Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/1311 |
Resumo: | The bone defects are caused by several factors and the repair process can be slow, where inflammatory and proliferative phases of remodeling of this tissue are extremely important for the quality of the repair. There are several therapies where the main is the surgery and in this case, the use of bone substitutes can be indicated. However the repair process may require assistance. Thus, the use of activated charcoal as bone substitute when the implementation of low-power laser to aid bone repair can be an alternative to these problems. The aim of this study was to verify the use of activated carbon as bone substitute and the interaction with the laser in the process of bone repair in rat tibias, assessing biochemical, histological and biomechanical changes. Material and methods: male wistar rats, 35 were used between 150 g to 200 g, with 3 months of age. The animals were anesthetized with ketamine hydrochloride and Association (90mg/Kg and 10mg/Kg, IP). Once anesthetized, the animals were put on surgical table, the skin was dissected and were made monocortical bone defects in the central region of the right tibia of mice. Immediately after surgery the rats were randomized and divided into the following groups: control (CTL), untreated Injury (NT), Lesion treated with activated carbon (CA), Lesion treated with association of activated carbon and laser 830nm, 6J-100mW (CA+L) and injury treated with Hydroxyapatite (HA). After 28 days the animals were euthanized with overdose of the same anesthetic, blood was collected and the tibia was taken for biochemical, histological and biomechanical analysis. Results: the NT group reduction in bending forces and histological changes related to disorganization of the tissue. The groups showed no CA+L and HA improves mechanical properties, however, the CA+L group presented histological aspects of improvement. Only the CA group presented better flexion forces, related with improvement of histological aspects and reduced levels of alkaline phosphatase. The NT groups, CA+L and HA presented high alkaline phosphatase levels. Conclusion: the use of activated carbon seems to improve the bone repair induced in this study. The laser association with activated carbon showed no improvement of biomechanical properties in spite of the histological results have a better aspect. |
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Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Marcos, Rodrigo Labathttp://lattes.cnpq.br/2964112163504080Casarotto, Raquel Aparecidahttp://lattes.cnpq.br/7166781592793122Oliveira, Marcelo Tavares dehttp://lattes.cnpq.br/0262402232086674http://lattes.cnpq.br/0079193968489021Sampaio, Alexandre Botelho de Abreu2016-05-19T14:48:16Z2014-12-17Sampaio, Alexandre Botelho de Abreu. Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos. 2014. 70 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1311The bone defects are caused by several factors and the repair process can be slow, where inflammatory and proliferative phases of remodeling of this tissue are extremely important for the quality of the repair. There are several therapies where the main is the surgery and in this case, the use of bone substitutes can be indicated. However the repair process may require assistance. Thus, the use of activated charcoal as bone substitute when the implementation of low-power laser to aid bone repair can be an alternative to these problems. The aim of this study was to verify the use of activated carbon as bone substitute and the interaction with the laser in the process of bone repair in rat tibias, assessing biochemical, histological and biomechanical changes. Material and methods: male wistar rats, 35 were used between 150 g to 200 g, with 3 months of age. The animals were anesthetized with ketamine hydrochloride and Association (90mg/Kg and 10mg/Kg, IP). Once anesthetized, the animals were put on surgical table, the skin was dissected and were made monocortical bone defects in the central region of the right tibia of mice. Immediately after surgery the rats were randomized and divided into the following groups: control (CTL), untreated Injury (NT), Lesion treated with activated carbon (CA), Lesion treated with association of activated carbon and laser 830nm, 6J-100mW (CA+L) and injury treated with Hydroxyapatite (HA). After 28 days the animals were euthanized with overdose of the same anesthetic, blood was collected and the tibia was taken for biochemical, histological and biomechanical analysis. Results: the NT group reduction in bending forces and histological changes related to disorganization of the tissue. The groups showed no CA+L and HA improves mechanical properties, however, the CA+L group presented histological aspects of improvement. Only