Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/1784 |
Resumo: | Currently, chronic obstructive pulmonary disease (COPD) has an impact on morbidity and mortality throughout the world with high prevalence and a high economic and social cost. It is characterized by slow and progressive airflow limitation, triggered by the inhalation of harmful particles present in cigarette smoke. In this context, several experimental models have been proposed, aiming at the discovery of new therapeutic options. In this regard, low-power laser therapy (LBP) is a relatively new and effective therapy for very low cost, no side effects and possible use in the treatment of chronic pulmonary diseases. In the present study we study some parameters in animals with COPD undergoing therapy diode laser (660 nm), 30 mW, 60 s per point (3 points per application) for 15 days prior to euthanasia. The protocol used for COPD induction consisted of nebulized female C57BL / 6 with cigarette smoke for 75 days (2 times / day). On the day 76, the animals were anesthetized, tracheotomy, canulated and bronchoalveolar lavage (BAL) was collected. Structural and functional parameters were studied, the total and differential counts of cells recovered from BAL fluid, cytokine levels (IL-1??? , IL-6, IL-10, IL-17, TNF-??? and CXCL1/KC) as well as the accumulation of mucus and collagen. It also performed lung histology to quantify the number of lymphocytes in the airway, and bronchial remodeling. Moreover, we will evaluate the expression of the purinergic receptors P2Y2 and P2X7 in the homogenate of lung tissue by Western Blotting technique. The results showed that LLLT significantly reduced the number of total cells in the bronchoalveolar (BAL), the levels of cytokines IL-6, IL-1??, IL-17, TNF-?? and CXCL1/KC, mucus production and collagen, cell death, alveolar enlargement, as well as the expression purinergic P2X7 and increased cytokine anti-inflammatory (IL???10). Therefore,we suggested that the laser 808nm is effective to reduce lung inflammation in an experimental model of chronic obstructive pulmonary disease (COPD). |
id |
NOVE_d9552b44bdb5d220f0f5ef528f2e3314 |
---|---|
oai_identifier_str |
oai:localhost:tede/1784 |
network_acronym_str |
NOVE |
network_name_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
repository_id_str |
|
spelling |
Oliveira, Ana Paula Ligeiro deVieira, Rodolfo de PaulaOliveira, Ana Paula Ligeiro deVieira, Rodolfo de PaulaRomanholo, Beatriz Mangueira Saraivahttp://lattes.cnpq.br/5498099541360496Moraes, Gabriel de Assis Cunha2018-06-15T14:33:13Z2016-02-23Moraes, Gabriel de Assis Cunha. Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica. 2016. 33 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo.http://bibliotecatede.uninove.br/handle/tede/1784Currently, chronic obstructive pulmonary disease (COPD) has an impact on morbidity and mortality throughout the world with high prevalence and a high economic and social cost. It is characterized by slow and progressive airflow limitation, triggered by the inhalation of harmful particles present in cigarette smoke. In this context, several experimental models have been proposed, aiming at the discovery of new therapeutic options. In this regard, low-power laser therapy (LBP) is a relatively new and effective therapy for very low cost, no side effects and possible use in the treatment of chronic pulmonary diseases. In the present study we study some parameters in animals with COPD undergoing therapy diode laser (660 nm), 30 mW, 60 s per point (3 points per application) for 15 days prior to euthanasia. The protocol used for COPD induction consisted of nebulized female C57BL / 6 with cigarette smoke for 75 days (2 times / day). On the day 76, the animals were anesthetized, tracheotomy, canulated and bronchoalveolar lavage (BAL) was collected. Structural and functional parameters were studied, the total and differential counts of cells recovered from BAL fluid, cytokine levels (IL-1??? , IL-6, IL-10, IL-17, TNF-??? and CXCL1/KC) as well as the accumulation of mucus and collagen. It also performed lung histology to quantify the number of lymphocytes in the airway, and bronchial remodeling. Moreover, we will evaluate the expression of the purinergic receptors P2Y2 and P2X7 in the homogenate of lung tissue by Western Blotting technique. The results showed that LLLT significantly reduced the number of total cells in the bronchoalveolar (BAL), the levels of cytokines IL-6, IL-1??, IL-17, TNF-?? and CXCL1/KC, mucus production and collagen, cell death, alveolar enlargement, as well as the expression purinergic P2X7 and increased cytokine anti-inflammatory (IL???10). Therefore,we suggested that the laser 808nm is effective to reduce lung inflammation in an experimental model of chronic obstructive pulmonary disease (COPD).Atualmente