Effect of antineoplastic chemotherapy with cisplatinum (cis-diammino dichloroplatinum-Il) on the healing of anastomoses of the small intestine of rats. Histological aspects
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/2934 |
Resumo: | The authors studied the effeCt of the cisplatinum (Cis-diamminodichioroplatinum-ll) intra peritoneally administered, over the healing of the small intestine of rat from the histological p0/nt of view, 48 Wistar's male rats with an average weight of 315,5 grams, were opera ted in the Experimental Surgery Laboratory at the Surgical Department of the Medical School from the "Universidade Federal do Rio de Janeiro". The control group of 24 animais, received sodium chioride 0,9% (20% of the corporeal weight) intraperitoneally, and 24 hours Iate, was performed a medical laparotomy associated with the ressection of 1 cm of the ileum and end-to-end anastomosis with 6-0 sllk suture in total single with continous suture. In the experimental group, cisplatinum was administered (5 mg/kg of body weight togheter with sodium chloride 0,9% in the proportion of 20% of the body weight) and, after one day, the same surgical procedure used in the control, were performed. The animais were sacrified at the 7h 14h and 21s1 postoperative day. The optical microscopic histological survey evidenced: the number of vesseis/field was greater in the group of rats treated with cisplatinum (p < 0,01) and that the trans forming histiocyte and fibroblast number (fusiforme nucleous/field) was greater on the control group (p <0,01) on 7h day postoperative; on the 14 Ih day postoperative, the granulation (p < 0,01); on the 21s1 postoperative, the number of vessels/field was greater in the control group (p <0,001). They're concluded that, the cisplatinum deiays the healing process in anastomosis of the small intestine in rats. |
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Effect of antineoplastic chemotherapy with cisplatinum (cis-diammino dichloroplatinum-Il) on the healing of anastomoses of the small intestine of rats. Histological aspects Efeito da quimioterapia com cisplatina (Cis-diaminodicloroplatina-Il) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos histológicosCicatrização das FeridasAnastomoses IntestinaisCisplatinoQuimioterapiaEfeitos AdversosIntestino DelgadoWound HealingIntestinal AnastomosisCisplatinumChemotherapyAdverses EffectsSmall IntestineThe authors studied the effeCt of the cisplatinum (Cis-diamminodichioroplatinum-ll) intra peritoneally administered, over the healing of the small intestine of rat from the histological p0/nt of view, 48 Wistar's male rats with an average weight of 315,5 grams, were opera ted in the Experimental Surgery Laboratory at the Surgical Department of the Medical School from the "Universidade Federal do Rio de Janeiro". The control group of 24 animais, received sodium chioride 0,9% (20% of the corporeal weight) intraperitoneally, and 24 hours Iate, was performed a medical laparotomy associated with the ressection of 1 cm of the ileum and end-to-end anastomosis with 6-0 sllk suture in total single with continous suture. In the experimental group, cisplatinum was administered (5 mg/kg of body weight togheter with sodium chloride 0,9% in the proportion of 20% of the body weight) and, after one day, the same surgical procedure used in the control, were performed. The animais were sacrified at the 7h 14h and 21s1 postoperative day. The optical microscopic histological survey evidenced: the number of vesseis/field was greater in the group of rats treated with cisplatinum (p < 0,01) and that the trans forming histiocyte and fibroblast number (fusiforme nucleous/field) was greater on the control group (p <0,01) on 7h day postoperative; on the 14 Ih day postoperative, the granulation (p < 0,01); on the 21s1 postoperative, the number of vessels/field was greater in the control group (p <0,001). They're concluded that, the cisplatinum deiays the healing process in anastomosis of the small intestine in rats.Foi estudada a ação da cisplatina (Cis-diaminodicloroplatina-li) administrada intraperitonealmente sobre a cicatrização de anastomoses do intestino delgado do rato, do ponto de vista histológico. Foram operados 48 ratos Wistar machos, com peso médio de 315,5 gramas, no Laboratório de Cirurgia Experimental do Departamento de Cirurgia da Faculdade de Medicina da Universidade Federal do Rio de Janeiro. Nos 24 animais do grupo-controle foi injetado, por via intraperitoneal, soro fisiológico a 0,9% (20% do peso corporal) e 24 horas após realizou-se laparotomia mediana associada à ressecção de 1 cm de íleo e anastomose término-terminal com fio de seda 6-0 em plano único total com sutura contínua. Nos ratos do grupo-experimento foi administrada cisplatina (5 mglkg de peso corporal) associada a soro fisiológico a 0,9% na proporção de 20% de peso corpóreo e, após um dia, foi efetuado o mesmo procedimento cirúrgico do grupo-controle. Os animais foram sacrificados nos 79, 142e 219dias de pós-operatório. O estudo histológico com microscopia óptica evidenciou: o número de vasos/campo foi maior no grupo de ratos tratados com cisplatina (p < 0,01), e o número de fibroblastos e histiócitos em transformação (núcleos, fusiformes/campo) foi maior no controle (p < 0,01) no 79 dia de pós-operatório; o tecido de granulação e a área de necrose foram maiores nos tratados com cisplatina (p < 0,01); no 212dia de pós-operatório o número de vasos/campo foi maior no grupo controle (p < 0,01). Concluem que a cisplatina retarda a cicatrização de anastomoses do intestino delgado em ratos.INCA2023-06-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/293410.32635/2176-9745.RBC.1995v41n2.2934Revista