Carcinosarcoma of the Uterus: Report of a Case with Invasion of the Urinary Bladder, Resembling Mullerianosis with Malignant Transformation

Detalhes bibliográficos
Autor(a) principal: Ogata, Daniel Cury
Data de Publicação: 2012
Outros Autores: Busato, Wilson S. F., Almeida, Gilberto Laurindo, Pereira Neto, Elisiário, Moreira, Stefan Gerlach Braz, Santos, João Vitor Quadra Vieira dos
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/638
Resumo: Introduction: Uterine carcinosarcoma are infrequent neoplasms, corresponding to 3-9% of all gynecologic neoplasms only. They represent 48% of all sarcomas, with an incidence of 8.2 per 1 million women/year. The main clinical manifestations are postmenopausal vaginal bleeding and abdominal pain. Tumors are morphologically characterized by epithelial and stromal elements. They can eventually invade adjacent structures, including the urinary bladder. Case Report: We present a case of uterine carcinosarcoma with invasion of the urinary bladder resembling mullerianosis with malignant transformation. A 69 year-old female patient had macroscopic hematuria as the single complaint. During diagnostic investigations, after cystoscopy with anatomical and pathological exam was performed, the hypothesis of mullerianosis with benign transformation was suggested. The patient was thus submitted to surgical resection of this lesion. During the surgical procedure, we noticed the existence of a uterine tumor mass that was invading the urinary bladder, and after anatomical and pathological analysis, it was identified as a carcinosarcoma of the uterus with invasion of the urinary bladder. Conclusion: Unusual manifestation of diseases with great malignant potential, in addition to delay the process of diagnosis, directly interferes with the patient’s prognosis.  
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spelling Carcinosarcoma of the Uterus: Report of a Case with Invasion of the Urinary Bladder, Resembling Mullerianosis with Malignant TransformationCarcinosarcoma Uterino: Reporte de un Caso de Invasión de la Vejiga, Mimetismo Mülleriano con Transformación MalignaCarcinossarcoma Uterino: Relato de um Caso com Invasão da Bexiga, Mimetizando Mullerianose com Transformação MalignaNeoplasias UterinasCarcinossarcomaÚteroBexiga UrináriaUterine NeoplasmsCarcinosarcomaUterusUrinary BladderNeoplasias UterinasCarcinosarcomaÚteroVejiga UrinariaIntroduction: Uterine carcinosarcoma are infrequent neoplasms, corresponding to 3-9% of all gynecologic neoplasms only. They represent 48% of all sarcomas, with an incidence of 8.2 per 1 million women/year. The main clinical manifestations are postmenopausal vaginal bleeding and abdominal pain. Tumors are morphologically characterized by epithelial and stromal elements. They can eventually invade adjacent structures, including the urinary bladder. Case Report: We present a case of uterine carcinosarcoma with invasion of the urinary bladder resembling mullerianosis with malignant transformation. A 69 year-old female patient had macroscopic hematuria as the single complaint. During diagnostic investigations, after cystoscopy with anatomical and pathological exam was performed, the hypothesis of mullerianosis with benign transformation was suggested. The patient was thus submitted to surgical resection of this lesion. During the surgical procedure, we noticed the existence of a uterine tumor mass that was invading the urinary bladder, and after anatomical and pathological analysis, it was identified as a carcinosarcoma of the uterus with invasion of the urinary bladder. Conclusion: Unusual manifestation of diseases with great malignant potential, in addition to delay the process of diagnosis, directly interferes with the patient’s prognosis.  Introducción: Los carcinosarcomas uterinos son neoplasias poco frecuentes, correspondiente a solo 3-9% de todos los cánceres ginecológicos, lo que representa 48% do todos los sarcomas, e incidencia de 8,2 por 1 millón de mujeres/ año. Las principales manifestaciones clínicas son la sangría vaginal anormal en edad post-menopausa y dolor abdominal. Se caracterizan morfológicamente por elementos epiteliales y estromales. Pueden casualmente invadir estructuras adyacentes, incluso la vejiga urinaria. Informe de caso: Presentamos un caso de carcinosarcoma uterino con invasión de la vejiga, mimetismo mülleriano con transformación maligna. La paciente de 69 años presentaba hematuria macroscópica como queja única. Durante la investigación de diagnóstico, tras cistoscopia con examen anatómico e patológico, se planteó la posibilidad de mimetismo mülleriano con transformación benigna. La paciente fue luego remitida para la resección quirúrgica del tumor. Durante el procedimiento, se observó la existencia de un tumor uterino que invadía la vejiga urinaria, y después de un análisis anatómico y patológico demostró que se trataba de un carcinosarcoma uterino con invasión de la vejiga. Conclusión: Manifestaciones inusuales de enfermedades con alto potencial de malignidad, además de retrasar el proceso de diagnóstico, interfieren directamente en el pronóstico del paciente.  