the CA group presented better flexion forces, related with improvement of histological aspects and reduced levels of alkaline phosphatase. The NT groups, CA+L and HA presented high alkaline phosphatase levels. Conclusion: the use of activated carbon seems to improve the bone repair induced in this study. The laser association with activated carbon showed no improvement of biomechanical properties in spite of the histological results have a better aspect.Os defeitos ??sseos s??o causados por diversos fatores e o processo de reparo pode ser lento, onde as fases inflamat??ria, proliferativa e de remodela????o deste tecido s??o extremamente importantes para a qualidade do reparo. Existem diversas terapias onde a principal ?? a cir??rgica e neste caso, o uso de substitutos ??sseos pode ser indicado. No entanto o processo de reparo pode necessitar de auxilio. Assim, a utiliza????o do carv??o ativado como substituto ??sseo quando a aplica????o do laser de baixa pot??ncia para auxilio do reparo ??sseo pode ser uma alternativa para estes problemas. O objetivo deste trabalho foi verificar a utiliza????o do carv??o ativado como substituto ??sseo e a intera????o deste com a laserterapia, no processo de reparo ??sseo em t??bias de ratos, avaliando altera????es histol??gicas, bioqu??micas e biomec??nicas. Material e M??todos: Foram utilizados 35 ratos wistar, entre 150g ?? 200g, com 3 meses de idade. Os animais foram anestesiados com associa????o de cloridrato de quetamina e (90mg/Kg e 10mg/Kg, IP). Depois de anestesiados, os animais foram colocados em mesa cir??rgica, a pele foi dissecada e foram confeccionados defeitos ??sseos monocorticais na regi??o central da t??bia direita dos ratos. Imediatamente ap??s a cirurgia os ratos foram randomizados e divididos nos seguintes grupos: Controle (CTL), Les??o n??o tratado (NT), Les??o tratado com carv??o ativado (CA), Les??o tratado com associa????o do carv??o ativo e laser 830nm, 6J ??? 100mW (CA+L) e les??o tratado com Hidroxiapatita (HA). Ap??s 28 dias os animais foram eutanasiados com hiperdosagem do mesmo anest??sico, o sangue foi coletado e a t??bia foi retirada para an??lises histol??gicas, bioqu??micas e biomec??nicas. Resultados: O grupo NT apresentou redu????o nas for??as de flex??o e altera????es histol??gicas relacionadas a desorganiza????o do tecido. Os grupos HA e CA+L n??o apresentaram melhora das propriedades mec??nicas, por??m, o grupo CA+L apresentou melhora dos aspectos histol??gicos. Somente o grupo CA apresentou melhora das for??as de flex??o, relacionado com melhora dos aspectos histol??gicos e redu????o dos n??veis de fosfatase alcalina. Os grupos NT, CA+L e HA apresentaram n??veis de fosfatase alcalina elevados. Conclus??o: A utiliza????o de carv??o ativado parece melhorar o reparo ??sseo induzido neste estudo. A associa????o do laser com o carv??o ativado n??o apresentou melhora das propriedades biomec??nicas apesar dos resultados histol??gicos apresentarem um aspecto melhor.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2016-05-19T14:48:16Z No. of bitstreams: 1 Alexandre Botelho de Abreu Sampaio.pdf: 1511081 bytes, checksum: 0c16332d21fef3838342a4bf3977e18e (MD5)Made available in DSpace on 2016-05-19T14:48:16Z (GMT). No. of bitstreams: 1 Alexandre Botelho de Abreu Sampaio.pdf: 1511081 bytes, checksum: 0c16332d21fef3838342a4bf3977e18e (MD5) Previous issue date: 2014-12-17application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??deUNINOVEBrasilSa??dereparo ??sseolaser de baixa pot??nciacarv??o ativadopropriedades mec??nicasbone repairlow-level laseractivated carbonmechanical propertiesCIENCIAS DA SAUDEEfeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratosEffect of low level laser associated with activated carbon in bone repair of ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALAlexandre Botelho de Abreu Sampaio.pdfAlexandre Botelho de Abreu Sampaio.pdfapplication/pdf1511081http://localhost:8080/tede/bitstream/tede/1311/2/Alexandre+Botelho+de+Abreu+Sampaio.pdf0c16332d21fef3838342a4bf3977e18eMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/1311/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/13112016-05-19 11:48:16.488oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2016-05-19T14:48:16Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos |
dc.title.alternative.eng.fl_str_mv |
Effect of low level laser associated with activated carbon in bone repair of rats |
title |
Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos |
spellingShingle |
Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos Sampaio, Alexandre Botelho de Abreu reparo ??sseo laser de baixa pot??ncia carv??o ativado propriedades mec??nicas bone repair low-level laser activated carbon mechanical properties CIENCIAS DA SAUDE |
title_short |
Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos |
