Pulse Pressure Variation Patterns in a Swine Model of Hypovolemia under Spontaneous Breathing vs. Invasive Positive-Pressure Ventilation
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | MedicalExpress (São Paulo. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000600359 |
Resumo: | OBJECTIVE: This study was performed to obtain the title of Master in Medicine, Nov/2012-Jul/2013. Improvement in cardiac output after fluid administration is known as fluid responsiveness. A reliable parameter for its evaluation is pulse pressure variation: it has established its utility in predicting volume responsiveness in mechanically ventilated patients. METHOD: Pulse pressure variation was analyzed in 10 anesthetized male pigs at four different stages: I) normovolemia and spontaneous breathing; II) hypovolemia and spontaneous breathing; III) hypovolemia under mechanical ventilation; and IV) after volume replacement, under mechanical ventilation. Cardiac output, pulmonary artery occlusion pressure, systolic pressure variation, mean arterial pressure, and heart rate were measured at all stages; red blood cell count was determined at stages I, II, and IV. RESULTS: Mean pulse pressure variation values during hypovolemia with spontaneous breathing (stage II) were significantly higher than at any other stage. After institution of mechanical ventilation, pulse pressure variation values returned to baseline without fluid administration. The lowest values were achieved after volume replacement. CONCLUSION: Pulse pressure variation values are higher during spontaneous breathing than during mechanical ventilation. Thus, it may be useful for assessment of fluid volume under these conditions, with baseline values as a starting point to which serial measurements should be compared after institution of specific therapy. |
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Pulse Pressure Variation Patterns in a Swine Model of Hypovolemia under Spontaneous Breathing vs. Invasive Positive-Pressure Ventilationpulse pressure variationhypovolemiaswine modelspontaneous breathing OBJECTIVE: This study was performed to obtain the title of Master in Medicine, Nov/2012-Jul/2013. Improvement in cardiac output after fluid administration is known as fluid responsiveness. A reliable parameter for its evaluation is pulse pressure variation: it has established its utility in predicting volume responsiveness in mechanically ventilated patients. METHOD: Pulse pressure variation was analyzed in 10 anesthetized male pigs at four different stages: I) normovolemia and spontaneous breathing; II) hypovolemia and spontaneous breathing; III) hypovolemia under mechanical ventilation; and IV) after volume replacement, under mechanical ventilation. Cardiac output, pulmonary artery occlusion pressure, systolic pressure variation, mean arterial pressure, and heart rate were measured at all stages; red blood cell count was determined at stages I, II, and IV. RESULTS: Mean pulse pressure variation values during hypovolemia with spontaneous breathing (stage II) were significantly higher than at any other stage. After institution of mechanical ventilation, pulse pressure variation values returned to baseline without fluid administration. The lowest values were achieved after volume replacement. CONCLUSION: Pulse pressure variation values are higher during spontaneous breathing than during mechanical ventilation. Thus, it may be useful for assessment of fluid volume under these conditions, with baseline values as a starting point to which serial measurements should be compared after institution of specific therapy.Mavera Edições Técnicas e Científicas Ltda2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000600359MedicalExpress v.1 n.6 2014reponame:MedicalExpress (São Paulo. Online)instname:Mavera Edições Científicas e Técnicas Ltda-MEinstacron:METC10.5935/MedicalExpress.2014.06.13info:eu-repo/semantics/openAccessRocha,Mauricio MacárioSouza,José Marconi Almeida dePaola,Angelo Amato Vincenzo deCarvalho,Antônio Carlos CamargoBarbosa,Adriano Henrique PereiraCosta,Guilherme Drummond Feneloneng2016-03-24T00:00:00Zoai:scielo:S2358-04292014000600359Revistahttp://www.medicalexpress.net.brhttps://old.scielo.br/oai/scielo-oai.php||medicalexpress@me.net.br2358-04292318-8111opendoar:2016-03-24T00:00MedicalExpress (São Paulo. Online) - Mavera Edições Científicas e Técnicas Ltda-MEfalse |
dc.title.none.fl_str_mv |
Pulse Pressure Variation Patterns in a Swine Model of Hypovolemia under Spontaneous Breathing vs. Invasive Positive-Pressure Ventilation |
