Clinical-Epidemiological Profile and Survival of the Cases of Retinoblastoma in a Reference Hospital in Oncology in the State of Goiás
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng spa |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/3894 |
Resumo: | Introduction: Retinoblastoma is the most common intraocular primary malignancy in childhood, it is rare and accounts for 2% to 4% of pediatric malignant tumors. Objective: To describe the clinical-epidemiological profile and survival of cases of retinoblastoma in a reference hospital in oncology in the state of Goiás, between 2008 and 2014. Method: Cross-sectional analytical observational study built from the analysis of medical records of patients diagnosed with retinoblastoma between 2008 and 2014. Analyzes were performed using descriptive statistics and chi-square association test. A significance level of 5% was adopted. Survival was assessed using the Kaplan-Meier method. Results: 55 patients with retinoblastoma were treated, with predominance of females (54.5%), in the age group of 1 to 4 years (27.3%) and of brown ethnicity (50.9%). The most prevalent clinical characteristics were intraocular involvement (74.5%), unilateral (65.5%), with no family history (56.4%) and with clinical signs of leukocoria (80%). Most of them did not present metastases at diagnosis (87.3%), the main treatment being unilateral enucleation (72.7%). Association between the clinical evolution of the patient and extraocular location (p = 0.001) was found, presence of metastasis (p = 0.001), and stage IV classified by Chantada et al. (p = 0.001). Patients classified as E were submitted to higher volume of enucleation (right eye – p = 0.05 and left eye – p = 0.001). The 5-year overall survival was 72.7%. Conclusion: These findings are relevant for planning preventive actions, as early diagnosis is one of the main allies in determining the cure and preserving vision. |
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Clinical-Epidemiological Profile and Survival of the Cases of Retinoblastoma in a Reference Hospital in Oncology in the State of GoiásPerfil Clínico-Epidemiológico y Sobrevida de los Casos de Retinoblastoma en un Hospital de Referencia en Oncología del Estado de GoiásPerfil Clínico-Epidemiológico e Sobrevida dos Casos de Retinoblastoma em um Hospital Referência em Oncologia do Estado de GoiásretinoblastomachildblindnessepidemiologyretinoblastomaniñocegueraepidemiologíaretinoblastomacriançacegueiraepidemiologiaIntroduction: Retinoblastoma is the most common intraocular primary malignancy in childhood, it is rare and accounts for 2% to 4% of pediatric malignant tumors. Objective: To describe the clinical-epidemiological profile and survival of cases of retinoblastoma in a reference hospital in oncology in the state of Goiás, between 2008 and 2014. Method: Cross-sectional analytical observational study built from the analysis of medical records of patients diagnosed with retinoblastoma between 2008 and 2014. Analyzes were performed using descriptive statistics and chi-square association test. A significance level of 5% was adopted. Survival was assessed using the Kaplan-Meier method. Results: 55 patients with retinoblastoma were treated, with predominance of females (54.5%), in the age group of 1 to 4 years (27.3%) and of brown ethnicity (50.9%). The most prevalent clinical characteristics were intraocular involvement (74.5%), unilateral (65.5%), with no family history (56.4%) and with clinical signs of leukocoria (80%). Most of them did not present metastases at diagnosis (87.3%), the main treatment being unilateral enucleation (72.7%). Association between the clinical evolution of the patient and extraocular location (p = 0.001) was found, presence of metastasis (p = 0.001), and stage IV classified by Chantada et al. (p = 0.001). Patients classified as E were submitted to higher volume of enucleation (right eye – p = 0.05 and left eye – p = 0.001). The 5-year overall survival was 72.7%. Conclusion: These findings are relevant for planning preventive actions, as early diagnosis is one of the main allies in determining the cure and preserving vision.Introducción: El retinoblastoma es la neoplasia maligna intraocular primaria más frecuente en la infancia, rara, correspondiendo del 2 al 4% de los tumores malignos pediátricos. Objetivo: describir el perfil clínico-epidemiológico del retinoblastoma en un hospital de referencia en oncología del estado de Goiás, entre 2008 y 2014. Métodos: estudio analítico, observacional, transversal, construido a partir del análisis de prontuarios de pacientes diagnosticados con retinoblastoma entre 2008 y 2014. Los análisis se realizaron mediante estadística descriptiva, prueba de asociación de chi-cuadrado. Se adoptó un nivel de significancia del 5%. Resultados: fueron tratados 55 pacientes con retinoblastoma, lo que permitió identificar un predominio del sexo