Introdução: Os carcinossarcomas uterinos são neoplasias infrequentes, correspondendo a apenas 3-9% de todas as neoplasias ginecológicas, representam 48% de todos os sarcomas, e possuem incidência de 8,2 por 1 milhão mullheres/ano. As principais manifestações clínicas são o sangramento vaginal anormal em idade pós-menopausa e dor abdominal. Caracterizam-se morfologicamente por elementos epiteliais e estromais. Podem eventualmente invadir estruturas adjacentes, inclusive a bexiga urinária. Relato do caso: Apresentamos um caso de carcinossarcoma uterino com invasão de bexiga mimetizando mullerianose com transformação maligna. A paciente do sexo feminino de 69 anos apresentava hematuria macroscópica como queixa única. Durante a investigação diagnóstica, após cistoscopia com exame anatomopatológico, foi sugerida a hipótese de mullerianose com transformação benigna. A paciente foi então encaminhada para ressecção cirúrgica da neoplasia. Durante o procedimento cirúrgico, notou-se a existência de uma massa tumoral uterina que invadia a bexiga urinária, e, após análise anatomopatológica, mostrou tratar-se de um carcinossarcoma uterino com invasão vesical. Conclusão: Manifestações incomuns em doenças com grande potencial de malignidade, além de retardar o processo diagnóstico, interferem diretamente no prognóstico do paciente.    INCA2012-03-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelato de Casoapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/63810.32635/2176-9745.RBC.2012v58n1.638Revista Brasileira de Cancerologia; Vol. 58 No. 1 (2012): Jan./Feb./Mar.; 79-83Revista Brasileira de Cancerologia; Vol. 58 Núm. 1 (2012): ene./feb./mar.; 79-83Revista Brasileira de Cancerologia; v. 58 n. 1 (2012): jan./fev./mar. ; 79-832176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/638/421Ogata, Daniel CuryBusato, Wilson S. F. Almeida, Gilberto LaurindoPereira Neto, Elisiário Moreira, Stefan Gerlach Braz Santos, João Vitor Quadra Vieira dos info:eu-repo/semantics/openAccess2021-11-29T20:15:05Zoai:rbc.inca.gov.br:article/638Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:15:05Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Carcinosarcoma of the Uterus: Report of a Case with Invasion of the Urinary Bladder, Resembling Mullerianosis with Malignant Transformation
Carcinosarcoma Uterino: Reporte de un Caso de Invasión de la Vejiga, Mimetismo Mülleriano con Transformación Maligna
Carcinossarcoma Uterino: Relato de um Caso com Invasão da Bexiga, Mimetizando Mullerianose com Transformação Maligna
title Carcinosarcoma of the Uterus: Report of a Case with Invasion of the Urinary Bladder, Resembling Mullerianosis with Malignant Transformation
spellingShingle Carcinosarcoma of the Uterus: Report of a Case with Invasion of the Urinary Bladder, Resembling Mullerianosis with Malignant Transformation
Ogata, Daniel Cury
Neoplasias Uterinas
Carcinossarcoma
Útero
Bexiga Urinária
Uterine Neoplasms
Carcinosarcoma
Uterus
Urinary Bladder
Neoplasias Uterinas
Carcinosarcoma
Útero
Vejiga Urinaria
title_short Carcinosarcoma of the Uterus: Report of a Case with Invasion of the Urinary Bladder, Resembling Mullerianosis with Malignant Transformation
title_full Carcinosarcoma of the Uterus: Report of a Case with Invasion of the Urinary Bladder, Resembling Mullerianosis with Malignant Transformation
title_fullStr Carcinosarcoma of the Uterus: Report of a Case with Invasion of the Urinary Bladder, Resembling Mullerianosis with Malignant Transformation
title_full_unstemmed Carcinosarcoma of the Uterus: Report of a Case with Invasion of the Urinary Bladder, Resembling Mullerianosis with Malignant Transformation
title_sort Carcinosarcoma of the Uterus: Report of a Case with Invasion of the Urinary Bladder, Resembling Mullerianosis with Malignant Transformation
author Ogata, Daniel Cury
author_facet Ogata, Daniel Cury
Busato, Wilson S. F.
