplasic changes. The cancer chemopreventive action in individuals with life-threatening liver disease, such as those with cirrhosis and hepatocellular carcinoma, may offer longer survival time and a better prognosis.
publishDate 2003
dc.date.none.fl_str_mv 2003-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2113
10.32635/2176-9745.RBC.2003v49n2.2113
url https://rbc.inca.gov.br/index.php/revista/article/view/2113
identifier_str_mv 10.32635/2176-9745.RBC.2003v49n2.2113
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2113/1309
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 49 No. 2 (2003): Apr./May/June; 113-120
Revista Brasileira de Cancerologia; Vol. 49 Núm. 2 (2003): abr./mayo/jun.; 113-120
Revista Brasileira de Cancerologia; v. 49 n. 2 (2003): abr./maio/jun.; 113-120
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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