Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue

Detalhes bibliográficos
Autor(a) principal: TELLES,Luciana Ortega
Data de Publicação: 2022
Outros Autores: SILVA,Bianca Sulzbacher da, PAULINO,Angélica Macedo Borges, MENDONÇA,Sabrina Trigueiro, SINHORIN,Valéria Dornelles Gindri, LIMA,Milena Campelo Freitas de, VEIGA JUNIOR,Valdir Florêncio, ANDRIGHETTI,Carla Regina, NASCIMENTO,André Ferreira do, BOMFIM,Gisele Facholi, LUVIZOTTO,Renata Azevedo Melo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Amazonica
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000400331
Resumo: ABSTRACT Obesogenic diets lead to fat accumulation and dysfunctional adipose tissue. Active compounds were described in copaiba oleoresin, which presents anti-inflammatory, antimicrobial, and antioxidant properties. However, there are no data regarding the effects of copaiba oleoresin in adipose tissue. Therefore, we tested the hypothesis that the copaiba oleoresin could prevent or minimize obesity and adipose tissue inflammation and oxidative stress in response to a high sucrose diet. Male Wistar rats were randomly assigned to receiving commercial chow (C, n = 8), commercial chow and 30% sucrose added to the drinking water (S, n = 8), or commercial chow and 30% sucrose added to the drinking water + copaiba oleoresin (S+CO, n = 8). Copaiba oleoresin was given at a dose of 200 mg kg-1 day-1 by gavage for eight weeks. C and S animals received vehicle, at equivalent volume, by gavage. At the end of the experiment, blood samples and epididymal adipose tissue were collected for biochemical, inflammatory, and oxidative stress analyses. Copaiba oleoresin supplementation prevented weight gain, adiposity, insulin resistance, and increased IL-1β levels. Additionally, copaiba oleoresin partially attenuated the increase in fasting glucose levels, lipids, and IL-6 levels, and improved the redox status in adipose tissue. Our results suggest that the use of copaiba oleoresin could be a good strategy for prevention of obesity and its complications.
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spelling Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissuenatural productshigh sucrose dietobesityCopaiferaABSTRACT Obesogenic diets lead to fat accumulation and dysfunctional adipose tissue. Active compounds were described in copaiba oleoresin, which presents anti-inflammatory, antimicrobial, and antioxidant properties. However, there are no data regarding the effects of copaiba oleoresin in adipose tissue. Therefore, we tested the hypothesis that the copaiba oleoresin could prevent or minimize obesity and adipose tissue inflammation and oxidative stress in response to a high sucrose diet. Male Wistar rats were randomly assigned to receiving commercial chow (C, n = 8), commercial chow and 30% sucrose added to the drinking water (S, n = 8), or commercial chow and 30% sucrose added to the drinking water + copaiba oleoresin (S+CO, n = 8). Copaiba oleoresin was given at a dose of 200 mg kg-1 day-1 by gavage for eight weeks. C and S animals received vehicle, at equivalent volume, by gavage. At the end of the experiment, blood samples and epididymal adipose tissue were collected for biochemical, inflammatory, and oxidative stress analyses. Copaiba oleoresin supplementation prevented weight gain, adiposity, insulin resistance, and increased IL-1β levels. Additionally, copaiba oleoresin partially attenuated the increase in fasting glucose levels, lipids, and IL-6 levels, and improved the redox status in adipose tissue. Our results suggest that the use of copaiba oleoresin could be a good strategy for prevention of obesity and its complications.Instituto Nacional de Pesquisas da Amazônia2022-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000400331Acta Amazonica v.52 n.4 2022reponame:Acta Amazonicainstname:Instituto Nacional de Pesquisas da Amazônia (INPA)instacron:INPA10.1590/1809-4392202201411info:eu-repo/semantics/openAccessTELLES,Luciana OrtegaSILVA,Bianca Sulzbacher daPAULINO,Angélica Macedo BorgesMENDONÇA,Sabrina TrigueiroSINHORIN,Valéria Dornelles GindriLIMA,Milena Campelo Freitas deVEIGA JUNIOR,Valdir FlorêncioANDRIGHETTI,Carla ReginaNASCIMENTO,André Ferreira doBOMFIM,Gisele FacholiLUVIZOTTO,Renata Azevedo Meloeng2022-11-30T00:00:00Zoai:scielo:S0044-59672022000400331Revistahttps://acta.inpa.gov.br/PUBhttps://old.scielo.br/oai/scielo-oai.phpacta@inpa.gov.br||acta@inpa.gov.br1809-43920044-5967opendoar:2022-11-30T00:00Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA)false
