Correlation Among Clinical and Pathological Parameters and Disease-Free Survival of Patients with Renal Cancer Treated with Surgery at a Public Cancer Clinic in Curitiba

Detalhes bibliográficos
Autor(a) principal: Kappes, Ana Paula Trombetta
Data de Publicação: 2022
Outros Autores: Labegalini, André Luiz Camargo, Oliveira, André Matos de, Brunetto Neto, Antônio, Foiatto, Júlio Cesar, Tavares, Leonardo Pereira, Sebastiani, Santiago
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2679
Resumo: Introduction: Kidney cancer corresponds to the 13th most incident cancer in the world, and the third most common type of genitourinary cancer. Most patients are asymptomatic, and the diagnosis used to be incidental during routine imaging exams. Surgical treatment is the gold standard. Objective: To correlate clinical and pathological parameters with disease-free survival in renal cancer patients submitted to nephrectomy. Method: Retrospective study with 99 patients who underwent surgical treatment of kidney cancer from 2010 to 2020. Clinical and pathological parameters were compared with the clinical oncologic outcome after surgery. Results: Ninety-nine patients were followed-up postoperatively for an average time of 26.9 months, and the mean disease-free survival was 61.9%. Univariate analysis showed that tumor size >7 cm and Fuhrman grades III and IV were risk factors related to disease progression after nephrectomy (p=0.046 and CI=1.017-7.083; p=0.005 and CI=1.725-23.004, respectively). In the multivariate analysis, tumor size > 7cm (p=0.014 and CI=1.290-9.326) and Fuhrman grades III and IV (p=0.028 and CI=1.174-16.616) were identified as predictors of progression. Conclusion: Tumor size >7 cm and/or Fuhrman grades III or IV are risk factors for tumor recurrence after surgical treatment of renal cancer.
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spelling Correlation Among Clinical and Pathological Parameters and Disease-Free Survival of Patients with Renal Cancer Treated with Surgery at a Public Cancer Clinic in CuritibaCorrelación entre Parámetros Clínicos, Patológicos y Supervivência Libre de Enfermedad de Pacientes con Cáncer Renal Tratados con Cirugía en un Centro Oncológico Público de CuritibaCorrelação entre os Parâmetros Clínicos, Patológicos e a Sobrevida Livre de Doença de Pacientes com Câncer Renal Tratados com Cirurgia em um Centro Oncológico do Sistema Público de Curitibaneoplasias renaisanálise de sobrevidanefrectomiakidney neoplasmssurvival analysisnephrectomyneoplasias renalesanálisis de supervivencianefrectomíaIntroduction: Kidney cancer corresponds to the 13th most incident cancer in the world, and the third most common type of genitourinary cancer. Most patients are asymptomatic, and the diagnosis used to be incidental during routine imaging exams. Surgical treatment is the gold standard. Objective: To correlate clinical and pathological parameters with disease-free survival in renal cancer patients submitted to nephrectomy. Method: Retrospective study with 99 patients who underwent surgical treatment of kidney cancer from 2010 to 2020. Clinical and pathological parameters were compared with the clinical oncologic outcome after surgery. Results: Ninety-nine patients were followed-up postoperatively for an average time of 26.9 months, and the mean disease-free survival was 61.9%. Univariate analysis showed that tumor size >7 cm and Fuhrman grades III and IV were risk factors related to disease progression after nephrectomy (p=0.046 and CI=1.017-7.083; p=0.005 and CI=1.725-23.004, respectively). In the multivariate analysis, tumor size > 7cm (p=0.014 and CI=1.290-9.326) and Fuhrman grades III and IV (p=0.028 and CI=1.174-16.616) were identified as predictors of progression. Conclusion: Tumor size >7 cm and/or Fuhrman grades III or IV are risk factors for tumor recurrence after surgical treatment of renal cancer.Introducción: El cáncer de riñón corresponde a la 13a neoplasia mas incidente en el mundo, siendo el tercer tipo de cáncer genitourinario más común. La mayoría de los pacientes son asintomáticos, realizándose el diagnostico de forma incidental durante las pruebas de imagen. El tratamiento estándar de oro es el quirúrgico. Objetivo: Correlacionar parámetros clínicos y patológicos con la supervivencia libre de enfermedad en pacientes con cáncer renal sometidos a