Brasileira de Cancerologia; Vol. 41 No. 2 (1995): Apr./May/June; 109-120Revista Brasileira de Cancerologia; Vol. 41 Núm. 2 (1995): abr./mayo/jun.; 109-120Revista Brasileira de Cancerologia; v. 41 n. 2 (1995): abr./maio/jun.; 109-1202176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2934/1811https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCarneiro, Paulo Cesar Alves Gutman, Tereza Cristina Ferreira Castro, Onofre Ferreira de2023-06-19T13:29:57Zoai:rbc.inca.gov.br:article/2934Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-06-19T13:29:57Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Effect of antineoplastic chemotherapy with cisplatinum (cis-diammino dichloroplatinum-Il) on the healing of anastomoses of the small intestine of rats. Histological aspects Efeito da quimioterapia com cisplatina (Cis-diaminodicloroplatina-Il) na cicatrização de anastomoses do intestino delgado em ratos. Aspectos histológicos |
title |
Effect of antineoplastic chemotherapy with cisplatinum (cis-diammino dichloroplatinum-Il) on the healing of anastomoses of the small intestine of rats. Histological aspects |
spellingShingle |
Effect of antineoplastic chemotherapy with cisplatinum (cis-diammino dichloroplatinum-Il) on the healing of anastomoses of the small intestine of rats. Histological aspects Carneiro, Paulo Cesar Alves Cicatrização das Feridas Anastomoses Intestinais Cisplatino Quimioterapia Efeitos Adversos Intestino Delgado Wound Healing Intestinal Anastomosis Cisplatinum Chemotherapy Adverses Effects Small Intestine |
title_short |
Effect of antineoplastic chemotherapy with cisplatinum (cis-diammino dichloroplatinum-Il) on the healing of anastomoses of the small intestine of rats. Histological aspects |
title_full |
Effect of antineoplastic chemotherapy with cisplatinum (cis-diammino dichloroplatinum-Il) on the healing of anastomoses of the small intestine of rats. Histological aspects |
title_fullStr |
Effect of antineoplastic chemotherapy with cisplatinum (cis-diammino dichloroplatinum-Il) on the healing of anastomoses of the small intestine of rats. Histological aspects |
title_full_unstemmed |
Effect of antineoplastic chemotherapy with cisplatinum (cis-diammino dichloroplatinum-Il) on the healing of anastomoses of the small intestine of rats. Histological aspects |
title_sort |
Effect of antineoplastic chemotherapy with cisplatinum (cis-diammino dichloroplatinum-Il) on the healing of anastomoses of the small intestine of rats. Histological aspects |
author |
Carneiro, Paulo Cesar Alves |
author_facet |
Carneiro, Paulo Cesar Alves Gutman, Tereza Cristina Ferreira Castro, Onofre Ferreira de |
author_role |
author |
author2 |
Gutman, Tereza Cristina Ferreira Castro, Onofre Ferreira de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Carneiro, Paulo Cesar Alves Gutman, Tereza Cristina Ferreira Castro, Onofre Ferreira de |
dc.subject.por.fl_str_mv |
Cicatrização das Feridas Anastomoses Intestinais Cisplatino Quimioterapia Efeitos Adversos Intestino Delgado Wound Healing Intestinal Anastomosis Cisplatinum Chemotherapy Adverses Effects Small Intestine |
topic |
Cicatrização das Feridas Anastomoses Intestinais Cisplatino Quimioterapia Efeitos Adversos Intestino Delgado Wound Healing Intestinal Anastomosis Cisplatinum Chemotherapy Adverses Effects Small Intestine |
description |
The authors studied the effeCt of the cisplatinum (Cis-diamminodichioroplatinum-ll) intra peritoneally administered, over the healing of the small intestine of rat from the histological p0/nt of view, 48 Wistar's male rats with an average weight of 315,5 grams, were opera ted in the Experimental Surgery Laboratory at the Surgical Department of the Medical School from the "Universidade Federal do Rio de Janeiro". The control group of 24 animais, received sodium chioride 0,9% (20% of the corporeal weight) intraperitoneally, and 24 hours Iate, was performed a medical laparotomy associated with the ressection of 1 cm of the ileum and end-to-end anastomosis with 6-0 sllk suture in total single with continous suture. In the experimental group, cisplatinum was administered (5 mg/kg of body weight togheter with sodium chloride 0,9% in the proportion of 20% of the body weight) and, after one day, the same surgical procedure used in the control, were performed. The animais were sacrified at the 7h 14h and 21s1 postoperative day. The optical microscopic histological survey evidenced: the number of vesseis/field was greater in the group of rats treated with cisplatinum (p < 0,01) and that the trans forming histiocyte and fibroblast number (fusiforme nucleous/field) was greater on the control group (p <0,01) on 7h day postoperative; on the 14 Ih day postoperative, the granulation (p < 0,01); on the 21s1 postoperative, the number of vessels/field was greater in the control group (p <0,001). They're concluded that, the cisplatinum deiays the healing process in anastomosis of the small intestine in rats. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2934 10.32635/2176-9745.RBC.1995v41n2.2934 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/2934 |
identifier_str_mv |
10.32635/2176-9745.RBC.1995v41n2.2934 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2934/1811 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 41 No. 2 (1995): Apr./May/June; 109-120 Revista Brasileira de Cancerologia; Vol. 41 Núm. 2 (1995): abr./mayo/jun.; 109-120 Revista Brasileira de Cancerologia; v. 41 n. 2 (1995): abr./maio/jun.; 109-120 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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1797042233398001664 |