Efeito da quimioterapia antineoplásica com cisplatina (cis-diaminodicloroplatina-ll) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos macroscópicos

• Autor(a) principal: Carneiro, Paulo César Alves
• Data de Publicação: 2023
• Outros Autores: Gutman, Tereza Cristina Ferreira, Castro, Onofre Ferreira de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Brasileira de Cancerologia (Online)
• Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/3030
• topic: Cicatrização das Feridas; Anastomoses Intestinais; Aderências; Cisplatina; Macroscopia; Ratos; Wound Healing; Anastomosis; Adhesions; Cisplatinum; Macroscopy; Rats

The authors studied the effect of the cisplatinum (cis-diarninedichioroplatinum-ll) intraperitoneaily administered, on the healing of anastomosis of the small intestine of rats from the macroscopic point of view, 48 Wistar male rats having na average weighht of 315.5 grammes, were operated in the Experimental Surgery Laboratory at the Surgical Department of the Medical School of the Universidade Federal do Rio de Janeiro. The control group of 24 animais, received sedium chioride 0.9% (20% of the corporeai weight) intraperitoneally, and 24 hours late, was performed a median laparotomy associated with the resection of 1 cm of the iieum and end-to-end anastornosis with 6-0 silk suture in total single plain with a continuous suture. In the experimental group, cisplatinum was administered (5 rng/kg of body weight together with sodium chloride 0.9% in the proportion of 20% of the body weight) and, after one day, the sarne surgical procedure, used in the control group, were performed. A macroscopic appraisal of the wound on the abdomen wall, peritoneal cavity and of the intestinal anastomosis was made. The adhesions presence occurred in all the operated on animals, with intensity of different degrees. The adhesions were more extensivo and firm in subgroup A2 (seven days with cisplatinum). No infection, dehiscence, evitration or evisceration of the surgical wound on the abdominal wall as well as peritonitis, abscesses, phystulae or dehiscences of the intestinal suture in both groups was observed. it was observed macroscopically that in all the subgroups with cisplatinum the protuberance at the level of the intestinal suture une on the intraluminal side of the segment of the small intestine during the necropsy was smaller.