Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia

Detalhes bibliográficos
Autor(a) principal: Castro, L.
Data de Publicação: 2001
Outros Autores: Varjão, B., Silva, I., Duque, Bruno, Batista, A., Santana, R., Luz, P., Rocha Junior, M. A., Fregoneze, J. B., Castro e Silva, E. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6828
Resumo: p.791-796
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spelling Castro, L.Varjão, B.Silva, I.Duque, BrunoBatista, A.Santana, R.Luz, P.Rocha Junior, M. A.Fregoneze, J. B.Castro e Silva, E. deCastro, L.Varjão, B.Silva, I.Duque, BrunoBatista, A.Santana, R.Luz, P.Rocha Junior, M. A.Fregoneze, J. B.Castro e Silva, E. de2012-09-28T20:31:18Z2012-09-28T20:31:18Z2001-061414-431Xhttp://www.repositorio.ufba.br/ri/handle/ri/6828v. 34, n. 6p.791-796We demonstrate here that acute third ventricle injections of GR 113808, a highly selective 5-HT4 antagonist, decrease water intake induced by a previous salt load while potentiating drinking elicited by hypovolemia induced by previous subcutaneous administration of polyethylene glycol in male Wistar rats (200 ± 20 g). At the dose of 160 nmol/rat, third ventricle injections of GR 113808 induced a significant reduction of water intake in salt-loaded animals after 120 min as compared to salt-loaded animals receiving third ventricle injections of saline (salt load + GR = 3.44 ± 0.41 ml, N = 12; salt load + saline = 5.74 ± 0.40 ml, N = 9). At the dose of 80 nmol/rat, GR 113808 significantly enhanced water intake in hypovolemic animals after 120 min as compared to hypovolemic animals receiving third ventricle injections of saline (hypovol + GR = 4.01 ± 0.27 ml, N = 8; hypovol + saline = 2.41 ± 0.23 ml, N = 12). We suggest that central 5-HT4 receptors may exert a positive drive on water intake due to hyperosmolarity and a negative input on drinking provoked by hypovolemia.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-09-28T20:31:18Z No. of bitstreams: 1 Castro, L..pdf: 137021 bytes, checksum: c87d7dbd804c4c4c63387ac6ced635ef (MD5)Made available in DSpace on 2012-09-28T20:31:18Z (GMT). No. of bitstreams: 1 Castro, L..pdf: 137021 bytes, checksum: c87d7dbd804c4c4c63387ac6ced635ef (MD5) Previous issue date: 2001-06Ribeirão PretoBrazilian Journal of Medical and Biological Researchhttp://dx.doi.org/10.1590/S0100-879X2001000600015reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBA5-HT4 receptorsWater intakeHyperosmolarityHypovolemiaEffect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemiaBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6828/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALCastro, L..pdfCastro, L..pdfapplication/pdf137021https://repositorio.ufba.br/bitstream/ri/6828/1/Castro%2c%20L..pdfc87d7dbd804c4c4c63387ac6ced635efMD51TEXTCastro, L..pdf.txtCastro, L..pdf.txtExtracted texttext/plain21215https://repositorio.ufba.br/bitstream/ri/6828/3/Castro%2c%20L..pdf.txt055a8ab9528ebe8ad730565f99cc32c2MD53ri/68282022-07-05 14:03:23.262oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:23Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia
spellingShingle Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia
Castro, L.
5-HT4 receptors
Water intake
Hyperosmolarity
Hypovolemia
title_short Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia
title_full Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia
title_fullStr Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia
title_full_unstemmed Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia
title_sort Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia
author Castro, L.
author_facet Castro, L.
Varjão, B.
Silva, I.
Duque, Bruno
Batista, A.
Santana, R.
Luz, P.
Rocha Junior, M. A.
Fregoneze, J. B.
Castro e Silva, E. de
author_role author
author2 Varjão, B.
Silva, I.
Duque, Bruno
Batista, A.
Santana, R.
Luz, P.
Rocha Junior, M. A.
Fregoneze, J. B.
Castro e Silva, E. de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, L.
Varjão, B.
Silva, I.
Duque, Bruno
Batista, A.
Santana, R.
Luz, P.
Rocha Junior, M. A.
Fregoneze, J. B.
Castro e Silva, E. de
Castro, L.
Varjão, B.
Silva, I.
Duque, Bruno
Batista, A.
Santana, R.
Luz, P.
Rocha Junior, M. A.
Fregoneze, J. B.
Castro e Silva, E. de
dc.subject.por.fl_str_mv 5-HT4 receptors
Water intake
Hyperosmolarity
Hypovolemia
topic 5-HT4 receptors
Water intake
Hyperosmolarity
Hypovolemia
description p.791-796
publishDate 2001
dc.date.issued.fl_str_mv 2001-06
dc.date.accessioned.fl_str_mv 2012-09-28T20:31:18Z
dc.date.available.fl_str_mv 2012-09-28T20:31:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6828
dc.identifier.issn.none.fl_str_mv 1414-431X
dc.identifier.number.pt_BR.fl_str_mv v. 34, n. 6
identifier_str_mv 1414-431X
v. 34, n. 6
url http://www.repositorio.ufba.br/ri/handle/ri/6828
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2001000600015
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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