Stage 3 Medication-related osteonecrosis of the jaw (MRONJ): successful conservative treatment with ozone therapy

Detalhes bibliográficos
Autor(a) principal: Lima, Livia Bonjardim
Data de Publicação: 2020
Outros Autores: Paulo, Luiz Fernando Barbosa de, Silva, Cláudia Jordão, Filice, Letícia de Souza Castro, Barbosa, Gabriella Lopes de Rezende
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/11212
Resumo: Background: The medication-related osteonecrosis of the jaws is an uncommon severe complication following utilization of certain drugs, but its occurrence has great impact on the patient’s quality of life. Various treatment modalities are used to manage the lesions, including conservative and surgical procedures. Ozone (O3) therapy emerges as an alternative of non-invasive therapy that can benefit the affected patient without surgical risks, due to the potential of stimulate the activation and migration of fibroblasts in an injured area. Case presentation: This article reports the conservative treatment of a maxillary stage 3 medication-related osteonecrosis, in a partial edentulous patient previously treated with intravenous bisphosphonate for multiple myeloma, who had previous cardiac illness. Conclusion: The stage 3 medication-related osteonecrosis was successfully treated with ozone (O3) gas injection and irrigation with ozonated water, with full coverage of the bone and no suppuration or pain at the end of the treatment. No recurrence was seen after twelve months of follow-up.
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spelling Stage 3 Medication-related osteonecrosis of the jaw (MRONJ): successful conservative treatment with ozone therapyOsteonecrosis de los maxilares relacionada con medicamentos (ONMRM) en estado 3: tratamiento conservador exitoso con ozonoterapiaOsteonecrose dos maxilares associado ao uso de medicamentos (OMAM) em estágio 3: tratamento conservador bem sucedido com ozonioterapiaOsteonecrose da arcada osseodentária associada a difosfonatosOzônioOsteonecroseTerapêutica.Bisphosphonate-associated osteonecrosis of the jawOzoneOsteonecrosisTherapeutics.Background: The medication-related osteonecrosis of the jaws is an uncommon severe complication following utilization of certain drugs, but its occurrence has great impact on the patient’s quality of life. Various treatment modalities are used to manage the lesions, including conservative and surgical procedures. Ozone (O3) therapy emerges as an alternative of non-invasive therapy that can benefit the affected patient without surgical risks, due to the potential of stimulate the activation and migration of fibroblasts in an injured area. Case presentation: This article reports the conservative treatment of a maxillary stage 3 medication-related osteonecrosis, in a partial edentulous patient previously treated with intravenous bisphosphonate for multiple myeloma, who had previous cardiac illness. Conclusion: The stage 3 medication-related osteonecrosis was successfully treated with ozone (O3) gas injection and irrigation with ozonated water, with full coverage of the bone and no suppuration or pain at the end of the treatment. No recurrence was seen after twelve months of follow-up.Antecedentes: La osteonecrosis de los maxilares relacionada con medicamentos es una complicación grave poco común después de la utilización de ciertos medicamentos, pero su aparición tiene un gran impacto en la calidad de vida del paciente. Se utilizan diversas modalidades de tratamiento para tratar las lesiones, incluidos procedimientos conservadores y quirúrgicos. La terapia con ozono (O3) surge como una alternativa de terapia no invasiva que puede beneficiar al paciente afectado sin riesgos quirúrgicos, debido al potencial de estimular la activación y migración de fibroblastos en una zona lesionada. Presentación del caso: Este artículo informa sobre el tratamiento conservador de una osteonecrosis maxilar en estado 3 relacionada con medicamentos, en un paciente parcialmente edéntulo tratado previamente con bisfosfonato intravenoso por mieloma múltiple, que tenía enfermedad cardíaca previa. Conclusión: La osteonecrosis en estado 3 relacionada con medicamentos se trató con éxito con inyección de gas ozono (O3) e irrigación con agua ozonizada, con cobertura total del hueso y sin supuración ni dolor al final del tratamiento. No se observó recurrencia después de doce meses de seguimiento.Introdução: A osteonecrose dos maxilares associada ao uso de medicamentos é uma complicação grave incomum após o uso de certas medicações, mas sua ocorrência tem grande impacto na qualidade de vida do paciente. Várias modalidades de tratamento são utilizadas para o manejo das lesões, incluindo procedimentos conservadores e cirúrgicos. A terapia com ozônio (O3) surge como uma alternativa de terapia não invasiva que pode beneficiar o paciente acometido, sem riscos cirúrgicos, devido ao potencial de estimular a ativação e migração de fibroblastos em uma área lesionada. Apresentação do caso: Este artigo relata o tratamento conservador de uma osteonecrose associada ao uso de medicamento em estágio 3 da maxila, em um paciente edêntulo parcial, previamente tratado com bisfosfonato intravenoso para mieloma múltiplo, que apresentava doença cardíaca