The role of folic acid on oncologic prevention and intervention: review
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/2174 |
Resumo: | Folic acid, a vitamin involved in a large number of biochemical processes which are essential to life, has also an important role in oncology, mainly due to its action on the DNA methilation and on the purine and pirimidine synthesis. Genetic causes and/ or deficiency of this vitamin have been associated to colorectal cancer in several studies. Its role, however, is more extensive, and can be observed from cancer prevention to treatment, where it is largely used under the form of its chemical analogue, hindering the tumor's development and fostering its subsequent erradication. Throught the history of cancer's chemotherapy, toxicity control of the drug has been the object of extensive studies. The use of folic acid or of its reduced form during or before treatment is described in this paper on the role of folic acid in oncology, so that interventionist strategies aiming to reduce cancer risk and the toxicity related to antineoplastic treatment can be developed. |
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The role of folic acid on oncologic prevention and intervention: reviewO papel do ácido fólico na prevenção e na terapêutica oncológica: revisãoÁcido FólicoAntifolatosAlimentos FortificadosNeoplasiasPrevençãoTerapiaHomocisteínaFolic AcidAntifolateFortified FoodNeoplasmsPreventionTherapyHomocysteineFolic acid, a vitamin involved in a large number of biochemical processes which are essential to life, has also an important role in oncology, mainly due to its action on the DNA methilation and on the purine and pirimidine synthesis. Genetic causes and/ or deficiency of this vitamin have been associated to colorectal cancer in several studies. Its role, however, is more extensive, and can be observed from cancer prevention to treatment, where it is largely used under the form of its chemical analogue, hindering the tumor's development and fostering its subsequent erradication. Throught the history of cancer's chemotherapy, toxicity control of the drug has been the object of extensive studies. The use of folic acid or of its reduced form during or before treatment is described in this paper on the role of folic acid in oncology, so that interventionist strategies aiming to reduce cancer risk and the toxicity related to antineoplastic treatment can be developed.O ácido fólico, por ser uma vitamina envolvida em um grande número de processos bioquímicos essenciais para a vida, tem também importante papel na oncologia, principalmente a partir da sua ação na metilação do DNA e na síntese de purinas e pirimidinas. Causas genéticas ou de deficiência desta vitamina têm sido relacionadas ao câncer em vários estudos. Seu papel se estende e se prolonga desde a prevenção até o tratamento do câncer, onde ele é largamente utilizado na forma do seu análogo químico, prejudicando o desenvolvimento do tumor e levando à sua subseqüente erradicação. A utilização do ácido fólico ou da sua forma reduzida na prevenção e durante ou antes do tratamento oncológico é descrito neste levantamento bibliográfico, que tem a intenção de somar esforços na direção do estabelecimento de estratégias intervencionistas que reduzam o risco de câncer e a toxicidade relacionada ao tratamento.INCA2002-12-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/217410.32635/2176-9745.RBC.2002v48n4.2174Revista Brasileira de Cancerologia; Vol. 48 No. 4 (2002): Oct./Nov./Dec.; 597-607Revista Brasileira de Cancerologia; Vol. 48 Núm. 4 (2002): oct./nov./dic.; 597-607Revista Brasileira de Cancerologia; v. 48 n. 4 (2002): out./nov./dez.; 597-6072176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2174/1339Baluz, Kátia Carmo, Maria das Graças Tavares do Rosas, Glorimar info:eu-repo/semantics/openAccess2021-11-29T20:36:41Zoai:rbc.inca.gov.br:article/2174Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:36:41Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
The role of folic acid on oncologic prevention and intervention: review O papel do ácido fólico na prevenção e na terapêutica oncológica: revisão |
title |
The role of folic acid on oncologic prevention and intervention: review |
spellingShingle |
The role of folic acid on oncologic prevention and intervention: review Baluz, Kátia Ácido Fólico Antifolatos Alimentos Fortificados Neoplasias Prevenção Terapia Homocisteína Folic Acid Antifolate Fortified Food Neoplasms Prevention Therapy Homocysteine |
title_short |
The role of folic acid on oncologic prevention and intervention: review |
title_full |
The role of folic acid on oncologic prevention and intervention: review |
title_fullStr |
The role of folic acid on oncologic prevention and intervention: review |
title_full_unstemmed |
The role of folic acid on oncologic prevention and intervention: review |
title_sort |
The role of folic acid on oncologic prevention and intervention: review |
author |
Baluz, Kátia |
author_facet |
Baluz, Kátia Carmo, Maria das Graças Tavares do Rosas, Glorimar |
author_role |
author |
author2 |
Carmo, Maria das Graças Tavares do Rosas, Glorimar |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Baluz, Kátia Carmo, Maria das Graças Tavares do Rosas, Glorimar |
dc.subject.por.fl_str_mv |
Ácido Fólico Antifolatos Alimentos Fortificados Neoplasias Prevenção Terapia Homocisteína Folic Acid Antifolate Fortified Food Neoplasms Prevention Therapy Homocysteine |
topic |
Ácido Fólico Antifolatos Alimentos Fortificados Neoplasias Prevenção Terapia Homocisteína Folic Acid Antifolate Fortified Food Neoplasms Prevention Therapy Homocysteine |
description |
Folic acid, a vitamin involved in a large number of biochemical processes which are essential to life, has also an important role in oncology, mainly due to its action on the DNA methilation and on the purine and pirimidine synthesis. Genetic causes and/ or deficiency of this vitamin have been associated to colorectal cancer in several studies. Its role, however, is more extensive, and can be observed from cancer prevention to treatment, where it is largely used under the form of its chemical analogue, hindering the tumor's development and fostering its subsequent erradication. Throught the history of cancer's chemotherapy, toxicity control of the drug has been the object of extensive studies. The use of folic acid or of its reduced form during or before treatment is described in this paper on the role of folic acid in oncology, so that interventionist strategies aiming to reduce cancer risk and the toxicity related to antineoplastic treatment can be developed. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-12-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Revisão de literatura |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2174 10.32635/2176-9745.RBC.2002v48n4.2174 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/2174 |
identifier_str_mv |
10.32635/2176-9745.RBC.2002v48n4.2174 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/2174/1339 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 48 No. 4 (2002): Oct./Nov./Dec.; 597-607 Revista Brasileira de Cancerologia; Vol. 48 Núm. 4 (2002): oct./nov./dic.; 597-607 Revista Brasileira de Cancerologia; v. 48 n. 4 (2002): out./nov./dez.; 597-607 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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