Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da Uninove |
Texto Completo: | http://bibliotecatede.uninove.br/handle/tede/1140 |
Resumo: | The tissue repair of diabetics is changed and often inefficient, leading to the post surgical complications, dehiscence and infection. Lasertherapy is a promising tool to assist the closure of these wounds, but the lack of standardization of dosimetry, energy delivery systems and lack of understanding of the cellular and molecular mechanisms of action limited the spread of its use. Thus, the objective of this work is to evaluate the tissue repair of cutaneous lesions of diabetic animals subjected to two schemes of laser light delivery, namely: single dose and dose fractionation. 54 Wistar rats were used (Rattus novergicus albinus) with diabetes induced by intraperitoneal injection of Streptozotocina (50 mg/kg). The ulcer was held with punch of 8 mm on the back of the animal after shaving. Experimental groups: (1) control group (GC)-dorsal ulcer is not treatment; (2) single dose (GU)-dorsal ulcer received laser therapy two hours after the completion of the wound; (3) fractionated dose (GF)-dorsal ulcer received lllt in days 1, 3, 8 and 10. The parameters of the laser application on GU group were: ?? = (660 ?? 2) nm, P= 30mW, D = 4 J/cm2, spot area of 0,785 cm2, t = 104 s; and the Group GF were four applications of ?? = (660 ?? 2) nm, P=30 mW, D = 1 J/cm2, spot area of 0,785 cm2, t = 26 s totaling 4 J/cm2. The ulcers were photographed and three animals in each group were submitted to euthanasia, the ulcers were removed, processed routinely for hematoxylin and eosin staining and immunohistochemistry for the detection of neutrophils, lymphocytes, macrophages and activated T cells of the angiogenic lineage. When compared to the control group, the two forms of energy delivery proved effective in the treatment of cutaneous lesions in experimental models used. The single-dose group showed the highest acceleration in immune system activation and faster wound healing, but with greater intensity of collagen deposition causing fibrosis. The fractional dose group showed from the start trend of modulated inflammatory response, without peaks and the healing occurred more slowly, however collagen deposition was lower providing a scar with higher quality. |
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Fran??a, Cristiane Mirandahttp://lattes.cnpq.br/3818545357716126Nunez, Silvia Cristinahttp://lattes.cnpq.br/8874666790779781Carvalho, Paulo de Tarso Camilo de25619820840http://lattes.cnpq.br/4525819343222992Santana, Cristiano de Loura2015-07-21T15:19:55Z2013-12-11Santana, Cristiano de Loura. Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio. 2013. 67 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo .http://bibliotecatede.uninove.br/handle/tede/1140The tissue repair of diabetics is changed and often inefficient, leading to the post surgical complications, dehiscence and infection. Lasertherapy is a promising tool to assist the closure of these wounds, but the lack of standardization of dosimetry, energy delivery systems and lack of understanding of the cellular and molecular mechanisms of action limited the spread of its use. Thus, the objective of this work is to evaluate the tissue repair of cutaneous lesions of diabetic animals subjected to two schemes of laser light delivery, namely: single dose and dose fractionation. 54 Wistar rats were used (Rattus novergicus albinus) with diabetes induced by intraperitoneal injection of Streptozotocina (50 mg/kg). The ulcer was held with punch of 8 mm on the back of the animal after shaving. Experimental groups: (1) control group (GC)-dorsal ulcer is not treatment; (2) single dose (GU)-dorsal ulcer received laser therapy two hours after the completion of the wound; (3) fractionated dose (GF)-dorsal ulcer received lllt in days 1, 3, 8 and 10. The parameters of the laser application on GU group were: ?? = (660 ?? 2) nm, P= 30mW, D = 4 J/cm2, spot area of 0,785 cm2, t = 104 s; and the Group GF were four applications of ?? = (660 ?? 