Optical Coherence Tomography for blood glucose monitoring through signal attenuation
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo de conferência |
Título da fonte: | Repositório Institucional do IPEN |
Texto Completo: | http://repositorio.ipen.br/handle/123456789/27115 |
Resumo: | Development of non-invasive techniques for glucose monitoring is crucial to improve glucose control and treatment adherence in patients with diabetes. Hereafter, Optical Coherence Tomography (OCT) may offer a good alternative for portable glucometers, since it uses light to probe samples. Changes in the object of interest can alter the intensity of light returning from the sample and, through it, one can estimate the sample's attenuation coefficient (??t) of light. In this work, we aimed to explore the behavior of ??t of mouse???s blood under increasing glucose concentrations. Different samples were prepared in four glucose concentrations using a mixture of heparinized blood, phosphate buffer saline and glucose. Blood glucose concentrations were measured with a blood glucometer, for reference. We have also prepared other samples diluting the blood in isotonic saline solution to check the effect of a higher multiple-scattering component on the ability of the technique to differentiate glucose levels based on ??t. The OCT system used was a commercial Spectral Radar OCT with 930 nm central wavelength and spectral bandwidth (FWHM) of 100 nm. The system proved to be sensitive for all blood glucose concentrations tested, with good correlations with the obtained attenuation coefficients. A linear tendency was observed, with an increase in attenuation with higher values of glucose. Statistical difference was observed between all groups (p<0.001). This work opens the possibility towards a non-invasive diagnostic modality using OCT for glycemic control, which eliminates the use of analytes and/or test strips, as in the case with commercially available glucometers. |
id |
IPEN_a5b6dacf669890932d96801b62a18c1f |
---|---|
oai_identifier_str |
oai:repositorio.ipen.br:123456789/27115 |
network_acronym_str |
IPEN |
network_name_str |
Repositório Institucional do IPEN |
repository_id_str |
4510 |
spelling |
IZATT, JOSEPH A.FUJIMOTO, JAMES G.TUCHIN, VALERY V.PRETTO, LUCAS R. deYOSHIMURA, TANIA M.RIBEIRO, MARTHA S.FREITAS, ANDERSON Z. deOPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE, 20th2017-03-07T12:58:37Z2017-03-07T12:58:37ZFebruary 13, 2016http://repositorio.ipen.br/handle/123456789/27115Development of non-invasive techniques for glucose monitoring is crucial to improve glucose control and treatment adherence in patients with diabetes. Hereafter, Optical Coherence Tomography (OCT) may offer a good alternative for portable glucometers, since it uses light to probe samples. Changes in the object of interest can alter the intensity of light returning from the sample and, through it, one can estimate the sample's attenuation coefficient (??t) of light. In this work, we aimed to explore the behavior of ??t of mouse???s blood under increasing glucose concentrations. Different samples were prepared in four glucose concentrations using a mixture of heparinized blood, phosphate buffer saline and glucose. Blood glucose concentrations were measured with a blood glucometer, for reference. We have also prepared other samples diluting the blood in isotonic saline solution to check the effect of a higher multiple-scattering component on the ability of the technique to differentiate glucose levels based on ??t. The OCT system used was a commercial Spectral Radar OCT with 930 nm central wavelength and spectral bandwidth (FWHM) of 100 nm. The system proved to be sensitive for all blood glucose concentrations tested, with good correlations with the obtained attenuation coefficients. A linear tendency was observed, with an increase in attenuation with higher values of glucose. Statistical difference was observed between all groups (p<0.001). This work opens the possibility towards a non-invasive diagnostic modality using OCT for glycemic control, which eliminates the use of analytes and/or test strips, as in the case with commercially available glucometers.Submitted by Marco Antonio Oliveira da Silva (maosilva@ipen.br) on 2017-03-07T12:58:37Z No. of bitstreams: 1 22984.pdf: 669499 bytes, checksum: 8a120726e91335010aa8ce702923a670 (MD5)Made available in DSpace on 2017-03-07T12:58:37Z (GMT). No. of bitstreams: 1 22984.pdf: 669499 bytes, checksum: 8a120726e91335010aa8ce702923a670 (MD5)96973F-1 - 96973F-9Bellingham, Washington USA: Society of Photo-optical Instrumentation EngineersSPIE Proceedings Series, 9697tomographyoptical systemscoherence lengthattenuationin vitrodiabetes mellitushyperglycemiabloodglucosemonitoringOptical Coherence Tomography for blood glucose monitoring through signal attenuationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectSPIEISan Francisco, California, USAinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional do IPENinstname:Instituto de Pesquisas Energéticas e Nucleares (IPEN)instacron:IPEN229842016PRETTO, LUCAS R. deYOSHIMURA, TANIA M.RIBEIRO, MARTHA S.FREITAS, ANDERSON Z. de17-03Proceedings1126810230574880PRETTO, LUCAS R. DE:11268:920:SYOSHIMURA, TANIA M.:10230:920:NRIBEIRO, MARTHA S.:574:920:NFREITAS, ANDERSON Z. DE:880:920:NORIGINAL22984.pdf22984.pdfapplication/pdf669499http://repositorio.ipen.br/bitstream/123456789/27115/1/22984.pdf8a120726e91335010aa8ce702923a670MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ipen.br/bitstream/123456789/27115/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/271152020-10-11 00:58:49.314oai:repositorio.ipen.br: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Repositório InstitucionalPUBhttp://repositorio.ipen.br/oai/requestbibl@ipen.bropendoar:45102020-10-11T00:58:49Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN)false |
