Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicos
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/3030 |
Resumo: | The authors studied the effect of the cisplatinum (cis-diarninedichioroplatinum-ll) intraperitoneaily administered, on the healing of anastomosis of the small intestine of rats from the macroscopic point of view, 48 Wistar male rats having na average weighht of 315.5 grammes, were operated in the Experimental Surgery Laboratory at the Surgical Department of the Medical School of the Universidade Federal do Rio de Janeiro. The control group of 24 animais, received sedium chioride 0.9% (20% of the corporeai weight) intraperitoneally, and 24 hours late, was performed a median laparotomy associated with the resection of 1 cm of the iieum and end-to-end anastornosis with 6-0 silk suture in total single plain with a continuous suture. In the experimental group, cisplatinum was administered (5 rng/kg of body weight together with sodium chloride 0.9% in the proportion of 20% of the body weight) and, after one day, the sarne surgical procedure, used in the control group, were performed. A macroscopic appraisal of the wound on the abdomen wall, peritoneal cavity and of the intestinal anastomosis was made. The adhesions presence occurred in all the operated on animals, with intensity of different degrees. The adhesions were more extensivo and firm in subgroup A2 (seven days with cisplatinum). No infection, dehiscence, evitration or evisceration of the surgical wound on the abdominal wall as well as peritonitis, abscesses, phystulae or dehiscences of the intestinal suture in both groups was observed. it was observed macroscopically that in all the subgroups with cisplatinum the protuberance at the level of the intestinal suture une on the intraluminal side of the segment of the small intestine during the necropsy was smaller. |
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Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicosCicatrização das FeridasAnastomoses IntestinaisAderênciasCisplatinaMacroscopiaRatosWound HealingAnastomosisAdhesionsCisplatinumMacroscopyRatsThe authors studied the effect of the cisplatinum (cis-diarninedichioroplatinum-ll) intraperitoneaily administered, on the healing of anastomosis of the small intestine of rats from the macroscopic point of view, 48 Wistar male rats having na average weighht of 315.5 grammes, were operated in the Experimental Surgery Laboratory at the Surgical Department of the Medical School of the Universidade Federal do Rio de Janeiro. The control group of 24 animais, received sedium chioride 0.9% (20% of the corporeai weight) intraperitoneally, and 24 hours late, was performed a median laparotomy associated with the resection of 1 cm of the iieum and end-to-end anastornosis with 6-0 silk suture in total single plain with a continuous suture. In the experimental group, cisplatinum was administered (5 rng/kg of body weight together with sodium chloride 0.9% in the proportion of 20% of the body weight) and, after one day, the sarne surgical procedure, used in the control group, were performed. A macroscopic appraisal of the wound on the abdomen wall, peritoneal cavity and of the intestinal anastomosis was made. The adhesions presence occurred in all the operated on animals, with intensity of different degrees. The adhesions were more extensivo and firm in subgroup A2 (seven days with cisplatinum). No infection, dehiscence, evitration or evisceration of the surgical wound on the abdominal wall as well as peritonitis, abscesses, phystulae or dehiscences of the intestinal suture in both groups was observed. it was observed macroscopically that in all the subgroups with cisplatinum the protuberance at the level of the intestinal suture une on the intraluminal side of the segment of the small intestine during the necropsy was smaller.Os AA. estudaram a ação da cisplatina (cis-diaminocloroplatina-ll) administrada intraperitonealmente sobre a cicatrização de anastomoses do intestino delgado do rato, do ponto de vista macroscópico. Foram operados 48 ratos Wistar, machos, com peso médio de 315,5 gramas, no Laboratório de Cirurgia Experimental do Departamento de Cirurgia da Faculdade de Medicina da Universidade Federal do Rio de Janeiro. Nos 24 animais do grupo-controle foi injetado por via intraperitoneal soro fisiológico a 0,9% (20% do peso corporal) e 24 horas após realizou-se laparotomia mediana associada a ressecção de 1 cm de íleo e anastomose término-terminal com fio de seda 6-0 em plano único total com sutura contínua. Nos ratos do grupo-experimento foi administrada cisplatina (5 mg/kg de peso corporal associada a soro fisiológico a 0,9%, na proporção de 20% do peso corpóreo) e, após um dia, foi efetuado o mesmo procedimento cirúrgico no grupo-controle. Foi feita uma avaliação macroscópica da ferida da parede do abdome, da cavidade peritoneal e da anastomose intestinal. A presença de aderências ocorreu na totalidade dos animais operados, com distintos graus de intensidade. As aderências foram