The role of folic acid on oncologic prevention and intervention: review

Detalhes bibliográficos
Autor(a) principal: Baluz, Kátia
Data de Publicação: 2002
Outros Autores: Carmo, Maria das Graças Tavares do, Rosas, Glorimar
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2174
Resumo: Folic acid, a vitamin involved in a large number of biochemical processes which are essential to life, has also an important role in oncology, mainly due to its action on the DNA methilation and on the purine and pirimidine synthesis. Genetic causes and/ or deficiency of this vitamin have been associated to colorectal cancer in several studies. Its role, however, is more extensive, and can be observed from cancer prevention to treatment, where it is largely used under the form of its chemical analogue, hindering the tumor's development and fostering its subsequent erradication. Throught the history of cancer's chemotherapy, toxicity control of the drug has been the object of extensive studies. The use of folic acid or of its reduced form during or before treatment is described in this paper on the role of folic acid in oncology, so that interventionist strategies aiming to reduce cancer risk and the toxicity related to antineoplastic treatment can be developed.
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spelling The role of folic acid on oncologic prevention and intervention: reviewO papel do ácido fólico na prevenção e na terapêutica oncológica: revisãoÁcido FólicoAntifolatosAlimentos FortificadosNeoplasiasPrevençãoTerapiaHomocisteínaFolic AcidAntifolateFortified FoodNeoplasmsPreventionTherapyHomocysteineFolic acid, a vitamin involved in a large number of biochemical processes which are essential to life, has also an important role in oncology, mainly due to its action on the DNA methilation and on the purine and pirimidine synthesis. Genetic causes and/ or deficiency of this vitamin have been associated to colorectal cancer in several studies. Its role, however, is more extensive, and can be observed from cancer prevention to treatment, where it is largely used under the form of its chemical analogue, hindering the tumor's development and fostering its subsequent erradication. Throught the history of cancer's chemotherapy, toxicity control of the drug has been the object of extensive studies. The use of folic acid or of its reduced form during or before treatment is described in this paper on the role of folic acid in oncology, so that interventionist strategies aiming to reduce cancer risk and the toxicity related to antineoplastic treatment can be developed.O ácido fólico, por ser uma vitamina envolvida em um grande número de processos bioquímicos essenciais para a vida, tem também importante papel na oncologia, principalmente a partir da sua ação na metilação do DNA e na síntese de purinas e pirimidinas. Causas genéticas ou de deficiência desta vitamina têm sido relacionadas ao câncer em vários estudos. Seu papel se estende e se prolonga desde a prevenção até o tratamento do câncer, onde ele é largamente utilizado na forma do seu análogo químico, prejudicando o desenvolvimento do tumor e levando à sua subseqüente erradicação. A utilização do ácido fólico ou da sua forma reduzida na prevenção e durante ou antes do tratamento oncológico é descrito neste levantamento bibliográfico, que tem a intenção de somar esforços na direção do estabelecimento de estratégias intervencionistas que reduzam o risco de câncer e a toxicidade relacionada ao tratamento.INCA2002-12-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/217410.32635/2176-9745.RBC.2002v48n4.2174Revista Brasileira de Cancerologia; Vol. 48 No. 4 (2002): Oct./Nov./Dec.; 597-607Revista Brasileira de Cancerologia; Vol. 48 Núm. 4 (2002): oct./nov./dic.; 597-607Revista Brasileira de Cancerologia; v. 48 n. 4 (2002): out./nov./dez.; 597-6072176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2174/1339Baluz, Kátia Carmo, Maria das Graças Tavares do Rosas, Glorimar info:eu-repo/semantics/openAccess2021-11-29T20:36:41Zoai:rbc.inca.gov.br:article/2174Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:36:41Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv The role of folic acid on oncologic prevention and intervention: review
O papel do ácido fólico na prevenção e na terapêutica oncológica: revisão
title The role of folic acid on oncologic prevention and intervention: review
spellingShingle The role of folic acid on oncologic prevention and intervention: review
Baluz, Kátia
Ácido Fólico
Antifolatos
Alimentos Fortificados
Neoplasias
Prevenção
Terapia
Homocisteína
Folic Acid
Antifolate
Fortified Food
Neoplasms
Prevention
Therapy
Homocysteine
title_short The role of folic acid on oncologic prevention and intervention: review
title_full The role of folic acid on oncologic prevention and intervention: review
title_fullStr The role of folic acid on oncologic prevention and intervention: review
title_full_unstemmed The role of folic acid on oncologic prevention and intervention: review
title_sort The role of folic acid on oncologic prevention and intervention: review
author Baluz, Kátia
author_facet Baluz, Kátia
Carmo, Maria das Graças Tavares do
Rosas, Glorimar
author_role author
author2 Carmo, Maria das Graças Tavares do
Rosas, Glorimar
author2_role author
author
dc.contributor.author.fl_str_mv Baluz, Kátia
Carmo, Maria das Graças Tavares do
Rosas, Glorimar
dc.subject.por.fl_str_mv Ácido Fólico
Antifolatos
Alimentos Fortificados
Neoplasias
Prevenção
Terapia
Homocisteína
Folic Acid
Antifolate
Fortified Food
Neoplasms
Prevention
Therapy
Homocysteine
topic Ácido Fólico
Antifolatos
Alimentos Fortificados
Neoplasias
Prevenção
Terapia
Homocisteína
Folic Acid
Antifolate
Fortified Food
Neoplasms
Prevention
Therapy
Homocysteine
description Folic acid, a vitamin involved in a large number of biochemical processes which are essential to life, has also an important role in oncology, mainly due to its action on the DNA methilation and on the purine and pirimidine synthesis. Genetic causes and/ or deficiency of this vitamin have been associated to colorectal cancer in several studies. Its role, however, is more extensive, and can be observed from cancer prevention to treatment, where it is largely used under the form of its chemical analogue, hindering the tumor's development and fostering its subsequent erradication. Throught the history of cancer's chemotherapy, toxicity control of the drug has been the object of extensive studies. The use of folic acid or of its reduced form during or before treatment is described in this paper on the role of folic acid in oncology, so that interventionist strategies aiming to reduce cancer risk and the toxicity related to antineoplastic treatment can be developed.
publishDate 2002
dc.date.none.fl_str_mv 2002-12-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2174
10.32635/2176-9745.RBC.2002v48n4.2174
url https://rbc.inca.gov.br/index.php/revista/article/view/2174
identifier_str_mv 10.32635/2176-9745.RBC.2002v48n4.2174
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2174/1339
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 48 No. 4 (2002): Oct./Nov./Dec.; 597-607
Revista Brasileira de Cancerologia; Vol. 48 Núm. 4 (2002): oct./nov./dic.; 597-607
Revista Brasileira de Cancerologia; v. 48 n. 4 (2002): out./nov./dez.; 597-607
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
_version_ 1797042249591160832

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