Evaluation of Cases of GIST in the Ceará Cancer Hospital: a 8-year Analysis
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/618 |
Resumo: | Introduction: The gastrointestinal stromal tumors (GIST) represent the majority of mesenchymal tumors of the digestive tract. Objective: To describe the prognostic factors and clinical presentation of GIST diagnosed in patients treated at the Ceará Cancer Hospital in the period 2000 to 2008. Method: A retrospective cohort study, by reviewing records of 45 patients diagnosed with GIST . The statistical method used was the descriptive statistical analysis. Results: The median age was 65 years. The tumor size ranged between 1 and 27 cm. Pain (73.3%) and palpable mass (51.1%) were the most common symptoms. The main location sites were stomach and small intestine. Surgical resection was the treatment used in 97.8% of patients, obtaining a complete resection in most of them (77.8%). Imatinib was used in 57.8% of patients, and in most cases (73.1%), it was used as a palliative treatment and, in others, as an adjuvant treatment. Among the evaluated patients, 80.0% had tumors with high risk of malignancy and the main sites of recurrence were the liver (50.0%) and the peritoneum (31.8%). The overall survival in 5 years was 60% and the overall recurrence rate was 55.0% (n=22). Among the prognostic factors tested, only the type of resection exerted an adverse impact on patient survival (p=0.05). Conclusion: In this study, the only prognostic factor that had an impact on overall survival was the type of resection, and patients who underwent complete resection (R0) had better survival compared with those who underwent R2/ 3 resection. |
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Evaluation of Cases of GIST in the Ceará Cancer Hospital: a 8-year AnalysisEvaluación de los Casos de GIST en el Hospital del Cáncer de Ceará: Análisis de 8 AnõsAvaliação dos Casos de GIST do Hospital do Câncer do Ceará: Análise de 8 AnosTumores do Estroma GastrointestinalPrognósticoNeoplasias GástricasAnálise de SobrevidaEstudos de CoortesGastrointestinal Stromal TumorsPrognosisStomach NeoplasmsSurvival AnalysisCohort StudiesTumores del Estroma GastrointestinalPronósticoNeoplasias GástricasAnálisis de SupervivenciaEstudios de CohortesIntroduction: The gastrointestinal stromal tumors (GIST) represent the majority of mesenchymal tumors of the digestive tract. Objective: To describe the prognostic factors and clinical presentation of GIST diagnosed in patients treated at the Ceará Cancer Hospital in the period 2000 to 2008. Method: A retrospective cohort study, by reviewing records of 45 patients diagnosed with GIST . The statistical method used was the descriptive statistical analysis. Results: The median age was 65 years. The tumor size ranged between 1 and 27 cm. Pain (73.3%) and palpable mass (51.1%) were the most common symptoms. The main location sites were stomach and small intestine. Surgical resection was the treatment used in 97.8% of patients, obtaining a complete resection in most of them (77.8%). Imatinib was used in 57.8% of patients, and in most cases (73.1%), it was used as a palliative treatment and, in others, as an adjuvant treatment. Among the evaluated patients, 80.0% had tumors with high risk of malignancy and the main sites of recurrence were the liver (50.0%) and the peritoneum (31.8%). The overall survival in 5 years was 60% and the overall recurrence rate was 55.0% (n=22). Among the prognostic factors tested, only the type of resection exerted an adverse impact on patient survival (p=0.05). Conclusion: In this study, the only prognostic factor that had an impact on overall survival was the type of resection, and patients who underwent complete resection (R0) had better survival compared with those who underwent R2/ 3 resection. Introducción: Los tumores del estroma gastrointestinal (GIST ) constituyen la mayoria de los tumores mesenquimales del tubo digestivo. Objetivo: Describir los factores diagnósticos y la presentación clínica de los GIST diagnosticados en pacientes atendidos en el Hospital del Cáncer de Ceará, en el período de 2000 a 2008. Método: