The role of vitamin A and carotenoids in the liver carcinogenesis

Detalhes bibliográficos
Autor(a) principal: Peres, Wilza Arantes Ferreira
Data de Publicação: 2003
Outros Autores: Paula, Tatiana Pereira de, Silva, Rejane Andréa Ramalho Nunes da, Coelho, Henrique Sérgio Moraes
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
DOI: 10.32635/2176-9745.RBC.2003v49n2.2113
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2113
Resumo: Hepatocellular carcinoma (HCC) is a highly malignant neoplasm with an extremely poor prognosis. Considerable evidence in literature suggests a relationship between nutrition and cancer. Many epidemiological studies suggested that an increased consumption of vitamin A and carotenoids may prevent the development of a wide range of cancers. The objective of this work, therefore, was to review in the scientific literature the effects of vitamin A and carotenoids on hepatocarcinogenesis. A number of studies suggests that retinol acts as an agent that controls both cellular proliferation and differentiation, which may affect carcinogenesis. The antitumor action of vitamin A and carotenoids can be correlated with an enhancement of the immune response, gap junction communications, antioxidant properties and protection against pre-neoplasic changes. The cancer chemopreventive action in individuals with life-threatening liver disease, such as those with cirrhosis and hepatocellular carcinoma, may offer longer survival time and a better prognosis.
id INCA-1_294d207736c705d8156807280734df90
oai_identifier_str oai:rbc.inca.gov.br:article/2113
network_acronym_str INCA-1
network_name_str Revista Brasileira de Cancerologia (Online)
spelling The role of vitamin A and carotenoids in the liver carcinogenesisA atuação da vitamina A e carotenóides na hepatocarcinogêneseCarcinoma HepatocelularNeoplasias HepáticasPrognósticoRetinóidesVitamina ACarotenóidesQuimioprevençãoHepatocellular CarcinomaLiver NeoplasmsPrognosticRetinoidsVitamin ACarotenoidsChemopreventionHepatocellular carcinoma (HCC) is a highly malignant neoplasm with an extremely poor prognosis. Considerable evidence in literature suggests a relationship between nutrition and cancer. Many epidemiological studies suggested that an increased consumption of vitamin A and carotenoids may prevent the development of a wide range of cancers. The objective of this work, therefore, was to review in the scientific literature the effects of vitamin A and carotenoids on hepatocarcinogenesis. A number of studies suggests that retinol acts as an agent that controls both cellular proliferation and differentiation, which may affect carcinogenesis. The antitumor action of vitamin A and carotenoids can be correlated with an enhancement of the immune response, gap junction communications, antioxidant properties and protection against pre-neoplasic changes. The cancer chemopreventive action in individuals with life-threatening liver disease, such as those with cirrhosis and hepatocellular carcinoma, may offer longer survival time and a better prognosis.O carcinoma hepatocelular (CHC) é um tumor maligno de baixo prognóstico. Evidências demonstrando a relação entre nutrição e risco de desenvolvimento de câncer são freqüentes na literatura. Vários estudos epidemiológicos têm sugerido que o consumo freqüente de alimentos com elevado teor de carotenóides e vitamina A está associado ao risco reduzido de desenvolvimento de certos tipos de neoplasias. Objetivando verificar o volume de evidências científicas da atuação da vitamina A e dos carotenóides no processo de hepatocarcinogênese, foram revisados dados na literatura. Diversos estudos realizados até o momento apontam os retinóides como agentes que controlam tanto a diferenciação como a proliferação celular, podendo, dessa forma, serem úteis na quimioprevenção do câncer. Os mecanismos propostos pelos quais a vitamina A e os carotenóides exercem sua ação protetora incluem o aumento da função imunológica, dos canais de comunicação intercelular e da atividade antioxidante, apresentando ação inibitória nas lesões pré-neoplásicas. A quimioprevenção por meio da vitamina A ou carotenóides, pode resultar em melhor prognóstico e aumento de sobrevida para população de alto risco, tais como, pacientes com cirrose e CHC.INCA2003-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/211310.32635/2176-9745.RBC.2003v49n2.2113Revista Brasileira de Cancerologia; Vol. 49 No. 2 (2003): Apr./May/June; 113-120Revista Brasileira de Cancerologia; Vol. 49 Núm. 2 (2003): abr./mayo/jun.; 113-120Revista Brasileira de Cancerologia; v. 49 n. 2 (2003): abr./maio/jun.; 113-1202176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2113/1309Peres, Wilza Arantes Ferreira Paula, Tatiana Pereira de Silva, Rejane Andréa Ramalho Nunes da Coelho, Henrique Sérgio Moraes info:eu-repo/semantics/openAccess2021-11-29T20:35:36Zoai:rbc.inca.gov.br:article/2113Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:35:36Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv The role of vitamin A and carotenoids in the liver carcinogenesis
