Cancer mortality in relatives of desmoid sarcoma patients
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Cancerologia (Online) |
Texto Completo: | https://rbc.inca.gov.br/index.php/revista/article/view/3123 |
Resumo: | Desmoid sarcoma patients from the U.S. and Canada, diagnosed under the age of 16 years and referred to the University of Texas, M.D. Anderson Hospital - MDAH - between 1944 and 1975 were surveyed. Family information was collected for grandparents, parents, parental siblings, proband offspring and siblirtgs. Expected mortality was calculated by applying age-race-sex specific U.S. mortality rates to the person-years at risk. Standardized mortality ratio's - SMR- were calculated. Among 429 relatives of 26 desmoid sarcoma probands no overali cancer excess was found, observed/expected = 13/24.7. The risk among parents, the ones more informative for genetic analysis were also not significant, observed/expected = 2/1.83. An updated follow-up of incidence data of the study population and of the general population is suggested in the years to come, and in doing so, the inclusion of all familly members history should pull the results to a number closer to reality. |
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Cancer mortality in relatives of desmoid sarcoma patientsSarcoma DesmóideMortalidade de Parentes no Sarcoma DesmóideDesmoid SarcomaRelatives Mortality in Desmoid SarcomaDesmoid sarcoma patients from the U.S. and Canada, diagnosed under the age of 16 years and referred to the University of Texas, M.D. Anderson Hospital - MDAH - between 1944 and 1975 were surveyed. Family information was collected for grandparents, parents, parental siblings, proband offspring and siblirtgs. Expected mortality was calculated by applying age-race-sex specific U.S. mortality rates to the person-years at risk. Standardized mortality ratio's - SMR- were calculated. Among 429 relatives of 26 desmoid sarcoma probands no overali cancer excess was found, observed/expected = 13/24.7. The risk among parents, the ones more informative for genetic analysis were also not significant, observed/expected = 2/1.83. An updated follow-up of incidence data of the study population and of the general population is suggested in the years to come, and in doing so, the inclusion of all familly members history should pull the results to a number closer to reality.Pacientes menores de 16 anos, com diagnóstico de sarcoma do tipo desmóide atendidos no Hospital M.D. Anderson da Universidade do Texas pelo período de 1944 e 1975, foram revistos. A mortalidade esperada foi calculada aplicando-se as taxas de mortalidade específicas por idade, raça e sexo dos Estados Unidos sobre a mortalidade pessoa/ano de risco observado. A razão da mortalidade padronizada - SMR - foi computada. Para o conjunto dos 429 parentes dos 26 casos de sarcoma do tipo desmóide aqui analisados, não foi encontrado excesso de mortes, observado/esperado = 13/24.7. O risco dos pais terem câncer também não foi significativo, observado/esperado = 2/1.83. Esses resultados são indicativos de que as taxas de mortalidade por este tipo de tumor, tanto para este grupo particular de famílias como para a população em geral, não são os parâmetros adequados para estudar fatores hereditários e ocorrência de tumores desmóides. Sugere-se a comparação de taxas de incidência de tumores benignos em tecidos moles entre os membros da familia dos casos com as taxas destes mesmos tumores na população em geral.INCA2023-07-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigos, Avaliado pelos paresapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/312310.32635/2176-9745.RBC.1990v36n1/4.3123Revista Brasileira de Cancerologia; Vol. 36 No. 1/4 (1990): Jan./Dec.; 45-48Revista Brasileira de Cancerologia; Vol. 36 Núm. 1/4 (1990): ene./dic.; 45-48Revista Brasileira de Cancerologia; v. 36 n. 1/4 (1990): jan./dez.; 45-482176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAenghttps://rbc.inca.gov.br/index.php/revista/article/view/3123/1982https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessStrong, Louise C.Schnitman, Anita2023-07-31T15:41:28Zoai:rbc.inca.gov.br:article/3123Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2023-07-31T15:41:28Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false |
dc.title.none.fl_str_mv |
Cancer mortality in relatives of desmoid sarcoma patients |
title |
Cancer mortality in relatives of desmoid sarcoma patients |
spellingShingle |
Cancer mortality in relatives of desmoid sarcoma patients Strong, Louise C. Sarcoma Desmóide Mortalidade de Parentes no Sarcoma Desmóide Desmoid Sarcoma Relatives Mortality in Desmoid Sarcoma |
title_short |
Cancer mortality in relatives of desmoid sarcoma patients |
title_full |
Cancer mortality in relatives of desmoid sarcoma patients |
title_fullStr |
Cancer mortality in relatives of desmoid sarcoma patients |
title_full_unstemmed |
Cancer mortality in relatives of desmoid sarcoma patients |
title_sort |
Cancer mortality in relatives of desmoid sarcoma patients |
author |
Strong, Louise C. |
author_facet |
Strong, Louise C. Schnitman, Anita |
author_role |
author |
author2 |
Schnitman, Anita |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Strong, Louise C. Schnitman, Anita |
dc.subject.por.fl_str_mv |
Sarcoma Desmóide Mortalidade de Parentes no Sarcoma Desmóide Desmoid Sarcoma Relatives Mortality in Desmoid Sarcoma |
topic |
Sarcoma Desmóide Mortalidade de Parentes no Sarcoma Desmóide Desmoid Sarcoma Relatives Mortality in Desmoid Sarcoma |
description |
Desmoid sarcoma patients from the U.S. and Canada, diagnosed under the age of 16 years and referred to the University of Texas, M.D. Anderson Hospital - MDAH - between 1944 and 1975 were surveyed. Family information was collected for grandparents, parents, parental siblings, proband offspring and siblirtgs. Expected mortality was calculated by applying age-race-sex specific U.S. mortality rates to the person-years at risk. Standardized mortality ratio's - SMR- were calculated. Among 429 relatives of 26 desmoid sarcoma probands no overali cancer excess was found, observed/expected = 13/24.7. The risk among parents, the ones more informative for genetic analysis were also not significant, observed/expected = 2/1.83. An updated follow-up of incidence data of the study population and of the general population is suggested in the years to come, and in doing so, the inclusion of all familly members history should pull the results to a number closer to reality. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-31 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Artigos, Avaliado pelos pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3123 10.32635/2176-9745.RBC.1990v36n1/4.3123 |
url |
https://rbc.inca.gov.br/index.php/revista/article/view/3123 |
identifier_str_mv |
10.32635/2176-9745.RBC.1990v36n1/4.3123 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rbc.inca.gov.br/index.php/revista/article/view/3123/1982 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
INCA |
publisher.none.fl_str_mv |
INCA |
dc.source.none.fl_str_mv |
Revista Brasileira de Cancerologia; Vol. 36 No. 1/4 (1990): Jan./Dec.; 45-48 Revista Brasileira de Cancerologia; Vol. 36 Núm. 1/4 (1990): ene./dic.; 45-48 Revista Brasileira de Cancerologia; v. 36 n. 1/4 (1990): jan./dez.; 45-48 2176-9745 reponame:Revista Brasileira de Cancerologia (Online) instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) instacron:INCA |
instname_str |
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
instacron_str |
INCA |
institution |
INCA |
reponame_str |
Revista Brasileira de Cancerologia (Online) |
collection |
Revista Brasileira de Cancerologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
repository.mail.fl_str_mv |
rbc@inca.gov.br |
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