femenino (54,5%); en el grupo de edad de 1 a 4 años (27,3%), con etnia parda (50,9%). Las características clínicas más prevalentes fueron: afectación intraocular (74,5%); unilateral (65,5%); y sin antecedentes familiares (56,4%) y con signos clínicos de leucocoria (80%). La mayoría no presentaba metástasis al diagnóstico (87,3%); siendo el principal tratamiento la enucleación unilateral (72,7%). Hubo asociación entre la evolución clínica del paciente y la localización extraocular (p=0,001), presencia de metástasis (p=0,001), estadio IV de Chantada (p=0,001). Los pacientes clasificados como E tenían más ojos enucleados (ojo derecho - p=0,05 y ojo izquierdo - p=0,001). Conclusión: Los pacientes analizados fueron en su mayoría niñas de 1 a 4 años, con el principal signo clínico de leucocoria. Los pacientes con tumor extraocular, metástasis, estadio IV de Chantada y clasificación E, tuvieron peor pronóstico. Dichos hallazgos son relevantes para planificar acciones preventivas, ya que el diagnóstico precoz es uno de los principales aliados para determinar la cura y preservar la visión. Palabras clave: RIntrodução: O retinoblastoma é a malignidade primária intraocular mais comum na infância, é raro e corresponde de 2% a 4% dos tumores malignos pediátricos. Objetivo: Descrever o perfil clínico-epidemiológico e a sobrevida dos casos de retinoblastoma em um hospital de referência em oncologia do Estado de Goiás, entre 2008 a 2014. Método: Estudo observacional analítico do tipo transversal, construído com base na análise de prontuários de pacientes diagnosticados com retinoblastoma entre 2008 e 2014. Realizaram-se análises por estatística descritiva e teste de associação qui-quadrado. Adotou-se o nível de significância de 5%. A sobrevida foi avaliada por meio do método de Kaplan-Meier. Resultados: Foram atendidos 55 pacientes com retinoblastoma, permitindo identificar o predomínio do sexo feminino (54,5%); na faixa etária de 1 a 4 anos (27,3%); com etnia parda (50,9%). As características clínicas mais prevalentes foram: acometimento intraocular (74,5%); unilateral (65,5%); sem histórico familiar (56,4%); e com sinal clínico de leucocoria (80%). A maioria não apresentou metástases ao diagnóstico (87,3%), sendo o principal tratamento a enucleação unilateral (72,7%). Verificou-se associação quanto à evolução clínica do paciente em relação à localização extraocular (p = 0,001), presença de metástase (p = 0,001) e estádio IV de Chantada et al. (p = 0,001). Pacientes classificados como E foram submetidos a maior número de enucleações (olho direito – p = 0,05 e olho esquerdo – p = 0,001). A sobrevida global em cinco anos foi 72,7%. Conclusão: Tais achados são relevantes para o planejamento de ações de prevenção, pois o diagnóstico precoce é um dos principais aliados na determinação da cura e na preservação da visão.INCA2023-09-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfapplication/pdfapplication/pdftext/htmlhttps://rbc.inca.gov.br/index.php/revista/article/view/389410.32635/2176-9745.RBC.2023v69n3.3894Revista Brasileira de Cancerologia; Vol. 69 No. 3 (2023): July/Aug./Sept.; e-243894Revista Brasileira de Cancerologia; Vol. 69 Núm. 3 (2023): jul./ago./sept.; e-243894Revista Brasileira de Cancerologia; v. 69 n. 3 (2023): jul./ago./set.; e-2438942176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporengspahttps://rbc.inca.gov.br/index.php/revista/article/view/3894/3186https://rbc.inca.gov.br/index.php/revista/article/view/3894/3329https://rbc.inca.gov.br/index.php/revista/article/view/3894/3253https://rbc.inca.gov.br/index.php/revista/article/view/3894/3203Copyright (c) 2023 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilveira, Heloisa BritoSilveira, Ana Paula Stievano Ferraz daBarcelos, Carolina CordeiroAlbuquerque, João Marcelo TocantinsGuerra, Rafaella Faria OliveiraSilva, Constanza Thaise Xavier2024-01-10T15:37:25Zoai:rbc.inca.gov.br:article/3894Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2024-01-10T15:37:25Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Clinical-Epidemiological Profile and Survival of the Cases of Retinoblastoma in a Reference Hospital in Oncology in the State of Goiás Perfil Clínico-Epidemiológico y Sobrevida de los Casos de Retinoblastoma en un Hospital de Referencia en Oncología del Estado de Goiás Perfil Clínico-Epidemiológico e Sobrevida dos Casos de Retinoblastoma em um Hospital Referência em Oncologia do Estado de Goiás |
title |
Clinical-Epidemiological Profile and Survival of the Cases of Retinoblastoma in a Reference Hospital in Oncology in the State of Goiás |
spellingShingle |
Clinical-Epidemiological Profile and Survival of the Cases of Retinoblastoma in a Reference Hospital in Oncology in the State of Goiás Silveira, Heloisa Brito retinoblastoma child blindness epidemiology retinoblastoma niño ceguera epidemiología retinoblastoma criança cegueira epidemiologia |
title_short |