prévia. Conclusão: A osteonecrose associada ao uso de medicamento em estágio 3 foi tratada com sucesso com injeção de gás ozônio (O3) e irrigação com água ozonizada, com recobrimento total do osso e sem supuração ou dor ao final do tratamento. Nenhuma recorrência foi observada após doze meses de acompanhamento.Research, Society and Development2020-12-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1121210.33448/rsd-v9i12.11212Research, Society and Development; Vol. 9 No. 12; e44591211212Research, Society and Development; Vol. 9 Núm. 12; e44591211212Research, Society and Development; v. 9 n. 12; e445912112122525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/11212/10093Copyright (c) 2020 Livia Bonjardim Lima; Luiz Fernando Barbosa de Paulo; Cláudia Jordão Silva; Letícia de Souza Castro Filice; Gabriella Lopes de Rezende Barbosahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLima, Livia BonjardimPaulo, Luiz Fernando Barbosa deSilva, Cláudia Jordão Filice, Letícia de Souza Castro Barbosa, Gabriella Lopes de Rezende 2020-12-30T23:32:22Zoai:ojs.pkp.sfu.ca:article/11212Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:06.047975Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Stage 3 Medication-related osteonecrosis of the jaw (MRONJ): successful conservative treatment with ozone therapy
Osteonecrosis de los maxilares relacionada con medicamentos (ONMRM) en estado 3: tratamiento conservador exitoso con ozonoterapia
Osteonecrose dos maxilares associado ao uso de medicamentos (OMAM) em estágio 3: tratamento conservador bem sucedido com ozonioterapia
title Stage 3 Medication-related osteonecrosis of the jaw (MRONJ): successful conservative treatment with ozone therapy
spellingShingle Stage 3 Medication-related osteonecrosis of the jaw (MRONJ): successful conservative treatment with ozone therapy
Lima, Livia Bonjardim
Osteonecrose da arcada osseodentária associada a difosfonatos
Ozônio
Osteonecrose
Terapêutica.
Bisphosphonate-associated osteonecrosis of the jaw
Ozone
Osteonecrosis
Therapeutics.
title_short Stage 3 Medication-related osteonecrosis of the jaw (MRONJ): successful conservative treatment with ozone therapy
title_full Stage 3 Medication-related osteonecrosis of the jaw (MRONJ): successful conservative treatment with ozone therapy
title_fullStr Stage 3 Medication-related osteonecrosis of the jaw (MRONJ): successful conservative treatment with ozone therapy
title_full_unstemmed Stage 3 Medication-related osteonecrosis of the jaw (MRONJ): successful conservative treatment with ozone therapy
title_sort Stage 3 Medication-related osteonecrosis of the jaw (MRONJ): successful conservative treatment with ozone therapy
author Lima, Livia Bonjardim
author_facet Lima, Livia Bonjardim
Paulo, Luiz Fernando Barbosa de
Silva, Cláudia Jordão
Filice, Letícia de Souza Castro
Barbosa, Gabriella Lopes de Rezende
author_role author
author2 Paulo, Luiz Fernando Barbosa de
Silva, Cláudia Jordão
Filice, Letícia de Souza Castro
Barbosa, Gabriella Lopes de Rezende
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lima, Livia Bonjardim
Paulo, Luiz Fernando Barbosa de
Silva, Cláudia Jordão
Filice, Letícia de Souza Castro
Barbosa, Gabriella Lopes de Rezende
dc.subject.por.fl_str_mv Osteonecrose da arcada osseodentária associada a difosfonatos
Ozônio
Osteonecrose
Terapêutica.
Bisphosphonate-associated osteonecrosis of the jaw
Ozone
Osteonecrosis
Therapeutics.
topic Osteonecrose da arcada osseodentária associada a difosfonatos
Ozônio
Osteonecrose
Terapêutica.
Bisphosphonate-associated osteonecrosis of the jaw
Ozone
Osteonecrosis
Therapeutics.
description Background: The medication-related osteonecrosis of the jaws is an uncommon severe complication following utilization of certain drugs, but its occurrence has great impact on the patient’s quality of life. Various treatment modalities are used to manage the lesions, including conservative and surgical procedures. Ozone (O3) therapy emerges as an alternative of non-invasive therapy that can benefit the affected patient without surgical risks, due to the potential of stimulate the activation and migration of fibroblasts in an injured area. Case presentation: This article reports the conservative treatment of a maxillary stage 3 medication-related osteonecrosis, in a partial edentulous patient previously treated with intravenous bisphosphonate for multiple myeloma, who had previous cardiac illness. Conclusion: The stage 3 medication-related osteonecrosis was successfully treated with ozone (O3) gas injection and irrigation with ozonated water, with full coverage of the bone and no suppuration or pain at the end of the treatment. No recurrence was seen after twelve months of follow-up.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11212
10.33448/rsd-v9i12.11212
url https://rsdjournal.org/index.php/rsd/article/view/11212
identifier_str_mv 10.33448/rsd-v9i12.11212
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/11212/10093
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 12; e44591211212
Research, Society and Development; Vol. 9 Núm. 12; e44591211212
Research, Society and Development; v. 9 n. 12; e44591211212
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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