Uterine Carcinosarcoma: Clinicopathological Features and Prognostic Factors
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078 |
Resumo: | Introduction: Uterine carcinosarcoma is a rare and aggressive biphasic malignancy and is currently included in the high risk endometrial carcinoma group. The aims of this study were to determine the clinicopathological profile, treatment, recurrence/progression patterns, survival and prognostic factors.Material and Methods: Retrospective study of 42 patients, surgically staged and followed-up at a cancer centre, between 2005 and 2013. Clinical data was retrieved from records and pathological characteristics were reviewed for this study.Results: Median age was 72 years (61 - 78) and the majority presented comorbid diseases. Stage distribution as follows: 13 (31.0%) stage I; eight (19.0%) stage II; nine (21.4%) stage III; and 12 (28.6%) stage IV. Chemotherapy was instituted in 12 patients and 21 received radiotherapy. Disease progressed in 16 patients and recurred in nine after a short interval. Median overall survival was 18 months (6.8 - 40) and median disease-free survival was 6 months (0 – 22.8). The only independent prognostic factor related with poor survival was serosal invasion (p = 0.02; HR adjusted 4.22; IC 95% 1.29 – 13.79).Discussion: In accordance to other studies, diagnosis of uterine carcinosarcoma is frequently done with advanced disease and presents a high rate of progression/recurrence. The variable which has been consistently identified as main prognostic factor is stage, but in this study the only independent factor was serosal invasion.Conclusion: The present study represents the larger series of uterine carcinosarcoma studied in Portugal and reflects the clinical presentation, histopathological characteristics and stage at diagnosis and confirms the aggressiveness of this rare tumor. |
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Uterine Carcinosarcoma: Clinicopathological Features and Prognostic FactorsCarcinossarcoma Uterino: Características ClinicoPatológicas e Fatores de PrognósticoCarcinosarcomaNeoplasm StagingPrognosisSurvival RateUterine Neoplasms.CarcinossarcomaEstadiamento de NeoplasiasNeoplasias UterinasPrognósticoTaxa de Sobrevida.Introduction: Uterine carcinosarcoma is a rare and aggressive biphasic malignancy and is currently included in the high risk endometrial carcinoma group. The aims of this study were to determine the clinicopathological profile, treatment, recurrence/progression patterns, survival and prognostic factors.Material and Methods: Retrospective study of 42 patients, surgically staged and followed-up at a cancer centre, between 2005 and 2013. Clinical data was retrieved from records and pathological characteristics were reviewed for this study.Results: Median age was 72 years (61 - 78) and the majority presented comorbid diseases. Stage distribution as follows: 13 (31.0%) stage I; eight (19.0%) stage II; nine (21.4%) stage III; and 12 (28.6%) stage IV. Chemotherapy was instituted in 12 patients and 21 received radiotherapy. Disease progressed in 16 patients and recurred in nine after a short interval. Median overall survival was 18 months (6.8 - 40) and median disease-free survival was 6 months (0 – 22.8). The only independent prognostic factor related with poor survival was serosal invasion (p = 0.02; HR adjusted 4.22; IC 95% 1.29 – 13.79).Discussion: In accordance to other studies, diagnosis of uterine carcinosarcoma is frequently done with advanced disease and presents a high rate of progression/recurrence. The variable which has been consistently identified as main prognostic factor is stage, but in this study the only independent factor was serosal invasion.Conclusion: The present study represents the larger series of uterine carcinosarcoma studied in Portugal and reflects the clinical presentation, histopathological characteristics and stage at diagnosis and confirms the aggressiveness of this rare tumor.Introdução: O carcinossarcoma uterino é uma neoplasia bifásica rara e agressiva e está atualmente incluído no grupo de carcinoma do endométrio de alto risco. Os objetivos deste estudo foram determinar o perfil clinico-patológico, tratamento, padrões de recidiva/progressão, sobrevivência e fatores de prognóstico.Material e Métodos: Estudo retrospetivo de 42 doentes, estadiadas cirurgicamente e vigiadas num centro oncológico, entre 2005 e 2013. Os dados clínicos foram consultados nos processos e as características histopatológicas foram revistas para este estudo.Resultados: A idade mediana das doentes foi de 72 anos (61 - 81) e a maioria apresentava co-morbilidades. A distribuição por estádio foi a seguinte: 13 (31,0%) estádio I; oito (19,0%) estádio II; nove (21,4%) estádio III; e 12 (28,6%) estádio IV. A quimioterapia adjuvante foi instituída em 12 doentes e 21 realizaram radioterapia. A doença progrediu em 16 doentes e recidivou em nove após um intervalo curto. A sobrevivência global mediana foi de 18 meses (6,8 - 40) e a sobrevivência livre de doença mediana de 6 meses (0 - 22,8). O único fator prognóstico independente associado a pior sobrevivência foi a invasão da serosa (p = 0,02; HR ajustado 4,22; IC 95% 1,29 - 13,79).Discussão: Em concordância com outros estudos, o diagnóstico de carcinossarcoma uterino é frequentemente realizado com doença avançada e apresenta elevada taxa de progressão/recidiva. A variável que tem sido consistentemente identificada como principal fator de prognóstico é o estádio inicial, mas neste estudo o único fator independente foi a invasão da serosa.Conclusão: O presente estudo representa a maior série de carcinossarcoma uterino estudada em Portugal e reflete o quadro clínico,características histopatológicas e estádio no momento do diagnóstico e confirma a agressividade deste raro tumor.Ordem dos Médicos2016-10-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/jpegapplication/mswordapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078oai:ojs.www.actamedicaportuguesa.com:article/7078Acta Médica Portuguesa; Vol. 29 No. 10 (2016): October; 621-628Acta Médica Portuguesa; Vol. 29 N.