Genes Related to Helicobacter Pylori Virulence

Detalhes bibliográficos
Autor(a) principal: Lima, Valeska Portela
Data de Publicação: 2009
Outros Autores: Rabenhorst, Silvia Helena Baren
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1599
Resumo: Gastric cancer is a multifactorial disease in which interactions between the individual's genetic characteristics and the environment are absolutely important. Among the factors involved in gastric carcinogenesis, the infection caused by Helicobacter pylori is highlighted. However, not all the individuals infected by this bacterium develop gastric cancer, because this disease is related to factors bore by both host organism and  microorganism. Recent evidences have demonstrated that H. pylori strains are genotypic diverse, whose products start the inflammatory process by mediators, who can take the host organism to different inflammatory answer degrees, resulting in different pathological destinations. Some more virulent genotypes have already been described, like the vacA and cagA genes, but they are not sufficient to explain this association of this bacterium to gastrointestinal diseases, mainly those related to gastric cancer. Therefore, other genotypes are the focus of studies so that this deadlock can be explained, and data about these potential genes are constantly being introduced in the literature. This review aimed to compile the studies available so far about the H. pylori genes related to either its pathogenicity or its gastric diseases, primarily gastric cancer. It was observed that, despite numerous studies on the genes of H. pylori, there is no consensus regarding illnesses associated with these genotypes. In conclusion, there should be more studies on these H. pylori genes in order to uncover their relationship with gastrointestinal diseases, mainly with gastric cancer.
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spelling Genes Related to Helicobacter Pylori VirulenceLos Genes Asociados con la Virulencia de Helicobacter PyloriGenes Associados à Virulência de Helicobacter PyloriNeoplasias GástricasAtributos de DoençaInfecções por HelicobacterGenótipoStomach NeoplasmsDisease AttributesHelicobacter InfectionsGenotypeNeoplasias GástricasAtributos de EnfermedadInfecciones por HelicobacterGenotipoGastric cancer is a multifactorial disease in which interactions between the individual's genetic characteristics and the environment are absolutely important. Among the factors involved in gastric carcinogenesis, the infection caused by Helicobacter pylori is highlighted. However, not all the individuals infected by this bacterium develop gastric cancer, because this disease is related to factors bore by both host organism and  microorganism. Recent evidences have demonstrated that H. pylori strains are genotypic diverse, whose products start the inflammatory process by mediators, who can take the host organism to different inflammatory answer degrees, resulting in different pathological destinations. Some more virulent genotypes have already been described, like the vacA and cagA genes, but they are not sufficient to explain this association of this bacterium to gastrointestinal diseases, mainly those related to gastric cancer. Therefore, other genotypes are the focus of studies so that this deadlock can be explained, and data about these potential genes are constantly being introduced in the literature. This review aimed to compile the studies available so far about the H. pylori genes related to either its pathogenicity or its gastric diseases, primarily gastric cancer. It was observed that, despite numerous studies on the genes of H. pylori, there is no consensus regarding illnesses associated with these genotypes. In conclusion, there should be more studies on these H. pylori genes in order to uncover their relationship with gastrointestinal diseases, mainly with gastric cancer.El cáncer gástrico es una enfermedad multifactorial donde la interacción de las características genéticas del individuo con su ambiente es de suma importancia. Entre los factores que intervienen en la carcinogénesis gástrica, se destaca la infección por Helicobacter pylori. Sin embargo, no todos los individuos portadores de la infección por esa bacteria desarrollan cáncer gástrico, ya que esa enfermedad está relacionada tanto con los factores del huésped como del microorganismo. Las evidencias recientes han demostrado que cepas de la H. pylori presentan diversidad genotípica, cuyos productos desencadenan el proceso inflamatorio a través de mediadores, que pueden conducir a patológicos. Algunos genotipos más virulentos están bien descritos, tales como los genes vacA y cagA, sin embargo, no son suficientes para explicar la asociación de esa bacteria con los trastornos gastrointestinales, principalmente relacionada con el cáncer gástrico. Por lo tanto, tratamos de estudiar otros genotipos que puedan aclarar ese callejón sin salida, donde son constantemente introducidos en la literatura datos sobre esos genes potenciales. Esa revisión tuvo como objetivo hacer una compilación de los estudios disponibles sobre los genes de H. pylori en relación con su patogenicidad y las enfermedades gastrointestinales, principalmente el cáncer gástrico. Se ha concluido que debe haber más estudios sobre esos genes de H. pylori, a fin de descubrir su relación con las enfermedades gastrointestinales, especialmente con el cáncer gástrico.O câncer gástrico é uma doença multifatorial, na qual a interação das características genéticas do indivíduo com o ambiente é de suma importância. Entre os fatores envolvidos na carcinogênese gástrica, destaca-se a infecção por Helicobacter pylori. Entretanto, nem todos os indivíduos portadores da infecção