Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography

Detalhes bibliográficos
Autor(a) principal: Maciel, Marino Jesus Correia
Data de Publicação: 2022
Outros Autores: Pereira, Hugo Martins, Pimenta, Sara Filomena Ribeiro, Miranda, Alice Augusta Macedo, Nunes-Pereira, Eduardo J., Correia, J. H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/89544
Resumo: Optical coherence tomography (OCT) is a well-established imaging technology for high-resolution, cross-sectional imaging of biological tissues. Imaging processing and light attenuation coefficient estimation allows to further improve the OCT diagnostic capability. In this paper we use a commercial OCT system, Telesto II-1325LR from Thorlabs, and demonstrate its ability to differentiate normal and tumor mammary mouse glands with the OCT attenuation coefficient. Using several OCT images of normal and tumor mammary mouse glands (n = 26), a statistical analysis was performed. The attenuation coefficient was calculated in depth, considering a slope of 0.5 mm. The normal glands present a median attenuation coefficient of 0.403 mm-1, comparatively to 0.561 mm-1obtained for tumor mammary glands. This translates in an attenuation coefficient approximately 39% higher for tumor mammary glands when compared to normal mammary glands. The OCT attenuation coefficient estimation eliminates the subjective analysis provided by direct visualization of the OCT images.
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spelling Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomographyAnimalsMiceNeoplasmsTomography, Optical CoherenceOCT imagingAttenuation coefficientMammary mouse glandsScience & TechnologyOptical coherence tomography (OCT) is a well-established imaging technology for high-resolution, cross-sectional imaging of biological tissues. Imaging processing and light attenuation coefficient estimation allows to further improve the OCT diagnostic capability. In this paper we use a commercial OCT system, Telesto II-1325LR from Thorlabs, and demonstrate its ability to differentiate normal and tumor mammary mouse glands with the OCT attenuation coefficient. Using several OCT images of normal and tumor mammary mouse glands (n = 26), a statistical analysis was performed. The attenuation coefficient was calculated in depth, considering a slope of 0.5 mm. The normal glands present a median attenuation coefficient of 0.403 mm-1, comparatively to 0.561 mm-1obtained for tumor mammary glands. This translates in an attenuation coefficient approximately 39% higher for tumor mammary glands when compared to normal mammary glands. The OCT attenuation coefficient estimation eliminates the subjective analysis provided by direct visualization of the OCT images.This work is supported by:-OCT-RAMAN, PTDC/FISOTI/28296/2017 with the operation code NORTE-01- 0145-FEDER-028296;—MPhotonBiopsy, PTDC/FISOTI/1259/2020;—CMEMS-UMinho Strategic Project UIDB/04436/2020;- Infrastructures Micro&NanoFabs@PT, operation code NORTE 01-0145-FEDER022090, POR Norte, Portugal.IOP PublishingUniversidade do MinhoMaciel, Marino Jesus CorreiaPereira, Hugo MartinsPimenta, Sara Filomena RibeiroMiranda, Alice Augusta MacedoNunes-Pereira, Eduardo J.Correia, J. H.20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/89544engMarino J Maciel et al 2022 Biomed. Phys. Eng. Express 8 0150072057-19762057-197610.1088/2057-1976/ac37ca34753120015007https://iopscience.iop.org/article/10.1088/2057-1976/ac37cainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-16T01:21:31Zoai:repositorium.sdum.uminho.pt:1822/89544Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:01:09.710215Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography
title Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography
spellingShingle Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography
Maciel, Marino Jesus Correia
Animals
Mice
Neoplasms
Tomography, Optical Coherence
OCT imaging
Attenuation coefficient
Mammary mouse glands
Science & Technology
title_short Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography
title_full Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography
title_fullStr Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography
title_full_unstemmed Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography
title_sort Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography
author Maciel, Marino Jesus Correia
author_facet Maciel, Marino Jesus Correia
Pereira, Hugo Martins
Pimenta, Sara Filomena Ribeiro
Miranda, Alice Augusta Macedo
Nunes-Pereira, Eduardo J.
Correia, J. H.
author_role author
author2 Pereira, Hugo Martins
Pimenta, Sara Filomena Ribeiro
Miranda, Alice Augusta Macedo
Nunes-Pereira, Eduardo J.
Correia, J. H.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Maciel, Marino Jesus Correia
Pereira, Hugo Martins
Pimenta, Sara Filomena Ribeiro
Miranda, Alice Augusta Macedo
Nunes-Pereira, Eduardo J.
Correia, J. H.
dc.subject.por.fl_str_mv Animals
Mice
Neoplasms
Tomography, Optical Coherence
OCT imaging
Attenuation coefficient
Mammary mouse glands
Science & Technology
topic Animals
Mice
Neoplasms
Tomography, Optical Coherence
OCT imaging
Attenuation coefficient
Mammary mouse glands
Science & Technology
description Optical coherence tomography (OCT) is a well-established imaging technology for high-resolution, cross-sectional imaging of biological tissues. Imaging processing and light attenuation coefficient estimation allows to further improve the OCT diagnostic capability. In this paper we use a commercial OCT system, Telesto II-1325LR from Thorlabs, and demonstrate its ability to differentiate normal and tumor mammary mouse glands with the OCT attenuation coefficient. Using several OCT images of normal and tumor mammary mouse glands (n = 26), a statistical analysis was performed. The attenuation coefficient was calculated in depth, considering a slope of 0.5 mm. The normal glands present a median attenuation coefficient of 0.403 mm-1, comparatively to 0.561 mm-1obtained for tumor mammary glands. This translates in an attenuation coefficient approximately 39% higher for tumor mammary glands when compared to normal mammary glands. The OCT attenuation coefficient estimation eliminates the subjective analysis provided by direct visualization of the OCT images.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/89544
url https://hdl.handle.net/1822/89544
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Marino J Maciel et al 2022 Biomed. Phys. Eng. Express 8 015007
2057-1976
2057-1976
10.1088/2057-1976/ac37ca
34753120
015007
https://iopscience.iop.org/article/10.1088/2057-1976/ac37ca
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOP Publishing
publisher.none.fl_str_mv IOP Publishing
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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