title |
Pulse Pressure Variation Patterns in a Swine Model of Hypovolemia under Spontaneous Breathing vs. Invasive Positive-Pressure Ventilation |
spellingShingle |
Pulse Pressure Variation Patterns in a Swine Model of Hypovolemia under Spontaneous Breathing vs. Invasive Positive-Pressure Ventilation Rocha,Mauricio Macário pulse pressure variation hypovolemia swine model spontaneous breathing |
title_short |
Pulse Pressure Variation Patterns in a Swine Model of Hypovolemia under Spontaneous Breathing vs. Invasive Positive-Pressure Ventilation |
title_full |
Pulse Pressure Variation Patterns in a Swine Model of Hypovolemia under Spontaneous Breathing vs. Invasive Positive-Pressure Ventilation |
title_fullStr |
Pulse Pressure Variation Patterns in a Swine Model of Hypovolemia under Spontaneous Breathing vs. Invasive Positive-Pressure Ventilation |
title_full_unstemmed |
Pulse Pressure Variation Patterns in a Swine Model of Hypovolemia under Spontaneous Breathing vs. Invasive Positive-Pressure Ventilation |
title_sort |
Pulse Pressure Variation Patterns in a Swine Model of Hypovolemia under Spontaneous Breathing vs. Invasive Positive-Pressure Ventilation |
author |
Rocha,Mauricio Macário |
author_facet |
Rocha,Mauricio Macário Souza,José Marconi Almeida de Paola,Angelo Amato Vincenzo de Carvalho,Antônio Carlos Camargo Barbosa,Adriano Henrique Pereira Costa,Guilherme Drummond Fenelon |
author_role |
author |
author2 |
Souza,José Marconi Almeida de Paola,Angelo Amato Vincenzo de Carvalho,Antônio Carlos Camargo Barbosa,Adriano Henrique Pereira Costa,Guilherme Drummond Fenelon |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rocha,Mauricio Macário Souza,José Marconi Almeida de Paola,Angelo Amato Vincenzo de Carvalho,Antônio Carlos Camargo Barbosa,Adriano Henrique Pereira Costa,Guilherme Drummond Fenelon |
dc.subject.por.fl_str_mv |
pulse pressure variation hypovolemia swine model spontaneous breathing |
topic |
pulse pressure variation hypovolemia swine model spontaneous breathing |
description |
OBJECTIVE: This study was performed to obtain the title of Master in Medicine, Nov/2012-Jul/2013. Improvement in cardiac output after fluid administration is known as fluid responsiveness. A reliable parameter for its evaluation is pulse pressure variation: it has established its utility in predicting volume responsiveness in mechanically ventilated patients. METHOD: Pulse pressure variation was analyzed in 10 anesthetized male pigs at four different stages: I) normovolemia and spontaneous breathing; II) hypovolemia and spontaneous breathing; III) hypovolemia under mechanical ventilation; and IV) after volume replacement, under mechanical ventilation. Cardiac output, pulmonary artery occlusion pressure, systolic pressure variation, mean arterial pressure, and heart rate were measured at all stages; red blood cell count was determined at stages I, II, and IV. RESULTS: Mean pulse pressure variation values during hypovolemia with spontaneous breathing (stage II) were significantly higher than at any other stage. After institution of mechanical ventilation, pulse pressure variation values returned to baseline without fluid administration. The lowest values were achieved after volume replacement. CONCLUSION: Pulse pressure variation values are higher during spontaneous breathing than during mechanical ventilation. Thus, it may be useful for assessment of fluid volume under these conditions, with baseline values as a starting point to which serial measurements should be compared after institution of specific therapy. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000600359 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000600359 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/MedicalExpress.2014.06.13 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Mavera Edições Técnicas e Científicas Ltda |
publisher.none.fl_str_mv |
Mavera Edições Técnicas e Científicas Ltda |
dc.source.none.fl_str_mv |
MedicalExpress v.1 n.6 2014 reponame:MedicalExpress (São Paulo. Online) instname:Mavera Edições Científicas e Técnicas Ltda-ME instacron:METC |
instname_str |
Mavera Edições Científicas e Técnicas Ltda-ME |
instacron_str |
METC |
institution |
METC |
reponame_str |
MedicalExpress (São Paulo. Online) |
collection |
MedicalExpress (São Paulo. Online) |
repository.name.fl_str_mv |
MedicalExpress (São Paulo. Online) - Mavera Edições Científicas e Técnicas Ltda-ME |
repository.mail.fl_str_mv |
||medicalexpress@me.net.br |
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1754734596632608768 |