a Doen??a Pulmonar Obstrutiva Cr??nica (DPOC)apresenta impacto em morbidade e mortalidade em todo o mundo,com alta preval??ncia e um elevado custo econ??mico e social. Ela ?? caracterizada por limita????o lenta e progressiva do fluxo a??reo, desencadeado pela inala????o de part??culas nocivas presente na fuma??a do cigarro. Neste contexto, v??rios modelos experimentais t??m sido propostos, objetivando a descoberta de novas op????es terap??uticas. Neste sentido, a terapia com Laser de Baixa Pot??ncia (LBP) ?? uma terapia relativamente nova e eficaz, de baix??ssimo custo, sem efeitos colaterais e de poss??vel utiliza????o no tratamento das doen??as cr??nicas pulmonares. No presente estudo estudamos alguns par??metros em animais com DPOC submetidos ?? terapia com laser de diodo (808nm), 30 mW, 60s por ponto (3 pontos por aplica????o) por 15 dias antes da eutan??sia. O protocolo utilizado para a indu????o da DPOC consistiu em nebulizar camundongos f??meas C57BL/6 com fuma??a de cigarro por 75 dias (2 vezes/dia). No dia 76, os animais foram anestesiados, traqueostomizados, canulados e o lavado broncoalveolar (LBA) coletado. Foram estudados par??metros funcionais e estruturais, como contagem total e diferencial de c??lulas recuperadas do LBA, os n??veis de citocinas (IL-1???, IL-6, IL-10, IL-17, TNF-??? e CXCL1/KC) bem como o ac??mulo de muco e col??geno. Foi realizada tamb??m a histologia nos pulm??es para a quantifica????o do n??mero de linf??citos nas vias a??reas, assim como o remodelamento br??nquico. Al??m disso, avaliamos a express??o dos receptores purin??rgicos P2X7 e P2Y2 no homogenato do tecido pulmonar por meio da t??cnica de Western Blotting.Os nossos resultados mostraram que a terapia com laser de baixa pot??ncia em um modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC), diminuiu o n??mero de c??lulas no LBA, a produ????o de citocinas pr??-inflamat??rias (IL-1??, TNF-??, IL-6, IL-17), quimiocina (CXCL1/KC), produ????o de muco e col??geno, morte celular, alargamento alveolar, bem como a diminui????o da express??o do receptor purin??rgico P2X7 e tamb??m aumento da citocina anti-inflamat??ria (IL-10). Portanto, sugerimos que o laser 808nm ?? eficaz para reduzir a inflama????o pulmonar em modelo experimental de doen??a pulmonar obstrutiva cr??nica (DPOC).Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-06-15T14:33:13Z No. of bitstreams: 1 Gabriel de Assis Cunha Moraes.pdf: 731214 bytes, checksum: b44750e89f86da0b9dbb4c3f5e30fbca (MD5)Made available in DSpace on 2018-06-15T14:33:13Z (GMT). No. of bitstreams: 1 Gabriel de Assis Cunha Moraes.pdf: 731214 bytes, checksum: b44750e89f86da0b9dbb4c3f5e30fbca (MD5) Previous issue date: 2016-02-23application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??deUNINOVEBrasilSa??dedoen??a pulmonar obstrutiva cr??nicalaser de baixa intensidadeinflama????o pulmonarchronic obstructive pulmonary diseaselow level laserlung inflammationCIENCIAS DA SAUDEEfeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgicaLow level laser therapy effect in a COPD model: the purinergic pathway roleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALGabriel de Assis Cunha Moraes.pdfGabriel de Assis Cunha Moraes.pdfapplication/pdf731214http://localhost:8080/tede/bitstream/tede/1784/2/Gabriel+de+Assis+Cunha+Moraes.pdfb44750e89f86da0b9dbb4c3f5e30fbcaMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/tede/1784/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/17842018-06-15 11:33:13.222oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2018-06-15T14:33:13Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica |
dc.title.alternative.eng.fl_str_mv |
Low level laser therapy effect in a COPD model: the purinergic pathway role |
title |
Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica |
spellingShingle |
Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica Moraes, Gabriel de Assis Cunha doen??a pulmonar obstrutiva cr??nica laser de baixa intensidade inflama????o pulmonar chronic obstructive pulmonary disease low level laser lung inflammation CIENCIAS DA SAUDE |
title_short |
Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica |
title_full |
Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica |
title_fullStr |
Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica |
title_full_unstemmed |
Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica |
title_sort |
Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica |
author |
Moraes, Gabriel de Assis Cunha |
author_facet |
Moraes, Gabriel de Assis Cunha |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Oliveira, Ana Paula Ligeiro de |
dc.contributor.advisor-co1.fl_str_mv |
Vieira, Rodolfo de Paula |
dc.contributor.referee1.fl_str_mv |
Oliveira, Ana Paula Ligeiro de |
dc.contributor.referee2.fl_str_mv |
Vieira, Rodolfo de Paula |