dc.title.pt_BR.fl_str_mv |
Optical Coherence Tomography for blood glucose monitoring through signal attenuation |
title |
Optical Coherence Tomography for blood glucose monitoring through signal attenuation |
spellingShingle |
Optical Coherence Tomography for blood glucose monitoring through signal attenuation PRETTO, LUCAS R. de tomography optical systems coherence length attenuation in vitro diabetes mellitus hyperglycemia blood glucose monitoring |
title_short |
Optical Coherence Tomography for blood glucose monitoring through signal attenuation |
title_full |
Optical Coherence Tomography for blood glucose monitoring through signal attenuation |
title_fullStr |
Optical Coherence Tomography for blood glucose monitoring through signal attenuation |
title_full_unstemmed |
Optical Coherence Tomography for blood glucose monitoring through signal attenuation |
title_sort |
Optical Coherence Tomography for blood glucose monitoring through signal attenuation |
author |
PRETTO, LUCAS R. de |
author_facet |
PRETTO, LUCAS R. de YOSHIMURA, TANIA M. RIBEIRO, MARTHA S. FREITAS, ANDERSON Z. de OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE, 20th |
author_role |
author |
author2 |
YOSHIMURA, TANIA M. RIBEIRO, MARTHA S. FREITAS, ANDERSON Z. de OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE, 20th |
author2_role |
author author author author |
dc.contributor.editor.none.fl_str_mv |
IZATT, JOSEPH A. FUJIMOTO, JAMES G. TUCHIN, VALERY V. |
dc.contributor.author.fl_str_mv |
PRETTO, LUCAS R. de YOSHIMURA, TANIA M. RIBEIRO, MARTHA S. FREITAS, ANDERSON Z. de OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE, 20th |
dc.subject.por.fl_str_mv |
tomography optical systems coherence length attenuation in vitro diabetes mellitus hyperglycemia blood glucose monitoring |
topic |
tomography optical systems coherence length attenuation in vitro diabetes mellitus hyperglycemia blood glucose monitoring |
description |
Development of non-invasive techniques for glucose monitoring is crucial to improve glucose control and treatment adherence in patients with diabetes. Hereafter, Optical Coherence Tomography (OCT) may offer a good alternative for portable glucometers, since it uses light to probe samples. Changes in the object of interest can alter the intensity of light returning from the sample and, through it, one can estimate the sample's attenuation coefficient (??t) of light. In this work, we aimed to explore the behavior of ??t of mouse???s blood under increasing glucose concentrations. Different samples were prepared in four glucose concentrations using a mixture of heparinized blood, phosphate buffer saline and glucose. Blood glucose concentrations were measured with a blood glucometer, for reference. We have also prepared other samples diluting the blood in isotonic saline solution to check the effect of a higher multiple-scattering component on the ability of the technique to differentiate glucose levels based on ??t. The OCT system used was a commercial Spectral Radar OCT with 930 nm central wavelength and spectral bandwidth (FWHM) of 100 nm. The system proved to be sensitive for all blood glucose concentrations tested, with good correlations with the obtained attenuation coefficients. A linear tendency was observed, with an increase in attenuation with higher values of glucose. Statistical difference was observed between all groups (p<0.001). This work opens the possibility towards a non-invasive diagnostic modality using OCT for glycemic control, which eliminates the use of analytes and/or test strips, as in the case with commercially available glucometers. |
publishDate |
2017 |
dc.date.evento.none.fl_str_mv |
February 13, 2016 |
dc.date.accessioned.fl_str_mv |
2017-03-07T12:58:37Z |
dc.date.available.fl_str_mv |
2017-03-07T12:58:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ipen.br/handle/123456789/27115 |
url |
http://repositorio.ipen.br/handle/123456789/27115 |
dc.relation.ispartofseries.pt_BR.fl_str_mv |
SPIE Proceedings Series, 9697 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
96973F-1 - 96973F-9 |
dc.coverage.pt_BR.fl_str_mv |
I |
dc.publisher.none.fl_str_mv |
Bellingham, Washington USA: Society of Photo-optical Instrumentation Engineers |
publisher.none.fl_str_mv |
Bellingham, Washington USA: Society of Photo-optical Instrumentation Engineers |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional do IPEN instname:Instituto de Pesquisas Energéticas e Nucleares (IPEN) instacron:IPEN |
instname_str |
Instituto de Pesquisas Energéticas e Nucleares (IPEN) |
instacron_str |
IPEN |
institution |
IPEN |
reponame_str |
Repositório Institucional do IPEN |
collection |
Repositório Institucional do IPEN |
bitstream.url.fl_str_mv |
http://repositorio.ipen.br/bitstream/123456789/27115/1/22984.pdf http://repositorio.ipen.br/bitstream/123456789/27115/2/license.txt |
bitstream.checksum.fl_str_mv |
8a120726e91335010aa8ce702923a670 8a4605be74aa9ea9d79846c1fba20a33 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional do IPEN - Instituto de Pesquisas Energéticas e Nucleares (IPEN) |
repository.mail.fl_str_mv |
bibl@ipen.br |
_version_ |
1767254240352272384 |