dc.title.none.fl_str_mv Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue
title Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue
spellingShingle Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue
TELLES,Luciana Ortega
natural products
high sucrose diet
obesity
Copaifera
title_short Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue
title_full Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue
title_fullStr Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue
title_full_unstemmed Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue
title_sort Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue
author TELLES,Luciana Ortega
author_facet TELLES,Luciana Ortega
SILVA,Bianca Sulzbacher da
PAULINO,Angélica Macedo Borges
MENDONÇA,Sabrina Trigueiro
SINHORIN,Valéria Dornelles Gindri
LIMA,Milena Campelo Freitas de
VEIGA JUNIOR,Valdir Florêncio
ANDRIGHETTI,Carla Regina
NASCIMENTO,André Ferreira do
BOMFIM,Gisele Facholi
LUVIZOTTO,Renata Azevedo Melo
author_role author
author2 SILVA,Bianca Sulzbacher da
PAULINO,Angélica Macedo Borges
MENDONÇA,Sabrina Trigueiro
SINHORIN,Valéria Dornelles Gindri
LIMA,Milena Campelo Freitas de
VEIGA JUNIOR,Valdir Florêncio
ANDRIGHETTI,Carla Regina
NASCIMENTO,André Ferreira do
BOMFIM,Gisele Facholi
LUVIZOTTO,Renata Azevedo Melo
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv TELLES,Luciana Ortega
SILVA,Bianca Sulzbacher da
PAULINO,Angélica Macedo Borges
MENDONÇA,Sabrina Trigueiro
SINHORIN,Valéria Dornelles Gindri
LIMA,Milena Campelo Freitas de
VEIGA JUNIOR,Valdir Florêncio
ANDRIGHETTI,Carla Regina
NASCIMENTO,André Ferreira do
BOMFIM,Gisele Facholi
LUVIZOTTO,Renata Azevedo Melo
dc.subject.por.fl_str_mv natural products
high sucrose diet
obesity
Copaifera
topic natural products
high sucrose diet
obesity
Copaifera
description ABSTRACT Obesogenic diets lead to fat accumulation and dysfunctional adipose tissue. Active compounds were described in copaiba oleoresin, which presents anti-inflammatory, antimicrobial, and antioxidant properties. However, there are no data regarding the effects of copaiba oleoresin in adipose tissue. Therefore, we tested the hypothesis that the copaiba oleoresin could prevent or minimize obesity and adipose tissue inflammation and oxidative stress in response to a high sucrose diet. Male Wistar rats were randomly assigned to receiving commercial chow (C, n = 8), commercial chow and 30% sucrose added to the drinking water (S, n = 8), or commercial chow and 30% sucrose added to the drinking water + copaiba oleoresin (S+CO, n = 8). Copaiba oleoresin was given at a dose of 200 mg kg-1 day-1 by gavage for eight weeks. C and S animals received vehicle, at equivalent volume, by gavage. At the end of the experiment, blood samples and epididymal adipose tissue were collected for biochemical, inflammatory, and oxidative stress analyses. Copaiba oleoresin supplementation prevented weight gain, adiposity, insulin resistance, and increased IL-1β levels. Additionally, copaiba oleoresin partially attenuated the increase in fasting glucose levels, lipids, and IL-6 levels, and improved the redox status in adipose tissue. Our results suggest that the use of copaiba oleoresin could be a good strategy for prevention of obesity and its complications.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000400331
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672022000400331
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1809-4392202201411
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Nacional de Pesquisas da Amazônia
publisher.none.fl_str_mv Instituto Nacional de Pesquisas da Amazônia
dc.source.none.fl_str_mv Acta Amazonica v.52 n.4 2022
reponame:Acta Amazonica
instname:Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron:INPA
instname_str Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron_str INPA
institution INPA
reponame_str Acta Amazonica
collection Acta Amazonica
repository.name.fl_str_mv Acta Amazonica - Instituto Nacional de Pesquisas da Amazônia (INPA)
repository.mail.fl_str_mv acta@inpa.gov.br||acta@inpa.gov.br
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