nefrectomia. Método: Estudio retrospectivo con 99 pacientes sometidos a tratamiento quirúrgico de cáncer renal desde 2010 hasta 2020. Se compararon los parámetros clínicos y patológicos con el resultado clínico oncológico tras la nefrectomia. Resultados: Los 99 pacientes tuvieron un seguimiento postoperatorio medio de 26,9 meses, siendo la supervivencia libre de enfermedad (mediana) de 61,9%. El análisis univariado demostró que las variables tamaño del tumor >7 cm y grados III y IV de Fuhrman fueron factores relacionados con la progresión de la enfermedad tras la nefrectomia (p=0,046 e IC=1,017-7,083; p=0,005 e IC=1,725-23,004, respectivamente). En el análisis multivariante, el tamaño del tumor >7 cm (p=0,014 e IC=1,290-9,326) y grados de Fuhrman III y IV (p=0,028 e IC=1,174-16,616) fueron identificados como predictores de progresión. Conclusión: El tamaño tumoral >7 cm y/o los grados III o IV de Fuhrman son factores de riesgo para la recidiva tumoral tras el tratamiento quirúrgico del cáncer renal.Introdução: O câncer renal corresponde a 13ª neoplasia mais incidente no mundo, sendo o terceiro tipo de câncer geniturinário mais comum. A maioria dos pacientes é assintomática, ocorrendo o diagnóstico de maneira incidental durante a realização de exames de imagem. O tratamento padrão-ouro é o cirúrgico. Objetivo: Correlacionar os parâmetros clínicos e patológicos com a sobrevida livre de doença em pacientes com câncer renal submetidos à nefrectomia. Método: Estudo retrospectivo com 99 pacientes submetidos a tratamento cirúrgico do câncer renal no período de 2010 a 2020. Foram comparados os parâmetros clínicos e patológicos com o desfecho clínico oncológico após nefrectomia. Resultados: Os 99 pacientes tiveram seguimento pós-operatório médio de 26,9 meses, sendo a sobrevida livre de doença (média) de 61,9%. A análise univariada demonstrou que as variáveis tamanho de tumor >7 cm e graus de Fuhrman III e IV estiveram relacionadas à progressão de doença após a nefrectomia (p=0,046 e IC=1,017-7,083; p=0,005 e IC=1,725-23,004, respectivamente). Na análise multivariada, o tamanho do tumor >7 cm (p=0,014 e IC=1,290-9,326) e os graus de Fuhrman III e IV (p=0,028 e IC=1,174-16,616) foram identificados como fatores preditores à progressão. Conclusão: O tamanho tumoral >7 cm e/ou os graus III ou IV de Fuhrman são fatores de risco para recorrência tumoral após o tratamento cirúrgico do câncer renal.INCA2022-10-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdftext/htmlhttps://rbc.inca.gov.br/index.php/revista/article/view/267910.32635/2176-9745.RBC.2022v68n4.2679Revista Brasileira de Cancerologia; Vol. 68 No. 4 (2022): Oct./Nov./Dec.; e-082679Revista Brasileira de Cancerologia; Vol. 68 Núm. 4 (2022): oct./nov./dic.; e-082679Revista Brasileira de Cancerologia; v. 68 n. 4 (2022): out./nov./dez.; e-0826792176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/2679/2275https://rbc.inca.gov.br/index.php/revista/article/view/2679/2879https://rbc.inca.gov.br/index.php/revista/article/view/2679/2455Copyright (c) 2022 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessKappes, Ana Paula TrombettaLabegalini, André Luiz CamargoOliveira, André Matos deBrunetto Neto, AntônioFoiatto, Júlio CesarTavares, Leonardo PereiraSebastiani, Santiago2023-05-24T16:35:23Zoai:rbc.inca.gov.br:article/2679Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-05-24T16:35:23Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Correlation Among Clinical and Pathological Parameters and Disease-Free Survival of Patients with Renal Cancer Treated with Surgery at a Public Cancer Clinic in Curitiba
Correlación entre Parámetros Clínicos, Patológicos y Supervivência Libre de Enfermedad de Pacientes con Cáncer Renal Tratados con Cirugía en un Centro Oncológico Público de Curitiba
Correlação entre os Parâmetros Clínicos, Patológicos e a Sobrevida Livre de Doença de Pacientes com Câncer Renal Tratados com Cirurgia em um Centro Oncológico do Sistema Público de Curitiba
title Correlation Among Clinical and Pathological Parameters and Disease-Free Survival of Patients with Renal Cancer Treated with Surgery at a Public Cancer Clinic in Curitiba
spellingShingle Correlation Among Clinical and Pathological Parameters and Disease-Free Survival of Patients with Renal Cancer Treated with Surgery at a Public Cancer Clinic in Curitiba
Kappes, Ana Paula Trombetta
