The involvement of genes and proteins in apoptosis - Carcinogenesis regulation

Detalhes bibliográficos
Autor(a) principal: Delfino, Ana Bárbara M.
Data de Publicação: 2022
Outros Autores: Barreto, Emandes Campos, Silva Jr., Edejar Teixeira da, Mendonça, Renato Gonçalves de, Ornellas, Maria Helena
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2852
Resumo: Apoptosis is an importante feature in many normal biological process, such as embryogenesis, development of the immune system, cell maturation and differentiation. In occurrence of diseases, apoptosis seems to be involved in immunodeficiency, drug resistance and carcinogenesis. It is well known that carcinogenesis involves cumulative genetic alterations in oncogenes and tumor suppressor genes. Therefore the prognosis of each human tumor seems to be dependent on several genes, and it is foreseeable that a deeper knowledge on the co-operation and antagonism the these genes could provide, in the future, clinically relevant informations. We review some of the most recent developments concerning the genes involved in apoptosis and human cancers (p53, bcl-2, c-myc, fas-APO-l, mdr-l) and their clinical implications.
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spelling The involvement of genes and proteins in apoptosis - Carcinogenesis regulationO envolvimento de genes e proteínas na regulação da apoptose – CarcinogêneseApoptoseOncogenesGenes Supressores de TumorCarcinogêneseApoptosisOncogenesTumor Suppressor GenesCarcinogenesisApoptosis is an importante feature in many normal biological process, such as embryogenesis, development of the immune system, cell maturation and differentiation. In occurrence of diseases, apoptosis seems to be involved in immunodeficiency, drug resistance and carcinogenesis. It is well known that carcinogenesis involves cumulative genetic alterations in oncogenes and tumor suppressor genes. Therefore the prognosis of each human tumor seems to be dependent on several genes, and it is foreseeable that a deeper knowledge on the co-operation and antagonism the these genes could provide, in the future, clinically relevant informations. We review some of the most recent developments concerning the genes involved in apoptosis and human cancers (p53, bcl-2, c-myc, fas-APO-l, mdr-l) and their clinical implications.A apoptose é um fator importante em muitos processos biológicos normais, tais como a embriogênese, o desenvolvimento do sistema imune, a maturação e a diferenciação celular. Em situações patológicas, a apoptose parece estar implicada na imunodeficiência, resistência a drogas e carcinogênese. Sabe-se que a carcinogênese envolve alterações genéticas cumulativas em oncogenes e genes supressores de tumor. Dessa forma, o prognóstico de cada tumor humano parece depender do equilíbrio entre os diversos genes, sendo previsível que um conhecimento mais profundo da cooperação e antagonismo entre esses genes possa fornecer num futuro próximo informações clinicamente relevantes. Nós revisamos alguns dos mais recentes progressos a respeito de genes envolvidos na apoptose e nos cânceres humanos (p53, bcl-2, c-myc, fas-APO-l, mdr-1) e suas implicações clínicas.INCA2022-09-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/285210.32635/2176-9745.RBC.1997v43n3.2852Revista Brasileira de Cancerologia; Vol. 43 No. 3 (1997): July/Aug./Sept.; 173-186Revista Brasileira de Cancerologia; Vol. 43 Núm. 3 (1997): jul./ago./sept.; 173-186Revista Brasileira de Cancerologia; v. 43 n. 3 (1997): jul./ago./set.; 173-1862176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2852/1727https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessDelfino, Ana Bárbara M.Barreto, Emandes CamposSilva Jr., Edejar Teixeira daMendonça, Renato Gonçalves deOrnellas, Maria Helena2023-01-18T14:51:28Zoai:rbc.inca.gov.br:article/2852Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-01-18T14:51:28Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv The involvement of genes and proteins in apoptosis - Carcinogenesis regulation
O envolvimento de genes e proteínas na regulação da apoptose – Carcinogênese
title The involvement of genes and proteins in apoptosis - Carcinogenesis regulation
spellingShingle The involvement of genes and proteins in apoptosis - Carcinogenesis regulation
Delfino, Ana Bárbara M.
Apoptose
Oncogenes
Genes Supressores de Tumor
Carcinogênese
Apoptosis
Oncogenes
Tumor Suppressor Genes
Carcinogenesis
title_short The involvement of genes and proteins in apoptosis - Carcinogenesis regulation
title_full The involvement of genes and proteins in apoptosis - Carcinogenesis regulation
title_fullStr The involvement of genes and proteins in apoptosis - Carcinogenesis regulation
title_full_unstemmed The involvement of genes and proteins in apoptosis - Carcinogenesis regulation
title_sort The involvement of genes and proteins in apoptosis - Carcinogenesis regulation
author Delfino, Ana Bárbara M.
author_facet Delfino, Ana Bárbara M.
Barreto, Emandes Campos
Silva Jr., Edejar Teixeira da
Mendonça, Renato Gonçalves de
Ornellas, Maria Helena
author_role author
author2 Barreto, Emandes Campos
Silva Jr., Edejar Teixeira da
Mendonça, Renato Gonçalves de
Ornellas, Maria Helena
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Delfino, Ana Bárbara M.
Barreto, Emandes Campos
Silva Jr., Edejar Teixeira da
Mendonça, Renato Gonçalves de
Ornellas, Maria Helena
dc.subject.por.fl_str_mv Apoptose
Oncogenes
Genes Supressores de Tumor
Carcinogênese
Apoptosis
Oncogenes
Tumor Suppressor Genes
Carcinogenesis
topic Apoptose
Oncogenes
Genes Supressores de Tumor
Carcinogênese
Apoptosis
Oncogenes
Tumor Suppressor Genes
Carcinogenesis
description Apoptosis is an importante feature in many normal biological process, such as embryogenesis, development of the immune system, cell maturation and differentiation. In occurrence of diseases, apoptosis seems to be involved in immunodeficiency, drug resistance and carcinogenesis. It is well known that carcinogenesis involves cumulative genetic alterations in oncogenes and tumor suppressor genes. Therefore the prognosis of each human tumor seems to be dependent on several genes, and it is foreseeable that a deeper knowledge on the co-operation and antagonism the these genes could provide, in the future, clinically relevant informations. We review some of the most recent developments concerning the genes involved in apoptosis and human cancers (p53, bcl-2, c-myc, fas-APO-l, mdr-l) and their clinical implications.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2852
10.32635/2176-9745.RBC.1997v43n3.2852
url https://rbc.inca.gov.br/index.php/revista/article/view/2852
identifier_str_mv 10.32635/2176-9745.RBC.1997v43n3.2852
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2852/1727
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 43 No. 3 (1997): July/Aug./Sept.; 173-186
Revista Brasileira de Cancerologia; Vol. 43 Núm. 3 (1997): jul./ago./sept.; 173-186
Revista Brasileira de Cancerologia; v. 43 n. 3 (1997): jul./ago./set.; 173-186
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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