Estudo do sono, função pulmonar, força muscular ventilatória e validação de dois instrumentos de evolução clínica de pacientes com miastenia gravis: quantitative myasthenia gravis score e MG Composite Scale

• Autor(a) principal: Oliveira, Ezequiel Fernandes de
• Data de Publicação: 2017
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da Uninove
• Texto Completo: http://bibliotecatede.uninove.br/handle/tede/1903
• topic: miastenia gravis; sono; função pulmonar; qualidade de vida; validação de escalas; myasthenia gravis; sleep; pulmonary function; quality of life; validation of scales; CIENCIAS DA SAUDE

Introduction: Our hypothesis is that patients with MG present a poor sleep due to the presence of respiratory disorders, compromised by the weakness of the ventilatory muscles, causing worsening of the clinical condition and quality of life. Objectives: To investigate the physiological pattern of sleep through polysomnography, to verify pulmonary function and ventilatory muscle strength through spirometry and manovacuometry, and to perform the translation, cultural adaptation and validation of two specific scales to evaluate the clinical evolution of patients with MG, denominated "Quantitative Test for Myasthenia Gravis" and "Composite Scale for Myasthenia Gravis". Material and methods: This is a cross-sectional study involving patients with MG. Clinical evaluations were performed at the UNINOVE Sleep Laboratory, at the Neuromuscular Diseases Research Unit at UNIFESP, at the Santa Casa de São Paulo Department of Neurology and at the Department of Neurology at the Hospital do Servidor Público Estadual of São Paulo. Results: The results of this thesis are separated into three studies. Study I: article entitled "Sleep, lung function and quality of life in patients with Myasthenia gravis: A cross-sectional study" published in the journal Neuromuscular Disorders. Study II: entitled "Brazilian- Portuguese translation, cross-cultural adaptation and validation of the Myasthenia Gravis Composite scale. A multicentric study." published in the journal Arquivos de Neuropsiquiatria. Study III: entitled "Quantitative Myasthenia gravis Score: a Brazilian multicenter study for translation, cultural adaptation and validation", published in the journal Arquivos de Neuropsiquiatria. Conclusion: Patients with MG presented a considerable presence of DRS with worsening quality of life. They presented reduced values in the maximum ventilatory pressures associated with normal values of pulmonary function. The translation and validation of the scales were performed successfully and we believe that the use of our Portuguese version from Brazil will assist in the care of patients with MG, including a more accurate monitoring of the clinical rehabilitation process.