Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Psychology & Neuroscience (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882009000200017 |
Resumo: | The enhanced availability of tryptophan in the brain, as a consequence of exogenous tryptophan administration, can increase neuronal serotonin synthesis and this can interfere with brain function. REM sleep deprivation (D) constitutes another external factor that can change brain excitability, facilitating, in some cases, the manifestation of neurological diseases like epilepsy. Here we used cortical spreading depression (CSD) as a neurophysiological parameter to investigate the effects of a single L-tryptophan intraperitoneal injection combined or not with 72h D-condition (water-tank technique) in rats. A 1h baseline CSD-recording was performed under urethane+chloralose (1g/kg + 40mg/kg) anesthesia and revealed increased CSD propagation velocities in D rats, as compared with non-deprived (ND), or pseudo-deprived (Pseudo) controls. After the baseline CSD recording, L-tryptophan was immediately injected (125 mg/kg ip, dissolved in water at pH about 3) and this was followed by a significant decrease of CSD propagation velocities, as compared to the baseline values in the same animals of the Pseudo, ND and D condition. In an additional control group (ND rats injected with the vehicle), no CSD propagation change was seen. Our findings indicate an important acute antagonistic influence of tryptophan on CSD propagation, which is not affected by REM sleep deprivation. We suggest that this tryptophan effect may be due to a serotonin-mediated action, probably caused by increased serotonin synthesis as a consequence of enhanced tryptophan availability in the brain. |
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Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult ratsL-tryptophanbrain excitabilitycortical spreading depressionREM-sleep deprivationserotonin systemThe enhanced availability of tryptophan in the brain, as a consequence of exogenous tryptophan administration, can increase neuronal serotonin synthesis and this can interfere with brain function. REM sleep deprivation (D) constitutes another external factor that can change brain excitability, facilitating, in some cases, the manifestation of neurological diseases like epilepsy. Here we used cortical spreading depression (CSD) as a neurophysiological parameter to investigate the effects of a single L-tryptophan intraperitoneal injection combined or not with 72h D-condition (water-tank technique) in rats. A 1h baseline CSD-recording was performed under urethane+chloralose (1g/kg + 40mg/kg) anesthesia and revealed increased CSD propagation velocities in D rats, as compared with non-deprived (ND), or pseudo-deprived (Pseudo) controls. After the baseline CSD recording, L-tryptophan was immediately injected (125 mg/kg ip, dissolved in water at pH about 3) and this was followed by a significant decrease of CSD propagation velocities, as compared to the baseline values in the same animals of the Pseudo, ND and D condition. In an additional control group (ND rats injected with the vehicle), no CSD propagation change was seen. Our findings indicate an important acute antagonistic influence of tryptophan on CSD propagation, which is not affected by REM sleep deprivation. We suggest that this tryptophan effect may be due to a serotonin-mediated action, probably caused by increased serotonin synthesis as a consequence of enhanced tryptophan availability in the brain.Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo2009-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882009000200017Psychology & Neuroscience v.2 n.2 2009reponame:Psychology & Neuroscience (Online)instname:Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)instacron:PUCRJ10.3922/j.psns.2009.2.017info:eu-repo/semantics/openAccessTrindade-Filho,Euclides MauricioVasconcelos,Carlos Augusto Carvalho deGuedes,Rubem Carlos Araújoeng2011-01-17T00:00:00Zoai:scielo:S1983-32882009000200017Revistahttps://www.apa.org/pubs/journals/pnePRIhttps://old.scielo.br/oai/scielo-oai.phppsycneuro@psycneuro.org1983-32881984-3054opendoar:2011-01-17T00:00Psychology & Neuroscience (Online) - Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC)false |
dc.title.none.fl_str_mv |
Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats |
title |
Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats |
spellingShingle |
Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats Trindade-Filho,Euclides Mauricio L-tryptophan brain excitability cortical spreading depression REM-sleep deprivation serotonin system |
title_short |
Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats |
title_full |
Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats |
title_fullStr |
Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats |
title_full_unstemmed |
Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats |
title_sort |
Acute tryptophan administration impairs cortical spreading depression propagation in REM sleep deprived and non-deprived adult rats |
author |
Trindade-Filho,Euclides Mauricio |
author_facet |
Trindade-Filho,Euclides Mauricio Vasconcelos,Carlos Augusto Carvalho de Guedes,Rubem Carlos Araújo |
author_role |
author |
author2 |
Vasconcelos,Carlos Augusto Carvalho de Guedes,Rubem Carlos Araújo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Trindade-Filho,Euclides Mauricio Vasconcelos,Carlos Augusto Carvalho de Guedes,Rubem Carlos Araújo |
dc.subject.por.fl_str_mv |
L-tryptophan brain excitability cortical spreading depression REM-sleep deprivation serotonin system |
topic |
L-tryptophan brain excitability cortical spreading depression REM-sleep deprivation serotonin system |
description |
The enhanced availability of tryptophan in the brain, as a consequence of exogenous tryptophan administration, can increase neuronal serotonin synthesis and this can interfere with brain function. REM sleep deprivation (D) constitutes another external factor that can change brain excitability, facilitating, in some cases, the manifestation of neurological diseases like epilepsy. Here we used cortical spreading depression (CSD) as a neurophysiological parameter to investigate the effects of a single L-tryptophan intraperitoneal injection combined or not with 72h D-condition (water-tank technique) in rats. A 1h baseline CSD-recording was performed under urethane+chloralose (1g/kg + 40mg/kg) anesthesia and revealed increased CSD propagation velocities in D rats, as compared with non-deprived (ND), or pseudo-deprived (Pseudo) controls. After the baseline CSD recording, L-tryptophan was immediately injected (125 mg/kg ip, dissolved in water at pH about 3) and this was followed by a significant decrease of CSD propagation velocities, as compared to the baseline values in the same animals of the Pseudo, ND and D condition. In an additional control group (ND rats injected with the vehicle), no CSD propagation change was seen. Our findings indicate an important acute antagonistic influence of tryptophan on CSD propagation, which is not affected by REM sleep deprivation. We suggest that this tryptophan effect may be due to a serotonin-mediated action, probably caused by increased serotonin synthesis as a consequence of enhanced tryptophan availability in the brain. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882009000200017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-32882009000200017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.3922/j.psns.2009.2.017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de Janeiro Universidade de Brasília Universidade de São Paulo |
publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de Janeiro Universidade de Brasília Universidade de São Paulo |
dc.source.none.fl_str_mv |
Psychology & Neuroscience v.2 n.2 2009 reponame:Psychology & Neuroscience (Online) instname:Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) instacron:PUCRJ |
instname_str |
Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) |
instacron_str |
PUCRJ |
institution |
PUCRJ |
reponame_str |
Psychology & Neuroscience (Online) |
collection |
Psychology & Neuroscience (Online) |
repository.name.fl_str_mv |
Psychology & Neuroscience (Online) - Instituto Brasileiro de Neuropsicologia e Comportamento (IBNeC) |
repository.mail.fl_str_mv |
psycneuro@psycneuro.org |
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1754821072324132864 |