2) nm, P=30 mW, D = 1 J/cm2, spot area of 0,785 cm2, t = 26 s totaling 4 J/cm2. The ulcers were photographed and three animals in each group were submitted to euthanasia, the ulcers were removed, processed routinely for hematoxylin and eosin staining and immunohistochemistry for the detection of neutrophils, lymphocytes, macrophages and activated T cells of the angiogenic lineage. When compared to the control group, the two forms of energy delivery proved effective in the treatment of cutaneous lesions in experimental models used. The single-dose group showed the highest acceleration in immune system activation and faster wound healing, but with greater intensity of collagen deposition causing fibrosis. The fractional dose group showed from the start trend of modulated inflammatory response, without peaks and the healing occurred more slowly, however collagen deposition was lower providing a scar with higher quality.O reparo tecidual dos diab??ticos ?? alterado e muitas vezes ineficiente levando a complica????es p??s-cir??rgicas importantes, como retardo no reparo, deisc??ncia e infec????o. A laserterapia ?? uma ferramenta promissora para auxiliar o fechamento destas feridas, por??m a falta de padroniza????o da dosimetria, dos regimes de entrega de energia e falta de entendimento dos seus mecanismos celulares e moleculares de a????o limitam a dissemina????o do seu uso. Assim, o objetivo deste trabalho ?? avaliar o reparo tecidual de les??es cut??neas de animais diab??ticos submetidos a dois regimes de entrega de luz laser, a saber: dose ??nica e dose fracionada. Foram utilizadas 54 ratas Wistar (Rattus novergicus albinus) com diabetes induzido por inje????o intraperitoneal de Streptozotocina (50mg/kg). A ??lcera foi realizada com punch de 8 mm no dorso do animal ap??s tricotomia. Grupos experimentais: (1) grupo controle (GC) - a ??lcera dorsal n??o foi submetida a tratamento; (2) dose ??nica (GU) - a ??lcera dorsal recebeu laserterapia duas horas ap??s a realiza????o da ferida; (3) dose fracionada (GF) - a ??lcera dorsal recebeu laserterapia nos dias 1, 3, 8 e 10. Os par??metros da aplica????o do laser no grupo GU foram: ?? = (660 ?? 2) nm, P= 30mW, ??rea do feixe: 0,785 cm2, D= 4 J/cm2, t = 104 s; e no grupo GF foram quatro aplica????es de ?? = (660 ?? 2) nm, P= 30mW, D= 1 J/cm2, ??rea: 0,785 cm2, t = 26 s totalizando um tratamento de 4 J/cm2. As ??lceras foram fotografadas e tr??s animais de cada grupo sofreram eutan??sia, as ??lceras foram removidas, processadas rotineiramente para colora????o de hematoxilina e eosina e imunohistoqu??mica para detec????o de neutr??filos, linf??citos, linf??citos T ativados, macr??fagos e c??lulas da linhagem angiog??nica. Quando comparadas ao grupo controle, as duas formas de entrega de energia se mostraram eficazes no tratamento de les??es cut??neas nos modelos experimentais utilizados. O grupo dose ??nica apresentou maior acelera????o na ativa????o do sistema imunol??gico e mais rapidez na cicatriza????o, por??m com maior intensidade de deposi????o de col??geno ocasionando fibrose. O grupo dose fracionada apresentou desde o in??cio tend??ncia de resposta inflamat??ria modulada, sem picos e a cicatriza????o ocorreu de forma mais lenta, no entanto a deposi????o de col??geno foi menor proporcionando uma cicatriz com maior qualidade.Submitted by Nadir Basilio (nadirsb@uninove.br) on 2015-07-21T15:19:55Z No. of bitstreams: 1 Cristiano de Loura Santana.pdf: 1613559 bytes, checksum: 18f6715396567dec3de8eff238c0471b (MD5)Made available in DSpace on 2015-07-21T15:19:55Z (GMT). No. of bitstreams: 1 Cristiano de Loura Santana.pdf: 1613559 bytes, checksum: 18f6715396567dec3de8eff238c0471b (MD5) Previous issue date: 2013-12-11application/pdfporUniversidade Nove de JulhoPrograma de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??deUNINOVEBrasilSa??dediabetes mellitusfot??nicacicatriza????oinflama????oreparodiabetes mellitusphotonicswound healinginflammationrepairCIENCIAS DA SAUDEInflu??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rioinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis8765449414823306929600info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da Uninoveinstname:Universidade Nove de Julho (UNINOVE)instacron:UNINOVEORIGINALCristiano de Loura Santana.pdfCristiano de Loura Santana.pdfapplication/pdf1613559http://localhost:8080/tede/bitstream/tede/1140/2/Cristiano+de+Loura+Santana.pdf18f6715396567dec3de8eff238c0471bMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://localhost:8080/tede/bitstream/tede/1140/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51tede/11402015-07-21 12:19:55.324oai:localhost: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Biblioteca Digital de Teses e Dissertaçõeshttp://bibliotecatede.uninove.br/PRIhttp://bibliotecatede.uninove.br/oai/requestbibliotecatede@uninove.br||bibliotecatede@uninove.bropendoar:2015-07-21T15:19:55Biblioteca Digital de Teses e Dissertações da Uninove - Universidade Nove de Julho (UNINOVE)false |
dc.title.por.fl_str_mv |
Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio |
title |
Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio |
spellingShingle |
Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio Santana, Cristiano de Loura diabetes mellitus fot??nica cicatriza????o inflama????o reparo diabetes mellitus photonics wound healing inflammation repair CIENCIAS DA SAUDE |