Un estudio de cohorte retrospectivo por revisión de historias clínicas de 45 pacientes diagnosticados con GIST. El método estadístico utilizado fue el análisis estadístico descriptivo. Resultados: La edad mediana fue de 65 años. El tamaño del tumor oscilo entre 1 y 27 cm. El dolor (73,3%) y masa palpable (51,1%) han sido los sintomas más comunes. Las principales ubicaciones son el estómago y intestino delgado La resección quirúrgica fue el tratamiento utilizado en el 97,8% de los pacientes, la obtención de una resección completa en la mayoría de ellos (77,8%). Imatinib se utilizó en el 57,8% de los pacientes, y en la mayoría de los casos (73,1%) se utilizó como tratamiento paliativo y en otros, como tratamiento adyuvante. 80,0% tenían tumores con alto riesgo de malignidad y los sitios de recurrencia fueron el hígado (50,0%) y el peritoneo (31,8%). La sobrevida global en 5 años fue del 60% y la tasa global de recidiva del 55,0% (n=22). De los factores pronósticos probados, sólo el tipo de resección ha ejercido un impacto negativo en la sobrevida del paciente (p=0,05). Conclusión: En este estudio, el único factor pronóstico que ejerce impacto en la sobrevida global fue el tipo de resección, y los pacientes que han sido sometidos à resección completa (R0) tuvieron una mejor sobrevida em comparación con aquellos sometidos a resección R2/3. Introdução: Os tumores do estroma gastrointestinal (GIST ) representam a maioria dos tumores mesenquimais do tubo digestivo. Objetivo: Descrever os fatores prognósticos e apresentação clínica dos GIST diagnosticados em pacientes atendidos no Hospital do Câncer do Ceará, no período entre 2000 a 2008. Método: Estudo de coorte retrospectivo, através de revisão de prontuários de 45 pacientes com diagnóstico de GIST. O método estatístico utilizado foi a análise estatística descritiva. Resultados: A idade mediana foi 65 anos. O tamanho tumoral variou entre 1 e 27 cm. Dor (73,3%) e massa palpável (51,1%) foram os sintomas mais comuns. Os principais sitios de localização foram estômago e intestino delgado. A ressecção cirúrgica foi o tratamento utilizado em 97,8% dos pacientes, obtendo-se ressecção completa na maioria deles (77,8%). O imatinibe foi utilizado em 57,8% dos pacientes, sendo que, na maioria dos casos (73,1%), foi empregado como tratamento paliativo e, nos demais, como tratamento adjuvante. Entre os pacientes analisados, 80,0% apresentaram tumores com alto risco de malignidade e os principais sítios de recidiva foram fígado (50,0%) e peritônio (31,8%). A sobrevida global em cinco anos foi 60% e a taxa de recorrência global 55,0% (n=22). Dos fatores prognósticos testados, somente o tipo de ressecção exerceu impacto adverso na sobrevida dos pacientes (p=0,05). Conclusão: Neste estudo, o único fator prognóstico que exerceu impacto sobre a sobrevida global foi tipo de ressecção, sendo que os pacientes submetidos à ressecção completa (R0) apresentaram melhor sobrevida quando comparados aqueles submetidos a ressecção R2/3.INCA2012-06-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/61810.32635/2176-9745.RBC.2012v58n2.618Revista Brasileira de Cancerologia; Vol. 58 No. 2 (2012): Apr./May/June; 189-195Revista Brasileira de Cancerologia; Vol. 58 Núm. 2 (2012): abr./mayo/jun.; 189-195Revista Brasileira de Cancerologia; v. 58 n. 2 (2012): abr./maio/jun. ; 189-1952176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/618/387Santos Júnior, Herbert Meneses dosAraújo, Elis Raquel da SilvaLeão, Frankeline Gonçalves de Arêainfo:eu-repo/semantics/openAccess2021-11-29T20:14:41Zoai:rbc.inca.gov.br:article/618Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:14:41Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Evaluation of Cases of GIST in the Ceará Cancer Hospital: a 8-year Analysis Evaluación de los Casos de GIST en el Hospital del Cáncer de Ceará: Análisis de 8 Anõs Avaliação dos Casos de GIST do Hospital do Câncer do Ceará: Análise de 8 Anos |
title |
Evaluation of Cases of GIST in the Ceará Cancer Hospital: a 8-year Analysis |
spellingShingle |