Almeida, Gilberto Laurindo
Pereira Neto, Elisiário
Moreira, Stefan Gerlach Braz
Santos, João Vitor Quadra Vieira dos
author_role author
author2 Busato, Wilson S. F.
Almeida, Gilberto Laurindo
Pereira Neto, Elisiário
Moreira, Stefan Gerlach Braz
Santos, João Vitor Quadra Vieira dos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ogata, Daniel Cury
Busato, Wilson S. F.
Almeida, Gilberto Laurindo
Pereira Neto, Elisiário
Moreira, Stefan Gerlach Braz
Santos, João Vitor Quadra Vieira dos
dc.subject.por.fl_str_mv Neoplasias Uterinas
Carcinossarcoma
Útero
Bexiga Urinária
Uterine Neoplasms
Carcinosarcoma
Uterus
Urinary Bladder
Neoplasias Uterinas
Carcinosarcoma
Útero
Vejiga Urinaria
topic Neoplasias Uterinas
Carcinossarcoma
Útero
Bexiga Urinária
Uterine Neoplasms
Carcinosarcoma
Uterus
Urinary Bladder
Neoplasias Uterinas
Carcinosarcoma
Útero
Vejiga Urinaria
description Introduction: Uterine carcinosarcoma are infrequent neoplasms, corresponding to 3-9% of all gynecologic neoplasms only. They represent 48% of all sarcomas, with an incidence of 8.2 per 1 million women/year. The main clinical manifestations are postmenopausal vaginal bleeding and abdominal pain. Tumors are morphologically characterized by epithelial and stromal elements. They can eventually invade adjacent structures, including the urinary bladder. Case Report: We present a case of uterine carcinosarcoma with invasion of the urinary bladder resembling mullerianosis with malignant transformation. A 69 year-old female patient had macroscopic hematuria as the single complaint. During diagnostic investigations, after cystoscopy with anatomical and pathological exam was performed, the hypothesis of mullerianosis with benign transformation was suggested. The patient was thus submitted to surgical resection of this lesion. During the surgical procedure, we noticed the existence of a uterine tumor mass that was invading the urinary bladder, and after anatomical and pathological analysis, it was identified as a carcinosarcoma of the uterus with invasion of the urinary bladder. Conclusion: Unusual manifestation of diseases with great malignant potential, in addition to delay the process of diagnosis, directly interferes with the patient’s prognosis.  
publishDate 2012
dc.date.none.fl_str_mv 2012-03-30
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url https://rbc.inca.gov.br/index.php/revista/article/view/638
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dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/638/421
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 58 No. 1 (2012): Jan./Feb./Mar.; 79-83
Revista Brasileira de Cancerologia; Vol. 58 Núm. 1 (2012): ene./feb./mar.; 79-83
Revista Brasileira de Cancerologia; v. 58 n. 1 (2012): jan./fev./mar. ; 79-83
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
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instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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