Ozonotherapy for Treatment of Radiation Therapy-induced Jaw Osteonecrosis and Bisphosphonates: Case Report

• Autor(a) principal: Oliveira, Cleidiana Celi Bonfim
• Data de Publicação: 2021
• Outros Autores: Dantas, Juliana Borges de Lima, Borges, Danilo de Paula Oliveira, Martins, Gabriela Botelho, Medrado , Alena Ribeiro Alves Peixoto, Reis , Júlia Vianna Neri Andrade, Marchionni, Antônio Márcio Teixeira
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Cancerologia (Online)
• Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/785
• topic: Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/radioterapia; Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/tratamento farmacológico; Osteonecrose/radioterapia; Ozônio/uso terapêutico; Neoplasias; Bisphosphonate-Associated Osteonecrosis of the Jaw/radiotherapy; Bisphosphonate-Associated Osteonecrosis of the Jaw/ drug therapy; Osteonecrosis/radiotherapy; Ozone/therapeutic use; Neoplasms; Osteonecrosis de los Maxilares Asociada a Difosfonatos/ radioterapia; Osteonecrosis de los Maxilares Asociada a Difosfonatos/ tratamiento farmacológico; Osteonecrosis/radioterapia; Ozono/uso terapéutico; Neoplasias

Introduction: The inhibition of osteoclastic activity, associated with different treatment modalities in patients with head and neck cancer, make bones unable to respond to repair processes related to physiological traumas or infection and may result in bone necrosis. The present study aims to report a clinical case of osteoradionecrosis in mandible, and how its sequels were controlled by ozonotherapy. Case report: A 73-year-old female patient with infiltrative ductal breast carcinoma with mandibular metastasis was submitted to chemo and radiotherapy at head and neck region associated with bisphosphonate. Three years later, she was diagnosed with hemimandibular osteoradionecrosis that exhibited communication with oral cavity and with a chronic, suppurative and persistent associated infection. It was applied adjuvant therapy with ozone through the cutaneous fistula and the exposed and necrotic bone. Additionally, non-vital bone debridement was proceeded in two surgical steps. The patient is after a 1-year follow-up non-symptomatic. Conclusion: It is supposed that ozonotherapy, due to its antibacterial and immunoregulatory mechanism of action, was an important therapeutic agent for improving the patient’s quality of life.