Evaluation of Cases of GIST in the Ceará Cancer Hospital: a 8-year Analysis Santos Júnior, Herbert Meneses dos Tumores do Estroma Gastrointestinal Prognóstico Neoplasias Gástricas Análise de Sobrevida Estudos de Coortes Gastrointestinal Stromal Tumors Prognosis Stomach Neoplasms Survival Analysis Cohort Studies Tumores del Estroma Gastrointestinal Pronóstico Neoplasias Gástricas Análisis de Supervivencia Estudios de Cohortes |
title_short |
Evaluation of Cases of GIST in the Ceará Cancer Hospital: a 8-year Analysis |
title_full |
Evaluation of Cases of GIST in the Ceará Cancer Hospital: a 8-year Analysis |
title_fullStr |
Evaluation of Cases of GIST in the Ceará Cancer Hospital: a 8-year Analysis |
title_full_unstemmed |
Evaluation of Cases of GIST in the Ceará Cancer Hospital: a 8-year Analysis |
title_sort |
Evaluation of Cases of GIST in the Ceará Cancer Hospital: a 8-year Analysis |
author |
Santos Júnior, Herbert Meneses dos |
author_facet |
Santos Júnior, Herbert Meneses dos Araújo, Elis Raquel da Silva Leão, Frankeline Gonçalves de Arêa |
author_role |
author |
author2 |
Araújo, Elis Raquel da Silva Leão, Frankeline Gonçalves de Arêa |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Santos Júnior, Herbert Meneses dos Araújo, Elis Raquel da Silva Leão, Frankeline Gonçalves de Arêa |
dc.subject.por.fl_str_mv |
Tumores do Estroma Gastrointestinal Prognóstico Neoplasias Gástricas Análise de Sobrevida Estudos de Coortes Gastrointestinal Stromal Tumors Prognosis Stomach Neoplasms Survival Analysis Cohort Studies Tumores del Estroma Gastrointestinal Pronóstico Neoplasias Gástricas Análisis de Supervivencia Estudios de Cohortes |
topic |
Tumores do Estroma Gastrointestinal Prognóstico Neoplasias Gástricas Análise de Sobrevida Estudos de Coortes Gastrointestinal Stromal Tumors Prognosis Stomach Neoplasms Survival Analysis Cohort Studies Tumores del Estroma Gastrointestinal Pronóstico Neoplasias Gástricas Análisis de Supervivencia Estudios de Cohortes |
description |
Introduction: The gastrointestinal stromal tumors (GIST) represent the majority of mesenchymal tumors of the digestive tract. Objective: To describe the prognostic factors and clinical presentation of GIST diagnosed in patients treated at the Ceará Cancer Hospital in the period 2000 to 2008. Method: A retrospective cohort study, by reviewing records of 45 patients diagnosed with GIST . The statistical method used was the descriptive statistical analysis. Results: The median age was 65 years. The tumor size ranged between 1 and 27 cm. Pain (73.3%) and palpable mass (51.1%) were the most common symptoms. The main location sites were stomach and small intestine. Surgical resection was the treatment used in 97.8% of patients, obtaining a complete resection in most of them (77.8%). Imatinib was used in 57.8% of patients, and in most cases (73.1%), it was used as a palliative treatment and, in others, as an adjuvant treatment. Among the evaluated patients, 80.0% had tumors with high risk of malignancy and the main sites of recurrence were the liver (50.0%) and the peritoneum (31.8%). The overall survival in 5 years was 60% and the overall recurrence rate was 55.0% (n=22). Among the prognostic factors tested, only the type of resection exerted an adverse impact on patient survival (p=0.05). Conclusion: In this study, the only prognostic factor that had an impact on overall survival was the type of resection, and patients who underwent complete resection (R0) had better survival compared with those who underwent R2/ 3 resection. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/618 10.32635/2176-9745.RBC.2012v58n2.618 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/618 |
identifier_str_mv |
10.32635/2176-9745.RBC.2012v58n2.618 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/618/387 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 58 No. 2 (2012): Apr./May/June; 189-195 Revista Brasileira de Cancerologia; Vol. 58 Núm. 2 (2012): abr./mayo/jun.; 189-195 Revista Brasileira de Cancerologia; v. 58 n. 2 (2012): abr./maio/jun. ; 189-195 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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rbc@inca.gov.br |
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1797042244671242240 |