mais extensas e firmes no subgrupo-A2(sete dias com cisplatina). Não foram observadas infecção, deiscências, eventração ou evisceração da ferida cirúrgica da parede abdominal, bem como peritonite, abscessos, fístulas ou deiscências da sutura intestinal em ambos os grupos. Observou-se, macroscopicamente, que em todos os subgrupos com cisplatina foi menor a protuberância ao nível da linha de sutura intestinal do lado intraluminal do segmento do intestino delgado durante a necrópsia.INCA2023-06-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/303010.32635/2176-9745.RBC.1993v39n3.3030Revista Brasileira de Cancerologia; Vol. 39 No. 3 (1993): July/Aug./Sept.; 143-151Revista Brasileira de Cancerologia; Vol. 39 Núm. 3 (1993): jul./ago./sept.; 143-151Revista Brasileira de Cancerologia; v. 39 n. 3 (1993): jul./ago./set.; 143-1512176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/3030/1889https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCarneiro, Paulo César Alves Gutman, Tereza Cristina Ferreira Castro, Onofre Ferreira de 2023-06-19T13:33:18Zoai:rbc.inca.gov.br:article/3030Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-06-19T13:33:18Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicos |
title |
Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicos |
spellingShingle |
Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicos Carneiro, Paulo César Alves Cicatrização das Feridas Anastomoses Intestinais Aderências Cisplatina Macroscopia Ratos Wound Healing Anastomosis Adhesions Cisplatinum Macroscopy Rats |
title_short |
Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicos |
title_full |
Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicos |
title_fullStr |
Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicos |
title_full_unstemmed |
Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicos |
title_sort |
Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicos |
author |
Carneiro, Paulo César Alves |
author_facet |
Carneiro, Paulo César Alves Gutman, Tereza Cristina Ferreira Castro, Onofre Ferreira de |
author_role |
author |
author2 |
Gutman, Tereza Cristina Ferreira Castro, Onofre Ferreira de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Carneiro, Paulo César Alves Gutman, Tereza Cristina Ferreira Castro, Onofre Ferreira de |
dc.subject.por.fl_str_mv |
Cicatrização das Feridas Anastomoses Intestinais Aderências Cisplatina Macroscopia Ratos Wound Healing Anastomosis Adhesions Cisplatinum Macroscopy Rats |
topic |
Cicatrização das Feridas Anastomoses Intestinais Aderências Cisplatina Macroscopia Ratos Wound Healing Anastomosis Adhesions Cisplatinum Macroscopy Rats |
description |
The authors studied the effect of the cisplatinum (cis-diarninedichioroplatinum-ll) intraperitoneaily administered, on the healing of anastomosis of the small intestine of rats from the macroscopic point of view, 48 Wistar male rats having na average weighht of 315.5 grammes, were operated in the Experimental Surgery Laboratory at the Surgical Department of the Medical School of the Universidade Federal do Rio de Janeiro. The control group of 24 animais, received sedium chioride 0.9% (20% of the corporeai weight) intraperitoneally, and 24 hours late, was performed a median laparotomy associated with the resection of 1 cm of the iieum and end-to-end anastornosis with 6-0 silk suture in total single plain with a continuous suture. In the experimental group, cisplatinum was administered (5 rng/kg of body weight together with sodium chloride 0.9% in the proportion of 20% of the body weight) and, after one day, the sarne surgical procedure, used in the control group, were performed. A macroscopic appraisal of the wound on the abdomen wall, peritoneal cavity and of the intestinal anastomosis was made. The adhesions presence occurred in all the operated on animals, with intensity of different degrees. The adhesions were more extensivo and firm in subgroup A2 (seven days with cisplatinum). No infection, dehiscence, evitration or evisceration of the surgical wound on the abdominal wall as well as peritonitis, abscesses, phystulae or dehiscences of the intestinal suture in both groups was observed. it was observed macroscopically that in all the subgroups with cisplatinum the protuberance at the level of the intestinal suture une on the intraluminal side of the segment of the small intestine during the necropsy was smaller. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3030 10.32635/2176-9745.RBC.1993v39n3.3030 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/3030 |
identifier_str_mv |
10.32635/2176-9745.RBC.1993v39n3.3030 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3030/1889 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 39 No. 3 (1993): July/Aug./Sept.; 143-151 Revista Brasileira de Cancerologia; Vol. 39 Núm. 3 (1993): jul./ago./sept.; 143-151 Revista Brasileira de Cancerologia; v. 39 n. 3 (1993): jul./ago./set.; 143-151 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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