Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Amazonica |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000300245 |
Resumo: | ABSTRACT The oil of Caryocar villosum is used in Amazonian folk medicine to treat pain and inflammatory conditions. So, we assessed the anti-inflammatory and antinociceptive properties of the ethanolic extract obtained from the fruit peels of this species. The acetic acid-induced writhing, carrageenan-induced mechanical hyperalgesia, formalin, carrageenan-induced paw edema and carrageenan-induced peritonitis tests were used on mice. The C. villosum ethanolic extract significantly inhibited the number of abdominal writhes, mechanical hyperalgesia and paw licking time in the second phase of the formalin test. At a dose of 300 mg kg-1, the extract also significantly reduced the volume of edema formed in the late phase and reduced the recruitment of leukocytes and neutrophils in the peritoneal cavity, as well as CXCL1 chemokine levels. It is suggested that the extract attenuates the leukocyte recruitment by inhibiting the CXCL1 activation. The peripheral antinociceptive activity occured through opioid pathway modulation because pretreatment with C. villosum ethanolic extract reversed the naltrexone-induced antinociception. |
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Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulationpainantinociceptionchemokineleukocyte recruitmentABSTRACT The oil of Caryocar villosum is used in Amazonian folk medicine to treat pain and inflammatory conditions. So, we assessed the anti-inflammatory and antinociceptive properties of the ethanolic extract obtained from the fruit peels of this species. The acetic acid-induced writhing, carrageenan-induced mechanical hyperalgesia, formalin, carrageenan-induced paw edema and carrageenan-induced peritonitis tests were used on mice. The C. villosum ethanolic extract significantly inhibited the number of abdominal writhes, mechanical hyperalgesia and paw licking time in the second phase of the formalin test. At a dose of 300 mg kg-1, the extract also significantly reduced the volume of edema formed in the late phase and reduced the recruitment of leukocytes and neutrophils in the peritoneal cavity, as well as CXCL1 chemokine levels. It is suggested that the extract attenuates the leukocyte recruitment by inhibiting the CXCL1 activation. The peripheral antinociceptive activity occured through opioid pathway modulation because pretreatment with C. villosum ethanolic extract reversed the naltrexone-induced antinociception.Instituto Nacional de Pesquisas da Amazônia2022-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000300245Acta Amazonica v.52 n.3 2022reponame:Acta Amazonicainstname:Instituto Nacional de Pesquisas da Amazônia (INPA)instacron:INPA10.1590/1809-4392202200552info:eu-repo/semantics/openAccessSOARES,Gutemberg LopesHILGENBERG,Lívia Christine RibeiroBATISTA,Giovana ReisSOUZA,Matheus Kleber de JesusFERREIRA,Renata Cristina MendesSILVA,Irismara SousaMACHADO,Tallita MarquesPINHEIRO,Carlos Cleomir de SouzaGUILHON-SIMPLICIO,FernandaKLEIN,AndrePEREZ,Andrea de CastroLIMA,Emerson SilvaMOURA,Clarice de Carvalho Velosoeng2022-09-08T00:00:00Zoai:scielo:S0044-59672022000300245Revistahttps://acta.inpa.gov.br/PUBhttps://old.scielo.br/oai/scielo-oai.phpacta@inpa.gov.br||acta@inpa.gov.br1809-43920044-5967opendoar:2022-09-08T00:00Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA)false |
dc.title.none.fl_str_mv |
Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation |
title |
Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation |
spellingShingle |
Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation SOARES,Gutemberg Lopes pain antinociception chemokine leukocyte recruitment |
title_short |
Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation |
title_full |
Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation |
title_fullStr |
Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation |
title_full_unstemmed |
Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation |
title_sort |
Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation |
author |
SOARES,Gutemberg Lopes |
author_facet |
SOARES,Gutemberg Lopes HILGENBERG,Lívia Christine Ribeiro BATISTA,Giovana Reis SOUZA,Matheus Kleber de Jesus FERREIRA,Renata Cristina Mendes SILVA,Irismara Sousa MACHADO,Tallita Marques PINHEIRO,Carlos Cleomir de Souza GUILHON-SIMPLICIO,Fernanda KLEIN,Andre PEREZ,Andrea de Castro LIMA,Emerson Silva MOURA,Clarice de Carvalho Veloso |
author_role |
author |
author2 |
HILGENBERG,Lívia Christine Ribeiro BATISTA,Giovana Reis SOUZA,Matheus Kleber de Jesus FERREIRA,Renata Cristina Mendes SILVA,Irismara Sousa MACHADO,Tallita Marques PINHEIRO,Carlos Cleomir de Souza GUILHON-SIMPLICIO,Fernanda KLEIN,Andre PEREZ,Andrea de Castro LIMA,Emerson Silva MOURA,Clarice de Carvalho Veloso |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
SOARES,Gutemberg Lopes HILGENBERG,Lívia Christine Ribeiro BATISTA,Giovana Reis SOUZA,Matheus Kleber de Jesus FERREIRA,Renata Cristina Mendes SILVA,Irismara Sousa MACHADO,Tallita Marques PINHEIRO,Carlos Cleomir de Souza GUILHON-SIMPLICIO,Fernanda KLEIN,Andre PEREZ,Andrea de Castro LIMA,Emerson Silva MOURA,Clarice de Carvalho Veloso |
dc.subject.por.fl_str_mv |
pain antinociception chemokine leukocyte recruitment |
topic |
pain antinociception chemokine leukocyte recruitment |
description |
ABSTRACT The oil of Caryocar villosum is used in Amazonian folk medicine to treat pain and inflammatory conditions. So, we assessed the anti-inflammatory and antinociceptive properties of the ethanolic extract obtained from the fruit peels of this species. The acetic acid-induced writhing, carrageenan-induced mechanical hyperalgesia, formalin, carrageenan-induced paw edema and carrageenan-induced peritonitis tests were used on mice. The C. villosum ethanolic extract significantly inhibited the number of abdominal writhes, mechanical hyperalgesia and paw licking time in the second phase of the formalin test. At a dose of 300 mg kg-1, the extract also significantly reduced the volume of edema formed in the late phase and reduced the recruitment of leukocytes and neutrophils in the peritoneal cavity, as well as CXCL1 chemokine levels. It is suggested that the extract attenuates the leukocyte recruitment by inhibiting the CXCL1 activation. The peripheral antinociceptive activity occured through opioid pathway modulation because pretreatment with C. villosum ethanolic extract reversed the naltrexone-induced antinociception. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000300245 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000300245 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1809-4392202200552 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Nacional de Pesquisas da Amazônia |
publisher.none.fl_str_mv |
Instituto Nacional de Pesquisas da Amazônia |
dc.source.none.fl_str_mv |
Acta Amazonica v.52 n.3 2022 reponame:Acta Amazonica instname:Instituto Nacional de Pesquisas da Amazônia (INPA) instacron:INPA |
instname_str |
Instituto Nacional de Pesquisas da Amazônia (INPA) |
instacron_str |
INPA |
institution |
INPA |
reponame_str |
Acta Amazonica |
collection |
Acta Amazonica |
repository.name.fl_str_mv |
Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA) |
repository.mail.fl_str_mv |
acta@inpa.gov.br||acta@inpa.gov.br |
_version_ |
1752129841612718080 |