title_full |
Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos |
title_fullStr |
Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos |
title_full_unstemmed |
Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos |
title_sort |
Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos |
author |
Sampaio, Alexandre Botelho de Abreu |
author_facet |
Sampaio, Alexandre Botelho de Abreu |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Marcos, Rodrigo Labat |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/2964112163504080 |
dc.contributor.referee1.fl_str_mv |
Marcos, Rodrigo Labat |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2964112163504080 |
dc.contributor.referee2.fl_str_mv |
Casarotto, Raquel Aparecida |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/7166781592793122 |
dc.contributor.referee3.fl_str_mv |
Oliveira, Marcelo Tavares de |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/0262402232086674 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0079193968489021 |
dc.contributor.author.fl_str_mv |
Sampaio, Alexandre Botelho de Abreu |
contributor_str_mv |
Marcos, Rodrigo Labat Marcos, Rodrigo Labat Casarotto, Raquel Aparecida Oliveira, Marcelo Tavares de |
dc.subject.por.fl_str_mv |
reparo ??sseo laser de baixa pot??ncia carv??o ativado propriedades mec??nicas |
topic |
reparo ??sseo laser de baixa pot??ncia carv??o ativado propriedades mec??nicas bone repair low-level laser activated carbon mechanical properties CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
bone repair low-level laser activated carbon mechanical properties |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
The bone defects are caused by several factors and the repair process can be slow, where inflammatory and proliferative phases of remodeling of this tissue are extremely important for the quality of the repair. There are several therapies where the main is the surgery and in this case, the use of bone substitutes can be indicated. However the repair process may require assistance. Thus, the use of activated charcoal as bone substitute when the implementation of low-power laser to aid bone repair can be an alternative to these problems. The aim of this study was to verify the use of activated carbon as bone substitute and the interaction with the laser in the process of bone repair in rat tibias, assessing biochemical, histological and biomechanical changes. Material and methods: male wistar rats, 35 were used between 150 g to 200 g, with 3 months of age. The animals were anesthetized with ketamine hydrochloride and Association (90mg/Kg and 10mg/Kg, IP). Once anesthetized, the animals were put on surgical table, the skin was dissected and were made monocortical bone defects in the central region of the right tibia of mice. Immediately after surgery the rats were randomized and divided into the following groups: control (CTL), untreated Injury (NT), Lesion treated with activated carbon (CA), Lesion treated with association of activated carbon and laser 830nm, 6J-100mW (CA+L) and injury treated with Hydroxyapatite (HA). After 28 days the animals were euthanized with overdose of the same anesthetic, blood was collected and the tibia was taken for biochemical, histological and biomechanical analysis. Results: the NT group reduction in bending forces and histological changes related to disorganization of the tissue. The groups showed no CA+L and HA improves mechanical properties, however, the CA+L group presented histological aspects of improvement. Only the CA group presented better flexion forces, related with improvement of histological aspects and reduced levels of alkaline phosphatase. The NT groups, CA+L and HA presented high alkaline phosphatase levels. Conclusion: the use of activated carbon seems to improve the bone repair induced in this study. The laser association with activated carbon showed no improvement of biomechanical properties in spite of the histological results have a better aspect. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-12-17 |
dc.date.accessioned.fl_str_mv |
2016-05-19T14:48:16Z |
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info:eu-repo/semantics/publishedVersion |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Sampaio, Alexandre Botelho de Abreu. Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos. 2014. 70 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1311 |
identifier_str_mv |
Sampaio, Alexandre Botelho de Abreu. Efeito do laser de baixa pot??ncia associado ao uso de carv??o ativado no processo de reparo ??sseo em t??bia de ratos. 2014. 70 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo. |
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http://bibliotecatede.uninove.br/handle/tede/1311 |
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