Clinical-Epidemiological Profile and Survival of the Cases of Retinoblastoma in a Reference Hospital in Oncology in the State of Goiás |
title_full |
Clinical-Epidemiological Profile and Survival of the Cases of Retinoblastoma in a Reference Hospital in Oncology in the State of Goiás |
title_fullStr |
Clinical-Epidemiological Profile and Survival of the Cases of Retinoblastoma in a Reference Hospital in Oncology in the State of Goiás |
title_full_unstemmed |
Clinical-Epidemiological Profile and Survival of the Cases of Retinoblastoma in a Reference Hospital in Oncology in the State of Goiás |
title_sort |
Clinical-Epidemiological Profile and Survival of the Cases of Retinoblastoma in a Reference Hospital in Oncology in the State of Goiás |
author |
Silveira, Heloisa Brito |
author_facet |
Silveira, Heloisa Brito Silveira, Ana Paula Stievano Ferraz da Barcelos, Carolina Cordeiro Albuquerque, João Marcelo Tocantins Guerra, Rafaella Faria Oliveira Silva, Constanza Thaise Xavier |
author_role |
author |
author2 |
Silveira, Ana Paula Stievano Ferraz da Barcelos, Carolina Cordeiro Albuquerque, João Marcelo Tocantins Guerra, Rafaella Faria Oliveira Silva, Constanza Thaise Xavier |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silveira, Heloisa Brito Silveira, Ana Paula Stievano Ferraz da Barcelos, Carolina Cordeiro Albuquerque, João Marcelo Tocantins Guerra, Rafaella Faria Oliveira Silva, Constanza Thaise Xavier |
dc.subject.por.fl_str_mv |
retinoblastoma child blindness epidemiology retinoblastoma niño ceguera epidemiología retinoblastoma criança cegueira epidemiologia |
topic |
retinoblastoma child blindness epidemiology retinoblastoma niño ceguera epidemiología retinoblastoma criança cegueira epidemiologia |
description |
Introduction: Retinoblastoma is the most common intraocular primary malignancy in childhood, it is rare and accounts for 2% to 4% of pediatric malignant tumors. Objective: To describe the clinical-epidemiological profile and survival of cases of retinoblastoma in a reference hospital in oncology in the state of Goiás, between 2008 and 2014. Method: Cross-sectional analytical observational study built from the analysis of medical records of patients diagnosed with retinoblastoma between 2008 and 2014. Analyzes were performed using descriptive statistics and chi-square association test. A significance level of 5% was adopted. Survival was assessed using the Kaplan-Meier method. Results: 55 patients with retinoblastoma were treated, with predominance of females (54.5%), in the age group of 1 to 4 years (27.3%) and of brown ethnicity (50.9%). The most prevalent clinical characteristics were intraocular involvement (74.5%), unilateral (65.5%), with no family history (56.4%) and with clinical signs of leukocoria (80%). Most of them did not present metastases at diagnosis (87.3%), the main treatment being unilateral enucleation (72.7%). Association between the clinical evolution of the patient and extraocular location (p = 0.001) was found, presence of metastasis (p = 0.001), and stage IV classified by Chantada et al. (p = 0.001). Patients classified as E were submitted to higher volume of enucleation (right eye – p = 0.05 and left eye – p = 0.001). The 5-year overall survival was 72.7%. Conclusion: These findings are relevant for planning preventive actions, as early diagnosis is one of the main allies in determining the cure and preserving vision. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3894 10.32635/2176-9745.RBC.2023v69n3.3894 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/3894 |
identifier_str_mv |
10.32635/2176-9745.RBC.2023v69n3.3894 |
dc.language.iso.fl_str_mv |
por eng spa |
language |
por eng spa |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3894/3186 https://rbc.inca.gov.br/index.php/revista/article/view/3894/3329 https://rbc.inca.gov.br/index.php/revista/article/view/3894/3253 https://rbc.inca.gov.br/index.php/revista/article/view/3894/3203 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Revista Brasileira de Cancerologia https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf text/html |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 69 No. 3 (2023): July/Aug./Sept.; e-243894 Revista Brasileira de Cancerologia; Vol. 69 Núm. 3 (2023): jul./ago./sept.; e-243894 Revista Brasileira de Cancerologia; v. 69 n. 3 (2023): jul./ago./set.; e-243894 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
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Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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INCA |
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INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
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Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
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rbc@inca.gov.br |
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