Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in Patients with Appendix Mucinous Adenocarcinoma: Series of 43 Cases

Detalhes bibliográficos
Autor(a) principal: Cordeiro, Priscila Jessica Davila
Data de Publicação: 2022
Outros Autores: Muzi, Camila Drumond
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1696
Resumo: Introduction: Primary appendix carcinoma is a rare condition. Many international retrospective reviews outline the experience of different centers in appendicular neoplasms. The cancer treatment in this location is complex and depends on the histological subtype and the extent of the disease. One of the most promising treatments is cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). In Brazil, there is no description of series of cases with this therapeutic approach. The purpose of this case series is to analyze the sociodemographic characteristics and the type of therapeutic intervention in patients with malignant diseases of the appendix in a High Complexity Care Center in Oncology III (Cacon III). Case reports: 43 cases of primary appendix tumors were included. Low-grade mucinous adenocarcinoma was the most diagnosed neoplasm. The main protocol used was 1 to 2 surgeries and application of mitomycin C at an average temperature of 40 degrees. There was great heterogeneity regarding the use of the protocol. Conclusion: The present report of 43 cases is important because it is a rare tumor with this location. The therapeutic modality described is promising, but there is no defined protocol for this purpose. It is necessary to update the therapeutic guidelines to standardize the conduct internally, especially in the case of a national reference unit.
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spelling Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in Patients with Appendix Mucinous Adenocarcinoma: Series of 43 CasesCirugía Citorreductiva con Quimioterapia Intraperitoneal Hipertermal en Pacientes con Adenocarcinoma Mucinoso de Apéndice: Serie de 43 CasosCirurgia Citorredutora com Quimioterapia Intraperitoneal Hipertérmica em Pacientes com Adenocarcinoma Mucinoso de Apêndice: Série de 43 Casosquimioterapia intraperitoneal hipertérmicaneoplasias do apêndiceprocedimentos cirúrgicos de citorreduçãohyperthermic intraperitoneal chemotherapyappendiceal neoplasmscytoreduction surgical proceduresquimioterapia intraperitoneal hipertérmicaneoplasias del apéndiceprocedimientos quirúrgicos de citorreducciónIntroduction: Primary appendix carcinoma is a rare condition. Many international retrospective reviews outline the experience of different centers in appendicular neoplasms. The cancer treatment in this location is complex and depends on the histological subtype and the extent of the disease. One of the most promising treatments is cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). In Brazil, there is no description of series of cases with this therapeutic approach. The purpose of this case series is to analyze the sociodemographic characteristics and the type of therapeutic intervention in patients with malignant diseases of the appendix in a High Complexity Care Center in Oncology III (Cacon III). Case reports: 43 cases of primary appendix tumors were included. Low-grade mucinous adenocarcinoma was the most diagnosed neoplasm. The main protocol used was 1 to 2 surgeries and application of mitomycin C at an average temperature of 40 degrees. There was great heterogeneity regarding the use of the protocol. Conclusion: The present report of 43 cases is important because it is a rare tumor with this location. The therapeutic modality described is promising, but there is no defined protocol for this purpose. It is necessary to update the therapeutic guidelines to standardize the conduct internally, especially in the case of a national reference unit.Introducción: El carcinoma primario de apéndice es una entidad poco frecuente. Numerosas revisiones retrospectivas internacionales describen la experiencia de diferentes centros en neoplasias apendiculares. A su vez, el tratamiento de esta localización del cáncer es complejo y depende del subtipo histológico y la extensión de la enfermedad. Uno de los tratamientos más prometedores es la cirugía citorreductora (CCR) asociada a quimioterapia intraperitoneal hipertérmica (HIPEC). En Brasil, no hay descripción de series de casos que tuvieran este abordaje terapéutico. El propósito de esta serie de casos es analizar las características sociodemográficas y el tipo de intervención terapéutica en pacientes con enfermedades malignas del apéndice en un Centro Asistencial de Alta Complejidad en Oncología III (Cacón III). Reporte de los casos: Se incluyeron 43 casos de tumores primarios de apéndice. El adenocarcinoma mucinoso de bajo grado tuvo la mayor incidencia. El protocolo principal utilizado fue de una a dos cirugías y aplicación de mitomicina C a una temperatura promedio de 40 grados. Los casos mostraron gran heterogeneidad en cuanto al uso del protocolo. Conclusión: El presente informe es importante porque es un tumor raro. La modalidad terapéutica descrita es prometedora, pero no existe un protocolo definido para tal fin. Es necesario actualizar las pautas terapéuticas para normalizar la conducta internamente, especialmente en el caso de una unidad de referencia nacional.Introdução: O carcinoma primário de apêndice é uma condição rara. Muitas revisões retrospectivas internacionais delineiam a experiência de diferentes centros em neoplasias apendiculares. Por sua vez, o tratamento do câncer nessa localização é complexo e depende do subtipo histológico e da extensão da doença. Um dos tratamentos mais promissores é a cirurgia citorredutora (CCR) associada à quimioterapia intraperitoneal hipertérmica (HIPEC). No Brasil, não há descrição de séries de casos que tiveram essa abordagem terapêutica. O objetivo desta série de casos é analisar as características sociodemográficas e o tipo de intervenção terapêutica em pacientes com doenças malignas de apêndice em um Centro de Assistência de Alta Complexidade em Oncologia III (Cacon III). Relato dos casos: Foram incluídos 43 casos de tumores primários de apêndice. O adenocarcinoma do apêndice do tipo mucinoso de baixo grau foi a neoplasia mais diagnosticada. O principal protocolo utilizado foi de uma a duas cirurgias e aplicação de mitomicina C em temperatura