por essa bactéria desenvolvem câncer gástrico, já que essa doença está relacionada tanto a fatores do hospedeiro como do microorganismo. Evidências recentes demonstram que cepas da H. pylori apresentam diversidade genotípica, cujos produtos acionam o processo inflamatório por meio de mediadores, que podem levar a diferentes graus de resposta inflamatória do hospedeiro, resultando em diferentes destinos patológicos. Alguns genótipos mais virulentos já são bem descritos, como os genes vacA e cagA, entretanto não são suficientes para explicar a associação dessa bactéria com doenças gastrointestinais, principalmente relacionada ao câncer gástrico. Portanto, busca-se estudar outros genótipos que possam esclarecer esse impasse, sendo constantemente introduzidos na literatura dados sobre esses potenciais genes. Essa revisão objetivou fazer uma compilação dos estudos até agora disponíveis sobre os genes de H. pylori relacionados à sua patogenicidade e às doenças gastrointestinais, principalmente o câncer gástrico. Concluiu-se que deve haver mais estudos sobre esses genes de H. pylori, a fim de desvendar sua relação com doenças gastrointestinais, principalmente com o câncer gástrico.INCA2009-12-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/159910.32635/2176-9745.RBC.2009v55n4.1599Revista Brasileira de Cancerologia; Vol. 55 No. 4 (2009): Oct./Nov./Dec.; 389-396Revista Brasileira de Cancerologia; Vol. 55 Núm. 4 (2009): oct./nov./dic.; 389-396Revista Brasileira de Cancerologia; v. 55 n. 4 (2009): out./nov./dez; 389-3962176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/1599/948Lima, Valeska PortelaRabenhorst, Silvia Helena Bareninfo:eu-repo/semantics/openAccess2021-11-29T20:19:52Zoai:rbc.inca.gov.br:article/1599Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:19:52Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Genes Related to Helicobacter Pylori Virulence
Los Genes Asociados con la Virulencia de Helicobacter Pylori
Genes Associados à Virulência de Helicobacter Pylori
title Genes Related to Helicobacter Pylori Virulence
spellingShingle Genes Related to Helicobacter Pylori Virulence
Lima, Valeska Portela
Neoplasias Gástricas
Atributos de Doença
Infecções por Helicobacter
Genótipo
Stomach Neoplasms
Disease Attributes
Helicobacter Infections
Genotype
Neoplasias Gástricas
Atributos de Enfermedad
Infecciones por Helicobacter
Genotipo
title_short Genes Related to Helicobacter Pylori Virulence
title_full Genes Related to Helicobacter Pylori Virulence
title_fullStr Genes Related to Helicobacter Pylori Virulence
title_full_unstemmed Genes Related to Helicobacter Pylori Virulence
title_sort Genes Related to Helicobacter Pylori Virulence
author Lima, Valeska Portela
author_facet Lima, Valeska Portela
Rabenhorst, Silvia Helena Baren
author_role author
author2 Rabenhorst, Silvia Helena Baren
author2_role author
dc.contributor.author.fl_str_mv Lima, Valeska Portela
Rabenhorst, Silvia Helena Baren
dc.subject.por.fl_str_mv Neoplasias Gástricas
Atributos de Doença
Infecções por Helicobacter
Genótipo
Stomach Neoplasms
Disease Attributes
Helicobacter Infections
Genotype
Neoplasias Gástricas
Atributos de Enfermedad
Infecciones por Helicobacter
Genotipo
topic Neoplasias Gástricas
Atributos de Doença
Infecções por Helicobacter
Genótipo
Stomach Neoplasms
Disease Attributes
Helicobacter Infections
Genotype
Neoplasias Gástricas
Atributos de Enfermedad
Infecciones por Helicobacter
Genotipo
description Gastric cancer is a multifactorial disease in which interactions between the individual's genetic characteristics and the environment are absolutely important. Among the factors involved in gastric carcinogenesis, the infection caused by Helicobacter pylori is highlighted. However, not all the individuals infected by this bacterium develop gastric cancer, because this disease is related to factors bore by both host organism and  microorganism. Recent evidences have demonstrated that H. pylori strains are genotypic diverse, whose products start the inflammatory process by mediators, who can take the host organism to different inflammatory answer degrees, resulting in different pathological destinations. Some more virulent genotypes have already been described, like the vacA and cagA genes, but they are not sufficient to explain this association of this bacterium to gastrointestinal diseases, mainly those related to gastric cancer. Therefore, other genotypes are the focus of studies so that this deadlock can be explained, and data about these potential genes are constantly being introduced in the literature. This review aimed to compile the studies available so far about the H. pylori genes related to either its pathogenicity or its gastric diseases, primarily gastric cancer. It was observed that, despite numerous studies on the genes of H. pylori, there is no consensus regarding illnesses associated with these genotypes. In conclusion, there should be more studies on these H. pylori genes in order to uncover their relationship with gastrointestinal diseases, mainly with gastric cancer.
publishDate 2009
dc.date.none.fl_str_mv 2009-12-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1599
10.32635/2176-9745.RBC.2009v55n4.1599
url https://rbc.inca.gov.br/index.php/revista/article/view/1599
identifier_str_mv 10.32635/2176-9745.RBC.2009v55n4.1599
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1599/948
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 55 No. 4 (2009): Oct./Nov./Dec.; 389-396
Revista Brasileira de Cancerologia; Vol. 55 Núm. 4 (2009): oct./nov./dic.; 389-396
Revista Brasileira de Cancerologia; v. 55 n. 4 (2009): out./nov./dez; 389-396
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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