dc.contributor.referee3.fl_str_mv |
Romanholo, Beatriz Mangueira Saraiva |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5498099541360496 |
dc.contributor.author.fl_str_mv |
Moraes, Gabriel de Assis Cunha |
contributor_str_mv |
Oliveira, Ana Paula Ligeiro de Vieira, Rodolfo de Paula Oliveira, Ana Paula Ligeiro de Vieira, Rodolfo de Paula Romanholo, Beatriz Mangueira Saraiva |
dc.subject.por.fl_str_mv |
doen??a pulmonar obstrutiva cr??nica laser de baixa intensidade inflama????o pulmonar |
topic |
doen??a pulmonar obstrutiva cr??nica laser de baixa intensidade inflama????o pulmonar chronic obstructive pulmonary disease low level laser lung inflammation CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
chronic obstructive pulmonary disease low level laser lung inflammation |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Currently, chronic obstructive pulmonary disease (COPD) has an impact on morbidity and mortality throughout the world with high prevalence and a high economic and social cost. It is characterized by slow and progressive airflow limitation, triggered by the inhalation of harmful particles present in cigarette smoke. In this context, several experimental models have been proposed, aiming at the discovery of new therapeutic options. In this regard, low-power laser therapy (LBP) is a relatively new and effective therapy for very low cost, no side effects and possible use in the treatment of chronic pulmonary diseases. In the present study we study some parameters in animals with COPD undergoing therapy diode laser (660 nm), 30 mW, 60 s per point (3 points per application) for 15 days prior to euthanasia. The protocol used for COPD induction consisted of nebulized female C57BL / 6 with cigarette smoke for 75 days (2 times / day). On the day 76, the animals were anesthetized, tracheotomy, canulated and bronchoalveolar lavage (BAL) was collected. Structural and functional parameters were studied, the total and differential counts of cells recovered from BAL fluid, cytokine levels (IL-1??? , IL-6, IL-10, IL-17, TNF-??? and CXCL1/KC) as well as the accumulation of mucus and collagen. It also performed lung histology to quantify the number of lymphocytes in the airway, and bronchial remodeling. Moreover, we will evaluate the expression of the purinergic receptors P2Y2 and P2X7 in the homogenate of lung tissue by Western Blotting technique. The results showed that LLLT significantly reduced the number of total cells in the bronchoalveolar (BAL), the levels of cytokines IL-6, IL-1??, IL-17, TNF-?? and CXCL1/KC, mucus production and collagen, cell death, alveolar enlargement, as well as the expression purinergic P2X7 and increased cytokine anti-inflammatory (IL???10). Therefore,we suggested that the laser 808nm is effective to reduce lung inflammation in an experimental model of chronic obstructive pulmonary disease (COPD). |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-02-23 |
dc.date.accessioned.fl_str_mv |
2018-06-15T14:33:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Moraes, Gabriel de Assis Cunha. Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica. 2016. 33 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo. |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1784 |
identifier_str_mv |
Moraes, Gabriel de Assis Cunha. Efeito da terapia com Laser de Baixa Pot??ncia (LBP) em modelo experimental de Doen??a Pulmonar Obstrutiva Cr??nica (DPOC): participa????o da via purin??rgica. 2016. 33 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo. |
url |
http://bibliotecatede.uninove.br/handle/tede/1784 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
8765449414823306929 |
dc.relation.confidence.fl_str_mv |
600 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.publisher.program.fl_str_mv |
Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de |
dc.publisher.initials.fl_str_mv |
UNINOVE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Sa??de |
publisher.none.fl_str_mv |
Universidade Nove de Julho |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da Uninove instname:Universidade Nove de Julho (UNINOVE) instacron:UNINOVE |
instname_str |
Universidade Nove de Julho (UNINOVE) |
instacron_str |
UNINOVE |
institution |
UNINOVE |
reponame_str |
Biblioteca Digital de Teses e Dissertações da Uninove |
collection |
Biblioteca Digital de Teses e Dissertações da Uninove |
bitstream.url.fl_str_mv |
http://localhost:8080/tede/bitstream/tede/1784/2/Gabriel+de+Assis+Cunha+Moraes.pdf http://localhost:8080/tede/bitstream/tede/1784/1/license.txt |
bitstream.checksum.fl_str_mv |
b44750e89f86da0b9dbb4c3f5e30fbca bd3efa91386c1718a7f26a329fdcb468 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE) |
repository.mail.fl_str_mv |
bibliotecatede@uninove.br||bibliotecatede@uninove.br |
_version_ |
1811016874228449280 |