HUMAN EXPOSURE TO BENZENE AND ITS RELATION TO HEMATOLOGICAL CHANGES

• Autor(a) principal: Silva, Leticia Amorim
• Data de Publicação: 2020
• Outros Autores: Torres, Danielly de Souza, Caixeta, Bruno Tolentino
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Scientia Generalis
• Texto Completo: https://scientiageneralis.com.br/index.php/SG/article/view/v1n3a7
• topic: Benzene; occupational exposure; hydrocarbon and hematoxicity; Benzeno; exposição ocupacional; hidrocarboneto e hematoxicidade

Benzene is a hydrocarbon that, when in contact with humans, can cause several damages to the health of the individual. The metabolites from benzene metabolization have a high capacity to cause myelotoxicity, as soon as changes in hematopoiesis occur and more severely, mutations that consequently generate neoplastic cells. The present article consists of a bibliographic narrative review that had as main objective to approach general aspects about benzene, its metabolism and its relation with the possible changes that it can cause in the organism of a person who is frequently in contact with this type of organic solvent, be it in an acute or chronic way and also, address the importance of specific biomarkers as a way of early identification of changes. It was concluded that among the most common changes of this exposure are cases of anemia and leukopenia and in chronic cases, serious pathological processes such as aplastic anemia, myelodysplastic syndrome and leukemia. It is essential to monitor the metabolites with specific biomarkers in the body of subjects, in order to identify possible changes early and avoid risks and damage to health.