Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Ambiente & Água |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000200308 |
Resumo: | Abstract This work sought to determine the two psychotropic drugs most commonly released by Psychosocial Care Centers (CAPS) into urban river waters (Belém sub-basin, Curitiba, PR, Brazil). A simple analytical method using SPE followed by a HPLC-DAD was developed and validated. Strata-X® cartridges were used to extract (carbamazepine) CZ and diazepam (DZ) from water and SPE conditions were optimized by 23 factorial design. The validated method was specific for target compounds; correlation coefficients were above 0.9998, recovery between 85.8 and 98.4% and precision below 6.60% (RSD, n=3). This method was successfully applied to analyze river samples and pollution hotspots were identified. The CZ and DZ concentrations found ranged from 0.670 to 0.856 µg L-1 and from LOQ to 0.763 µg L-1, respectively, and confirmed that drug consumption is directly related to river pollution in the studied region. |
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Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazilcarbamazepinediazepamemerging pollutantsAbstract This work sought to determine the two psychotropic drugs most commonly released by Psychosocial Care Centers (CAPS) into urban river waters (Belém sub-basin, Curitiba, PR, Brazil). A simple analytical method using SPE followed by a HPLC-DAD was developed and validated. Strata-X® cartridges were used to extract (carbamazepine) CZ and diazepam (DZ) from water and SPE conditions were optimized by 23 factorial design. The validated method was specific for target compounds; correlation coefficients were above 0.9998, recovery between 85.8 and 98.4% and precision below 6.60% (RSD, n=3). This method was successfully applied to analyze river samples and pollution hotspots were identified. The CZ and DZ concentrations found ranged from 0.670 to 0.856 µg L-1 and from LOQ to 0.763 µg L-1, respectively, and confirmed that drug consumption is directly related to river pollution in the studied region.Instituto de Pesquisas Ambientais em Bacias Hidrográficas2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000200308Revista Ambiente & Água v.13 n.2 2018reponame:Revista Ambiente & Águainstname:Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI)instacron:IPABHI10.4136/ambi-agua.2196info:eu-repo/semantics/openAccessBöger,BeatrizAmaral,Bianca doEstevão,Priscila Lagner da SilveiraWagner,RicardoPeralta-Zamora,Patricio GuillermoGomes,Eliane Carneiroeng2018-04-12T00:00:00Zoai:scielo:S1980-993X2018000200308Revistahttp://www.ambi-agua.net/PUBhttps://old.scielo.br/oai/scielo-oai.php||ambi.agua@gmail.com1980-993X1980-993Xopendoar:2018-04-12T00:00Revista Ambiente & Água - Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI)false |
dc.title.none.fl_str_mv |
Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil |
title |
Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil |
spellingShingle |
Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil Böger,Beatriz carbamazepine diazepam emerging pollutants |
title_short |
Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil |
title_full |
Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil |
title_fullStr |
Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil |
title_full_unstemmed |
Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil |
title_sort |
Determination of carbamazepine and diazepam by SPE-HPLC-DAD in Belém River water, Curitiba-PR/Brazil |
author |
Böger,Beatriz |
author_facet |
Böger,Beatriz Amaral,Bianca do Estevão,Priscila Lagner da Silveira Wagner,Ricardo Peralta-Zamora,Patricio Guillermo Gomes,Eliane Carneiro |
author_role |
author |
author2 |
Amaral,Bianca do Estevão,Priscila Lagner da Silveira Wagner,Ricardo Peralta-Zamora,Patricio Guillermo Gomes,Eliane Carneiro |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Böger,Beatriz Amaral,Bianca do Estevão,Priscila Lagner da Silveira Wagner,Ricardo Peralta-Zamora,Patricio Guillermo Gomes,Eliane Carneiro |
dc.subject.por.fl_str_mv |
carbamazepine diazepam emerging pollutants |
topic |
carbamazepine diazepam emerging pollutants |
description |
Abstract This work sought to determine the two psychotropic drugs most commonly released by Psychosocial Care Centers (CAPS) into urban river waters (Belém sub-basin, Curitiba, PR, Brazil). A simple analytical method using SPE followed by a HPLC-DAD was developed and validated. Strata-X® cartridges were used to extract (carbamazepine) CZ and diazepam (DZ) from water and SPE conditions were optimized by 23 factorial design. The validated method was specific for target compounds; correlation coefficients were above 0.9998, recovery between 85.8 and 98.4% and precision below 6.60% (RSD, n=3). This method was successfully applied to analyze river samples and pollution hotspots were identified. The CZ and DZ concentrations found ranged from 0.670 to 0.856 µg L-1 and from LOQ to 0.763 µg L-1, respectively, and confirmed that drug consumption is directly related to river pollution in the studied region. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000200308 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000200308 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.4136/ambi-agua.2196 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Pesquisas Ambientais em Bacias Hidrográficas |
publisher.none.fl_str_mv |
Instituto de Pesquisas Ambientais em Bacias Hidrográficas |
dc.source.none.fl_str_mv |
Revista Ambiente & Água v.13 n.2 2018 reponame:Revista Ambiente & Água instname:Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI) instacron:IPABHI |
instname_str |
Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI) |
instacron_str |
IPABHI |
institution |
IPABHI |
reponame_str |
Revista Ambiente & Água |
collection |
Revista Ambiente & Água |
repository.name.fl_str_mv |
Revista Ambiente & Água - Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI) |
repository.mail.fl_str_mv |
||ambi.agua@gmail.com |
_version_ |
1752129750361440256 |