Análise das concentrações salivares de desidroepiandrosterona (DHEA) e de cortisol, escores de depressão, ansiedade e estresse em pacientes com líquen plano oral

• Autor(a) principal: Girardi, Carla
• Data de Publicação: 2010
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Repositório Institucional PUCRS
• Texto Completo: http://hdl.handle.net/10923/436
• topic: ODONTOLOGIA; ESTOMATOLOGIA CLÍNICA; LÍQUEN PLANO BUCAL; DEPRESSÃO; ANSIEDADE; ESTRESSE

Lichen planus is a mucocutaneous disease, immunologicaly mediated by T lymphocytes, which manifests often in the oral mucosa. The mechanism that leads to the development of lesions remains unknown, but there is evidence suggesting the participation of psychological disturbances in the etiopathogenicity of this disease. The aim of this study was to identify the risk factors and salivary biomarkers for oral lichen planus (OLP). An analysis was made of the levels of dehydroepiandrosterone (DHEA) and cortisol, as well as the scores of depression, anxiety and stress in patients with this disease. Thirty-one patients with a histopathologic diagnosis of OLP were selected; they were of both sexes, with ages between 32 and 71 years. These patients were matched by sex and age with 31 control patients who did not present oral lesions. Symptoms of depression, anxiety and stress were investigated by the instruments The Beck Depression Inventory, The Beck Anxiety Inventory and Lipp’s Inventory of Symptoms of Stress for Adults, respectively. Saliva was collected in the morning and at night for determination of the DHEA and cortisol levels by radioimmunoassay. There was no significant difference between the groups with respect to scores of depression (P=0. 832), anxiety (P=0. 061) or stress (P=0. 611), or with respect to morning and night salivary levels of DHEA (P=0. 888, P=0. 297) and cortisol (P=0. 443, P=0. 983). Also, there was no difference between the groups with regard to the cortisol/DHEA ratio in the morning (P=0. 526) and night (P=0. 678) salivary samples. No correlation was observed between the salivary DHEA or cortisol levels and the scores of depression, anxiety and stress in the patients with OLP. In the sample investigated, it can be concluded that there is no association between the psychological variables depression, anxiety and stress with OLP. The levels of cortisol and DHEA or the ratio of these two steroids does not differ between individuals with the disease and controls, and therefore, these parameters cannot be used as salivary biomarkers for OLP.