title_short |
Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio |
title_full |
Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio |
title_fullStr |
Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio |
title_full_unstemmed |
Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio |
title_sort |
Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio |
author |
Santana, Cristiano de Loura |
author_facet |
Santana, Cristiano de Loura |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Fran??a, Cristiane Miranda |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3818545357716126 |
dc.contributor.referee1.fl_str_mv |
Nunez, Silvia Cristina |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/8874666790779781 |
dc.contributor.referee2.fl_str_mv |
Carvalho, Paulo de Tarso Camilo de |
dc.contributor.authorID.fl_str_mv |
25619820840 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4525819343222992 |
dc.contributor.author.fl_str_mv |
Santana, Cristiano de Loura |
contributor_str_mv |
Fran??a, Cristiane Miranda Nunez, Silvia Cristina Carvalho, Paulo de Tarso Camilo de |
dc.subject.por.fl_str_mv |
diabetes mellitus fot??nica cicatriza????o inflama????o reparo |
topic |
diabetes mellitus fot??nica cicatriza????o inflama????o reparo diabetes mellitus photonics wound healing inflammation repair CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
diabetes mellitus photonics wound healing inflammation repair |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
The tissue repair of diabetics is changed and often inefficient, leading to the post surgical complications, dehiscence and infection. Lasertherapy is a promising tool to assist the closure of these wounds, but the lack of standardization of dosimetry, energy delivery systems and lack of understanding of the cellular and molecular mechanisms of action limited the spread of its use. Thus, the objective of this work is to evaluate the tissue repair of cutaneous lesions of diabetic animals subjected to two schemes of laser light delivery, namely: single dose and dose fractionation. 54 Wistar rats were used (Rattus novergicus albinus) with diabetes induced by intraperitoneal injection of Streptozotocina (50 mg/kg). The ulcer was held with punch of 8 mm on the back of the animal after shaving. Experimental groups: (1) control group (GC)-dorsal ulcer is not treatment; (2) single dose (GU)-dorsal ulcer received laser therapy two hours after the completion of the wound; (3) fractionated dose (GF)-dorsal ulcer received lllt in days 1, 3, 8 and 10. The parameters of the laser application on GU group were: ?? = (660 ?? 2) nm, P= 30mW, D = 4 J/cm2, spot area of 0,785 cm2, t = 104 s; and the Group GF were four applications of ?? = (660 ?? 2) nm, P=30 mW, D = 1 J/cm2, spot area of 0,785 cm2, t = 26 s totaling 4 J/cm2. The ulcers were photographed and three animals in each group were submitted to euthanasia, the ulcers were removed, processed routinely for hematoxylin and eosin staining and immunohistochemistry for the detection of neutrophils, lymphocytes, macrophages and activated T cells of the angiogenic lineage. When compared to the control group, the two forms of energy delivery proved effective in the treatment of cutaneous lesions in experimental models used. The single-dose group showed the highest acceleration in immune system activation and faster wound healing, but with greater intensity of collagen deposition causing fibrosis. The fractional dose group showed from the start trend of modulated inflammatory response, without peaks and the healing occurred more slowly, however collagen deposition was lower providing a scar with higher quality. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-12-11 |
dc.date.accessioned.fl_str_mv |
2015-07-21T15:19:55Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Santana, Cristiano de Loura. Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio. 2013. 67 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo . |
dc.identifier.uri.fl_str_mv |
http://bibliotecatede.uninove.br/handle/tede/1140 |
identifier_str_mv |
Santana, Cristiano de Loura. Influ??ncia de dois regimes de entrega do laser em baixa intensidade no reparo cut??neo de ratos diab??ticos - avalia????o do infiltrado inflamat??rio. 2013. 67 f. Disserta????o( Programa de P??s-Gradua????o em Biofot??nica Aplicada ??s Ci??ncias da Sa??de) - Universidade Nove de Julho, S??o Paulo . |
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http://bibliotecatede.uninove.br/handle/tede/1140 |
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por |
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por |
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