º 10 (2016): Outubro; 621-6281646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078/4785https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078/7986https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078/8436https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078/8477Direitos de Autor (c) 2016 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessLuz, RitaFerreira, JoanaRocha, MaraJorge, Ana FranciscaFélix, Ana2022-12-20T11:05:05Zoai:ojs.www.actamedicaportuguesa.com:article/7078Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:24.593481Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Uterine Carcinosarcoma: Clinicopathological Features and Prognostic Factors Carcinossarcoma Uterino: Características ClinicoPatológicas e Fatores de Prognóstico |
title |
Uterine Carcinosarcoma: Clinicopathological Features and Prognostic Factors |
spellingShingle |
Uterine Carcinosarcoma: Clinicopathological Features and Prognostic Factors Luz, Rita Carcinosarcoma Neoplasm Staging Prognosis Survival Rate Uterine Neoplasms. Carcinossarcoma Estadiamento de Neoplasias Neoplasias Uterinas Prognóstico Taxa de Sobrevida. |
title_short |
Uterine Carcinosarcoma: Clinicopathological Features and Prognostic Factors |
title_full |
Uterine Carcinosarcoma: Clinicopathological Features and Prognostic Factors |
title_fullStr |
Uterine Carcinosarcoma: Clinicopathological Features and Prognostic Factors |
title_full_unstemmed |
Uterine Carcinosarcoma: Clinicopathological Features and Prognostic Factors |
title_sort |
Uterine Carcinosarcoma: Clinicopathological Features and Prognostic Factors |
author |
Luz, Rita |
author_facet |
Luz, Rita Ferreira, Joana Rocha, Mara Jorge, Ana Francisca Félix, Ana |
author_role |
author |
author2 |
Ferreira, Joana Rocha, Mara Jorge, Ana Francisca Félix, Ana |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Luz, Rita Ferreira, Joana Rocha, Mara Jorge, Ana Francisca Félix, Ana |
dc.subject.por.fl_str_mv |
Carcinosarcoma Neoplasm Staging Prognosis Survival Rate Uterine Neoplasms. Carcinossarcoma Estadiamento de Neoplasias Neoplasias Uterinas Prognóstico Taxa de Sobrevida. |
topic |
Carcinosarcoma Neoplasm Staging Prognosis Survival Rate Uterine Neoplasms. Carcinossarcoma Estadiamento de Neoplasias Neoplasias Uterinas Prognóstico Taxa de Sobrevida. |
description |
Introduction: Uterine carcinosarcoma is a rare and aggressive biphasic malignancy and is currently included in the high risk endometrial carcinoma group. The aims of this study were to determine the clinicopathological profile, treatment, recurrence/progression patterns, survival and prognostic factors.Material and Methods: Retrospective study of 42 patients, surgically staged and followed-up at a cancer centre, between 2005 and 2013. Clinical data was retrieved from records and pathological characteristics were reviewed for this study.Results: Median age was 72 years (61 - 78) and the majority presented comorbid diseases. Stage distribution as follows: 13 (31.0%) stage I; eight (19.0%) stage II; nine (21.4%) stage III; and 12 (28.6%) stage IV. Chemotherapy was instituted in 12 patients and 21 received radiotherapy. Disease progressed in 16 patients and recurred in nine after a short interval. Median overall survival was 18 months (6.8 - 40) and median disease-free survival was 6 months (0 – 22.8). The only independent prognostic factor related with poor survival was serosal invasion (p = 0.02; HR adjusted 4.22; IC 95% 1.29 – 13.79).Discussion: In accordance to other studies, diagnosis of uterine carcinosarcoma is frequently done with advanced disease and presents a high rate of progression/recurrence. The variable which has been consistently identified as main prognostic factor is stage, but in this study the only independent factor was serosal invasion.Conclusion: The present study represents the larger series of uterine carcinosarcoma studied in Portugal and reflects the clinical presentation, histopathological characteristics and stage at diagnosis and confirms the aggressiveness of this rare tumor. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078 oai:ojs.www.actamedicaportuguesa.com:article/7078 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/7078 |
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por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078/4785 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078/7986 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078/8436 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7078/8477 |
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Direitos de Autor (c) 2016 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2016 Acta Médica Portuguesa |
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openAccess |
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application/pdf image/jpeg application/msword application/pdf |
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Ordem dos Médicos |
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Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 29 No. 10 (2016): October; 621-628 Acta Médica Portuguesa; Vol. 29 N.º 10 (2016): Outubro; 621-628 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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