Treatment effect on temperament and character in panic disorder: a prospective randomized double-blind study

Detalhes bibliográficos
Autor(a) principal: Mochcovitch,Marina Dyskant
Data de Publicação: 2015
Outros Autores: Baczynski,Tathiana P., Silva,Adriana Cardoso de Oliveira e, Nardi,Antonio E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: MedicalExpress (São Paulo. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292015000300003
Resumo: OBJECTIVE: The present study aims to analyze the effect of pharmacological treatment for panic disorder on temperament and character dimensions and to compare the effect of imipramine and fluoxetine on this outcome. METHOD: Temperament and character dimensions were evaluated in panic disorder patients before and after six months of pharmacological treatment with imipramine and fluoxetine, using the Temperament and Character Inventory-Revised. Patients were randomized between groups and both (patient and investigators) were blinded to the intervention drug. Furthermore, 34 non-panic controls answered the revised Temperament and Character Inventory through an Internet survey. RESULTS: Panic disorder patients showed higher scores for Harm Avoidance and lower scores for Persistence, Self-Directedness, and Cooperativeness than controls at baseline, but only the low Persistence value remained different from controls after treatment. Responder patients presented significant reduction in Harm Avoidance scores and a significant increase in Self-Directedness scores, whereas non-responders showed a significant increase of Harm Avoidance levels. Fluoxetine and Imipramine showed similar effects on the revised Temperament and Character Inventory dimensions. CONCLUSION: High Harm Avoidance and low Self-Directedness, Persistence, and Cooperativeness are associated with panic disorder. Treatment of acute panic disorder symptoms lead to the reduction of Harm Avoidance and to an increase in Self-Directedness scores. However, there was no difference between treatment with fluoxetine and imipramine for the effect on the revised Temperament and Character Inventory dimensions.
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spelling Treatment effect on temperament and character in panic disorder: a prospective randomized double-blind studyPanic disorderTemperamentCharacterImipramineFluoxetine OBJECTIVE: The present study aims to analyze the effect of pharmacological treatment for panic disorder on temperament and character dimensions and to compare the effect of imipramine and fluoxetine on this outcome. METHOD: Temperament and character dimensions were evaluated in panic disorder patients before and after six months of pharmacological treatment with imipramine and fluoxetine, using the Temperament and Character Inventory-Revised. Patients were randomized between groups and both (patient and investigators) were blinded to the intervention drug. Furthermore, 34 non-panic controls answered the revised Temperament and Character Inventory through an Internet survey. RESULTS: Panic disorder patients showed higher scores for Harm Avoidance and lower scores for Persistence, Self-Directedness, and Cooperativeness than controls at baseline, but only the low Persistence value remained different from controls after treatment. Responder patients presented significant reduction in Harm Avoidance scores and a significant increase in Self-Directedness scores, whereas non-responders showed a significant increase of Harm Avoidance levels. Fluoxetine and Imipramine showed similar effects on the revised Temperament and Character Inventory dimensions. CONCLUSION: High Harm Avoidance and low Self-Directedness, Persistence, and Cooperativeness are associated with panic disorder. Treatment of acute panic disorder symptoms lead to the reduction of Harm Avoidance and to an increase in Self-Directedness scores. However, there was no difference between treatment with fluoxetine and imipramine for the effect on the revised Temperament and Character Inventory dimensions.Mavera Edições Técnicas e Científicas Ltda2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292015000300003MedicalExpress v.2 n.3 2015reponame:MedicalExpress (São Paulo. Online)instname:Mavera Edições Científicas e Técnicas Ltda-MEinstacron:METC10.5935/MedicalExpress.2015.03.03info:eu-repo/semantics/openAccessMochcovitch,Marina DyskantBaczynski,Tathiana P.Silva,Adriana Cardoso de Oliveira eNardi,Antonio E.eng2016-03-11T00:00:00Zoai:scielo:S2358-04292015000300003Revistahttp://www.medicalexpress.net.brhttps://old.scielo.br/oai/scielo-oai.php||medicalexpress@me.net.br2358-04292318-8111opendoar:2016-03-11T00:00MedicalExpress (São Paulo. Online) - Mavera Edições Científicas e Técnicas Ltda-MEfalse
dc.title.none.fl_str_mv Treatment effect on temperament and character in panic disorder: a prospective randomized double-blind study
title Treatment effect on temperament and character in panic disorder: a prospective randomized double-blind study
spellingShingle Treatment effect on temperament and character in panic disorder: a prospective randomized double-blind study
Mochcovitch,Marina Dyskant
Panic disorder
Temperament
Character
Imipramine
Fluoxetine
title_short Treatment effect on temperament and character in panic disorder: a prospective randomized double-blind study
title_full Treatment effect on temperament and character in panic disorder: a prospective randomized double-blind study
title_fullStr Treatment effect on temperament and character in panic disorder: a prospective randomized double-blind study
title_full_unstemmed Treatment effect on temperament and character in panic disorder: a prospective randomized double-blind study
title_sort Treatment effect on temperament and character in panic disorder: a prospective randomized double-blind study
author Mochcovitch,Marina Dyskant
author_facet Mochcovitch,Marina Dyskant
Baczynski,Tathiana P.
Silva,Adriana Cardoso de Oliveira e
Nardi,Antonio E.
author_role author
author2 Baczynski,Tathiana P.
Silva,Adriana Cardoso de Oliveira e
Nardi,Antonio E.
author2_role author
author
author
dc.contributor.author.fl_str_mv Mochcovitch,Marina Dyskant
Baczynski,Tathiana P.
Silva,Adriana Cardoso de Oliveira e
Nardi,Antonio E.
dc.subject.por.fl_str_mv Panic disorder
Temperament
Character
Imipramine
Fluoxetine
topic Panic disorder
Temperament
Character
Imipramine
Fluoxetine
description OBJECTIVE: The present study aims to analyze the effect of pharmacological treatment for panic disorder on temperament and character dimensions and to compare the effect of imipramine and fluoxetine on this outcome. METHOD: Temperament and character dimensions were evaluated in panic disorder patients before and after six months of pharmacological treatment with imipramine and fluoxetine, using the Temperament and Character Inventory-Revised. Patients were randomized between groups and both (patient and investigators) were blinded to the intervention drug. Furthermore, 34 non-panic controls answered the revised Temperament and Character Inventory through an Internet survey. RESULTS: Panic disorder patients showed higher scores for Harm Avoidance and lower scores for Persistence, Self-Directedness, and Cooperativeness than controls at baseline, but only the low Persistence value remained different from controls after treatment. Responder patients presented significant reduction in Harm Avoidance scores and a significant increase in Self-Directedness scores, whereas non-responders showed a significant increase of Harm Avoidance levels. Fluoxetine and Imipramine showed similar effects on the revised Temperament and Character Inventory dimensions. CONCLUSION: High Harm Avoidance and low Self-Directedness, Persistence, and Cooperativeness are associated with panic disorder. Treatment of acute panic disorder symptoms lead to the reduction of Harm Avoidance and to an increase in Self-Directedness scores. However, there was no difference between treatment with fluoxetine and imipramine for the effect on the revised Temperament and Character Inventory dimensions.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.5935/MedicalExpress.2015.03.03
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dc.publisher.none.fl_str_mv Mavera Edições Técnicas e Científicas Ltda
publisher.none.fl_str_mv Mavera Edições Técnicas e Científicas Ltda
dc.source.none.fl_str_mv MedicalExpress v.2 n.3 2015
reponame:MedicalExpress (São Paulo. Online)
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