neoplasias renais
análise de sobrevida
nefrectomia
kidney neoplasms
survival analysis
nephrectomy
neoplasias renales
análisis de supervivencia
nefrectomía
title_short Correlation Among Clinical and Pathological Parameters and Disease-Free Survival of Patients with Renal Cancer Treated with Surgery at a Public Cancer Clinic in Curitiba
title_full Correlation Among Clinical and Pathological Parameters and Disease-Free Survival of Patients with Renal Cancer Treated with Surgery at a Public Cancer Clinic in Curitiba
title_fullStr Correlation Among Clinical and Pathological Parameters and Disease-Free Survival of Patients with Renal Cancer Treated with Surgery at a Public Cancer Clinic in Curitiba
title_full_unstemmed Correlation Among Clinical and Pathological Parameters and Disease-Free Survival of Patients with Renal Cancer Treated with Surgery at a Public Cancer Clinic in Curitiba
title_sort Correlation Among Clinical and Pathological Parameters and Disease-Free Survival of Patients with Renal Cancer Treated with Surgery at a Public Cancer Clinic in Curitiba
author Kappes, Ana Paula Trombetta
author_facet Kappes, Ana Paula Trombetta
Labegalini, André Luiz Camargo
Oliveira, André Matos de
Brunetto Neto, Antônio
Foiatto, Júlio Cesar
Tavares, Leonardo Pereira
Sebastiani, Santiago
author_role author
author2 Labegalini, André Luiz Camargo
Oliveira, André Matos de
Brunetto Neto, Antônio
Foiatto, Júlio Cesar
Tavares, Leonardo Pereira
Sebastiani, Santiago
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kappes, Ana Paula Trombetta
Labegalini, André Luiz Camargo
Oliveira, André Matos de
Brunetto Neto, Antônio
Foiatto, Júlio Cesar
Tavares, Leonardo Pereira
Sebastiani, Santiago
dc.subject.por.fl_str_mv neoplasias renais
análise de sobrevida
nefrectomia
kidney neoplasms
survival analysis
nephrectomy
neoplasias renales
análisis de supervivencia
nefrectomía
topic neoplasias renais
análise de sobrevida
nefrectomia
kidney neoplasms
survival analysis
nephrectomy
neoplasias renales
análisis de supervivencia
nefrectomía
description Introduction: Kidney cancer corresponds to the 13th most incident cancer in the world, and the third most common type of genitourinary cancer. Most patients are asymptomatic, and the diagnosis used to be incidental during routine imaging exams. Surgical treatment is the gold standard. Objective: To correlate clinical and pathological parameters with disease-free survival in renal cancer patients submitted to nephrectomy. Method: Retrospective study with 99 patients who underwent surgical treatment of kidney cancer from 2010 to 2020. Clinical and pathological parameters were compared with the clinical oncologic outcome after surgery. Results: Ninety-nine patients were followed-up postoperatively for an average time of 26.9 months, and the mean disease-free survival was 61.9%. Univariate analysis showed that tumor size >7 cm and Fuhrman grades III and IV were risk factors related to disease progression after nephrectomy (p=0.046 and CI=1.017-7.083; p=0.005 and CI=1.725-23.004, respectively). In the multivariate analysis, tumor size > 7cm (p=0.014 and CI=1.290-9.326) and Fuhrman grades III and IV (p=0.028 and CI=1.174-16.616) were identified as predictors of progression. Conclusion: Tumor size >7 cm and/or Fuhrman grades III or IV are risk factors for tumor recurrence after surgical treatment of renal cancer.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-11
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigos, Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2679
10.32635/2176-9745.RBC.2022v68n4.2679
url https://rbc.inca.gov.br/index.php/revista/article/view/2679
identifier_str_mv 10.32635/2176-9745.RBC.2022v68n4.2679
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2679/2275
https://rbc.inca.gov.br/index.php/revista/article/view/2679/2879
https://rbc.inca.gov.br/index.php/revista/article/view/2679/2455
dc.rights.driver.fl_str_mv Copyright (c) 2022 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
text/html
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 68 No. 4 (2022): Oct./Nov./Dec.; e-082679
Revista Brasileira de Cancerologia; Vol. 68 Núm. 4 (2022): oct./nov./dic.; e-082679
Revista Brasileira de Cancerologia; v. 68 n. 4 (2022): out./nov./dez.; e-082679
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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