A atuação da vitamina A e carotenóides na hepatocarcinogênese
title The role of vitamin A and carotenoids in the liver carcinogenesis
spellingShingle The role of vitamin A and carotenoids in the liver carcinogenesis
The role of vitamin A and carotenoids in the liver carcinogenesis
Peres, Wilza Arantes Ferreira
Carcinoma Hepatocelular
Neoplasias Hepáticas
Prognóstico
Retinóides
Vitamina A
Carotenóides
Quimioprevenção
Hepatocellular Carcinoma
Liver Neoplasms
Prognostic
Retinoids
Vitamin A
Carotenoids
Chemoprevention
Peres, Wilza Arantes Ferreira
Carcinoma Hepatocelular
Neoplasias Hepáticas
Prognóstico
Retinóides
Vitamina A
Carotenóides
Quimioprevenção
Hepatocellular Carcinoma
Liver Neoplasms
Prognostic
Retinoids
Vitamin A
Carotenoids
Chemoprevention
title_short The role of vitamin A and carotenoids in the liver carcinogenesis
title_full The role of vitamin A and carotenoids in the liver carcinogenesis
title_fullStr The role of vitamin A and carotenoids in the liver carcinogenesis
The role of vitamin A and carotenoids in the liver carcinogenesis
title_full_unstemmed The role of vitamin A and carotenoids in the liver carcinogenesis
The role of vitamin A and carotenoids in the liver carcinogenesis
title_sort The role of vitamin A and carotenoids in the liver carcinogenesis
author Peres, Wilza Arantes Ferreira
author_facet Peres, Wilza Arantes Ferreira
Peres, Wilza Arantes Ferreira
Paula, Tatiana Pereira de
Silva, Rejane Andréa Ramalho Nunes da
Coelho, Henrique Sérgio Moraes
Paula, Tatiana Pereira de
Silva, Rejane Andréa Ramalho Nunes da
Coelho, Henrique Sérgio Moraes
author_role author
author2 Paula, Tatiana Pereira de
Silva, Rejane Andréa Ramalho Nunes da
Coelho, Henrique Sérgio Moraes
author2_role author
author
author
dc.contributor.author.fl_str_mv Peres, Wilza Arantes Ferreira
Paula, Tatiana Pereira de
Silva, Rejane Andréa Ramalho Nunes da
Coelho, Henrique Sérgio Moraes
dc.subject.por.fl_str_mv Carcinoma Hepatocelular
Neoplasias Hepáticas
Prognóstico
Retinóides
Vitamina A
Carotenóides
Quimioprevenção
Hepatocellular Carcinoma
Liver Neoplasms
Prognostic
Retinoids
Vitamin A
Carotenoids
Chemoprevention
topic Carcinoma Hepatocelular
Neoplasias Hepáticas
Prognóstico
Retinóides
Vitamina A
Carotenóides
Quimioprevenção
Hepatocellular Carcinoma
Liver Neoplasms
Prognostic
Retinoids
Vitamin A
Carotenoids
Chemoprevention
description Hepatocellular carcinoma (HCC) is a highly malignant neoplasm with an extremely poor prognosis. Considerable evidence in literature suggests a relationship between nutrition and cancer. Many epidemiological studies suggested that an increased consumption of vitamin A and carotenoids may prevent the development of a wide range of cancers. The objective of this work, therefore, was to review in the scientific literature the effects of vitamin A and carotenoids on hepatocarcinogenesis. A number of studies suggests that retinol acts as an agent that controls both cellular proliferation and differentiation, which may affect carcinogenesis. The antitumor action of vitamin A and carotenoids can be correlated with an enhancement of the immune response, gap junction communications, antioxidant properties and protection against pre-neoplasic changes. The cancer chemopreventive action in individuals with life-threatening liver disease, such as those with cirrhosis and hepatocellular carcinoma, may offer longer survival time and a better prognosis.
publishDate 2003
dc.date.none.fl_str_mv 2003-06-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2113
10.32635/2176-9745.RBC.2003v49n2.2113
url https://rbc.inca.gov.br/index.php/revista/article/view/2113
identifier_str_mv 10.32635/2176-9745.RBC.2003v49n2.2113
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2113/1309
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 49 No. 2 (2003): Apr./May/June; 113-120
Revista Brasileira de Cancerologia; Vol. 49 Núm. 2 (2003): abr./mayo/jun.; 113-120
Revista Brasileira de Cancerologia; v. 49 n. 2 (2003): abr./maio/jun.; 113-120
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
_version_ 1822181974534520832
dc.identifier.doi.none.fl_str_mv 10.32635/2176-9745.RBC.2003v49n2.2113

Registros relacionados