média de 40 graus. Os casos apresentaram grande heterogeneidade quanto ao uso do protocolo. Conclusão: O presente relato de 43 casos é importante por se tratar de um tumor raro nessa localização. A modalidade terapêutica descrita é promissora, mas não há protocolo definido para essa finalidade. É necessário atualizar as diretrizes terapêuticas para normatizar a conduta internamente, especialmente em se tratando de uma unidade de referência nacional.INCA2022-03-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelato de Casoapplication/pdfapplication/pdftext/htmlhttps://rbc.inca.gov.br/index.php/revista/article/view/169610.32635/2176-9745.RBC.2022v68n1.1696Revista Brasileira de Cancerologia; Vol. 68 No. 1 (2022): Jan./Feb./Mar.; e-241696Revista Brasileira de Cancerologia; Vol. 68 Núm. 1 (2022): ene./feb./mar.; e-241696Revista Brasileira de Cancerologia; v. 68 n. 1 (2022): jan./fev./mar.; e-2416962176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/1696/2479https://rbc.inca.gov.br/index.php/revista/article/view/1696/1932https://rbc.inca.gov.br/index.php/revista/article/view/1696/2436Copyright (c) 2022 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCordeiro, Priscila Jessica Davila Muzi, Camila Drumond 2022-12-13T16:30:01Zoai:rbc.inca.gov.br:article/1696Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2022-12-13T16:30:01Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in Patients with Appendix Mucinous Adenocarcinoma: Series of 43 Cases
Cirugía Citorreductiva con Quimioterapia Intraperitoneal Hipertermal en Pacientes con Adenocarcinoma Mucinoso de Apéndice: Serie de 43 Casos
Cirurgia Citorredutora com Quimioterapia Intraperitoneal Hipertérmica em Pacientes com Adenocarcinoma Mucinoso de Apêndice: Série de 43 Casos
title Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in Patients with Appendix Mucinous Adenocarcinoma: Series of 43 Cases
spellingShingle Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in Patients with Appendix Mucinous Adenocarcinoma: Series of 43 Cases
Cordeiro, Priscila Jessica Davila
quimioterapia intraperitoneal hipertérmica
neoplasias do apêndice
procedimentos cirúrgicos de citorredução
hyperthermic intraperitoneal chemotherapy
appendiceal neoplasms
cytoreduction surgical procedures
quimioterapia intraperitoneal hipertérmica
neoplasias del apéndice
procedimientos quirúrgicos de citorreducción
title_short Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in Patients with Appendix Mucinous Adenocarcinoma: Series of 43 Cases
title_full Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in Patients with Appendix Mucinous Adenocarcinoma: Series of 43 Cases
title_fullStr Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in Patients with Appendix Mucinous Adenocarcinoma: Series of 43 Cases
title_full_unstemmed Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in Patients with Appendix Mucinous Adenocarcinoma: Series of 43 Cases
title_sort Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in Patients with Appendix Mucinous Adenocarcinoma: Series of 43 Cases
author Cordeiro, Priscila Jessica Davila
author_facet Cordeiro, Priscila Jessica Davila
Muzi, Camila Drumond
author_role author
author2 Muzi, Camila Drumond
author2_role author
dc.contributor.author.fl_str_mv Cordeiro, Priscila Jessica Davila
Muzi, Camila Drumond
dc.subject.por.fl_str_mv quimioterapia intraperitoneal hipertérmica
neoplasias do apêndice
procedimentos cirúrgicos de citorredução
hyperthermic intraperitoneal chemotherapy
appendiceal neoplasms
cytoreduction surgical procedures
quimioterapia intraperitoneal hipertérmica
neoplasias del apéndice
procedimientos quirúrgicos de citorreducción
topic quimioterapia intraperitoneal hipertérmica
neoplasias do apêndice
procedimentos cirúrgicos de citorredução
hyperthermic intraperitoneal chemotherapy
appendiceal neoplasms
cytoreduction surgical procedures
quimioterapia intraperitoneal hipertérmica
neoplasias del apéndice
procedimientos quirúrgicos de citorreducción
description Introduction: Primary appendix carcinoma is a rare condition. Many international retrospective reviews outline the experience of different centers in appendicular neoplasms. The cancer treatment in this location is complex and depends on the histological subtype and the extent of the disease. One of the most promising treatments is cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). In Brazil, there is no description of series of cases with this therapeutic approach. The purpose of this case series is to analyze the sociodemographic characteristics and the type of therapeutic intervention in patients with malignant diseases of the appendix in a High Complexity Care Center in Oncology III (Cacon III). Case reports: 43 cases of primary appendix tumors were included. Low-grade mucinous adenocarcinoma was the most diagnosed neoplasm. The main protocol used was 1 to 2 surgeries and application of mitomycin C at an average temperature of 40 degrees. There was great heterogeneity regarding the use of the protocol. Conclusion: The present report of 43 cases is important because it is a rare tumor with this location. The therapeutic modality described is promising, but there is no defined protocol for this purpose. It is necessary to update the therapeutic guidelines to standardize the conduct internally, especially in the case of a national reference unit.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-24
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url https://rbc.inca.gov.br/index.php/revista/article/view/1696
identifier_str_mv 10.32635/2176-9745.RBC.2022v68n1.1696
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1696/2479
https://rbc.inca.gov.br/index.php/revista/article/view/1696/1932
https://rbc.inca.gov.br/index.php/revista/article/view/1696/2436
dc.rights.driver.fl_str_mv Copyright (c) 2022 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
text/html
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 68 No. 1 (2022): Jan./Feb./Mar.; e-241696
Revista Brasileira de Cancerologia; Vol. 68 Núm. 1 (2022): ene./feb./mar.; e-241696
Revista Brasileira de Cancerologia; v. 68 n. 1 (2022): jan./fev./mar.; e-241696
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
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instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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