Hypertonic saline for treatment of shock: have we looked for everything?

Detalhes bibliográficos
Autor(a) principal: Silva,Mauricio Rocha e
Data de Publicação: 2014
Tipo de documento: Artigo
Idioma: eng
Título da fonte: MedicalExpress (São Paulo. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000100014
Resumo: This review is dedicated to the memory of Luis Poli de Figueiredo, who is responsible for much of what we know about small volume resuscitation. Small volume hypertonic resuscitation was originally based on the concept that a physiologically significant blood volume expansion follows the administration of a comparatively small volume of hypertonic fluid. Because hypertonicity is a physiological vasodilator, its use after severe blood loss induces reperfusion. Previously reported research disclosed a number of additional properties of hypertonic NaCl, amongst them (i) the correction of endothelial and red cell edema with significant consequences in terms of capillary blood flow; (ii) modulation of the immune system, with applications repercussions in the field of sepsis. This review covers developments in this field that occurred from 2005 through 2013. We discuss the discrepancy between animal experiments and human trials, and argue that the basic objective of most multicenter clinical trials may have been based upon a poor strategy.
id METC-1_1d8f99915c275d5a4285c9bc9814a8b8
oai_identifier_str oai:scielo:S2358-04292014000100014
network_acronym_str METC-1
network_name_str MedicalExpress (São Paulo. Online)
repository_id_str
spelling Hypertonic saline for treatment of shock: have we looked for everything?ShockHemorrhageSepsis Hypertonic salineImmune circulationThis review is dedicated to the memory of Luis Poli de Figueiredo, who is responsible for much of what we know about small volume resuscitation. Small volume hypertonic resuscitation was originally based on the concept that a physiologically significant blood volume expansion follows the administration of a comparatively small volume of hypertonic fluid. Because hypertonicity is a physiological vasodilator, its use after severe blood loss induces reperfusion. Previously reported research disclosed a number of additional properties of hypertonic NaCl, amongst them (i) the correction of endothelial and red cell edema with significant consequences in terms of capillary blood flow; (ii) modulation of the immune system, with applications repercussions in the field of sepsis. This review covers developments in this field that occurred from 2005 through 2013. We discuss the discrepancy between animal experiments and human trials, and argue that the basic objective of most multicenter clinical trials may have been based upon a poor strategy.Mavera Edições Técnicas e Científicas Ltda2014-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000100014MedicalExpress v.1 n.1 2014reponame:MedicalExpress (São Paulo. Online)instname:Mavera Edições Científicas e Técnicas Ltda-MEinstacron:METC10.5935/MedicalExpress.2014.01.04info:eu-repo/semantics/openAccessSilva,Mauricio Rocha eeng2016-06-07T00:00:00Zoai:scielo:S2358-04292014000100014Revistahttp://www.medicalexpress.net.brhttps://old.scielo.br/oai/scielo-oai.php||medicalexpress@me.net.br2358-04292318-8111opendoar:2016-06-07T00:00MedicalExpress (São Paulo. Online) - Mavera Edições Científicas e Técnicas Ltda-MEfalse
dc.title.none.fl_str_mv Hypertonic saline for treatment of shock: have we looked for everything?
title Hypertonic saline for treatment of shock: have we looked for everything?
spellingShingle Hypertonic saline for treatment of shock: have we looked for everything?
Silva,Mauricio Rocha e
Shock
Hemorrhage
Sepsis Hypertonic saline
Immune circulation
title_short Hypertonic saline for treatment of shock: have we looked for everything?
title_full Hypertonic saline for treatment of shock: have we looked for everything?
title_fullStr Hypertonic saline for treatment of shock: have we looked for everything?
title_full_unstemmed Hypertonic saline for treatment of shock: have we looked for everything?
title_sort Hypertonic saline for treatment of shock: have we looked for everything?
author Silva,Mauricio Rocha e
author_facet Silva,Mauricio Rocha e
author_role author
dc.contributor.author.fl_str_mv Silva,Mauricio Rocha e
dc.subject.por.fl_str_mv Shock
Hemorrhage
Sepsis Hypertonic saline
Immune circulation
topic Shock
Hemorrhage
Sepsis Hypertonic saline
Immune circulation
description This review is dedicated to the memory of Luis Poli de Figueiredo, who is responsible for much of what we know about small volume resuscitation. Small volume hypertonic resuscitation was originally based on the concept that a physiologically significant blood volume expansion follows the administration of a comparatively small volume of hypertonic fluid. Because hypertonicity is a physiological vasodilator, its use after severe blood loss induces reperfusion. Previously reported research disclosed a number of additional properties of hypertonic NaCl, amongst them (i) the correction of endothelial and red cell edema with significant consequences in terms of capillary blood flow; (ii) modulation of the immune system, with applications repercussions in the field of sepsis. This review covers developments in this field that occurred from 2005 through 2013. We discuss the discrepancy between animal experiments and human trials, and argue that the basic objective of most multicenter clinical trials may have been based upon a poor strategy.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000100014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000100014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/MedicalExpress.2014.01.04
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Mavera Edições Técnicas e Científicas Ltda
publisher.none.fl_str_mv Mavera Edições Técnicas e Científicas Ltda
dc.source.none.fl_str_mv MedicalExpress v.1 n.1 2014
reponame:MedicalExpress (São Paulo. Online)
instname:Mavera Edições Científicas e Técnicas Ltda-ME
instacron:METC
instname_str Mavera Edições Científicas e Técnicas Ltda-ME
instacron_str METC
institution METC
reponame_str MedicalExpress (São Paulo. Online)
collection MedicalExpress (São Paulo. Online)
repository.name.fl_str_mv MedicalExpress (São Paulo. Online) - Mavera Edições Científicas e Técnicas Ltda-ME
repository.mail.fl_str_mv ||medicalexpress@me.net.br
_version_ 1754734596541382656