Strain and sex differences in fear conditioning: 22 kHz ultrasonic vocalizations and freezing in rats
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Psychology & Neuroscience (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882009000200015 |
Resumo: | Strain and sex differences in fear conditioning were investigated in two commonly used laboratory rats: Sprague Dawleys and Long-Evans. Twenty-two kHz ultrasonic vocalization (USV) distress calls and freezing behavior were used to measure fear responses to contextual and auditory conditioned stimuli (CSs), which were previously paired with a footshock unconditioned stimulus (US). Both strain and sex had significant effects on USVs and freezing during training and subsequent context and tone tests. Overall, the male Sprague Dawley rats froze and emitted USVs more than the other groups. Additionally, levels of freezing and USVs were differentially influenced by the type of CS (context or tone). These results suggest that species-specific defense responses in laboratory rats are highly influenced by the strain and sex of the subject, and that these factors should be considered in future fear conditioning studies. |
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Strain and sex differences in fear conditioning: 22 kHz ultrasonic vocalizations and freezing in ratsclassical conditioninglearningmemoryamygdalahippocampusStrain and sex differences in fear conditioning were investigated in two commonly used laboratory rats: Sprague Dawleys and Long-Evans. Twenty-two kHz ultrasonic vocalization (USV) distress calls and freezing behavior were used to measure fear responses to contextual and auditory conditioned stimuli (CSs), which were previously paired with a footshock unconditioned stimulus (US). Both strain and sex had significant effects on USVs and freezing during training and subsequent context and tone tests. Overall, the male Sprague Dawley rats froze and emitted USVs more than the other groups. Additionally, levels of freezing and USVs were differentially influenced by the type of CS (context or tone). These results suggest that species-specific defense responses in laboratory rats are highly influenced by the strain and sex of the subject, and that these factors should be considered in future fear conditioning studies.Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882009000200015Psychology & Neuroscience v.2 n.2 2009reponame:Psychology & Neuroscience (Online)instname:Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)instacron:PUCRJ10.3922/j.psns.2009.2.015info:eu-repo/semantics/openAccessGraham,Lauren K.Yoon,TaejibLee,Hongjoo J.Kim,Jeansok J.eng2011-01-17T00:00:00Zoai:scielo:S1983-32882009000200015Revistahttps://www.apa.org/pubs/journals/pnePRIhttps://old.scielo.br/oai/scielo-oai.phppsycneuro@psycneuro.org1983-32881984-3054opendoar:2011-01-17T00:00Psychology & Neuroscience (Online) - Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)false |
dc.title.none.fl_str_mv |
Strain and sex differences in fear conditioning: 22 kHz ultrasonic vocalizations and freezing in rats |
title |
Strain and sex differences in fear conditioning: 22 kHz ultrasonic vocalizations and freezing in rats |
spellingShingle |
Strain and sex differences in fear conditioning: 22 kHz ultrasonic vocalizations and freezing in rats Graham,Lauren K. classical conditioning learning memory amygdala hippocampus |
title_short |
Strain and sex differences in fear conditioning: 22 kHz ultrasonic vocalizations and freezing in rats |
title_full |
Strain and sex differences in fear conditioning: 22 kHz ultrasonic vocalizations and freezing in rats |
title_fullStr |
Strain and sex differences in fear conditioning: 22 kHz ultrasonic vocalizations and freezing in rats |
title_full_unstemmed |
Strain and sex differences in fear conditioning: 22 kHz ultrasonic vocalizations and freezing in rats |
title_sort |
Strain and sex differences in fear conditioning: 22 kHz ultrasonic vocalizations and freezing in rats |
author |
Graham,Lauren K. |
author_facet |
Graham,Lauren K. Yoon,Taejib Lee,Hongjoo J. Kim,Jeansok J. |
author_role |
author |
author2 |
Yoon,Taejib Lee,Hongjoo J. Kim,Jeansok J. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Graham,Lauren K. Yoon,Taejib Lee,Hongjoo J. Kim,Jeansok J. |
dc.subject.por.fl_str_mv |
classical conditioning learning memory amygdala hippocampus |
topic |
classical conditioning learning memory amygdala hippocampus |
description |
Strain and sex differences in fear conditioning were investigated in two commonly used laboratory rats: Sprague Dawleys and Long-Evans. Twenty-two kHz ultrasonic vocalization (USV) distress calls and freezing behavior were used to measure fear responses to contextual and auditory conditioned stimuli (CSs), which were previously paired with a footshock unconditioned stimulus (US). Both strain and sex had significant effects on USVs and freezing during training and subsequent context and tone tests. Overall, the male Sprague Dawley rats froze and emitted USVs more than the other groups. Additionally, levels of freezing and USVs were differentially influenced by the type of CS (context or tone). These results suggest that species-specific defense responses in laboratory rats are highly influenced by the strain and sex of the subject, and that these factors should be considered in future fear conditioning studies. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882009000200015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882009000200015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.3922/j.psns.2009.2.015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de Janeiro Universidade de Brasília Universidade de São Paulo |
publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de Janeiro Universidade de Brasília Universidade de São Paulo |
dc.source.none.fl_str_mv |
Psychology & Neuroscience v.2 n.2 2009 reponame:Psychology & Neuroscience (Online) instname:Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) instacron:PUCRJ |
instname_str |
Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) |
instacron_str |
PUCRJ |
institution |
PUCRJ |
reponame_str |
Psychology & Neuroscience (Online) |
collection |
Psychology & Neuroscience (Online) |
repository.name.fl_str_mv |
Psychology & Neuroscience (Online) - Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) |
repository.mail.fl_str_mv |
psycneuro@psycneuro.org |
_version_ |
1754821072319938560 |