Analysis of the Cochrane Review: Helicobacter pylori Eradication for the Prevention of Gastric Neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583.

Detalhes bibliográficos
Autor(a) principal: Libânio, Diogo
Data de Publicação: 2015
Outros Autores: Azevedo, Luís Filipe
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7128
Resumo: Helicobacter pylori infection is a risk factor for gastric adenocarcinoma. Identification of individuals with this infection and its eradication may be considered as a primary prevention strategy to reduce the incidence of gastric adenocarcinoma; however, the magnitude of benefit and the effectiveness of this strategy are still unclear. A systematic review and meta-analysis of randomized clinical trials was conducted comparing the incidence of gastric adenocarcinoma in infected individuals submitted to Helicobacter pylori eradication and individuals not submitted to this therapy. The results of the six included randomized clinical trials (all conducted in countries withhigh gastric cancer incidence) suggest that Helicobacter pylori eradication is associated with a relative risk reduction of 34% in gastric cancer incidence. However, generalization of the results to countries with lower gastric cancer incidence should be cautious and the cost-effectiveness of this strategy in this context remains uncertain.
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spelling Analysis of the Cochrane Review: Helicobacter pylori Eradication for the Prevention of Gastric Neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583.Análise da Revisão Cochrane: Erradicação da Helicobacter pylori na Prevenção do Cancro Gástrico. Cochrane Database Syst Rev. 2015;7:CD005583.Helicobacter InfectionsHelicobacter pyloriStomach NeoplasmsSystematic Reviews.Helicobacter pyloriInfecções por HelicobacterNeoplasias GástricasRevisões Sistemáticas.Helicobacter pylori infection is a risk factor for gastric adenocarcinoma. Identification of individuals with this infection and its eradication may be considered as a primary prevention strategy to reduce the incidence of gastric adenocarcinoma; however, the magnitude of benefit and the effectiveness of this strategy are still unclear. A systematic review and meta-analysis of randomized clinical trials was conducted comparing the incidence of gastric adenocarcinoma in infected individuals submitted to Helicobacter pylori eradication and individuals not submitted to this therapy. The results of the six included randomized clinical trials (all conducted in countries withhigh gastric cancer incidence) suggest that Helicobacter pylori eradication is associated with a relative risk reduction of 34% in gastric cancer incidence. However, generalization of the results to countries with lower gastric cancer incidence should be cautious and the cost-effectiveness of this strategy in this context remains uncertain.A infeção por Helicobacter pylori é um fator de risco para o desenvolvimento de cancro gástrico. A pesquisa e erradicação da Helicobacter pylori na população geral assintomática pode ser considerada para a prevenção primária do cancro gástrico, no entanto a magnitude do benefício e a efetividade desta estratégia ainda não estão completamente esclarecidas. Neste contexto, foi realizada uma revisão sistemática e meta-análise de ensaios clínicos aleatorizados comparando a incidência de cancro gástrico em indivíduos com a infeção que realizaram erradicação e indivíduos infetados que não realizaram a erradicação da Helicobacter pylori. Os resultados dos seis ensaios clínicos incluídos (realizados em países de elevada incidência de cancro gástrico) sugerem que a erradicação da Helicobacter pylori se associa a uma redução relativa do risco de cancro gástrico de 34%. Contudo, a generalização dos resultados para países com menor incidência de cancro gástrico deve ser feita com algum cuidado e a custo-efetividade desta estratégia, neste contexto, permanece ainda incerta.Ordem dos Médicos2015-10-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7128oai:ojs.www.actamedicaportuguesa.com:article/7128Acta Médica Portuguesa; Vol. 28 No. 6 (2015): November-December; 684-686Acta Médica Portuguesa; Vol. 28 N.º 6 (2015): Novembro-Dezembro; 684-6861646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7128https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7128/4545https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7128/8030https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7128/8099Libânio, DiogoAzevedo, Luís Filipeinfo:eu-repo/semantics/openAccess2022-12-20T11:05:06Zoai:ojs.www.actamedicaportuguesa.com:article/7128Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:24.938797Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Analysis of the Cochrane Review: Helicobacter pylori Eradication for the Prevention of Gastric Neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583.
Análise da Revisão Cochrane: Erradicação da Helicobacter pylori na Prevenção do Cancro Gástrico. Cochrane Database Syst Rev. 2015;7:CD005583.
title Analysis of the Cochrane Review: Helicobacter pylori Eradication for the Prevention of Gastric Neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583.
spellingShingle Analysis of the Cochrane Review: Helicobacter pylori Eradication for the Prevention of Gastric Neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583.
Libânio, Diogo
Helicobacter Infections
Helicobacter pylori
Stomach Neoplasms
Systematic Reviews.
Helicobacter pylori
Infecções por Helicobacter
Neoplasias Gástricas
Revisões Sistemáticas.
title_short Analysis of the Cochrane Review: Helicobacter pylori Eradication for the Prevention of Gastric Neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583.
title_full Analysis of the Cochrane Review: Helicobacter pylori Eradication for the Prevention of Gastric Neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583.
title_fullStr Analysis of the Cochrane Review: Helicobacter pylori Eradication for the Prevention of Gastric Neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583.
title_full_unstemmed Analysis of the Cochrane Review: Helicobacter pylori Eradication for the Prevention of Gastric Neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583.
title_sort Analysis of the Cochrane Review: Helicobacter pylori Eradication for the Prevention of Gastric Neoplasia. Cochrane Database Syst Rev. 2015;7:CD005583.
author Libânio, Diogo
author_facet Libânio, Diogo
Azevedo, Luís Filipe
author_role author
author2 Azevedo, Luís Filipe
author2_role author
dc.contributor.author.fl_str_mv Libânio, Diogo
Azevedo, Luís Filipe
dc.subject.por.fl_str_mv Helicobacter Infections
Helicobacter pylori
Stomach Neoplasms
Systematic Reviews.
Helicobacter pylori
Infecções por Helicobacter
Neoplasias Gástricas
Revisões Sistemáticas.
topic Helicobacter Infections
Helicobacter pylori
Stomach Neoplasms
Systematic Reviews.
Helicobacter pylori
Infecções por Helicobacter
Neoplasias Gástricas
Revisões Sistemáticas.
description Helicobacter pylori infection is a risk factor for gastric adenocarcinoma. Identification of individuals with this infection and its eradication may be considered as a primary prevention strategy to reduce the incidence of gastric adenocarcinoma; however, the magnitude of benefit and the effectiveness of this strategy are still unclear. A systematic review and meta-analysis of randomized clinical trials was conducted comparing the incidence of gastric adenocarcinoma in infected individuals submitted to Helicobacter pylori eradication and individuals not submitted to this therapy. The results of the six included randomized clinical trials (all conducted in countries withhigh gastric cancer incidence) suggest that Helicobacter pylori eradication is associated with a relative risk reduction of 34% in gastric cancer incidence. However, generalization of the results to countries with lower gastric cancer incidence should be cautious and the cost-effectiveness of this strategy in this context remains uncertain.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-26
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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oai:ojs.www.actamedicaportuguesa.com:article/7128
url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7128
identifier_str_mv oai:ojs.www.actamedicaportuguesa.com:article/7128
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7128/8030
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dc.format.none.fl_str_mv application/pdf
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application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 28 No. 6 (2015): November-December; 684-686
Acta Médica Portuguesa; Vol. 28 N.º 6 (2015): Novembro-Dezembro; 684-686
1646-0758
0870-399X
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